IL219348A - A method for cleaning colistin - Google Patents
A method for cleaning colistinInfo
- Publication number
- IL219348A IL219348A IL219348A IL21934812A IL219348A IL 219348 A IL219348 A IL 219348A IL 219348 A IL219348 A IL 219348A IL 21934812 A IL21934812 A IL 21934812A IL 219348 A IL219348 A IL 219348A
- Authority
- IL
- Israel
- Prior art keywords
- colistin
- purification
- Prior art date
Links
- 108010078777 Colistin Proteins 0.000 title 1
- 229960003346 colistin Drugs 0.000 title 1
- 238000000034 method Methods 0.000 title 1
- JORAUNFTUVJTNG-BSTBCYLQSA-N n-[(2s)-4-amino-1-[[(2s,3r)-1-[[(2s)-4-amino-1-oxo-1-[[(3s,6s,9s,12s,15r,18s,21s)-6,9,18-tris(2-aminoethyl)-3-[(1r)-1-hydroxyethyl]-12,15-bis(2-methylpropyl)-2,5,8,11,14,17,20-heptaoxo-1,4,7,10,13,16,19-heptazacyclotricos-21-yl]amino]butan-2-yl]amino]-3-h Chemical compound CC(C)CCCCC(=O)N[C@@H](CCN)C(=O)N[C@H]([C@@H](C)O)CN[C@@H](CCN)C(=O)N[C@H]1CCNC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CCN)NC(=O)[C@H](CCN)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](CCN)NC1=O.CCC(C)CCCCC(=O)N[C@@H](CCN)C(=O)N[C@H]([C@@H](C)O)CN[C@@H](CCN)C(=O)N[C@H]1CCNC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CCN)NC(=O)[C@H](CCN)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](CCN)NC1=O JORAUNFTUVJTNG-BSTBCYLQSA-N 0.000 title 1
- XDJYMJULXQKGMM-UHFFFAOYSA-N polymyxin E1 Natural products CCC(C)CCCCC(=O)NC(CCN)C(=O)NC(C(C)O)C(=O)NC(CCN)C(=O)NC1CCNC(=O)C(C(C)O)NC(=O)C(CCN)NC(=O)C(CCN)NC(=O)C(CC(C)C)NC(=O)C(CC(C)C)NC(=O)C(CCN)NC1=O XDJYMJULXQKGMM-UHFFFAOYSA-N 0.000 title 1
- KNIWPHSUTGNZST-UHFFFAOYSA-N polymyxin E2 Natural products CC(C)CCCCC(=O)NC(CCN)C(=O)NC(C(C)O)C(=O)NC(CCN)C(=O)NC1CCNC(=O)C(C(C)O)NC(=O)C(CCN)NC(=O)C(CCN)NC(=O)C(CC(C)C)NC(=O)C(CC(C)C)NC(=O)C(CCN)NC1=O KNIWPHSUTGNZST-UHFFFAOYSA-N 0.000 title 1
- 238000000746 purification Methods 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/50—Cyclic peptides containing at least one abnormal peptide link
- C07K7/54—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring
- C07K7/60—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring the cyclisation occurring through the 4-amino group of 2,4-diamino-butanoic acid
- C07K7/62—Polymyxins; Related peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/14—Extraction; Separation; Purification
- C07K1/16—Extraction; Separation; Purification by chromatography
- C07K1/18—Ion-exchange chromatography
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/14—Extraction; Separation; Purification
- C07K1/16—Extraction; Separation; Purification by chromatography
- C07K1/20—Partition-, reverse-phase or hydrophobic interaction chromatography
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70596—Molecules with a "CD"-designation not provided for elsewhere
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/25—Chemistry: analytical and immunological testing including sample preparation
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/25—Chemistry: analytical and immunological testing including sample preparation
- Y10T436/25375—Liberation or purification of sample or separation of material from a sample [e.g., filtering, centrifuging, etc.]
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Analytical Chemistry (AREA)
- Veterinary Medicine (AREA)
- Cell Biology (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Public Health (AREA)
- Immunology (AREA)
- Toxicology (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US25634409P | 2009-10-30 | 2009-10-30 | |
| PCT/EP2010/064472 WO2011051070A1 (en) | 2009-10-30 | 2010-09-29 | Method for purification of colistin and purified colistin components |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IL219348A0 IL219348A0 (en) | 2012-06-28 |
| IL219348A true IL219348A (en) | 2016-11-30 |
Family
ID=42983681
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL219348A IL219348A (en) | 2009-10-30 | 2012-04-22 | A method for cleaning colistin |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US9005990B2 (enExample) |
| EP (1) | EP2470555B1 (enExample) |
| JP (1) | JP5882219B2 (enExample) |
| KR (1) | KR20120112437A (enExample) |
| CN (1) | CN102596987B (enExample) |
| AU (1) | AU2010311759B2 (enExample) |
| CA (1) | CA2777112A1 (enExample) |
| DK (1) | DK2470555T3 (enExample) |
| ES (1) | ES2532408T3 (enExample) |
| HR (1) | HRP20150283T1 (enExample) |
| IL (1) | IL219348A (enExample) |
| IN (1) | IN2012DN02454A (enExample) |
| PL (1) | PL2470555T3 (enExample) |
| PT (1) | PT2470555E (enExample) |
| SI (1) | SI2470555T1 (enExample) |
| WO (1) | WO2011051070A1 (enExample) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TW201522364A (zh) * | 2013-06-07 | 2015-06-16 | Xellia Pharmaceuticals Aps | 黏菌素甲磺酸鈉（ｃｍｓ）之定性方法 |
| CN103993059B (zh) * | 2014-05-28 | 2016-08-17 | 河北圣雪大成制药有限责任公司 | 优化多粘芽孢杆菌发酵液中e1和e2组分比例的方法 |
| EP3166960B1 (en) * | 2014-07-09 | 2019-08-07 | Xellia Pharmaceuticals ApS | Low substituted polymyxins and compositions thereof |
| ES2721401T3 (es) | 2014-10-03 | 2019-07-31 | Xellia Pharmaceuticals Aps | Dispositivo de inhalación |
| HUE052028T2 (hu) | 2014-10-03 | 2021-04-28 | Xellia Pharmaceuticals Aps | Kompozíciók |
| WO2016166103A1 (en) | 2015-04-13 | 2016-10-20 | Xellia Pharmaceuticals Aps | Polymyxin derivatives |
| CN108226315B (zh) * | 2016-12-15 | 2022-04-12 | 上海医药工业研究院 | 一种检测多黏菌素e残留量的分析方法 |
| PL239311B1 (pl) * | 2018-02-28 | 2021-11-22 | Tarchomińskie Zakłady Farmaceutyczne Polfa Spółka Akcyjna | Sposób izolowania czystego składnika siarczanu polimyksyny E |
| CN115010788B (zh) * | 2022-05-10 | 2024-06-28 | 倪京满 | N-末端脂肪酸修饰的具有抗生物膜活性的低毒广谱抗菌肽类似物及其应用 |
| CN116161962A (zh) * | 2023-02-06 | 2023-05-26 | 中国科学院上海硅酸盐研究所 | 一种具有各向异性电学性能的碳化硅压敏陶瓷及其制备方法 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20907A (en) | 1858-07-13 | Refrigerator | ||
| GR6498B (el) | 1937-05-11 | 1937-05-12 | Ισιδωρος Τρατσης | Συστημα λειτουργιας επι των εξωτερικων παραθυρων δια την προστασιαν εκ της εισοδου των κωνωπων. |
| AU730546B2 (en) * | 1996-11-15 | 2001-03-08 | Pathogenesis Corporation | Pure biologically active colistin, its components and a colistin formulation for treatment of pulmonary infections |
| SE0300612D0 (sv) * | 2003-03-05 | 2003-03-05 | Amersham Biosciences Ab | A method of preparing ligands for hydrophobic interaction chromatography |
| US7413658B2 (en) * | 2003-11-21 | 2008-08-19 | Akzo Nobel N.V. | Separation method |
| WO2005116629A1 (ja) * | 2004-05-26 | 2005-12-08 | Ajinomoto Co., Inc. | アミノ官能性化合物の分析方法及び装置 |
| WO2007071767A1 (en) * | 2005-12-23 | 2007-06-28 | Novo Nordisk Health Care Ag | Purification of vitamin k-dependent polypeptides using preparative reverse phase chromatography (rpc) |
| CN101525377B (zh) * | 2008-03-07 | 2013-04-03 | 上海医药工业研究院 | 一种多黏菌素e甲磺酸钠的分离纯化方法 |
-
2010
- 2010-09-29 IN IN2454DEN2012 patent/IN2012DN02454A/en unknown
- 2010-09-29 ES ES10757791.8T patent/ES2532408T3/es active Active
- 2010-09-29 KR KR1020127014083A patent/KR20120112437A/ko not_active Abandoned
- 2010-09-29 AU AU2010311759A patent/AU2010311759B2/en not_active Ceased
- 2010-09-29 WO PCT/EP2010/064472 patent/WO2011051070A1/en not_active Ceased
- 2010-09-29 PL PL10757791T patent/PL2470555T3/pl unknown
- 2010-09-29 JP JP2012535718A patent/JP5882219B2/ja not_active Expired - Fee Related
- 2010-09-29 CN CN201080049616.8A patent/CN102596987B/zh not_active Expired - Fee Related
- 2010-09-29 PT PT10757791T patent/PT2470555E/pt unknown
- 2010-09-29 DK DK10757791T patent/DK2470555T3/en active
- 2010-09-29 SI SI201030885T patent/SI2470555T1/sl unknown
- 2010-09-29 CA CA2777112A patent/CA2777112A1/en not_active Abandoned
- 2010-09-29 HR HRP20150283AT patent/HRP20150283T1/hr unknown
- 2010-09-29 EP EP10757791.8A patent/EP2470555B1/en active Active
- 2010-09-29 US US13/504,485 patent/US9005990B2/en active Active
-
2012
- 2012-04-22 IL IL219348A patent/IL219348A/en not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| ES2532408T3 (es) | 2015-03-26 |
| US9005990B2 (en) | 2015-04-14 |
| WO2011051070A1 (en) | 2011-05-05 |
| CN102596987B (zh) | 2014-06-25 |
| IN2012DN02454A (enExample) | 2015-08-21 |
| SI2470555T1 (sl) | 2015-04-30 |
| JP2013509365A (ja) | 2013-03-14 |
| US20120208981A1 (en) | 2012-08-16 |
| AU2010311759B2 (en) | 2015-09-24 |
| CA2777112A1 (en) | 2011-05-05 |
| EP2470555A1 (en) | 2012-07-04 |
| KR20120112437A (ko) | 2012-10-11 |
| CN102596987A (zh) | 2012-07-18 |
| JP5882219B2 (ja) | 2016-03-09 |
| AU2010311759A1 (en) | 2012-04-19 |
| EP2470555B1 (en) | 2014-12-24 |
| IL219348A0 (en) | 2012-06-28 |
| HRP20150283T1 (hr) | 2015-04-10 |
| PT2470555E (pt) | 2015-03-23 |
| PL2470555T3 (pl) | 2015-05-29 |
| DK2470555T3 (en) | 2015-04-07 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FF | Patent granted | ||
| MM9K | Patent not in force due to non-payment of renewal fees |