IL216670A - Crystalline form of the sodium salt of pamirolast sodium salt, processes for its preparation and uses - Google Patents

Crystalline form of the sodium salt of pamirolast sodium salt, processes for its preparation and uses

Info

Publication number
IL216670A
IL216670A IL216670A IL21667011A IL216670A IL 216670 A IL216670 A IL 216670A IL 216670 A IL216670 A IL 216670A IL 21667011 A IL21667011 A IL 21667011A IL 216670 A IL216670 A IL 216670A
Authority
IL
Israel
Prior art keywords
pemirolast
preparation
sodium salt
hemihydrate form
crystalline hemihydrate
Prior art date
Application number
IL216670A
Other languages
English (en)
Hebrew (he)
Other versions
IL216670A0 (en
Original Assignee
Cardoz Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cardoz Ab filed Critical Cardoz Ab
Publication of IL216670A0 publication Critical patent/IL216670A0/en
Publication of IL216670A publication Critical patent/IL216670A/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/525—Isoalloxazines, e.g. riboflavins, vitamin B2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Diabetes (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Pulmonology (AREA)
  • Dermatology (AREA)
  • Neurosurgery (AREA)
  • Endocrinology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Emergency Medicine (AREA)
  • Child & Adolescent Psychology (AREA)
  • Immunology (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Reproductive Health (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Secondary Cells (AREA)
  • Dental Preparations (AREA)
IL216670A 2009-06-16 2011-11-29 Crystalline form of the sodium salt of pamirolast sodium salt, processes for its preparation and uses IL216670A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US18734809P 2009-06-16 2009-06-16
US18735509P 2009-06-16 2009-06-16
PCT/GB2010/001168 WO2010146348A2 (en) 2009-06-16 2010-06-15 New crystalline form of pemirolast

Publications (2)

Publication Number Publication Date
IL216670A0 IL216670A0 (en) 2012-02-29
IL216670A true IL216670A (en) 2017-02-28

Family

ID=43264726

Family Applications (1)

Application Number Title Priority Date Filing Date
IL216670A IL216670A (en) 2009-06-16 2011-11-29 Crystalline form of the sodium salt of pamirolast sodium salt, processes for its preparation and uses

Country Status (31)

Country Link
US (3) US20120157415A1 (cg-RX-API-DMAC7.html)
EP (2) EP2443120B1 (cg-RX-API-DMAC7.html)
JP (2) JP5722317B2 (cg-RX-API-DMAC7.html)
KR (2) KR20170049645A (cg-RX-API-DMAC7.html)
CN (1) CN102596202B (cg-RX-API-DMAC7.html)
AR (1) AR077915A1 (cg-RX-API-DMAC7.html)
AU (1) AU2010261540B2 (cg-RX-API-DMAC7.html)
BR (1) BRPI1015559A2 (cg-RX-API-DMAC7.html)
CA (1) CA2765408A1 (cg-RX-API-DMAC7.html)
CY (1) CY1118413T1 (cg-RX-API-DMAC7.html)
DK (1) DK2443120T3 (cg-RX-API-DMAC7.html)
EA (1) EA025865B1 (cg-RX-API-DMAC7.html)
ES (1) ES2613059T3 (cg-RX-API-DMAC7.html)
HR (1) HRP20170023T1 (cg-RX-API-DMAC7.html)
HU (1) HUE032978T2 (cg-RX-API-DMAC7.html)
IL (1) IL216670A (cg-RX-API-DMAC7.html)
LT (1) LT2443120T (cg-RX-API-DMAC7.html)
ME (1) ME02685B (cg-RX-API-DMAC7.html)
MX (1) MX2011013676A (cg-RX-API-DMAC7.html)
NZ (1) NZ596747A (cg-RX-API-DMAC7.html)
PL (1) PL2443120T3 (cg-RX-API-DMAC7.html)
PT (1) PT2443120T (cg-RX-API-DMAC7.html)
RS (1) RS55558B1 (cg-RX-API-DMAC7.html)
SA (1) SA114350792B1 (cg-RX-API-DMAC7.html)
SG (1) SG176295A1 (cg-RX-API-DMAC7.html)
SI (1) SI2443120T1 (cg-RX-API-DMAC7.html)
SM (2) SMT201700085T1 (cg-RX-API-DMAC7.html)
TW (1) TWI504599B (cg-RX-API-DMAC7.html)
UY (1) UY32711A (cg-RX-API-DMAC7.html)
WO (2) WO2010146348A2 (cg-RX-API-DMAC7.html)
ZA (1) ZA201109045B (cg-RX-API-DMAC7.html)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011058331A1 (en) * 2009-11-13 2011-05-19 Cardoz Ab Pemirolast for the treatment of systemic low grade inflammation
EP3978002A1 (en) * 2013-03-09 2022-04-06 Chiesi Farmaceutici S.p.A. Methods of treating, reducing the incidence of, and/or preventing ischemic events
US20160243122A1 (en) 2014-10-23 2016-08-25 Rspr Pharma Ab Use of pemirolast in the treatment of acute asthma
WO2016102941A1 (en) 2014-12-22 2016-06-30 Rspr Pharma Ab New combination of pemirolast and montelukast
GB201518831D0 (en) 2015-10-23 2015-12-09 Rspr Pharma Ab New use
WO2018066427A1 (ja) * 2016-10-03 2018-04-12 株式会社セレステ Ｔｒｈアナログ及びアルンド酸を組み合わせてなる組成物、並びにアルンド酸の薬学的に許容される塩

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4122274A (en) * 1977-05-25 1978-10-24 Bristol-Myers Company 3-Tetrazolo-5,6,7,8-substituted-pyrido[1,2-a]pyrimidin-4-ones
JP2504788B2 (ja) 1987-11-10 1996-06-05 東京田辺製薬株式会社 ９−メチル−３−（１Ｈ−テトラゾ―ル−５−イル）−４Ｈ−ピリド［１，２−ａ］ピリミジン−４−オンカリウム塩の水性製剤
JP2837449B2 (ja) * 1989-08-11 1998-12-16 東京田辺製薬株式会社 ピリド［１，２―ａ］ピリミジン誘導体の製造法
ITMI20011764A1 (it) 2001-08-10 2003-02-10 Dinamite Dipharma Spa Metodo per l'ottenimento del pemirolast ad elevata purezza
CN101263110B (zh) 2005-09-16 2013-04-03 第一三共株式会社 旋光性的二胺衍生物及其制造方法
SI2120919T1 (sl) * 2006-12-18 2012-12-31 Cardoz Ab Nova kombinacija za uporabo pri zdravljenju vnetnih obolenj
CA2673214A1 (en) * 2006-12-20 2008-06-26 Cardoz Ab New combination for use in the treatment of inflammatory disorders

Also Published As

Publication number Publication date
ES2613059T3 (es) 2017-05-22
CA2765408A1 (en) 2010-12-23
JP2015120750A (ja) 2015-07-02
WO2010146348A9 (en) 2012-05-03
SA114350792B1 (ar) 2015-11-10
PT2443120T (pt) 2017-02-08
US20120157415A1 (en) 2012-06-21
ME02685B (me) 2017-06-20
KR20120032530A (ko) 2012-04-05
MX2011013676A (es) 2012-02-08
NZ596747A (en) 2014-01-31
SMT201700085T1 (it) 2017-03-08
US20140329839A1 (en) 2014-11-06
IL216670A0 (en) 2012-02-29
EP3141549A1 (en) 2017-03-15
RS55558B1 (sr) 2017-05-31
WO2010146341A3 (en) 2011-03-03
EA025865B1 (ru) 2017-02-28
PL2443120T3 (pl) 2017-04-28
SG176295A1 (en) 2012-01-30
CN102596202A (zh) 2012-07-18
LT2443120T (lt) 2017-02-10
HRP20170023T1 (hr) 2017-03-10
DK2443120T3 (en) 2017-01-09
US20170202839A1 (en) 2017-07-20
EP2443120B1 (en) 2016-11-02
JP2012530118A (ja) 2012-11-29
WO2010146348A3 (en) 2011-03-03
CN102596202B (zh) 2015-01-21
SMT201700085B (it) 2017-03-08
TWI504599B (zh) 2015-10-21
HUE032978T2 (hu) 2017-11-28
KR20170049645A (ko) 2017-05-10
EA201200017A1 (ru) 2013-10-30
SI2443120T1 (sl) 2017-04-26
JP5722317B2 (ja) 2015-05-20
BRPI1015559A2 (pt) 2016-04-26
TW201100422A (en) 2011-01-01
WO2010146348A2 (en) 2010-12-23
AR077915A1 (es) 2011-10-05
AU2010261540B2 (en) 2016-04-14
EP2443120A2 (en) 2012-04-25
AU2010261540A1 (en) 2012-01-19
UY32711A (es) 2011-01-31
AU2010261540A2 (en) 2012-01-19
ZA201109045B (en) 2013-05-29
CY1118413T1 (el) 2017-06-28
US9006431B2 (en) 2015-04-14
WO2010146341A2 (en) 2010-12-23

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