IL213358A0 - Antibody design using anti-lipid antibody crystal structures - Google Patents

Antibody design using anti-lipid antibody crystal structures

Info

Publication number
IL213358A0
IL213358A0 IL213358A IL21335811A IL213358A0 IL 213358 A0 IL213358 A0 IL 213358A0 IL 213358 A IL213358 A IL 213358A IL 21335811 A IL21335811 A IL 21335811A IL 213358 A0 IL213358 A0 IL 213358A0
Authority
IL
Israel
Prior art keywords
antibody
crystal structures
lipid
design
antibody design
Prior art date
Application number
IL213358A
Other languages
English (en)
Original Assignee
Lpath Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lpath Inc filed Critical Lpath Inc
Publication of IL213358A0 publication Critical patent/IL213358A0/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39591—Stabilisation, fragmentation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2299/00—Coordinates from 3D structures of peptides, e.g. proteins or enzymes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55—Fab or Fab'
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Epidemiology (AREA)
  • Mycology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Microbiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
IL213358A 2008-12-05 2011-06-05 Antibody design using anti-lipid antibody crystal structures IL213358A0 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US12031808P 2008-12-05 2008-12-05
US15589509P 2009-02-26 2009-02-26
US23125809P 2009-08-04 2009-08-04
PCT/US2009/066862 WO2010065921A2 (en) 2008-12-05 2009-12-04 Antibody design using anti-lipid antibody crystal structures

Publications (1)

Publication Number Publication Date
IL213358A0 true IL213358A0 (en) 2011-07-31

Family

ID=42233904

Family Applications (1)

Application Number Title Priority Date Filing Date
IL213358A IL213358A0 (en) 2008-12-05 2011-06-05 Antibody design using anti-lipid antibody crystal structures

Country Status (9)

Country Link
US (1) US20110044990A1 (enExample)
EP (1) EP2374001A4 (enExample)
JP (1) JP2012511026A (enExample)
KR (1) KR20110097923A (enExample)
CN (1) CN102573905A (enExample)
AU (1) AU2009322185A1 (enExample)
CA (1) CA2745436A1 (enExample)
IL (1) IL213358A0 (enExample)
WO (1) WO2010065921A2 (enExample)

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WO2011153416A2 (en) * 2010-06-04 2011-12-08 Lpath, Inc. Novel anti-s1p antibody variants of lt1009
ITRM20100441A1 (it) * 2010-08-05 2012-02-06 Michele Pitaro Procedimento per la produzione di anticorpi monoclonali anti-idiotipo ad uso diagnostico e/o terapeutico
ES2859574T3 (es) * 2012-08-07 2021-10-04 Massachusetts Inst Technology Anticuerpos de antivirus del dengue y usos de los mismos
KR20160119806A (ko) 2014-02-11 2016-10-14 메사추세츠 인스티튜트 오브 테크놀로지 신규한 온전한 범위의 항-뎅기 항체
EP3212173A4 (en) 2014-10-30 2018-06-20 Textile-Based Delivery, Inc. Delivery systems
WO2017107973A1 (zh) * 2015-12-24 2017-06-29 凯惠科技发展(上海)有限公司 一种tpbg抗体及其制备方法、其偶联物和应用
WO2018052131A1 (ja) * 2016-09-16 2018-03-22 国立大学法人大阪大学 免疫実体クラスタリングソフトウェア
US11680110B2 (en) 2017-07-31 2023-06-20 Hoffmann-La Roche Inc. Three-dimensional structure-based humanization method
CN107480360B (zh) * 2017-08-03 2020-04-24 中北大学 光束细分和相界面漫反射的激光烧熔的数值计算方法
CN109837250B (zh) * 2019-01-15 2021-10-12 中国农业科学院兰州兽医研究所 羔羊睾丸支持细胞永生化细胞系及其建立方法和应用

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US6548640B1 (en) * 1986-03-27 2003-04-15 Btg International Limited Altered antibodies
US5567610A (en) * 1986-09-04 1996-10-22 Bioinvent International Ab Method of producing human monoclonal antibodies and kit therefor
JP3101690B2 (ja) * 1987-03-18 2000-10-23 エス・ビィ・２・インコーポレイテッド 変性抗体の、または変性抗体に関する改良
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US5777085A (en) * 1991-12-20 1998-07-07 Protein Design Labs, Inc. Humanized antibodies reactive with GPIIB/IIIA
ATE244763T1 (de) * 1992-02-11 2003-07-15 Cell Genesys Inc Erzielen von homozygotem durch zielgerichtete genetische ereignisse
US5714350A (en) * 1992-03-09 1998-02-03 Protein Design Labs, Inc. Increasing antibody affinity by altering glycosylation in the immunoglobulin variable region
US6129914A (en) * 1992-03-27 2000-10-10 Protein Design Labs, Inc. Bispecific antibody effective to treat B-cell lymphoma and cell line
US5573905A (en) * 1992-03-30 1996-11-12 The Scripps Research Institute Encoded combinatorial chemical libraries
GB9223377D0 (en) * 1992-11-04 1992-12-23 Medarex Inc Humanized antibodies to fc receptors for immunoglobulin on human mononuclear phagocytes
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US6096871A (en) * 1995-04-14 2000-08-01 Genentech, Inc. Polypeptides altered to contain an epitope from the Fc region of an IgG molecule for increased half-life
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AU2006294870B2 (en) * 2005-09-23 2011-08-04 WRAIR, a U.S Army Research institution under the United States Government, as represented by the Secretary of the Army Antibodies with simultaneous subsite specificities to protein and lipid epitopes
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CN101687031B (zh) * 2006-10-27 2014-05-14 勒帕斯公司 用于治疗眼疾和眼病的组合物及方法
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Also Published As

Publication number Publication date
CA2745436A1 (en) 2010-06-10
EP2374001A4 (en) 2013-03-13
JP2012511026A (ja) 2012-05-17
WO2010065921A2 (en) 2010-06-10
AU2009322185A1 (en) 2011-07-21
WO2010065921A3 (en) 2011-12-29
EP2374001A2 (en) 2011-10-12
KR20110097923A (ko) 2011-08-31
US20110044990A1 (en) 2011-02-24
CN102573905A (zh) 2012-07-11

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