KR20110097923A - 항-지질 항체 결정 구조를 이용한 항체 설계 - Google Patents

항-지질 항체 결정 구조를 이용한 항체 설계 Download PDF

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Publication number
KR20110097923A
KR20110097923A KR1020117015390A KR20117015390A KR20110097923A KR 20110097923 A KR20110097923 A KR 20110097923A KR 1020117015390 A KR1020117015390 A KR 1020117015390A KR 20117015390 A KR20117015390 A KR 20117015390A KR 20110097923 A KR20110097923 A KR 20110097923A
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KR
South Korea
Prior art keywords
antibody
lipid
antibodies
amino acid
optionally
Prior art date
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Withdrawn
Application number
KR1020117015390A
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English (en)
Korean (ko)
Inventor
로저 에이. 삽바디니
조나단 마이클 오즈시아크
톰 헉스포드
Original Assignee
엘파스, 인크.
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Application filed by 엘파스, 인크. filed Critical 엘파스, 인크.
Publication of KR20110097923A publication Critical patent/KR20110097923A/ko
Withdrawn legal-status Critical Current

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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/395Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39591Stabilisation, fragmentation
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/505Medicinal preparations containing antigens or antibodies comprising antibodies
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2299/00Coordinates from 3D structures of peptides, e.g. proteins or enzymes
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/20Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55Fab or Fab'
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565Complementarity determining region [CDR]
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/90Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Epidemiology (AREA)
  • Mycology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Microbiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
KR1020117015390A 2008-12-05 2009-12-04 항-지질 항체 결정 구조를 이용한 항체 설계 Withdrawn KR20110097923A (ko)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US12031808P 2008-12-05 2008-12-05
US61/120,318 2008-12-05
US15589509P 2009-02-26 2009-02-26
US61/155,895 2009-02-26
US23125809P 2009-08-04 2009-08-04
US61/231,258 2009-08-04

Publications (1)

Publication Number Publication Date
KR20110097923A true KR20110097923A (ko) 2011-08-31

Family

ID=42233904

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020117015390A Withdrawn KR20110097923A (ko) 2008-12-05 2009-12-04 항-지질 항체 결정 구조를 이용한 항체 설계

Country Status (9)

Country Link
US (1) US20110044990A1 (enExample)
EP (1) EP2374001A4 (enExample)
JP (1) JP2012511026A (enExample)
KR (1) KR20110097923A (enExample)
CN (1) CN102573905A (enExample)
AU (1) AU2009322185A1 (enExample)
CA (1) CA2745436A1 (enExample)
IL (1) IL213358A0 (enExample)
WO (1) WO2010065921A2 (enExample)

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WO2011153416A2 (en) * 2010-06-04 2011-12-08 Lpath, Inc. Novel anti-s1p antibody variants of lt1009
ITRM20100441A1 (it) * 2010-08-05 2012-02-06 Michele Pitaro Procedimento per la produzione di anticorpi monoclonali anti-idiotipo ad uso diagnostico e/o terapeutico
BR112015002605B1 (pt) 2012-08-07 2023-03-07 Massachusetts Institute Of Technology Agente de anticorpo específico para o vírus da dengue, seu uso, kit, composição farmacêutica e método para sua produção
EP3104888A4 (en) 2014-02-11 2017-08-09 Massachusetts Institute Of Technology Novel full spectrum anti-dengue antibody
CA3003397A1 (en) 2014-10-30 2016-05-06 Textile-Based Delivery, Inc. Delivery systems
CN106916227B (zh) * 2015-12-24 2019-12-13 凯惠科技发展(上海)有限公司 一种tpbg抗体及其制备方法、其偶联物和应用
JP6778932B2 (ja) * 2016-09-16 2020-11-04 国立大学法人大阪大学 免疫実体クラスタリングソフトウェア
EP3625254B1 (en) 2017-07-31 2023-12-13 F. Hoffmann-La Roche AG Three-dimensional structure-based humanization method
CN107480360B (zh) * 2017-08-03 2020-04-24 中北大学 光束细分和相界面漫反射的激光烧熔的数值计算方法
CN109837250B (zh) * 2019-01-15 2021-10-12 中国农业科学院兰州兽医研究所 羔羊睾丸支持细胞永生化细胞系及其建立方法和应用

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US6548640B1 (en) * 1986-03-27 2003-04-15 Btg International Limited Altered antibodies
US5567610A (en) * 1986-09-04 1996-10-22 Bioinvent International Ab Method of producing human monoclonal antibodies and kit therefor
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Also Published As

Publication number Publication date
WO2010065921A2 (en) 2010-06-10
JP2012511026A (ja) 2012-05-17
US20110044990A1 (en) 2011-02-24
WO2010065921A3 (en) 2011-12-29
EP2374001A4 (en) 2013-03-13
CA2745436A1 (en) 2010-06-10
EP2374001A2 (en) 2011-10-12
CN102573905A (zh) 2012-07-11
IL213358A0 (en) 2011-07-31
AU2009322185A1 (en) 2011-07-21

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Legal Events

Date Code Title Description
PA0105 International application

Patent event date: 20110704

Patent event code: PA01051R01D

Comment text: International Patent Application

PG1501 Laying open of application
PC1203 Withdrawal of no request for examination
WITN Application deemed withdrawn, e.g. because no request for examination was filed or no examination fee was paid