IL207032A - Synthetic phosphodiester oligonucleotides and their medical uses - Google Patents
Synthetic phosphodiester oligonucleotides and their medical usesInfo
- Publication number
- IL207032A IL207032A IL207032A IL20703210A IL207032A IL 207032 A IL207032 A IL 207032A IL 207032 A IL207032 A IL 207032A IL 20703210 A IL20703210 A IL 20703210A IL 207032 A IL207032 A IL 207032A
- Authority
- IL
- Israel
- Prior art keywords
- therapeutical uses
- phosphodiester oligonucleotides
- synthetic phosphodiester
- synthetic
- oligonucleotides
- Prior art date
Links
- 108091034117 Oligonucleotide Proteins 0.000 title 1
- JLCPHMBAVCMARE-UHFFFAOYSA-N [3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-hydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methyl [5-(6-aminopurin-9-yl)-2-(hydroxymethyl)oxolan-3-yl] hydrogen phosphate Polymers Cc1cn(C2CC(OP(O)(=O)OCC3OC(CC3OP(O)(=O)OCC3OC(CC3O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c3nc(N)[nH]c4=O)C(COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3CO)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cc(C)c(=O)[nH]c3=O)n3cc(C)c(=O)[nH]c3=O)n3ccc(N)nc3=O)n3cc(C)c(=O)[nH]c3=O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)O2)c(=O)[nH]c1=O JLCPHMBAVCMARE-UHFFFAOYSA-N 0.000 title 1
- 150000004713 phosphodiesters Chemical class 0.000 title 1
- 230000001225 therapeutic effect Effects 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/117—Nucleic acids having immunomodulatory properties, e.g. containing CpG-motifs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/17—Immunomodulatory nucleic acids
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2320/00—Applications; Uses
- C12N2320/30—Special therapeutic applications
- C12N2320/31—Combination therapy
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Biomedical Technology (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Molecular Biology (AREA)
- General Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Biotechnology (AREA)
- Zoology (AREA)
- Heart & Thoracic Surgery (AREA)
- Immunology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Cardiology (AREA)
- Plant Pathology (AREA)
- Physics & Mathematics (AREA)
- Microbiology (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP08425175A EP2103689A1 (en) | 2008-03-19 | 2008-03-19 | Synthetic phosphodiester oligonucleotides and therapeutical uses thereof |
| US5108808P | 2008-05-07 | 2008-05-07 | |
| PCT/EP2009/053002 WO2009115465A1 (en) | 2008-03-19 | 2009-03-13 | Synthetic phosphodiester oligonucleotides and therapeutical uses thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IL207032A0 IL207032A0 (en) | 2010-12-30 |
| IL207032A true IL207032A (en) | 2016-08-31 |
Family
ID=39683815
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL207032A IL207032A (en) | 2008-03-19 | 2010-07-15 | Synthetic phosphodiester oligonucleotides and their medical uses |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US20110092576A1 (https=) |
| EP (2) | EP2103689A1 (https=) |
| JP (1) | JP2011515357A (https=) |
| KR (1) | KR20100124820A (https=) |
| CN (2) | CN101978059A (https=) |
| AU (1) | AU2009226906B2 (https=) |
| CA (1) | CA2712705C (https=) |
| DK (1) | DK2252688T3 (https=) |
| ES (1) | ES2647772T3 (https=) |
| IL (1) | IL207032A (https=) |
| WO (1) | WO2009115465A1 (https=) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2010363814B2 (en) | 2010-11-12 | 2016-05-19 | Gentium S.R.L. | Defibrotide for use in prophylaxis and/or treatment of Graft versus Host Disease (GVHD). |
| CN110079580B (zh) | 2012-06-22 | 2022-12-06 | 真蒂奥姆责任有限公司 | 用于测定去纤维蛋白多核苷酸的生物活性的基于优球蛋白的方法 |
| EP3026122A1 (en) | 2014-11-27 | 2016-06-01 | Gentium S.p.A. | Cellular-based method for determining the potency of defibrotide |
| JP2020530004A (ja) | 2017-08-03 | 2020-10-15 | ジャズ ファーマシューティカルズ アイルランド リミテッド | 核酸を高濃度で含む製剤 |
| CN112236149A (zh) | 2018-04-12 | 2021-01-15 | 贾兹制药公司 | 用于预防和治疗细胞因子释放综合征和与免疫耗竭相关的神经毒性的去纤苷 |
| WO2020118165A1 (en) | 2018-12-07 | 2020-06-11 | Jazz Pharmaceuticals Ireland Limited | Subcutaneous delivery of high concentration formulations |
| EP4110287A1 (en) | 2020-02-28 | 2023-01-04 | Jazz Pharmaceuticals Ireland Limited | Delivery of low viscosity formulations |
| US20230086833A1 (en) | 2020-04-17 | 2023-03-23 | Jazz Pharmaceuticals Ireland Limited | Defibrotide treatment for the prevention of organ rejection and injury |
| TW202308659A (zh) | 2021-05-06 | 2023-03-01 | 愛爾蘭商爵士製藥愛爾蘭有限責任公司 | 用於急性呼吸窘迫症候群之治療及預防的去纖維蛋白多核苷酸 |
Family Cites Families (41)
| Publication number | Priority date | Publication date | Assignee | Title |
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| US178761A (en) * | 1876-06-13 | Improvement in refrigerating-cans | ||
| US1325962A (en) * | 1919-12-23 | Geared lifting-jack | ||
| US2006A (en) * | 1841-03-16 | Clamp for crimping leather | ||
| US876235A (en) * | 1904-11-07 | 1908-01-07 | Leonard G Quackenboss | Adjustable flower-box. |
| US1276497A (en) * | 1917-07-18 | 1918-08-20 | Wencel H Kirchman | Dirigible balloon. |
| IT1043823B (it) | 1970-11-03 | 1980-02-29 | Prephar | Procedimento per l estrazione di acidi nucleici da organi animali |
| US3899481A (en) | 1970-11-03 | 1975-08-12 | Crinos Industria Farmaco | Process for the controlled partial degradation of deoxyribonucleic acid extracted from animal organs |
| DE2154279A1 (de) | 1970-11-03 | 1972-05-25 | Crinos Industria Farmaco | Medikamente für das fibrinolytische System |
| US4853221A (en) * | 1980-11-13 | 1989-08-01 | Warner-Lambert Company | Method for treating non-small cell lung cancer, head and neck cancers and breast cancer |
| IT1170215B (it) * | 1983-09-12 | 1987-06-03 | Crinos Industria Farmaco | Composizione farmaceutica per il trattamento di stati di insufficienza renale acuta |
| IT1170214B (it) | 1983-09-12 | 1987-06-03 | Crinos Industria Farmaco | Composizione farmaceutica per la cura delle arteriopatie periferiche |
| IT1206341B (it) | 1984-02-16 | 1989-04-14 | Crinos Industria Farmaco | Composizione farmaceutica per il trattamento dell'ischemia acuta del miocardio. |
| US4694134A (en) | 1985-05-28 | 1987-09-15 | Ajax Magnethermic Corporation | Apparatus for overheating edges of skelp for the production of compression welded pipe |
| US5223609A (en) | 1986-04-17 | 1993-06-29 | Crinos Industria Farmacobiologica S.P.A. | Process for obtaining chemically defined and reproducible polydeoxyribonucleotides |
| IT1190313B (it) | 1986-04-17 | 1988-02-16 | Crinos Industria Farmaco | Procedimento per l'ottenimento di polidesossiribonucleotidi chimicamente definiti e riproducibili e prodotto farmacologicamente attivo risultante |
| US4753221A (en) * | 1986-10-22 | 1988-06-28 | Intravascular Surgical Instruments, Inc. | Blood pumping catheter and method of use |
| IT1231509B (it) | 1989-09-07 | 1991-12-07 | Crinos Industria Farmaco | Composizione farmceutica ad uso topico per la terapia della fragilita' capillare. |
| US5166617A (en) * | 1991-01-11 | 1992-11-24 | Varian Associates, Inc. | High power NMR probe |
| US5977083A (en) | 1991-08-21 | 1999-11-02 | Burcoglu; Arsinur | Method for using polynucleotides, oligonucleotides and derivatives thereof to treat various disease states |
| US6699985B2 (en) | 1991-08-21 | 2004-03-02 | Arsinur Burcoglu | Method of treating HIV infection and related secondary infections thereof |
| US5624912A (en) | 1991-08-21 | 1997-04-29 | Burcoglu; Arsinur | Method of treating HIV infection and related secondary infections with defibrotide |
| IT1252174B (it) * | 1991-12-09 | 1995-06-05 | Crinos Industria Farmaco | Oligodesossimibonucleotidi ad attivita' antiischemica e procedimenti per il loro ottenimento |
| US5578716A (en) * | 1993-12-01 | 1996-11-26 | Mcgill University | DNA methyltransferase antisense oligonucleotides |
| US5856444A (en) * | 1994-11-30 | 1999-01-05 | Chugai Seiyaku Kabushiki Kaisha | Thrombocytopoiesis stimulating factor |
| US6573372B2 (en) * | 1999-01-07 | 2003-06-03 | Heska Corporation | Feline immunoglobulin E molecules and compositions there of |
| ATE311907T1 (de) * | 1999-06-08 | 2005-12-15 | Gentium Spa | Anwendung von komplexen von kationischen liposomen und polydeoxyribonukleotiden wie arzneimitteln |
| EP1147777A1 (en) * | 2000-04-18 | 2001-10-24 | Crinos Industria Farmacobiologica S.p.A. | Combination of defibrotide and G-CSF and its use to activate haematopoietic progenitors |
| DE10046547A1 (de) | 2000-09-19 | 2002-03-28 | Innovat Ges Fuer Sondermaschb | Vorrichtung zum induktiven Aufheizen von Werkstücken |
| CA2426540A1 (en) * | 2000-10-20 | 2002-07-25 | Biocardia, Inc. | Leukocyte expression profiling |
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| US7514414B2 (en) * | 2001-09-24 | 2009-04-07 | The United States Of America As Represented By The Department Of Health And Human Services | Suppressors of CpG oligonucleotides and methods of use |
| US6965025B2 (en) * | 2001-12-10 | 2005-11-15 | Isis Pharmaceuticals, Inc. | Antisense modulation of connective tissue growth factor expression |
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| US20050215498A1 (en) * | 2002-05-31 | 2005-09-29 | Guenther Eissner | Method for the protection of endothelial and epithclial cells during chemotherapy |
| US20050196382A1 (en) * | 2002-09-13 | 2005-09-08 | Replicor, Inc. | Antiviral oligonucleotides targeting viral families |
| US7301265B2 (en) * | 2003-05-22 | 2007-11-27 | Seiko Epson Corporation | Light source unit, method of manufacturing light source unit, and projector |
| ITMI20031714A1 (it) | 2003-09-05 | 2005-03-06 | Gentium Spa | Formazioni ad azione antitumorale. |
| US7138558B2 (en) * | 2004-11-01 | 2006-11-21 | Uop Llc | Direct return of oxygenate recycle stream in olefin production process |
| WO2006094916A1 (en) | 2005-03-03 | 2006-09-14 | Gentium Spa | Defibrotide and/or oligodeoxyribonucleotides for treating angiogenesis-dependent tumors |
| WO2006119619A1 (en) * | 2005-05-06 | 2006-11-16 | Replicor Inc. | Oligonucleotides inhibiting cell proliferation |
| GB2462413B (en) * | 2008-08-04 | 2011-03-02 | Rolls Royce Plc | An actuator arrangement |
-
2008
- 2008-03-19 EP EP08425175A patent/EP2103689A1/en not_active Withdrawn
-
2009
- 2009-03-13 CN CN2009801097251A patent/CN101978059A/zh active Pending
- 2009-03-13 EP EP09721382.1A patent/EP2252688B1/en active Active
- 2009-03-13 DK DK09721382.1T patent/DK2252688T3/da active
- 2009-03-13 WO PCT/EP2009/053002 patent/WO2009115465A1/en not_active Ceased
- 2009-03-13 AU AU2009226906A patent/AU2009226906B2/en not_active Ceased
- 2009-03-13 JP JP2011500164A patent/JP2011515357A/ja active Pending
- 2009-03-13 CA CA2712705A patent/CA2712705C/en active Active
- 2009-03-13 CN CN201610647404.9A patent/CN106361763A/zh active Pending
- 2009-03-13 US US12/919,605 patent/US20110092576A1/en not_active Abandoned
- 2009-03-13 ES ES09721382.1T patent/ES2647772T3/es active Active
- 2009-03-13 KR KR1020107023194A patent/KR20100124820A/ko not_active Ceased
-
2010
- 2010-07-15 IL IL207032A patent/IL207032A/en active IP Right Grant
Also Published As
| Publication number | Publication date |
|---|---|
| CA2712705C (en) | 2017-08-15 |
| CN101978059A (zh) | 2011-02-16 |
| DK2252688T3 (da) | 2017-11-13 |
| EP2103689A1 (en) | 2009-09-23 |
| EP2252688B1 (en) | 2017-08-16 |
| ES2647772T3 (es) | 2017-12-26 |
| AU2009226906A1 (en) | 2009-09-24 |
| CN106361763A (zh) | 2017-02-01 |
| AU2009226906B2 (en) | 2015-05-07 |
| IL207032A0 (en) | 2010-12-30 |
| KR20100124820A (ko) | 2010-11-29 |
| CA2712705A1 (en) | 2009-09-24 |
| EP2252688A1 (en) | 2010-11-24 |
| JP2011515357A (ja) | 2011-05-19 |
| WO2009115465A1 (en) | 2009-09-24 |
| US20110092576A1 (en) | 2011-04-21 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FF | Patent granted | ||
| KB | Patent renewed | ||
| KB | Patent renewed |