IL200192A - Use of l-cannitin and / or alkonial l-carnitine, or their common pharmaceutical salt, in combination with statin, for the preparation of a drug for the treatment of type 2 diabetes - Google Patents

Use of l-cannitin and / or alkonial l-carnitine, or their common pharmaceutical salt, in combination with statin, for the preparation of a drug for the treatment of type 2 diabetes

Info

Publication number
IL200192A
IL200192A IL200192A IL20019209A IL200192A IL 200192 A IL200192 A IL 200192A IL 200192 A IL200192 A IL 200192A IL 20019209 A IL20019209 A IL 20019209A IL 200192 A IL200192 A IL 200192A
Authority
IL
Israel
Prior art keywords
carnitine
statin
alkanoyl
diabetes
medicament
Prior art date
Application number
IL200192A
Other languages
English (en)
Hebrew (he)
Other versions
IL200192A0 (en
Original Assignee
Sigma Tau Ind Farmaceuti
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sigma Tau Ind Farmaceuti filed Critical Sigma Tau Ind Farmaceuti
Publication of IL200192A0 publication Critical patent/IL200192A0/en
Publication of IL200192A publication Critical patent/IL200192A/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/205—Amine addition salts of organic acids; Inner quaternary ammonium salts, e.g. betaine, carnitine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/365—Lactones
    • A61K31/366—Lactones having six-membered rings, e.g. delta-lactones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
    • A61K31/225—Polycarboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A61K31/405—Indole-alkanecarboxylic acids; Derivatives thereof, e.g. tryptophan, indomethacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers

Landscapes

  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Emergency Medicine (AREA)
  • Diabetes (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Endocrinology (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Reproductive Health (AREA)
  • Child & Adolescent Psychology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
IL200192A 2007-02-27 2009-07-30 Use of l-cannitin and / or alkonial l-carnitine, or their common pharmaceutical salt, in combination with statin, for the preparation of a drug for the treatment of type 2 diabetes IL200192A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP07103137 2007-02-27
PCT/EP2007/062545 WO2008104239A1 (en) 2007-02-27 2007-11-20 Composition useful for the treatment of type 2 diabetes

Publications (2)

Publication Number Publication Date
IL200192A0 IL200192A0 (en) 2010-04-15
IL200192A true IL200192A (en) 2015-06-30

Family

ID=38093451

Family Applications (1)

Application Number Title Priority Date Filing Date
IL200192A IL200192A (en) 2007-02-27 2009-07-30 Use of l-cannitin and / or alkonial l-carnitine, or their common pharmaceutical salt, in combination with statin, for the preparation of a drug for the treatment of type 2 diabetes

Country Status (16)

Country Link
US (2) US20100029759A1 (enExample)
EP (1) EP2124925B1 (enExample)
JP (2) JP5697337B2 (enExample)
KR (1) KR101699430B1 (enExample)
CN (1) CN101616665B (enExample)
AU (1) AU2007348123B2 (enExample)
BR (1) BRPI0721333A8 (enExample)
CA (1) CA2678746C (enExample)
EA (1) EA016855B1 (enExample)
ES (1) ES2676529T3 (enExample)
IL (1) IL200192A (enExample)
MX (1) MX2009008873A (enExample)
PL (1) PL2124925T3 (enExample)
PT (1) PT2124925T (enExample)
SG (1) SG177993A1 (enExample)
WO (1) WO2008104239A1 (enExample)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008104239A1 (en) * 2007-02-27 2008-09-04 Sigma-Tau Industrie Farmaceutiche Riunite S.P.A. Composition useful for the treatment of type 2 diabetes
US20240342181A1 (en) * 2023-04-12 2024-10-17 Xygenyx Inc. Composition and methods of treatment using synergistically - enhanced supplementation

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1263004B (it) * 1992-10-08 1996-07-23 Sigma Tau Ind Farmaceuti Impiego della l-carnitina e acil l-carnitine nel trattamento a lungo termine di pazienti diabetici non insulino-dipendenti.
IT1293067B1 (it) * 1997-07-01 1999-02-11 Sigma Tau Ind Farmaceuti Composizione farmaceutica per il trattamento di patologie causate da alterato metabolismo lipidico
US20020061301A1 (en) * 1998-05-15 2002-05-23 Olga Bandman Human carbohydrate metabolism enzymes
US6245800B1 (en) * 1999-06-08 2001-06-12 Sigma-Tau Method of preventing or treating statin-induced toxic effects using L-carnitine or an alkanoyl L-carnitine
PL197899B1 (pl) * 1999-06-08 2008-05-30 Sigma Tau Ind Farmaceuti Zastosowanie przeciwlipemiczne środka zawierającego statyny i karnityny
US20080102138A1 (en) * 2006-06-21 2008-05-01 Bieley Harlan C Replacement of Vitamins, Minerals and Neurotransmitter Losses from Tobacco Smoking
WO2008104239A1 (en) * 2007-02-27 2008-09-04 Sigma-Tau Industrie Farmaceutiche Riunite S.P.A. Composition useful for the treatment of type 2 diabetes

Also Published As

Publication number Publication date
EP2124925A1 (en) 2009-12-02
BRPI0721333A2 (pt) 2014-02-25
EP2124925B1 (en) 2018-06-27
PL2124925T3 (pl) 2018-09-28
BRPI0721333A8 (pt) 2017-12-26
CN101616665A (zh) 2009-12-30
US20150045424A1 (en) 2015-02-12
JP5697337B2 (ja) 2015-04-08
MX2009008873A (es) 2009-08-28
CN101616665B (zh) 2013-03-27
JP2010519333A (ja) 2010-06-03
EA200970798A1 (ru) 2010-04-30
KR101699430B1 (ko) 2017-01-24
SG177993A1 (en) 2012-02-28
IL200192A0 (en) 2010-04-15
WO2008104239A1 (en) 2008-09-04
US20100029759A1 (en) 2010-02-04
ES2676529T3 (es) 2018-07-20
AU2007348123B2 (en) 2013-01-17
CA2678746A1 (en) 2008-09-04
JP2014040442A (ja) 2014-03-06
PT2124925T (pt) 2018-07-12
EA016855B1 (ru) 2012-08-30
AU2007348123A1 (en) 2008-09-04
KR20090115939A (ko) 2009-11-10
CA2678746C (en) 2018-05-01
HK1135030A1 (en) 2010-05-28

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