EA016855B1 - Применение l-карнитина и/или алканоил l-карнитина в комбинации со статином для лечения диабета 2 типа - Google Patents
Применение l-карнитина и/или алканоил l-карнитина в комбинации со статином для лечения диабета 2 типа Download PDFInfo
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- EA016855B1 EA016855B1 EA200970798A EA200970798A EA016855B1 EA 016855 B1 EA016855 B1 EA 016855B1 EA 200970798 A EA200970798 A EA 200970798A EA 200970798 A EA200970798 A EA 200970798A EA 016855 B1 EA016855 B1 EA 016855B1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- carnitine
- acid
- diabetes
- day
- use according
- Prior art date
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Classifications
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/205—Amine addition salts of organic acids; Inner quaternary ammonium salts, e.g. betaine, carnitine
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/365—Lactones
- A61K31/366—Lactones having six-membered rings, e.g. delta-lactones
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
- A61K31/225—Polycarboxylic acids
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- A—HUMAN NECESSITIES
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
- A61K31/405—Indole-alkanecarboxylic acids; Derivatives thereof, e.g. tryptophan, indomethacin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P13/12—Drugs for disorders of the urinary system of the kidneys
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A—HUMAN NECESSITIES
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- A61P3/06—Antihyperlipidemics
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- A—HUMAN NECESSITIES
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- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
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- A61P9/00—Drugs for disorders of the cardiovascular system
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- A—HUMAN NECESSITIES
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- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- A—HUMAN NECESSITIES
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- A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
Landscapes
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Emergency Medicine (AREA)
- Diabetes (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Endocrinology (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Child & Adolescent Psychology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Ophthalmology & Optometry (AREA)
- Reproductive Health (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP07103137 | 2007-02-27 | ||
| PCT/EP2007/062545 WO2008104239A1 (en) | 2007-02-27 | 2007-11-20 | Composition useful for the treatment of type 2 diabetes |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| EA200970798A1 EA200970798A1 (ru) | 2010-04-30 |
| EA016855B1 true EA016855B1 (ru) | 2012-08-30 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EA200970798A EA016855B1 (ru) | 2007-02-27 | 2007-11-20 | Применение l-карнитина и/или алканоил l-карнитина в комбинации со статином для лечения диабета 2 типа |
Country Status (16)
| Country | Link |
|---|---|
| US (2) | US20100029759A1 (enExample) |
| EP (1) | EP2124925B1 (enExample) |
| JP (2) | JP5697337B2 (enExample) |
| KR (1) | KR101699430B1 (enExample) |
| CN (1) | CN101616665B (enExample) |
| AU (1) | AU2007348123B2 (enExample) |
| BR (1) | BRPI0721333A8 (enExample) |
| CA (1) | CA2678746C (enExample) |
| EA (1) | EA016855B1 (enExample) |
| ES (1) | ES2676529T3 (enExample) |
| IL (1) | IL200192A (enExample) |
| MX (1) | MX2009008873A (enExample) |
| PL (1) | PL2124925T3 (enExample) |
| PT (1) | PT2124925T (enExample) |
| SG (1) | SG177993A1 (enExample) |
| WO (1) | WO2008104239A1 (enExample) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2008104239A1 (en) * | 2007-02-27 | 2008-09-04 | Sigma-Tau Industrie Farmaceutiche Riunite S.P.A. | Composition useful for the treatment of type 2 diabetes |
| US12697339B2 (en) * | 2023-04-12 | 2026-08-04 | Xygenyx Inc. | Composition and methods of treatment using synergistically-enhanced supplementation |
| KR20260004765A (ko) * | 2024-07-02 | 2026-01-09 | 건국대학교 글로컬산학협력단 | 스타틴이 결합된 담즙산을 포함하는 대사성 질환의 예방 또는 치료용 약학적 조성물 및 이의 제조방법 |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2000074675A1 (en) * | 1999-06-08 | 2000-12-14 | Sigma-Tau Industrie Farmaceutiche S.P.A. | Antilipemic combinations comprising hmg-coa reductase inhibitors and carnitines |
| US6245800B1 (en) * | 1999-06-08 | 2001-06-12 | Sigma-Tau | Method of preventing or treating statin-induced toxic effects using L-carnitine or an alkanoyl L-carnitine |
| EP1623708A2 (en) * | 1997-07-01 | 2006-02-08 | Sigma-Tau Industrie Farmaceutiche Riunite S.p.A. | Pharmaceutical composition comprising acetyl L-carnitine in combination with a statine for treating pathologies brought about by an altered lipid metabolism |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT1263004B (it) * | 1992-10-08 | 1996-07-23 | Sigma Tau Ind Farmaceuti | Impiego della l-carnitina e acil l-carnitine nel trattamento a lungo termine di pazienti diabetici non insulino-dipendenti. |
| US20020061301A1 (en) * | 1998-05-15 | 2002-05-23 | Olga Bandman | Human carbohydrate metabolism enzymes |
| US20080102138A1 (en) * | 2006-06-21 | 2008-05-01 | Bieley Harlan C | Replacement of Vitamins, Minerals and Neurotransmitter Losses from Tobacco Smoking |
| WO2008104239A1 (en) * | 2007-02-27 | 2008-09-04 | Sigma-Tau Industrie Farmaceutiche Riunite S.P.A. | Composition useful for the treatment of type 2 diabetes |
-
2007
- 2007-11-20 WO PCT/EP2007/062545 patent/WO2008104239A1/en not_active Ceased
- 2007-11-20 MX MX2009008873A patent/MX2009008873A/es active IP Right Grant
- 2007-11-20 CN CN2007800518413A patent/CN101616665B/zh not_active Expired - Fee Related
- 2007-11-20 EA EA200970798A patent/EA016855B1/ru unknown
- 2007-11-20 AU AU2007348123A patent/AU2007348123B2/en not_active Ceased
- 2007-11-20 EP EP07847224.8A patent/EP2124925B1/en active Active
- 2007-11-20 PT PT78472248T patent/PT2124925T/pt unknown
- 2007-11-20 ES ES07847224.8T patent/ES2676529T3/es active Active
- 2007-11-20 PL PL07847224T patent/PL2124925T3/pl unknown
- 2007-11-20 KR KR1020097017062A patent/KR101699430B1/ko not_active Expired - Fee Related
- 2007-11-20 SG SG2012003844A patent/SG177993A1/en unknown
- 2007-11-20 JP JP2009551926A patent/JP5697337B2/ja not_active Expired - Fee Related
- 2007-11-20 CA CA2678746A patent/CA2678746C/en active Active
- 2007-11-20 US US12/526,718 patent/US20100029759A1/en not_active Abandoned
- 2007-11-20 BR BRPI0721333A patent/BRPI0721333A8/pt not_active Application Discontinuation
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2009
- 2009-07-30 IL IL200192A patent/IL200192A/en active IP Right Grant
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2013
- 2013-09-27 JP JP2013201985A patent/JP2014040442A/ja active Pending
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2014
- 2014-10-28 US US14/526,076 patent/US20150045424A1/en not_active Abandoned
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1623708A2 (en) * | 1997-07-01 | 2006-02-08 | Sigma-Tau Industrie Farmaceutiche Riunite S.p.A. | Pharmaceutical composition comprising acetyl L-carnitine in combination with a statine for treating pathologies brought about by an altered lipid metabolism |
| WO2000074675A1 (en) * | 1999-06-08 | 2000-12-14 | Sigma-Tau Industrie Farmaceutiche S.P.A. | Antilipemic combinations comprising hmg-coa reductase inhibitors and carnitines |
| US6245800B1 (en) * | 1999-06-08 | 2001-06-12 | Sigma-Tau | Method of preventing or treating statin-induced toxic effects using L-carnitine or an alkanoyl L-carnitine |
Non-Patent Citations (4)
| Title |
|---|
| D.W. SECCOMBE, L. JAMES, P. HAHN, E. JONES: "L-Carnitine Treatment in the Hyperlipidemic Rabbit". METABOLISM, vol. 36, no. 12, 1987, pages 1192-1196, XP002437296, page 1192, column 1, paragraph 1, page 1193, column 2, paragraph 3, page 1195, column 2, paragraph 5 * |
| F. BRESCIA, E. BALESTRA, M.G. IASELLA, A.B. DAMATO: "Effects of Combined Treatment with Simvastatin and L-Carnitine on Triglyceride Levels in Diabetic Patients with Hyperlipidaemia". CLINICAL DRUG INVESTIGATION, vol. 22, no. suppll, 2002, pages 23-28, XP009084896, abstract, page 24, column 2, paragraphs 1, 3, page 26; table II, page 26, column 2, paragraph 1, page 27, column 1, paragraph 1, page 28, column 1, paragraph 2 * |
| S.M. HAFFNER: "Diabetes, Hyperlipidemia and Coronary Artery Disease". AMERICAN JOURNAL OF CARDIOLOGY, vol. 83, 1999, pages 17F-21F, XP002437295, page 17F, column 1, paragraphs 1, 2, page 18F, column 2, paragraph 2, page 19F; figure 2, page 21F, column 1, paragraphs 2, 3 * |
| SOLFRIZZI ET AL.: "Efficacy and tolerability of combined treatment with l-carnitine and simvastatin in lowering lipoprotein(a) serum levels in patients with type 2 diabetes mellitus". ATHEROSCLEROSIS, AMSTERDAM, NL, vol. 188, no. 2, October 2006 (2006-10), pages 455-461, XP005630950, ISSN: 0021-9150, cited in the application, page 456, column 1, paragraph 3, page 458; tables 2, 3 page 459, column 2, paragraph 2 - page 460, column 1, paragraph 2 * |
Also Published As
| Publication number | Publication date |
|---|---|
| EA200970798A1 (ru) | 2010-04-30 |
| PT2124925T (pt) | 2018-07-12 |
| JP2010519333A (ja) | 2010-06-03 |
| KR101699430B1 (ko) | 2017-01-24 |
| AU2007348123B2 (en) | 2013-01-17 |
| KR20090115939A (ko) | 2009-11-10 |
| BRPI0721333A8 (pt) | 2017-12-26 |
| IL200192A (en) | 2015-06-30 |
| CN101616665B (zh) | 2013-03-27 |
| BRPI0721333A2 (pt) | 2014-02-25 |
| CA2678746C (en) | 2018-05-01 |
| IL200192A0 (en) | 2010-04-15 |
| JP5697337B2 (ja) | 2015-04-08 |
| WO2008104239A1 (en) | 2008-09-04 |
| PL2124925T3 (pl) | 2018-09-28 |
| JP2014040442A (ja) | 2014-03-06 |
| US20100029759A1 (en) | 2010-02-04 |
| CA2678746A1 (en) | 2008-09-04 |
| AU2007348123A1 (en) | 2008-09-04 |
| US20150045424A1 (en) | 2015-02-12 |
| MX2009008873A (es) | 2009-08-28 |
| EP2124925A1 (en) | 2009-12-02 |
| EP2124925B1 (en) | 2018-06-27 |
| SG177993A1 (en) | 2012-02-28 |
| HK1135030A1 (en) | 2010-05-28 |
| CN101616665A (zh) | 2009-12-30 |
| ES2676529T3 (es) | 2018-07-20 |
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| PD4A | Registration of transfer of a eurasian patent in accordance with the succession in title |