IL185999A0 - Compounds having activity in correcting mutant-cftr processing and uses thereof - Google Patents

Compounds having activity in correcting mutant-cftr processing and uses thereof

Info

Publication number
IL185999A0
IL185999A0 IL185999A IL18599907A IL185999A0 IL 185999 A0 IL185999 A0 IL 185999A0 IL 185999 A IL185999 A IL 185999A IL 18599907 A IL18599907 A IL 18599907A IL 185999 A0 IL185999 A0 IL 185999A0
Authority
IL
Israel
Prior art keywords
activity
compounds
cftr processing
correcting mutant
mutant
Prior art date
Application number
IL185999A
Other languages
English (en)
Original Assignee
Univ California
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ California filed Critical Univ California
Publication of IL185999A0 publication Critical patent/IL185999A0/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
    • C07D277/62—Benzothiazoles
    • C07D277/68—Benzothiazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C07D277/82—Nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/428—Thiazoles condensed with carbocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
IL185999A 2005-03-18 2007-09-17 Compounds having activity in correcting mutant-cftr processing and uses thereof IL185999A0 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US66350105P 2005-03-18 2005-03-18
PCT/US2006/008267 WO2006101740A2 (en) 2005-03-18 2006-03-08 Compounds having activity in correcting mutant-cftr processing and uses thereof

Publications (1)

Publication Number Publication Date
IL185999A0 true IL185999A0 (en) 2008-08-07

Family

ID=37024308

Family Applications (1)

Application Number Title Priority Date Filing Date
IL185999A IL185999A0 (en) 2005-03-18 2007-09-17 Compounds having activity in correcting mutant-cftr processing and uses thereof

Country Status (12)

Country Link
US (1) US8143295B2 (US20080318984A1-20081225-C00035.png)
EP (1) EP1863522A4 (US20080318984A1-20081225-C00035.png)
JP (1) JP2008538107A (US20080318984A1-20081225-C00035.png)
KR (1) KR20070114820A (US20080318984A1-20081225-C00035.png)
CN (1) CN101605543A (US20080318984A1-20081225-C00035.png)
AU (1) AU2006227833A1 (US20080318984A1-20081225-C00035.png)
BR (1) BRPI0608453A2 (US20080318984A1-20081225-C00035.png)
CA (1) CA2600869A1 (US20080318984A1-20081225-C00035.png)
IL (1) IL185999A0 (US20080318984A1-20081225-C00035.png)
MX (1) MX2007011512A (US20080318984A1-20081225-C00035.png)
RU (1) RU2007138584A (US20080318984A1-20081225-C00035.png)
WO (1) WO2006101740A2 (US20080318984A1-20081225-C00035.png)

Families Citing this family (65)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20100074949A1 (en) 2008-08-13 2010-03-25 William Rowe Pharmaceutical composition and administration thereof
US7495103B2 (en) 2004-06-24 2009-02-24 Vertex Pharmaceuticals Incorporated Modulators of ATP-binding cassette transporters
EP1974212A1 (en) * 2005-12-27 2008-10-01 Vertex Pharmaceuticals Incorporated Compounds useful in cftr assays and methods therewith
PT1993360T (pt) 2005-12-28 2017-05-25 Vertex Pharma Formas sólidas de n-[2,4-bis(1,1-dimetiletil)-5-hidroxifenil]-1,4-di-hidro-4-oxoquinolina-3-carboxamida
US10022352B2 (en) 2006-04-07 2018-07-17 Vertex Pharmaceuticals Incorporated Modulators of ATP-binding cassette transporters
DK2674428T3 (en) 2006-04-07 2016-04-18 Vertex Pharma Modulators of ATP binding cassette transporters
US7645789B2 (en) 2006-04-07 2010-01-12 Vertex Pharmaceuticals Incorporated Indole derivatives as CFTR modulators
CN101096363B (zh) * 2006-06-27 2011-05-11 中国人民解放军军事医学科学院毒物药物研究所 2,4,5-三取代噻唑类化合物、其制备方法、药物组合物及其制药用途
US8563573B2 (en) 2007-11-02 2013-10-22 Vertex Pharmaceuticals Incorporated Azaindole derivatives as CFTR modulators
JP2010523579A (ja) 2007-04-02 2010-07-15 インスティテュート フォア ワンワールド ヘルス Ｃｆｔｒ阻害剤化合物およびそれらの使用
MX2009012077A (es) 2007-05-07 2009-11-19 Novartis Ag Compuestos organicos.
US20110177999A1 (en) * 2007-08-09 2011-07-21 Vertex Pharmaceuticals Incorporated Therapeutic Combinations Useful in Treating CFTR Related Diseases
AU2008310097B2 (en) 2007-10-09 2013-05-16 Merck Patent Gmbh Pyridine derivatives useful as glucokinase activators
US8389736B2 (en) * 2007-10-16 2013-03-05 The Regents Of The University Of California Compounds having activity in correcting mutant-CFTR processing and uses thereof
PL2578571T3 (pl) 2007-11-16 2016-03-31 Vertex Pharma Modulatory izochinolinowe transporterów zawierających kasetę wiążącą ATP
MX367154B (es) 2007-12-07 2019-08-07 Vertex Pharma Formas solidas de acido 3-(6-(1-(2,2-difluorobenzo[d] [1,3]dioxol-5-il)ciclopropancarboxamido)-3-metilpiridin-2-il)benz oico.
KR101578235B1 (ko) 2007-12-10 2015-12-16 노파르티스 아게 유기 화합물
ES2552990T3 (es) 2008-03-31 2015-12-03 Vertex Pharmaceuticals Incorporated Derivados de piridilo como moduladores del CFTR
US8236838B2 (en) * 2008-04-21 2012-08-07 Institute For Oneworld Health Compounds, compositions and methods comprising isoxazole derivatives
WO2009131952A1 (en) * 2008-04-21 2009-10-29 Institute For Oneworld Health Compounds, compositions and methods comprising thiazole derivatives
WO2009131957A2 (en) * 2008-04-21 2009-10-29 Institute For Oneworld Health Compounds, compositions and methods comprising oxadiazole derivatives
WO2009150137A2 (en) 2008-06-10 2009-12-17 Novartis Ag Organic compounds
US20120058918A1 (en) * 2009-02-02 2012-03-08 Chromocell Corporation Cell lines expressing cftr and methods of using them
NZ624460A (en) 2009-03-20 2015-12-24 Vertex Pharma Process for making modulators of cystic fibrosis transmembrane conductance regulator
US8343976B2 (en) 2009-04-20 2013-01-01 Institute For Oneworld Health Compounds, compositions and methods comprising pyrazole derivatives
US10253020B2 (en) 2009-06-12 2019-04-09 Abivax Compounds for preventing, inhibiting, or treating cancer, AIDS and/or premature aging
AU2010310449A1 (en) 2009-10-22 2012-05-03 Vertex Pharmaceuticals Incorporated Compositions for treatment of cystic fibrosis and other chronic diseases
US8802868B2 (en) 2010-03-25 2014-08-12 Vertex Pharmaceuticals Incorporated Solid forms of (R)-1(2,2-difluorobenzo[D][1,3]dioxo1-5-yl)-N-(1-(2,3-dihydroxypropyl-6-fluoro-2-(1-hydroxy-2-methylpropan2-yl)-1H-Indol-5-yl)-Cyclopropanecarboxamide
ES2951520T3 (es) 2010-03-25 2023-10-23 Vertex Pharma Síntesis e intermedios de (R)-1-(2,2-difluorobenzo[d][1,3]dioxol-5-il)-N-(1-(2,3-dihidroxipropil)-6-fluoro-2-(1-hidroxi-2-metilpropan-2-il)-1H-indol-5il)-ciclopropanocarboxamida
HUE029611T2 (en) 2010-04-07 2017-03-28 Vertex Pharma 3- (6- (1- (2,2-Difluorobenzo [d] [1,3] dioxol-5-yl) cyclopropanecarboxamido) -3-methylpyridin-2-yl) benzoic acid
CN102917692A (zh) 2010-04-07 2013-02-06 弗特克斯药品有限公司 3-(6-(1-(2,2-二氟苯并[d][1,3]二氧杂环戊烯-5-基)环丙甲酰胺基)-3-甲基吡啶-2-基)苯甲酸的药物组合物和其给药方法
RU2569678C2 (ru) 2010-04-22 2015-11-27 Вертекс Фармасьютикалз Инкорпорейтед Способ получения циклоалкилкарбоксамидо-индольных соединений
US8563593B2 (en) 2010-06-08 2013-10-22 Vertex Pharmaceuticals Incorporated Formulations of (R)-1-(2,2-difluorobenzo[D] [1,3] dioxol-5-yl)-N-(1-(2,3-dihydroxypropyl)-6-fluoro-2-(1-hydroxy-2-methylpropan-2-yl)-1H-indol-5-yl)cyclopropanecarboxamide
WO2012027247A2 (en) 2010-08-23 2012-03-01 Vertex Pharmaceuticals Incorporated Pharmaceutical composition of (r)-1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)-n-(1-(2,3-dihydroxy propyl)-6-fluoro-2-(1-hydroxy-2-methylpropan-2-yl)-1h-indol-5-yl) cyclopropanecarboxamide and administration therof
US20130303761A1 (en) 2010-09-14 2013-11-14 Instytut Biochemii I Biofizyki Pan Compounds as modulators of a mutant cftr protein and their use for treating diseases associated with cftr protein malfunction
US8372845B2 (en) 2010-09-17 2013-02-12 Novartis Ag Pyrazine derivatives as enac blockers
CA2754237A1 (en) 2011-05-27 2012-11-27 The Regents Of The University Of California Cyanoquinoline compounds having activity in correcting mutant-cftr processing and increasing ion transport and uses thereof
WO2012166654A1 (en) * 2011-05-27 2012-12-06 The Regents Of The University Of California Cyanoquinoline compounds having activity in correcting mutant-cftr processing and increasing ion transport and uses thereof
US8798939B2 (en) 2011-06-29 2014-08-05 Janssen Pharmaceutica N.V. Methods for designing, selecting and/or optimizing allosteric processing inhibitors for matrix metalloproteinases
US8753857B2 (en) 2011-06-29 2014-06-17 Janssen Pharmaceutica N.V. Crystal structure of the pro form of a matrix metalloproteinase and an allosteric processing inhibitor
WO2013003360A1 (en) * 2011-06-29 2013-01-03 Janssen Pharmaceutica Nv Methods of treatment using allosteric processing inhibitors for matrix metalloproteinases
ES2622154T3 (es) 2011-11-08 2017-07-05 Vertex Pharmaceuticals Incorporated Moduladores de transportadores de cassete de unión atp-binding
KR20140117612A (ko) 2012-01-25 2014-10-07 버텍스 파마슈티칼스 인코포레이티드 3-(6-(1-(2,2-다이플루오로벤조[d][1,3]다이옥솔-5-일) 사이클로프로판카르복사미도)-3-메틸피리딘-2-일)벤조산의 제형
MX2014010253A (es) 2012-02-27 2014-11-12 Vertex Pharma Composicion farmaceutica y administraciones de la misma.
US8809340B2 (en) 2012-03-19 2014-08-19 Novartis Ag Crystalline form
EP2872122A1 (en) 2012-07-16 2015-05-20 Vertex Pharmaceuticals Incorporated Pharmaceutical compositions of (r)-1-(2,2-diflurorbenzo[d][1,3]dioxol-5-yl)-n-(1-(2,3-dihydroxypropyl)-6-fluoro-2-(1-hydroxy-2-methylpropan-2-yl)-1h-indol-5-yl) cyclopropanecarboxamide and administration thereof
JP6302923B2 (ja) 2012-11-02 2018-03-28 バーテックス ファーマシューティカルズ インコーポレイテッドＶｅｒｔｅｘ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｉｎｃｏｒｐｏｒａｔｅｄ Ｃｆｔｒが媒介する疾患の処置のための医薬組成物
ITMI20122065A1 (it) 2012-12-03 2014-06-04 Univ Padova Uso dei correttori del cftr nel trattamento delle patologie del muscolo striato
EP2757161A1 (en) 2013-01-17 2014-07-23 Splicos miRNA-124 as a biomarker of viral infection
GB201405991D0 (en) * 2014-04-03 2014-05-21 Cambridge Entpr Ltd Novel compounds
PL3424534T3 (pl) 2014-04-15 2021-11-22 Vertex Pharmaceuticals Incorporated Kompozycje farmaceutyczne do leczenia chorób, w których pośredniczy mukowiscydozowy przezbłonowy regulator przewodnictwa
EP2974729A1 (en) 2014-07-17 2016-01-20 Abivax Quinoline derivatives for use in the treatment of inflammatory diseases
CN112279808B (zh) 2014-10-06 2024-03-08 弗特克斯药品有限公司 囊性纤维化跨膜转导调节因子调节剂
US9701639B2 (en) 2014-10-07 2017-07-11 Vertex Pharmaceuticals Incorporated Co-crystals of modulators of cystic fibrosis transmembrane conductance regulator
CA2969587A1 (en) 2014-12-05 2016-06-09 Centre National De La Recherche Scientifique (Cnrs) Compounds for treating cystic fibrosis
US10828288B2 (en) 2015-01-27 2020-11-10 Rutgers, The State University Of New Jersey Hydrazone derivatives for the treatment of cancer
WO2016123246A1 (en) 2015-01-27 2016-08-04 Rutgers, The State University Of New Jersey (thio, oxo and seleno) semicarbazone complexes with zinc and their use for treating cancer
WO2016123250A1 (en) 2015-01-27 2016-08-04 Rutgers, The State University Of New Jersey Zinc complexes of hydrazones and (thio)semicarbazones and their use for the treatment of cancer
US10604480B2 (en) 2015-01-27 2020-03-31 Rutgers, The State University Of New Jersey (Thio, oxo, and seleno) semicarbazone derivatives and their use for treating cancer
ITUB20153714A1 (it) * 2015-09-18 2017-03-18 Luigina Romani Timosina alfa 1 per l?uso nel trattamento della fibrosi cistica.
WO2016129005A1 (en) * 2015-02-09 2016-08-18 Luigina Romani Thymosin alpha 1 for use in treatment of cystic fibrosis
EP3359144A1 (en) * 2015-10-09 2018-08-15 AbbVie S.À.R.L. Potentiator-corrector combinations useful in the treatment of cystic fibrosis
JP7270641B2 (ja) 2018-01-11 2023-05-10 アンセルム（アンスティチュート・ナシオナル・ドゥ・ラ・サンテ・エ・ドゥ・ラ・ルシェルシュ・メディカル） サルコグリカン異常症の併用治療
EP3846801A1 (en) 2018-09-09 2021-07-14 Qanatpharma AG Use of cftr modulators for treating cerebrovascular conditions
KR102399037B1 (ko) * 2020-01-06 2022-05-17 성균관대학교산학협력단 아민화된 아진의 신규한 제조방법

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0069154B1 (en) * 1981-01-13 1986-10-15 Mitsui Toatsu Kagaku Kabushiki Kaisha Novel thiazole compounds, process for their preparation, and medicinal composition containing same
JPS649935A (en) * 1987-06-30 1989-01-13 Kyowa Hakko Kogyo Kk Remedy for hepatopathy
AU2000092A (en) 1991-06-21 1993-01-25 Boehringer Mannheim Italia S.P.A. 2-amino-4-aryl-thiazoles with antiasthmatic and anti-inflammatory activities on the respiratory tract
US6262096B1 (en) 1997-11-12 2001-07-17 Bristol-Myers Squibb Company Aminothiazole inhibitors of cyclin dependent kinases
EP1353676A4 (en) * 2000-12-29 2006-05-31 Alteon Inc METHOD FOR THE TREATMENT OF FIBROUS OR OTHER INDICATIONS
HN2002000156A (es) * 2001-07-06 2003-11-27 Inc Agouron Pharmaceuticals Derivados de benzamida tiazol y composiciones farmaceuticas para inhibir la proliferacion de celulas y metodos para su utilización.
SE0201837D0 (sv) * 2002-06-14 2002-06-14 Astrazeneca Ab Chemical compounds
US7329682B2 (en) * 2003-04-03 2008-02-12 Ewha University-Industry Collaboration Foundation Method for inhibiting 5-lipoxygenase using a benzoxazole derivative
WO2004098510A2 (en) * 2003-04-30 2004-11-18 Beth Israel Deaconess Medical Center Cystic fibrosis therapy
WO2004110352A2 (en) * 2003-05-16 2004-12-23 The Regents Of The University Of California Compounds having activity in increasing ion transport by mutant-cftr and uses thereof

Also Published As

Publication number Publication date
WO2006101740A3 (en) 2009-06-04
US8143295B2 (en) 2012-03-27
EP1863522A4 (en) 2010-11-10
BRPI0608453A2 (pt) 2009-12-29
US20080318984A1 (en) 2008-12-25
KR20070114820A (ko) 2007-12-04
EP1863522A2 (en) 2007-12-12
JP2008538107A (ja) 2008-10-09
WO2006101740A2 (en) 2006-09-28
AU2006227833A1 (en) 2006-09-28
RU2007138584A (ru) 2009-04-27
MX2007011512A (es) 2007-12-07
CA2600869A1 (en) 2006-09-28
CN101605543A (zh) 2009-12-16

Similar Documents

Publication Publication Date Title
IL185999A0 (en) Compounds having activity in correcting mutant-cftr processing and uses thereof
EP1765347A4 (en) COMPOUNDS WITH ION TRANSPORTER HEALING EFFECT BY MUTANT CFTR AND ITS USE
IL228770A0 (en) processes and intermediates
TWI350240B (en) Substrate processing system and substrate processing program
GB2428035B (en) Handling system, work system and program
EP1934853A4 (en) PROGRESSIVE GAME AND PROCESSING SYSTEM THEREFOR
HK1095045A1 (en) Modified exendins and uses thereof
EP1920216A4 (en) SIGNALING AND LOCATION ORIENTATION
EP2015781A4 (en) COMPOSITIONS HAVING ANTIANGIOGENIC ACTIVITY AND USES THEREOF
EP1895399A4 (en) PRINT SYSTEM AND PROGRAM
EP1848428A4 (en) THIAZOLE AMIDES, IMIDAZOLE AMIDES AND RELATED ANALOGS
AP2007004204A0 (en) Titanium intermediate processing
GB0516069D0 (en) Pharmaceutical and use thereof
IL189252A0 (en) Dihydroxyanthraquinones and their use
EP1912921A4 (en) COMPOUNDS ON TETRAAZAPORPHYRINBASE AND ITS USES
GB0404299D0 (en) Improved can processing
EP1931209A4 (en) ANTIMICROBIAL SOLUTIONS AND RELATED METHODS
IL185223A0 (en) Compounds and uses thereof
EP1872126A4 (en) CD39L3 AND ITS ROLE IN DIABETES
EP1965829A4 (en) ALTERNATIVE OXIDASE AND ITS USES
ZA200801248B (en) PEG-IFN alpha and ribaviriin for HBV treatment
GB0523637D0 (en) Process and compounds
EP1930406A4 (en) IN THE BRAIN WALKING CELL AND USE THEREOF
GB0422196D0 (en) Processing
GB0514849D0 (en) Treatment for kerationlytic and other fungal infections