IL182919A0 - Process for preparing telmisartan and telmisartan derivatives prepared thereby - Google Patents

Process for preparing telmisartan and telmisartan derivatives prepared thereby

Info

Publication number
IL182919A0
IL182919A0 IL182919A IL18291907A IL182919A0 IL 182919 A0 IL182919 A0 IL 182919A0 IL 182919 A IL182919 A IL 182919A IL 18291907 A IL18291907 A IL 18291907A IL 182919 A0 IL182919 A0 IL 182919A0
Authority
IL
Israel
Prior art keywords
telmisartan
preparing
derivatives prepared
derivatives
prepared
Prior art date
Application number
IL182919A
Other languages
English (en)
Original Assignee
Reddys Lab Ltd Dr
Reddys Lab Inc Dr
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Reddys Lab Ltd Dr, Reddys Lab Inc Dr filed Critical Reddys Lab Ltd Dr
Publication of IL182919A0 publication Critical patent/IL182919A0/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/45—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups
    • C07C233/53—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring
    • C07C233/54—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring having the carbon atom of the carboxamide group bound to a hydrogen atom or to a carbon atom of a saturated carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/28—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton
    • C07C237/42—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton having nitrogen atoms of amino groups bound to the carbon skeleton of the acid part, further acylated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
    • C07D235/08—Radicals containing only hydrogen and carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/20—Two benzimidazolyl-2 radicals linked together directly or via a hydrocarbon or substituted hydrocarbon radical

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Steroid Compounds (AREA)
IL182919A 2004-10-18 2007-05-02 Process for preparing telmisartan and telmisartan derivatives prepared thereby IL182919A0 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US61988104P 2004-10-18 2004-10-18
US62314004P 2004-10-27 2004-10-27
PCT/US2005/037185 WO2006044754A2 (en) 2004-10-18 2005-10-18 Process for preparing telmisartan

Publications (1)

Publication Number Publication Date
IL182919A0 true IL182919A0 (en) 2007-09-20

Family

ID=36203602

Family Applications (1)

Application Number Title Priority Date Filing Date
IL182919A IL182919A0 (en) 2004-10-18 2007-05-02 Process for preparing telmisartan and telmisartan derivatives prepared thereby

Country Status (4)

Country Link
US (1) US7943781B2 (de)
EP (1) EP1805146A4 (de)
IL (1) IL182919A0 (de)
WO (1) WO2006044754A2 (de)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7623682B2 (en) 2004-08-13 2009-11-24 Samsung Electronics Co., Ltd. Method and device for motion estimation and compensation for panorama image
KR20070061583A (ko) 2004-10-15 2007-06-13 테바 파마슈티컬 인더스트리즈 리미티드 텔미사르탄의 제조 방법
EP1912975B1 (de) * 2005-07-19 2013-01-16 Matrix Laboratories Ltd Verfahren zur herstellung von telmisartan
SI22297A (sl) * 2006-06-23 2007-12-31 Krka, Tovarna Zdravil, D.D., Novo Mesto Priprava soli telmisartana
CZ302272B6 (cs) * 2007-07-09 2011-01-19 Zentiva, A. S. Zpusob výroby 4´-[[4-methyl-6-(1-methyl-1H-benzimidazol-2-yl)-2-propyl-1H-benzimidazol-1-yl]methyl]biphenyl-2-karboxylové kyseliny (telmisartanu)
WO2010004385A1 (en) * 2008-06-17 2010-01-14 Aurobindo Pharma Limited Process for the preparation of pure 4'-[4-methyl-6-(1-methyl-2-benzimidazolyl)-2-propyl-1-benzimidazolyl]methyl]-2-biphenylcarboxylic acid
WO2010018441A2 (en) * 2008-08-11 2010-02-18 Cadila Pharmaceuticals Ltd. An improved process for the preparation of substantially pure telmisartan
WO2010081670A2 (en) 2009-01-14 2010-07-22 Lonza Ltd Process for the preparation of benzimidazoles
ES2415357T3 (es) 2009-06-19 2013-07-25 Krka Tovarna Zdravil, D.D., Novo Mesto Procedimiento para la preparación de telmisartán
WO2010149359A1 (en) 2009-06-26 2010-12-29 Lonza Ltd Process and intermediates for the preparation of benzimidazolecarboxylic acids
WO2010149360A1 (en) 2009-06-26 2010-12-29 Lonza Ltd Process for the preparation of benzimidazoles
KR20110094751A (ko) * 2010-02-17 2011-08-24 동화약품주식회사 텔미사탄의 개선된 제조방법
CN102219744B (zh) * 2010-04-13 2013-01-16 上海联化生物医药技术有限公司 一种替米沙坦的中间体的制备方法及一种中间体化合物
CN101838243B (zh) * 2010-05-25 2012-07-18 江西同和药业有限责任公司 一种替米沙坦的精制方法
EP2632438A1 (de) 2010-10-27 2013-09-04 KRKA, tovarna zdravil, d.d., Novo mesto Mehrschichtige pharmazeutische zusammensetzung mit telmisartan und amlodipin
CN102557964A (zh) * 2010-12-09 2012-07-11 宜昌长江药业有限公司 一种n-甲基邻苯二胺（盐）及其同分异构体的合成方法
CN102093297B (zh) * 2011-01-28 2012-08-01 海南美兰史克制药有限公司 替米沙坦化合物及其制法
CN105237457A (zh) * 2015-10-22 2016-01-13 威特(湖南)药业有限公司 2-正丙基-4-甲基-6-（1-甲基苯并咪唑-2-基）苯并咪唑的制备方法
CN108250148B (zh) * 2017-12-29 2021-06-08 江苏中邦制药有限公司 一种替米沙坦关键中间体的精制方法
CN112441984B (zh) * 2019-08-29 2024-04-19 上海特化医药科技有限公司 基于苯并咪唑取代的苯基正丁酰胺的化合物及其制备方法
CN110713463A (zh) * 2019-10-25 2020-01-21 合肥立方制药股份有限公司 2-正丙基-4-甲基-6-羧酸苯并咪唑的制备方法

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5614519A (en) * 1991-02-06 1997-03-25 Karl Thomae Gmbh (1-(2,3 or 4-N-morpholinoalkyl)-imidazol-4-yl)-benizimidazol-1-yl-methyl]-biphenyls useful as angiotensin-II antagonists
US6358986B1 (en) 1999-01-19 2002-03-19 Boehringer Ingelheim Pharma Kg Polymorphs of telmisartan
DE19901921C2 (de) 1999-01-19 2001-01-04 Boehringer Ingelheim Pharma Polymorphe von Telmisartan, Verfahren zu deren Herstellung und deren Verwendung zur Herstellung eines Arzneimittels
CN1182122C (zh) * 2001-07-30 2004-12-29 中国科学院上海药物研究所 替米沙坦的合成新路线
US6737432B2 (en) 2001-10-31 2004-05-18 Boehringer Ingelheim Pharma Kg Crystalline form of telmisartan sodium
DE10153737A1 (de) 2001-10-31 2003-05-28 Boehringer Ingelheim Pharma Kristallines Natriumsalz des Telmisartans, Verfahren zu dessen Herstellung und dessen Verwendung zur Herstellung eines Arzneimittels
DE10201725A1 (de) 2002-01-18 2003-08-14 Boehringer Ingelheim Pharma Verfahren zur Herstellung und Reinigung von 1,7'-Dimethyl-2'-propyl-2,5'-bi-1H-benzimidazol
US6770762B2 (en) 2002-01-18 2004-08-03 Boehringer Ingelheim Pharma Gmbh & Co. Kg Process for preparing and purifying 1,7′-dimethyl-2′-propyl-2,5′-bi-1H-benzimidazole
DE10314702A1 (de) 2003-03-31 2004-10-21 Boehringer Ingelheim Pharma Gmbh & Co. Kg Verfahren zur Herstellung von Telmisartan
DE10319450A1 (de) 2003-04-30 2004-11-18 Boehringer Ingelheim Pharma Gmbh & Co. Kg Pharmazeutische Formulierung des Telmisartan Natriumsalzes
GB2414019A (en) 2004-05-11 2005-11-16 Cipla Ltd One-step preparation of telmisartan by condensation and hydrolysis

Also Published As

Publication number Publication date
WO2006044754A2 (en) 2006-04-27
US20070287840A1 (en) 2007-12-13
WO2006044754A3 (en) 2006-12-14
EP1805146A4 (de) 2009-01-14
US7943781B2 (en) 2011-05-17
EP1805146A2 (de) 2007-07-11

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