IL173656A0 - Recombinant production of antimicrobial agents - Google Patents
Recombinant production of antimicrobial agentsInfo
- Publication number
- IL173656A0 IL173656A0 IL173656A IL17365606A IL173656A0 IL 173656 A0 IL173656 A0 IL 173656A0 IL 173656 A IL173656 A IL 173656A IL 17365606 A IL17365606 A IL 17365606A IL 173656 A0 IL173656 A0 IL 173656A0
- Authority
- IL
- Israel
- Prior art keywords
- antimicrobial
- enzyme
- alpha
- expression
- enzymes
- Prior art date
Links
- 239000004599 antimicrobial Substances 0.000 title abstract 4
- 238000004519 manufacturing process Methods 0.000 title abstract 2
- 108090000790 Enzymes Proteins 0.000 abstract 4
- 102000004190 Enzymes Human genes 0.000 abstract 4
- 229940088598 enzyme Drugs 0.000 abstract 4
- 102000044503 Antimicrobial Peptides Human genes 0.000 abstract 2
- 108700042778 Antimicrobial Peptides Proteins 0.000 abstract 2
- 108010011619 6-Phytase Proteins 0.000 abstract 1
- 101710152845 Arabinogalactan endo-beta-1,4-galactanase Proteins 0.000 abstract 1
- 102100032487 Beta-mannosidase Human genes 0.000 abstract 1
- 108010059892 Cellulase Proteins 0.000 abstract 1
- 108010001682 Dextranase Proteins 0.000 abstract 1
- 101710121765 Endo-1,4-beta-xylanase Proteins 0.000 abstract 1
- 101710147028 Endo-beta-1,4-galactanase Proteins 0.000 abstract 1
- 108010073178 Glucan 1,4-alpha-Glucosidase Proteins 0.000 abstract 1
- 102100022624 Glucoamylase Human genes 0.000 abstract 1
- 239000004366 Glucose oxidase Substances 0.000 abstract 1
- 108010015776 Glucose oxidase Proteins 0.000 abstract 1
- 108010014251 Muramidase Proteins 0.000 abstract 1
- 102000016943 Muramidase Human genes 0.000 abstract 1
- 108010062010 N-Acetylmuramoyl-L-alanine Amidase Proteins 0.000 abstract 1
- 108091005804 Peptidases Proteins 0.000 abstract 1
- 239000004365 Protease Substances 0.000 abstract 1
- 102100037486 Reverse transcriptase/ribonuclease H Human genes 0.000 abstract 1
- 102000004139 alpha-Amylases Human genes 0.000 abstract 1
- 108090000637 alpha-Amylases Proteins 0.000 abstract 1
- 102000005840 alpha-Galactosidase Human genes 0.000 abstract 1
- 108010030291 alpha-Galactosidase Proteins 0.000 abstract 1
- 229940024171 alpha-amylase Drugs 0.000 abstract 1
- 125000000539 amino acid group Chemical group 0.000 abstract 1
- 235000019730 animal feed additive Nutrition 0.000 abstract 1
- 230000000845 anti-microbial effect Effects 0.000 abstract 1
- 108010055059 beta-Mannosidase Proteins 0.000 abstract 1
- 230000004186 co-expression Effects 0.000 abstract 1
- 230000004927 fusion Effects 0.000 abstract 1
- 230000014509 gene expression Effects 0.000 abstract 1
- 229940116332 glucose oxidase Drugs 0.000 abstract 1
- 235000019420 glucose oxidase Nutrition 0.000 abstract 1
- 229960000274 lysozyme Drugs 0.000 abstract 1
- 239000004325 lysozyme Substances 0.000 abstract 1
- 235000010335 lysozyme Nutrition 0.000 abstract 1
- 108010087558 pectate lyase Proteins 0.000 abstract 1
- 229940085127 phytase Drugs 0.000 abstract 1
- 239000003910 polypeptide antibiotic agent Substances 0.000 abstract 1
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 1
- 238000010791 quenching Methods 0.000 abstract 1
- 230000000171 quenching effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/62—DNA sequences coding for fusion proteins
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
- A23K20/142—Amino acids; Derivatives thereof
- A23K20/147—Polymeric derivatives, e.g. peptides or proteins
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
- A23K20/189—Enzymes
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4723—Cationic antimicrobial peptides, e.g. defensins
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/02—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving viable microorganisms
- C12Q1/025—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving viable microorganisms for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- Biomedical Technology (AREA)
- General Engineering & Computer Science (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biotechnology (AREA)
- Polymers & Plastics (AREA)
- Molecular Biology (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Microbiology (AREA)
- Physics & Mathematics (AREA)
- Toxicology (AREA)
- Plant Pathology (AREA)
- Animal Husbandry (AREA)
- Medicinal Chemistry (AREA)
- Food Science & Technology (AREA)
- Immunology (AREA)
- Analytical Chemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Fodder In General (AREA)
- Enzymes And Modification Thereof (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Apparatus For Disinfection Or Sterilisation (AREA)
- Breeding Of Plants And Reproduction By Means Of Culturing (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DKPA200301310 | 2003-09-11 | ||
| PCT/DK2004/000605 WO2005024002A1 (en) | 2003-09-11 | 2004-09-13 | Recombinant production of antimicrobial agents |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IL173656A0 true IL173656A0 (en) | 2006-07-05 |
Family
ID=34259082
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL173656A IL173656A0 (en) | 2003-09-11 | 2006-02-09 | Recombinant production of antimicrobial agents |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US7935501B2 (https=) |
| EP (1) | EP1680503B1 (https=) |
| JP (1) | JP2007504810A (https=) |
| CN (1) | CN1845989B (https=) |
| AT (1) | ATE513904T1 (https=) |
| AU (1) | AU2004270815B2 (https=) |
| BR (1) | BRPI0413833A (https=) |
| CA (1) | CA2536782A1 (https=) |
| DK (1) | DK1680503T3 (https=) |
| ES (1) | ES2368221T3 (https=) |
| IL (1) | IL173656A0 (https=) |
| NZ (1) | NZ545564A (https=) |
| WO (1) | WO2005024002A1 (https=) |
| ZA (1) | ZA200601544B (https=) |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6855548B2 (en) * | 2000-02-08 | 2005-02-15 | F. Hoffman-La Roche Ag | Use of acid-stable proteases in animal feed |
| DE602004007766T2 (de) * | 2003-02-07 | 2008-06-05 | Novozymes A/S | Proteasen |
| US7763706B1 (en) * | 2003-07-17 | 2010-07-27 | Campina B.V. | Arginine/lysine-enriched peptides |
| DE602004030595D1 (de) | 2003-10-10 | 2011-01-27 | Novozymes As | Proteasevarianten |
| ES2380105T3 (es) | 2004-06-21 | 2012-05-08 | Novozymes A/S | Proteasas de Nocardiopsis |
| GB0815484D0 (en) | 2008-08-26 | 2008-10-01 | Univ Leuven Kath | Antibacterial agents |
| RU2501566C2 (ru) * | 2009-01-13 | 2013-12-20 | Пергамум АБ | Новые фармацевтические композиции |
| DK2445515T3 (en) * | 2009-06-26 | 2016-07-04 | Univ Leuven Kath | antimicrobial agents |
| KR101701890B1 (ko) | 2009-06-26 | 2017-02-02 | 뤼산도 아게 | 항균제 |
| CN102220295B (zh) * | 2011-05-26 | 2013-02-06 | 长沙理工大学 | 以稻谷加工副产物为原料生产饲用葡萄糖氧化酶的方法 |
| ES2700738T3 (es) * | 2011-11-17 | 2019-02-19 | Dsm Ip Assets Bv | Uso de proteasas estables al ácido en alimento para animales para aumentar el rendimiento de pollos de engorde vacunados contra coccidios |
| US10597430B2 (en) * | 2012-03-05 | 2020-03-24 | Instituto De Investigaciones Agropecuarias | Chimeric gene for heterologous expression which encodes for peptides with antimicrobial activity |
| WO2014052438A1 (en) | 2012-09-25 | 2014-04-03 | Regents Of The University Of Minnesota | Methods for making and using antimicrobial peptides |
| CN105734029B (zh) * | 2014-12-12 | 2020-09-25 | 丰益(上海)生物技术研发中心有限公司 | 磷脂酶抗菌肽 |
| CN105255939B (zh) * | 2015-11-13 | 2018-12-25 | 长沙中科晶博生物科技有限公司 | 一种用青蒿生产菌丝霉素的方法 |
| CN105274137B (zh) * | 2015-11-13 | 2018-12-25 | 长沙中科晶博生物科技有限公司 | 一种用青蒿生产乳铁蛋白的方法 |
| CN108794635B (zh) * | 2018-04-04 | 2021-03-19 | 浙江工业大学 | 一种牛乳铁蛋白肽-人溶菌酶融合蛋白、基因及其应用 |
| CN109295075B (zh) * | 2018-10-31 | 2021-04-20 | 上海市农业生物基因中心 | NfOCP1抗旱基因、其编码的氨基酸序列及其在提高植物抗旱性中的用途 |
| CN111118091A (zh) * | 2018-10-31 | 2020-05-08 | 宁夏乙征生物工程有限公司 | 一种抗菌肽的生产方法 |
| CN111349177B (zh) * | 2020-03-13 | 2022-04-22 | 西北农林科技大学 | 一种融合抗菌肽cat的制备方法和应用 |
| CN114478795B (zh) * | 2020-11-13 | 2024-06-04 | 安徽新熙盟生物科技有限公司 | 提高多肽类药物口服给药稳定性的融合蛋白及其应用 |
| CN113125689B (zh) * | 2021-03-29 | 2022-02-22 | 创芯国际生物科技(广州)有限公司 | 一种新型mtt细胞活力检测试剂盒及其应用 |
| EP4525615A2 (en) | 2022-05-14 | 2025-03-26 | Novozymes A/S | Compositions and methods for preventing, treating, supressing and/or eliminating phytopathogenic infestations and infections |
| CN114790237B (zh) * | 2022-05-31 | 2024-04-05 | 合肥工业大学 | 一种抗菌肽及其应用 |
| CN118064343B (zh) * | 2024-03-11 | 2025-01-03 | 华南农业大学 | 一种产四种抗菌肽的重组枯草芽孢杆菌、构建方法及其应用 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5094951A (en) | 1988-06-21 | 1992-03-10 | Chiron Corporation | Production of glucose oxidase in recombinant systems |
| US5571697A (en) * | 1989-05-05 | 1996-11-05 | Baylor College Of Medicine Texas Medical Center | Expression of processed recombinant lactoferrin and lactoferrin polypeptide fragments from a fusion product in Aspergillus |
| US5789377A (en) * | 1992-08-21 | 1998-08-04 | University Of British Columbia | Treatment of endotoxin-associated disorders with cationic peptides |
| KR100263583B1 (ko) | 1997-05-28 | 2000-08-01 | 박종헌 | 항균 펩타이드의 대량 제조방법 및 그에 유용한 플라즈미드 벡타 |
| AU4911600A (en) | 1999-06-02 | 2000-12-28 | Novo Nordisk A/S | Pectate lyase fusion for expression and secretion of polypeptides |
-
2004
- 2004-09-13 JP JP2006525631A patent/JP2007504810A/ja not_active Ceased
- 2004-09-13 DK DK04762825.0T patent/DK1680503T3/da active
- 2004-09-13 CN CN2004800249767A patent/CN1845989B/zh not_active Expired - Fee Related
- 2004-09-13 NZ NZ545564A patent/NZ545564A/en not_active IP Right Cessation
- 2004-09-13 ES ES04762825T patent/ES2368221T3/es not_active Expired - Lifetime
- 2004-09-13 BR BRPI0413833-3A patent/BRPI0413833A/pt not_active Application Discontinuation
- 2004-09-13 EP EP04762825A patent/EP1680503B1/en not_active Expired - Lifetime
- 2004-09-13 AT AT04762825T patent/ATE513904T1/de not_active IP Right Cessation
- 2004-09-13 CA CA002536782A patent/CA2536782A1/en not_active Abandoned
- 2004-09-13 WO PCT/DK2004/000605 patent/WO2005024002A1/en not_active Ceased
- 2004-09-13 AU AU2004270815A patent/AU2004270815B2/en not_active Ceased
- 2004-09-13 US US10/572,016 patent/US7935501B2/en not_active Expired - Fee Related
-
2006
- 2006-02-09 IL IL173656A patent/IL173656A0/en not_active IP Right Cessation
- 2006-02-22 ZA ZA200601544A patent/ZA200601544B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| AU2004270815B2 (en) | 2011-06-02 |
| CN1845989B (zh) | 2011-10-12 |
| US20070104764A1 (en) | 2007-05-10 |
| WO2005024002A1 (en) | 2005-03-17 |
| ZA200601544B (en) | 2007-04-25 |
| EP1680503A1 (en) | 2006-07-19 |
| CN1845989A (zh) | 2006-10-11 |
| US7935501B2 (en) | 2011-05-03 |
| CA2536782A1 (en) | 2005-03-17 |
| ES2368221T3 (es) | 2011-11-15 |
| ATE513904T1 (de) | 2011-07-15 |
| DK1680503T3 (da) | 2011-10-03 |
| BRPI0413833A (pt) | 2006-10-24 |
| JP2007504810A (ja) | 2007-03-08 |
| AU2004270815A1 (en) | 2005-03-17 |
| NZ545564A (en) | 2008-07-31 |
| EP1680503B1 (en) | 2011-06-22 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FF | Patent granted | ||
| MM9K | Patent not in force due to non-payment of renewal fees |