IL166789A0 - Fused benzene derivative and use - Google Patents
Fused benzene derivative and useInfo
- Publication number
- IL166789A0 IL166789A0 IL16678905A IL16678905A IL166789A0 IL 166789 A0 IL166789 A0 IL 166789A0 IL 16678905 A IL16678905 A IL 16678905A IL 16678905 A IL16678905 A IL 16678905A IL 166789 A0 IL166789 A0 IL 166789A0
- Authority
- IL
- Israel
- Prior art keywords
- benzene derivative
- fused benzene
- fused
- derivative
- benzene
- Prior art date
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- C07C255/49—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
- C07C255/52—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton to carbon atoms of six-membered aromatic rings being part of condensed ring systems
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
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- C07C217/04—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
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- C07C255/53—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and hydroxy groups bound to the carbon skeleton
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- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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- C07D265/02—1,2-Oxazines; Hydrogenated 1,2-oxazines
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- C—CHEMISTRY; METALLURGY
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- C07D267/00—Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one oxygen atom as the only ring hetero atoms
- C07D267/02—Seven-membered rings
- C07D267/08—Seven-membered rings having the hetero atoms in positions 1 and 4
- C07D267/10—Seven-membered rings having the hetero atoms in positions 1 and 4 not condensed with other rings
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- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/06—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by halogen atoms or nitro radicals
- C07D295/073—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by halogen atoms or nitro radicals with the ring nitrogen atoms and the substituents separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
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- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/10—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms
- C07D295/112—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms with the ring nitrogen atoms and the doubly bound oxygen or sulfur atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
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- C07—ORGANIC CHEMISTRY
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- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D295/155—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
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- C—CHEMISTRY; METALLURGY
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- C07D—HETEROCYCLIC COMPOUNDS
- C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
- C07D303/02—Compounds containing oxirane rings
- C07D303/38—Compounds containing oxirane rings with hydrocarbon radicals, substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D303/46—Compounds containing oxirane rings with hydrocarbon radicals, substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals by amide or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
- C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
- C07D333/54—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
- C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
- C07C2601/10—Systems containing only non-condensed rings with a five-membered ring the ring being unsaturated
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
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- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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- Urology & Nephrology (AREA)
- Diabetes (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Compounds Containing Sulfur Atoms (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
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JP2002235275 | 2002-08-12 | ||
PCT/JP2003/010228 WO2004016576A1 (ja) | 2002-08-12 | 2003-08-11 | 縮合ベンゼン誘導体および用途 |
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IL166789A0 true IL166789A0 (en) | 2006-01-15 |
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IL16678905A IL166789A0 (en) | 2002-08-12 | 2005-02-09 | Fused benzene derivative and use |
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US (1) | US7649001B2 (xx) |
EP (1) | EP1553074B1 (xx) |
KR (1) | KR20050044902A (xx) |
CN (1) | CN1688527A (xx) |
AU (1) | AU2003254993A1 (xx) |
BR (1) | BR0313405A (xx) |
CA (1) | CA2495383A1 (xx) |
HK (1) | HK1080067A1 (xx) |
IL (1) | IL166789A0 (xx) |
MX (1) | MXPA05001631A (xx) |
NO (1) | NO20051270L (xx) |
NZ (1) | NZ538713A (xx) |
PL (1) | PL375042A1 (xx) |
WO (1) | WO2004016576A1 (xx) |
Families Citing this family (32)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20050026161A1 (en) * | 2002-11-01 | 2005-02-03 | Edward Jablonski | Displacement sandwich immuno-PCR |
WO2005090282A1 (en) * | 2004-03-12 | 2005-09-29 | Ligand Pharmaceuticals Incorporated | Androgen receptor modulator compounds and methods |
CA2566942A1 (en) | 2004-05-17 | 2005-12-08 | Acadia Pharmaceuticals Inc. | Androgen receptor modulators and method of treating disease using the same |
US20070004679A1 (en) * | 2004-05-17 | 2007-01-04 | Nathalie Schlienger | Androgen receptor modulators and methods of treating disease using the same |
WO2006038119A1 (en) * | 2004-10-08 | 2006-04-13 | Warner-Lambert Company Llc | Stereoselective synthesis of n-protected alkoxy prolines |
PT1815028E (pt) | 2004-11-03 | 2012-01-24 | Iris Molecular Diagnostics Inc | Microbolhas para separação por afinidade |
CA2585781A1 (en) | 2004-11-03 | 2006-12-28 | Iris Molecular Diagnostics, Inc. | Homogeneous analyte detection |
AU2006205066B2 (en) | 2005-01-10 | 2012-05-17 | Acadia Pharmaceuticals Inc. | Aminophenyl derivatives as selective androgen receptor modulators |
ATE412647T1 (de) | 2005-05-13 | 2008-11-15 | Lilly Co Eli | Substituierte n-arylpyrrolidine als selektive modulatoren des androgenrezeptors |
US20060281768A1 (en) * | 2005-06-10 | 2006-12-14 | Gaul Michael D | Thienopyrimidine and thienopyridine kinase modulators |
EP1911743B8 (en) * | 2005-08-01 | 2013-01-16 | Takeda Pharmaceutical Company Limited | Cyclic amine compound |
EP1987827A1 (en) * | 2006-02-20 | 2008-11-05 | Takeda Pharmaceutical Company Limited | Novel pharmaceutical |
WO2008066117A1 (fr) | 2006-11-30 | 2008-06-05 | Takeda Pharmaceutical Company Limited | Composé amine cyclique |
US20100119452A1 (en) | 2007-06-13 | 2010-05-13 | Takeda Pharmaceutical Company Limited | Screening method |
DK2176220T3 (da) * | 2007-08-07 | 2013-06-10 | Takeda Pharmaceutical | Pyrrolidin-2-on-derivater som androgenreceptormodulatorer. |
KR20100122932A (ko) * | 2008-02-21 | 2010-11-23 | 아이리스 인터내셔널 인크. | 전립선 암에 대한 요법 후 재발의 조기 결정 방법 |
MX2010009162A (es) | 2008-02-22 | 2010-12-21 | Radius Health Inc | Moduladores selectivos del receptor de androgeno. |
US8268872B2 (en) * | 2008-02-22 | 2012-09-18 | Radius Health, Inc. | Selective androgen receptor modulators |
UY32481A (es) | 2009-03-10 | 2010-09-30 | Takeda Pharmaceutical | Derivados de benzofurano |
UY32826A (es) | 2009-08-04 | 2011-02-28 | Takeda Pharmaceutical | Compuestos heterocíclicos |
CA2788907A1 (en) | 2010-02-04 | 2011-08-11 | Radius Health, Inc. | Selective androgen receptor modulators |
MX342898B (es) | 2010-05-12 | 2016-10-18 | Radius Health Inc * | Regimen terapéutico de la sal de diclorhidrato del (r) -6-(2-(etil (4-2(etilamino) etil) bencil) amino)-4-metoxifenil)-5, 6,7,8-tetrahidronaftaleno-2-ol. |
US8642632B2 (en) | 2010-07-02 | 2014-02-04 | Radius Health, Inc. | Selective androgen receptor modulators |
ES2550319T3 (es) | 2010-09-28 | 2015-11-06 | Radius Health, Inc | Moduladores selectivos del receptor de andrógenos |
FI20116033A (fi) | 2011-10-18 | 2013-04-19 | Juha Pulkkinen | Uudet ei-steroidiset yhdisteet androgeenireseptorin muuntelijoina |
CN103130734A (zh) * | 2011-12-01 | 2013-06-05 | 上海药明康德新药开发有限公司 | 一种合成1,2-吗啉盐酸盐的方法 |
DK3889145T3 (da) | 2015-12-17 | 2024-03-18 | Merck Patent Gmbh | 8-cyano-5-piperidino-quinoliner som TLR7/8-antagonister og anvendelser deraf til behandling af immunsygdomme |
LT3474841T (lt) | 2016-06-22 | 2022-06-10 | Ellipses Pharma Ltd | Ar+ krūties vėžio gydymo būdai |
BR112019000696A2 (pt) | 2016-08-08 | 2019-04-24 | Merck Patent Gmbh | antagonistas de tlr7/8 e uso dos mesmos |
EP4248968A3 (en) * | 2017-07-18 | 2023-12-06 | Merck Patent GmbH | Tlr7/8 antagonists and uses thereof |
WO2024059951A1 (en) * | 2022-09-22 | 2024-03-28 | The University Of British Columbia | Inhibitors of the androgen receptor dna-binding domain |
CN115475158A (zh) * | 2022-09-27 | 2022-12-16 | 广西科技大学 | 一种萘腈类衍生物在制备抗肿瘤药物组合物中的应用 |
Family Cites Families (21)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DK203990D0 (da) | 1990-08-24 | 1990-08-24 | Novo Nordisk As | Piperazinylderivater |
DK148392D0 (da) | 1992-12-09 | 1992-12-09 | Lundbeck & Co As H | Heterocykliske forbindelser |
FR2712591B1 (fr) | 1993-11-19 | 1996-02-09 | Pf Medicament | Nouvelles arylpipérazines dérivées d'indole, leur préparation et leur utilisation thérapeutique. |
US6069143A (en) | 1994-12-20 | 2000-05-30 | Smithkline Beecham Corporation | Fibrinogen receptor antagonists |
WO2000020034A1 (fr) | 1998-10-08 | 2000-04-13 | Takeda Chemical Industries, Ltd. | Agents destines a retarder le passage d'un cancer hormono-dependant a un cancer hormono-independant |
US6211225B1 (en) | 1999-06-30 | 2001-04-03 | Bristol-Meyers Squibb | Heterocyclic aminopyrrolidine derivatives as melatonergic agents |
UA36514C2 (uk) * | 1999-12-28 | 2003-12-15 | Інститут Монокристалів Науково-Технологічного Концерну "Інститут Монокристалів" Нан України | Спосіб одержання похідних піразолінілнафталевої кислоти |
HUP0303165A3 (en) | 2000-06-28 | 2006-05-29 | Bristol Myers Squibb Co | Fused cyclic compounds as modulators of nuclear hormone receptor function, process for their preparation and pharmaceutical compositions containing them |
CZ20024214A3 (cs) | 2000-06-28 | 2003-04-16 | Bristol-Myers Squibb Company | Selektivní androgen receptorový modulátor, způsob jeho identifikace, jeho konstrukce a použití |
WO2002011209A2 (en) | 2000-08-01 | 2002-02-07 | Emagin Corporation | Method of patterning color changing media for organic light emitting diode display devices |
JP2002088073A (ja) | 2000-09-08 | 2002-03-27 | Yamanouchi Pharmaceut Co Ltd | 抗アンドロゲン剤 |
MXPA03002412A (es) | 2000-09-19 | 2004-05-05 | Bristol Myers Squibb Co | Compuestos de succinimida heterociclicos fusionados y analogos de los mismos, moduladores de la funcion del receptor de la hormona nuclear. |
GB2370270A (en) * | 2000-12-20 | 2002-06-26 | Lilly Co Eli | Pharmaceutical compounds |
US7144883B2 (en) | 2001-06-11 | 2006-12-05 | Biovitrum Ab | Bicyclic sulfonamide compounds |
WO2003006455A1 (en) | 2001-07-11 | 2003-01-23 | Eli Lilly And Company | Pharmaceutical compounds with serotonin receptor activity |
US20050215528A1 (en) | 2001-08-10 | 2005-09-29 | Shuichi Furuya | Gnrh agonist combination drugs |
WO2003057669A1 (fr) | 2001-12-28 | 2003-07-17 | Takeda Chemical Industries, Ltd. | Antagonistes du recepteur androgene |
US20050159361A1 (en) | 2002-03-11 | 2005-07-21 | Takahito Hara | Remedies for sex hormone-dependent disease |
JP4447826B2 (ja) | 2002-06-03 | 2010-04-07 | 武田薬品工業株式会社 | 変異アンドロゲン受容体、それを発現する癌細胞、それらの作出方法およびそれらの用途 |
US7223788B2 (en) * | 2003-02-14 | 2007-05-29 | Sanofi-Aventis Deutschland Gmbh | Substituted N-aryl heterocycles, process for their preparation and their use as medicaments |
US7709516B2 (en) * | 2005-06-17 | 2010-05-04 | Endorecherche, Inc. | Helix 12 directed non-steroidal antiandrogens |
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2003
- 2003-08-11 KR KR1020057002416A patent/KR20050044902A/ko not_active Application Discontinuation
- 2003-08-11 EP EP03788076.2A patent/EP1553074B1/en not_active Expired - Lifetime
- 2003-08-11 PL PL03375042A patent/PL375042A1/xx not_active Application Discontinuation
- 2003-08-11 AU AU2003254993A patent/AU2003254993A1/en not_active Abandoned
- 2003-08-11 US US10/524,452 patent/US7649001B2/en not_active Expired - Fee Related
- 2003-08-11 WO PCT/JP2003/010228 patent/WO2004016576A1/ja not_active Application Discontinuation
- 2003-08-11 NZ NZ538713A patent/NZ538713A/en unknown
- 2003-08-11 BR BR0313405-9A patent/BR0313405A/pt not_active IP Right Cessation
- 2003-08-11 CA CA002495383A patent/CA2495383A1/en not_active Abandoned
- 2003-08-11 MX MXPA05001631A patent/MXPA05001631A/es not_active Application Discontinuation
- 2003-08-11 CN CNA038241315A patent/CN1688527A/zh active Pending
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2005
- 2005-02-09 IL IL16678905A patent/IL166789A0/xx unknown
- 2005-03-11 NO NO20051270A patent/NO20051270L/no not_active Application Discontinuation
- 2005-12-30 HK HK05112218.6A patent/HK1080067A1/zh unknown
Also Published As
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PL375042A1 (en) | 2005-11-14 |
KR20050044902A (ko) | 2005-05-13 |
MXPA05001631A (es) | 2005-08-19 |
EP1553074B1 (en) | 2014-06-18 |
EP1553074A4 (en) | 2005-10-12 |
US20060106067A1 (en) | 2006-05-18 |
EP1553074A1 (en) | 2005-07-13 |
BR0313405A (pt) | 2005-07-12 |
NZ538713A (en) | 2007-01-26 |
CA2495383A1 (en) | 2004-02-26 |
NO20051270L (no) | 2005-05-09 |
US7649001B2 (en) | 2010-01-19 |
CN1688527A (zh) | 2005-10-26 |
HK1080067A1 (zh) | 2006-04-21 |
AU2003254993A1 (en) | 2004-03-03 |
WO2004016576A1 (ja) | 2004-02-26 |
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