IL165475A0 - Nitrooxyderivatives of eyclooxygenase-2 inhibitors - Google Patents
Nitrooxyderivatives of eyclooxygenase-2 inhibitorsInfo
- Publication number
- IL165475A0 IL165475A0 IL16547503A IL16547503A IL165475A0 IL 165475 A0 IL165475 A0 IL 165475A0 IL 16547503 A IL16547503 A IL 16547503A IL 16547503 A IL16547503 A IL 16547503A IL 165475 A0 IL165475 A0 IL 165475A0
- Authority
- IL
- Israel
- Prior art keywords
- eyclooxygenase
- nitrooxyderivatives
- inhibitors
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/16—Otologicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/01—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms
- C07C311/02—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
- C07C311/08—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton having the nitrogen atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C317/00—Sulfones; Sulfoxides
- C07C317/16—Sulfones; Sulfoxides having sulfone or sulfoxide groups and singly-bound oxygen atoms bound to the same carbon skeleton
- C07C317/22—Sulfones; Sulfoxides having sulfone or sulfoxide groups and singly-bound oxygen atoms bound to the same carbon skeleton with sulfone or sulfoxide groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/23—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
- C07C323/46—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton having at least one of the nitrogen atoms, not being part of nitro or nitroso groups, further bound to other hetero atoms
- C07C323/49—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton having at least one of the nitrogen atoms, not being part of nitro or nitroso groups, further bound to other hetero atoms to sulfur atoms
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Immunology (AREA)
- Obesity (AREA)
- Neurology (AREA)
- Pulmonology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Dermatology (AREA)
- Reproductive Health (AREA)
- Endocrinology (AREA)
- Rheumatology (AREA)
- Hospice & Palliative Care (AREA)
- Gynecology & Obstetrics (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Urology & Nephrology (AREA)
- Emergency Medicine (AREA)
- Vascular Medicine (AREA)
- Oncology (AREA)
- Ophthalmology & Optometry (AREA)
- Child & Adolescent Psychology (AREA)
- Pregnancy & Childbirth (AREA)
- Cardiology (AREA)
- Orthopedic Medicine & Surgery (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IT2002MI001391A ITMI20021391A1 (it) | 2002-06-25 | 2002-06-25 | Nitroderivati di inibitori della cicloossigenasi-2 |
IT0201391 | 2002-06-25 |
Publications (1)
Publication Number | Publication Date |
---|---|
IL165475A0 true IL165475A0 (en) | 2006-01-15 |
Family
ID=11450078
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IL16547503A IL165475A0 (en) | 2002-06-25 | 2003-06-20 | Nitrooxyderivatives of eyclooxygenase-2 inhibitors |
Country Status (16)
Country | Link |
---|---|
US (1) | US7776902B2 (ru) |
EP (1) | EP1517889A2 (ru) |
JP (1) | JP4445854B2 (ru) |
CN (1) | CN100516037C (ru) |
AU (1) | AU2003245972B2 (ru) |
CA (1) | CA2491209A1 (ru) |
HK (1) | HK1080069A1 (ru) |
IL (1) | IL165475A0 (ru) |
IT (1) | ITMI20021391A1 (ru) |
MX (1) | MXPA04012851A (ru) |
NO (1) | NO20050346L (ru) |
NZ (1) | NZ537043A (ru) |
PL (1) | PL374279A1 (ru) |
RU (1) | RU2339617C2 (ru) |
WO (1) | WO2004000781A2 (ru) |
ZA (1) | ZA200410060B (ru) |
Families Citing this family (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2006501161A (ja) | 2002-06-11 | 2006-01-12 | ニトロメッド インク. | ニトロソ化および/またはニトロシル化シクロオキシゲナーゼ−2選択的阻害剤、組成物ならびに使用方法 |
US20060003996A1 (en) * | 2002-06-17 | 2006-01-05 | Stephen Roth | Intralesional treatment of psoriasis |
EP1534683A4 (en) | 2002-06-27 | 2005-08-24 | Nitromed Inc | CYCLOOXYGENASE-2 SELECTIVE INHIBITORS, COMPOSITIONS AND METHOD OF USE |
CA2493082A1 (en) | 2002-07-26 | 2004-02-05 | Merck Frosst Canada & Co. | Nitric oxide releasing prodrugs of diaryl-2-(5h)-furanones as cyclooxygenase-2 inhibitors |
CA2503063A1 (en) * | 2002-10-22 | 2004-05-06 | Merck Frosst Canada & Co./Merck Frosst Canada & Cie | Nitric oxide releasing selective cyclooxygenase-2 inhibitors |
ATE432258T1 (de) | 2003-03-05 | 2009-06-15 | Merck Frosst Company | Stickstoffmonoxid freisetzende prodrugs von diaryl-2-(5h)-furanonen als inhibitoren von cyclooxygenase-2 |
TW200616604A (en) | 2004-08-26 | 2006-06-01 | Nicholas Piramal India Ltd | Nitric oxide releasing prodrugs containing bio-cleavable linker |
KR20070053214A (ko) | 2004-08-26 | 2007-05-23 | 니콜라스 피라말 인디아 리미티드 | 신규 생분해성 링커를 함유하는 프로드럭 |
US7521435B2 (en) | 2005-02-18 | 2009-04-21 | Pharma Diagnostics, N.V. | Silicon containing compounds having selective COX-2 inhibitory activity and methods of making and using the same |
US7807716B2 (en) * | 2008-09-24 | 2010-10-05 | Oral Delivery Technology Ltd. | Nitric oxide amino acid ester compound, compositions for increasing nitric oxide levels and method of use |
PT2968440T (pt) | 2013-03-15 | 2019-07-31 | Zymeworks Inc | Compostos citotóxicos e antimitóticos e métodos de utilização dos mesmos |
US9889145B2 (en) * | 2013-04-23 | 2018-02-13 | The Administrators Of The Tulane Educational Fund | Methods to treat infections |
CA2935064C (en) | 2013-12-27 | 2023-06-27 | Zymeworks Inc. | Var2csa-drug conjugates |
EP3086815B1 (en) | 2013-12-27 | 2022-02-09 | Zymeworks Inc. | Sulfonamide-containing linkage systems for drug conjugates |
WO2015109013A1 (en) | 2014-01-14 | 2015-07-23 | Euclises Pharmaceuticals, Inc. | Deuterated no-releasing nitrooxy-chromene conjugates |
EP3194421B1 (en) | 2014-09-17 | 2021-11-03 | Zymeworks Inc. | Cytotoxic and anti-mitotic compounds, and methods of using the same |
CN105503883B (zh) * | 2015-12-30 | 2018-03-02 | 西安交通大学 | 一类西格列汀‑硝酸酯杂合体及其制备方法和应用 |
CN110396064B (zh) * | 2019-07-25 | 2020-07-10 | 南京大学 | 甲磺酰胺衍生物及其制备方法和防治阿尔茨海默病的应用 |
CN112898201A (zh) * | 2021-01-21 | 2021-06-04 | 南京理工大学 | 硝酸酯化合物以及合成吡啶亚砜亚胺导向的c-h硝酸酯化的方法 |
Family Cites Families (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3840597A (en) | 1971-02-24 | 1974-10-08 | Riker Laboratories Inc | Substituted 2-phenoxy alkane-sulfonanilides |
US5604260A (en) | 1992-12-11 | 1997-02-18 | Merck Frosst Canada Inc. | 5-methanesulfonamido-1-indanones as an inhibitor of cyclooxygenase-2 |
EP0722434B1 (en) | 1993-10-06 | 1998-07-29 | Nicox S.A. | Nitric esters having anti-inflammatory and/or analgesic activity and process for their preparation |
US5466823A (en) | 1993-11-30 | 1995-11-14 | G.D. Searle & Co. | Substituted pyrazolyl benzenesulfonamides |
KR100387359B1 (ko) | 1994-05-10 | 2003-08-27 | 니콕스 에스. 에이. | 항-염증성,비알러지성및항-혈전성을가지는니트로화합물들과그들의조성물들 |
CA2200462A1 (en) | 1994-10-27 | 1996-05-09 | Merck Frosst Canada Inc. | Stilbene derivatives useful as cyclooxygenase-2 inhibitors |
FI945082A0 (fi) * | 1994-10-28 | 1994-10-28 | Risto Nikander | Foerfarande och anordning foer justering av glashaerdningshuvudet |
JP2636819B2 (ja) * | 1994-12-20 | 1997-07-30 | 日本たばこ産業株式会社 | オキサゾール系複素環式芳香族化合物 |
JP3181190B2 (ja) * | 1994-12-20 | 2001-07-03 | 日本たばこ産業株式会社 | オキサゾール誘導体 |
CN1107058C (zh) | 1995-02-13 | 2003-04-30 | G·D·瑟尔公司 | 用于治疗类症的取代的异噁唑 |
IT1288123B1 (it) | 1996-09-04 | 1998-09-10 | Nicox Sa | Uso di nitroderivati per l'incontinenza urinaria |
CO4960662A1 (es) | 1997-08-28 | 2000-09-25 | Novartis Ag | Ciertos acidos 5-alquil-2-arilaminofenilaceticos y sus derivados |
IT1308633B1 (it) | 1999-03-02 | 2002-01-09 | Nicox Sa | Nitrossiderivati. |
IT1311924B1 (it) | 1999-04-13 | 2002-03-20 | Nicox Sa | Composti farmaceutici. |
IT1311923B1 (it) | 1999-04-13 | 2002-03-20 | Nicox Sa | Composti farmaceutici. |
US6649629B2 (en) | 1999-12-23 | 2003-11-18 | Nitromed, Inc. | Nitrosated and nitrosylated cyclooxygenase-2 inhibitors, compositions and methods of use |
IT1319202B1 (it) | 2000-10-12 | 2003-09-26 | Nicox Sa | Farmaci per le malattie a base infiammatoria. |
-
2002
- 2002-06-25 IT IT2002MI001391A patent/ITMI20021391A1/it unknown
-
2003
- 2003-06-20 PL PL03374279A patent/PL374279A1/xx not_active Application Discontinuation
- 2003-06-20 JP JP2004514803A patent/JP4445854B2/ja not_active Expired - Fee Related
- 2003-06-20 IL IL16547503A patent/IL165475A0/xx unknown
- 2003-06-20 NZ NZ537043A patent/NZ537043A/en unknown
- 2003-06-20 RU RU2004138552/04A patent/RU2339617C2/ru not_active IP Right Cessation
- 2003-06-20 EP EP03738069A patent/EP1517889A2/en not_active Withdrawn
- 2003-06-20 CN CNB038146827A patent/CN100516037C/zh not_active Expired - Fee Related
- 2003-06-20 CA CA002491209A patent/CA2491209A1/en not_active Abandoned
- 2003-06-20 AU AU2003245972A patent/AU2003245972B2/en not_active Expired - Fee Related
- 2003-06-20 WO PCT/EP2003/006502 patent/WO2004000781A2/en active Application Filing
- 2003-06-20 US US10/516,938 patent/US7776902B2/en not_active Expired - Fee Related
- 2003-06-20 MX MXPA04012851A patent/MXPA04012851A/es not_active Application Discontinuation
-
2004
- 2004-12-13 ZA ZA200410060A patent/ZA200410060B/en unknown
-
2005
- 2005-01-21 NO NO20050346A patent/NO20050346L/no not_active Application Discontinuation
-
2006
- 2006-01-04 HK HK06100164.4A patent/HK1080069A1/zh unknown
Also Published As
Publication number | Publication date |
---|---|
JP2005530836A (ja) | 2005-10-13 |
RU2004138552A (ru) | 2005-10-20 |
CA2491209A1 (en) | 2003-12-31 |
WO2004000781A2 (en) | 2003-12-31 |
ZA200410060B (en) | 2005-10-20 |
NZ537043A (en) | 2006-09-29 |
US20060106082A1 (en) | 2006-05-18 |
HK1080069A1 (zh) | 2006-04-21 |
ITMI20021391A1 (it) | 2003-12-29 |
WO2004000781A3 (en) | 2004-10-14 |
NO20050346D0 (no) | 2005-01-21 |
ITMI20021391A0 (it) | 2002-06-25 |
NO20050346L (no) | 2005-02-28 |
RU2339617C2 (ru) | 2008-11-27 |
JP4445854B2 (ja) | 2010-04-07 |
MXPA04012851A (es) | 2005-02-24 |
PL374279A1 (en) | 2005-10-03 |
AU2003245972A1 (en) | 2004-01-06 |
CN100516037C (zh) | 2009-07-22 |
US7776902B2 (en) | 2010-08-17 |
CN1662490A (zh) | 2005-08-31 |
AU2003245972B2 (en) | 2009-09-17 |
EP1517889A2 (en) | 2005-03-30 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
HK1077762A1 (zh) | TFGß[轉化生長因子]的抑制劑 | |
EG25482A (en) | Inhibitors | |
HK1072545A1 (en) | Novel inhibitors of kinases | |
HK1080069A1 (zh) | 環氧酶2-抑制劑的硝酰氧基衍生物 | |
AU2003300832A8 (en) | Nf-kappab inhibitors | |
GB2412372B (en) | Pyrazine-based tubulin inhibitors | |
AU2003217105A8 (en) | Novel of cytokine inhibitors | |
AU2003211093A8 (en) | Inhibitors of rgs proteins | |
EP1532133A4 (en) | NF-: B INHIBITORS | |
EP1577280A4 (en) | DEUTERATION PROCESS | |
ZA200409686B (en) | Bicyclic 6-aklylidene-penems as ?-lactamases inhibitors | |
PL371217A1 (en) | Inhibitors of integrin alphavbeta6 | |
AU2003230392A8 (en) | Beta-secretase inhibitors | |
EP1570847A4 (en) | PHOSPHODIESTERASE 10A HEMMER | |
IL164898A0 (en) | Heterotricyclyl 6-alkylidene-penems as beta-lactamase inhibitors | |
AU2003295638A8 (en) | Novel inhibitors of beta-lactamase | |
AU2003256323A8 (en) | Sos1 inhibitors | |
AU2003224941A8 (en) | Nf-kappab inhibitors | |
AU2003216848A8 (en) | Deracemisation of amines | |
AU2003304374A8 (en) | Peptide inhibitors of beta-lactamases | |
AU2003232362A8 (en) | 4-pyrazol-phenylalanine derivatives as ace-nep inhibitors | |
PL356853A1 (en) | Application of bacteriphages | |
GB0226149D0 (en) | Inhibitors | |
GB0207491D0 (en) | Inhibitors | |
GB0217330D0 (en) | Inhibitors |