IL161406A0 - Method for the formation of ibuprofen crystals - Google Patents

Method for the formation of ibuprofen crystals

Info

Publication number
IL161406A0
IL161406A0 IL16140602A IL16140602A IL161406A0 IL 161406 A0 IL161406 A0 IL 161406A0 IL 16140602 A IL16140602 A IL 16140602A IL 16140602 A IL16140602 A IL 16140602A IL 161406 A0 IL161406 A0 IL 161406A0
Authority
IL
Israel
Prior art keywords
formation
ibuprofen crystals
ibuprofen
crystals
Prior art date
Application number
IL16140602A
Other languages
English (en)
Original Assignee
Basf Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Basf Ag filed Critical Basf Ag
Publication of IL161406A0 publication Critical patent/IL161406A0/xx

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/14Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/185Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19Carboxylic acids, e.g. valproic acid
    • A61K31/192Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid 
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/14Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/145Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic compounds
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/14Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/146Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/14Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682Processes
    • A61K9/1688Processes resulting in pure drug agglomerate optionally containing up to 5% of excipient
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicinal Preparation (AREA)
IL16140602A 2001-11-06 2002-10-25 Method for the formation of ibuprofen crystals IL161406A0 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10153934A DE10153934A1 (de) 2001-11-06 2001-11-06 Verfahren zur Kristallisation von Profenen
PCT/EP2002/011999 WO2003039513A1 (de) 2001-11-06 2002-10-25 Verfahren zur bildung von profenkristallen

Publications (1)

Publication Number Publication Date
IL161406A0 true IL161406A0 (en) 2004-09-27

Family

ID=7704443

Family Applications (1)

Application Number Title Priority Date Filing Date
IL16140602A IL161406A0 (en) 2001-11-06 2002-10-25 Method for the formation of ibuprofen crystals

Country Status (14)

Country Link
US (1) US20050003000A1 (de)
EP (1) EP1443906A1 (de)
JP (1) JP2005512994A (de)
KR (1) KR20050039732A (de)
CN (1) CN1585630A (de)
BR (1) BR0213878A (de)
CA (1) CA2464756A1 (de)
DE (1) DE10153934A1 (de)
HU (1) HUP0402006A2 (de)
IL (1) IL161406A0 (de)
MX (1) MXPA04004236A (de)
NO (1) NO20041850L (de)
RU (1) RU2004117167A (de)
WO (1) WO2003039513A1 (de)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102005037630A1 (de) 2005-08-09 2007-02-15 Glatt Gmbh Verfahren zur Herstellung von Teilchen aus pharmazeutischen Substanzen, Teilchen aus pharmazeutischen Substanzen sowie deren Verwendung
CZ297830B6 (cs) * 2005-08-30 2007-04-11 I.Q.A., A. S. Zpusob výroby jemne krystalické smesi obsahující nesteroidní protizánetlivé lécivo, jemne krystalická smes pripravitelná tímto zpusobem a pevný farmaceutický prostredek tuto smes obsahující
WO2008011426A2 (en) 2006-07-18 2008-01-24 Horizon Therapeutics, Inc. Methods and medicaments for administration of ibuprofen
WO2009008873A1 (en) * 2007-07-06 2009-01-15 Basf Corporation A gastroretentive composition on the basis of a water-soluble reaction product from a vinyl group- containing precursor
US8216495B2 (en) * 2008-03-25 2012-07-10 Formac Pharmaceuticals N.V. Preparation method for solid dispersions
EP2374478B1 (de) * 2008-12-04 2017-08-23 Next 21 K.K. Inklusionskomplexe aus einem nsaid und einem disaccharid zur linderung von schäden im magen-darm-schleimhautbereich
CN102470118B (zh) * 2009-07-24 2014-12-17 21世纪国际新技术株式会社 含有NSAIDs的外用剂及该外用剂的制造方法
JP5750856B2 (ja) * 2010-10-04 2015-07-22 ライオン株式会社 固形医薬組成物及び医薬製剤
US9248139B2 (en) * 2011-12-21 2016-02-02 Bristol-Myers Squibb Company Co-processing method and formulations for HIV attachment inhibitor prodrug compound and excipients
LT3258920T (lt) * 2015-02-17 2023-07-25 Universiteit Gent Kieta farmacinė dozavimo forma, tinkanti tirpinti geriamajame vandenyje ir vartoti kaip geriamąjį vaistinį tirpalą
CN106518655B (zh) * 2016-09-08 2019-01-04 山东理工大学 一种通过添加晶形控制剂自水溶液中制备片状布洛芬晶体的方法
CN106397181B (zh) * 2016-09-08 2019-01-01 山东理工大学 一种通过添加十二烷基硫酸钠自水溶液中制备长针状布洛芬晶体的方法
CN110627629A (zh) * 2019-10-15 2019-12-31 山东新华制药股份有限公司 一种多级连续反应结晶生产布洛芬的方法
JP2023084097A (ja) * 2021-12-06 2023-06-16 花王株式会社 芳香族ヒドロキシカルボン酸結晶の製造方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4476248A (en) * 1983-02-28 1984-10-09 The Upjohn Company Crystallization of ibuprofen
US5141961A (en) * 1991-06-27 1992-08-25 Richrdson-Vicks Inc. Process for solubilizing difficulty soluble pharmaceutical actives
GB9119052D0 (en) * 1991-09-06 1991-10-23 Boots Co Plc Pharmaceutical compositions
JP3390477B2 (ja) * 1993-01-25 2003-03-24 生化学工業株式会社 薬剤組成物及びその製造法
US5718919A (en) * 1995-02-24 1998-02-17 Nanosystems L.L.C. Nanoparticles containing the R(-)enantiomer of ibuprofen

Also Published As

Publication number Publication date
EP1443906A1 (de) 2004-08-11
BR0213878A (pt) 2004-08-31
NO20041850L (no) 2004-05-05
MXPA04004236A (es) 2004-07-08
HUP0402006A2 (hu) 2005-01-28
US20050003000A1 (en) 2005-01-06
CN1585630A (zh) 2005-02-23
WO2003039513A1 (de) 2003-05-15
KR20050039732A (ko) 2005-04-29
JP2005512994A (ja) 2005-05-12
RU2004117167A (ru) 2005-04-10
DE10153934A1 (de) 2003-05-22
CA2464756A1 (en) 2003-05-15

Similar Documents

Publication Publication Date Title
EP1425279A4 (de) Verfahren zur herstellung von kristallinen tetrahydrobenzothiepinen
HK1052183A1 (zh) 製造tetrahydrobenzothiepines的方法
IL157478A0 (en) Method for the synthesis of 2', 3'-didehydronucleosides
HK1068887A1 (en) Method for the preparation of hexahydro-furo
IL159183A0 (en) Method for the preparation of escitalopram
IL146598A0 (en) Method for the preparation of aggregates
EP1392332A4 (de) Verfahren zur zerstörung von oozysten
IL161406A0 (en) Method for the formation of ibuprofen crystals
IL161714A0 (en) Method for the preparation of escitalopram
AU2002305333A1 (en) Compounds and methods for the modulation of cd154
IL143106A (en) Process for the preparation of diphenylmethylthioacetamide
AU2002353310A8 (en) Method for the preparation of nucleic acids
EP1556400A4 (de) Verfahren zur herstellung von 2-halogen-2-desoxyadenosinverbindungen aus 2-desoxyguanosin
IL162140A0 (en) Method for the preparation of l-alpha-fluoro corticosteroids
GB0126716D0 (en) Method for the production of particles
HUP0303025A3 (en) Process for the preparation of arylethanoldiamines
IL162770A0 (en) Process for the preparation methylsteroids of 7
SG111997A1 (en) Improved process for the preparation of polyalkylphenoxyaminoalkanes
IL158119A0 (en) Method for the production of delta1-pyrrolines
IL164788A0 (en) Process for the preparation of 3-isochromanone
AU2002342862A1 (en) Method for the formation of ibuprofen crystals
PL368905A1 (en) Process for the preparation of beta-ionylideneacetaldehyde
GB2383350B (en) Removable anchor for memorials
AU2002352014A1 (en) Method for the production of organodiphosphonites
SI1395580T1 (en) Method for the purification of triazolylmethylepoxides