IL159494A0 - 6-2'-(phosphonomethoxy) alkoxy pyrimidine derivatives having antiviral activity - Google Patents
6-2'-(phosphonomethoxy) alkoxy pyrimidine derivatives having antiviral activityInfo
- Publication number
- IL159494A0 IL159494A0 IL15949402A IL15949402A IL159494A0 IL 159494 A0 IL159494 A0 IL 159494A0 IL 15949402 A IL15949402 A IL 15949402A IL 15949402 A IL15949402 A IL 15949402A IL 159494 A0 IL159494 A0 IL 159494A0
- Authority
- IL
- Israel
- Prior art keywords
- phosphonomethoxy
- antiviral activity
- pyrimidine derivatives
- alkoxy pyrimidine
- alkoxy
- Prior art date
Links
- -1 alkoxy pyrimidine derivatives Chemical class 0.000 title 1
- 230000000840 anti-viral effect Effects 0.000 title 1
- 229940083082 pyrimidine derivative acting on arteriolar smooth muscle Drugs 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/645—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having two nitrogen atoms as the only ring hetero atoms
- C07F9/6509—Six-membered rings
- C07F9/6512—Six-membered rings having the nitrogen atoms in positions 1 and 3
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Virology (AREA)
- Molecular Biology (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Biochemistry (AREA)
- Tropical Medicine & Parasitology (AREA)
- AIDS & HIV (AREA)
- Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US30221201P | 2001-06-29 | 2001-06-29 | |
| PCT/CZ2002/000038 WO2003002580A1 (fr) | 2001-06-29 | 2002-06-28 | Nouveaux composes et methodes therapeutiques |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IL159494A0 true IL159494A0 (en) | 2004-06-01 |
Family
ID=23166777
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL15949402A IL159494A0 (en) | 2001-06-29 | 2002-06-28 | 6-2'-(phosphonomethoxy) alkoxy pyrimidine derivatives having antiviral activity |
| IL159494A IL159494A (en) | 2001-06-29 | 2003-12-22 | Derivatives 6 – '2– (phosphonomethoxy) alkoxy pyrimidine with antiviral activity |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL159494A IL159494A (en) | 2001-06-29 | 2003-12-22 | Derivatives 6 – '2– (phosphonomethoxy) alkoxy pyrimidine with antiviral activity |
Country Status (21)
| Country | Link |
|---|---|
| US (2) | US6818633B2 (fr) |
| EP (1) | EP1406911B1 (fr) |
| JP (1) | JP4545434B2 (fr) |
| KR (1) | KR100891366B1 (fr) |
| CN (1) | CN1329404C (fr) |
| AP (1) | AP1622A (fr) |
| AU (1) | AU2002315625B2 (fr) |
| BR (1) | BRPI0210746B8 (fr) |
| CA (1) | CA2452036C (fr) |
| CZ (1) | CZ297267B6 (fr) |
| EA (1) | EA006020B1 (fr) |
| ES (1) | ES2564144T3 (fr) |
| HU (1) | HU230519B1 (fr) |
| IL (2) | IL159494A0 (fr) |
| MX (1) | MXPA04000138A (fr) |
| NO (2) | NO333788B1 (fr) |
| NZ (1) | NZ530685A (fr) |
| PL (1) | PL207187B1 (fr) |
| TR (1) | TR200302288T2 (fr) |
| WO (1) | WO2003002580A1 (fr) |
| ZA (1) | ZA200400236B (fr) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR101102815B1 (ko) * | 2003-06-16 | 2012-01-05 | 케이.유.루벤 리서치 앤드 디벨럽먼트 | 항바이러스 뉴클레오티드 유사체인 포스포네이트기를 갖는 피리미딘 화합물 |
| US20060211650A1 (en) * | 2004-12-16 | 2006-09-21 | Forest Laboratories, Inc. | Reducing carbohydrate derivatives of adamantane amines, and synthesis and methods of use thereof |
| ES2401285T3 (es) | 2004-12-16 | 2013-04-18 | The Regents Of The University Of California | Fármacos con el pulmón como diana |
| AU2006272521A1 (en) * | 2005-07-27 | 2007-02-01 | Gilead Sciences, Inc. | Antiviral phosphonate conjugates for inhibition of HIV |
| US7473683B2 (en) | 2005-09-14 | 2009-01-06 | The Board Of Trustees Of The Leland Stanford Junior University | Nonpolar thymidine analogs |
| US20080318986A1 (en) * | 2005-10-13 | 2008-12-25 | Schiffman Rhett M | Ddc Compositions |
| FR2908133B1 (fr) * | 2006-11-08 | 2012-12-14 | Centre Nat Rech Scient | Nouveaux analogues de nucleotides comme molecules precurseurs d'antiviraux |
| EP2707004A1 (fr) * | 2011-05-10 | 2014-03-19 | Okapi Sciences NV | Composés destinés à être utilisés dans le traitement d'infections rétrovirales chez les félins |
| ES2687958T3 (es) | 2013-03-15 | 2018-10-30 | The Regents Of The University Of California | Fosfonato diésteres de nucleósido acíclico |
| CN104119385B (zh) * | 2014-07-24 | 2017-04-05 | 廖国超 | 核苷类似物的磷酸酯前药及其应用 |
| SG11201701957XA (en) | 2014-09-15 | 2017-04-27 | Univ California | Nucleotide analogs |
| EP3350191B9 (fr) | 2015-09-15 | 2021-12-22 | The Regents of the University of California | Analogues nucléotidiques |
| WO2019206907A1 (fr) * | 2018-04-23 | 2019-10-31 | Centre National De La Recherche Scientifique | Nouveaux analogues d'acyclonucléosides antiviraux |
Family Cites Families (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CS233665B1 (en) | 1983-01-06 | 1985-03-14 | Antonin Holy | Processing of isomere o-phosphonylmethylderivative of anantiomere racemic vicinal diene |
| CS263952B1 (en) | 1985-04-25 | 1989-05-12 | Holy Antonin | Remedy with antiviral effect |
| CS263951B1 (en) | 1985-04-25 | 1989-05-12 | Antonin Holy | 9-(phosponylmethoxyalkyl)adenines and method of their preparation |
| CS264222B1 (en) | 1986-07-18 | 1989-06-13 | Holy Antonin | N-phosphonylmethoxyalkylderivatives of bases of pytimidine and purine and method of use them |
| NZ222553A (en) | 1986-11-18 | 1991-07-26 | Bristol Myers Co | Phosphonomethoxyalkylene purine and pyrimidine derivatives and pharmaceutical compositions |
| CA2001715C (fr) | 1988-11-14 | 1999-12-28 | Muzammil M. Mansuri | Nucleosides et nucleotides carbocycliques |
| CA2479846C (fr) | 1989-05-15 | 2007-07-24 | Institute Of Organic Chemistry And Biochemistry Of The Academy Of Scienc Es Of The Czech Republic | Derives de phosphonomethoxymethylpurine/pyrimidine |
| MY104575A (en) | 1989-12-22 | 1994-04-30 | The Wellcome Foundation Ltd | Therapeutic nucleosides. |
| US5302585A (en) * | 1990-04-20 | 1994-04-12 | Institute Of Organic Chemistry And Biochemistry Of The Academy Of Sciences Of The Czech Republic | Use of chiral 2-(phosphonomethoxy)propyl guanines as antiviral agents |
| CZ285420B6 (cs) | 1990-04-24 | 1999-08-11 | Ústav Organické Chemie A Biochemie Avčr | N-(3-Fluor-2-fosfonylmethoxypropyl)deriváty purinových a pyrimidinových heterocyklických bazí, způsoby jejich přípravy a použití |
| US5356886A (en) | 1990-07-19 | 1994-10-18 | Beecham Group P.L.C. | Antiviral phosphono-alken derivatives of purines |
| EP0468119A1 (fr) | 1990-07-24 | 1992-01-29 | Merrell Dow Pharmaceuticals Inc. | Nouveaux analogues carbocycliques de certains nucléosides |
| DK0481214T3 (da) | 1990-09-14 | 1999-02-22 | Acad Of Science Czech Republic | Prolægemidler af phosphonater |
| US5208221A (en) | 1990-11-29 | 1993-05-04 | Bristol-Myers Squibb Company | Antiviral (phosphonomethoxy) methoxy purine/pyrimidine derivatives |
| CZ284678B6 (cs) | 1991-05-20 | 1999-01-13 | Ústav Organické Chemie A Biochemie Avčr | Di(2-propyl)estery 1-fluor-2-fosfonomethoxy-3-p -toluensulfonyloxypropanů, způsob jejich přípravy a použití |
| EP0531597A1 (fr) * | 1991-09-12 | 1993-03-17 | Merrell Dow Pharmaceuticals Inc. | Dérivés acycliques insaturés d'acides phosphoniques puriniques ou pyrimidimiques |
| JP3497505B2 (ja) | 1991-10-11 | 2004-02-16 | インスティテュート オブ オルガニック ケミストリー アンド バイオケミストリー オブ ザ アカデミー オブ サイエンシズ オブ ザ チェコ パブリック | 抗ウイルス性非環式ホスホノメトキシアルキル置換アルケニル及びアルキニルプリン及びピリミジン誘導体 |
| US6057305A (en) | 1992-08-05 | 2000-05-02 | Institute Of Organic Chemistry And Biochemistry Of The Academy Of Sciences Of The Czech Republic | Antiretroviral enantiomeric nucleotide analogs |
| EP0618214A1 (fr) | 1993-04-01 | 1994-10-05 | Merrell Dow Pharmaceuticals Inc. | Dérivés phosphonates insaturés de purines et de pyrimidines |
| JP4086314B2 (ja) | 1993-09-17 | 2008-05-14 | ギリアード サイエンシーズ， インコーポレイテッド | ヌクレオチドアナログ |
| US5977061A (en) | 1995-04-21 | 1999-11-02 | Institute Of Organic Chemistry And Biochemistry Of The Academy Of Sciences Of The Czech Republic | N6 - substituted nucleotide analagues and their use |
-
2002
- 2002-06-28 KR KR1020037017181A patent/KR100891366B1/ko active IP Right Grant
- 2002-06-28 JP JP2003508961A patent/JP4545434B2/ja not_active Expired - Lifetime
- 2002-06-28 CZ CZ20040142A patent/CZ297267B6/cs not_active IP Right Cessation
- 2002-06-28 PL PL366852A patent/PL207187B1/pl unknown
- 2002-06-28 AP APAP/P/2004/002953A patent/AP1622A/en active
- 2002-06-28 MX MXPA04000138A patent/MXPA04000138A/es active IP Right Grant
- 2002-06-28 TR TR2003/02288T patent/TR200302288T2/xx unknown
- 2002-06-28 NZ NZ530685A patent/NZ530685A/en not_active IP Right Cessation
- 2002-06-28 ES ES02740215.5T patent/ES2564144T3/es not_active Expired - Lifetime
- 2002-06-28 CN CNB028145712A patent/CN1329404C/zh not_active Expired - Lifetime
- 2002-06-28 HU HU0400345A patent/HU230519B1/hu unknown
- 2002-06-28 EP EP02740215.5A patent/EP1406911B1/fr not_active Expired - Lifetime
- 2002-06-28 BR BR0210746-5 patent/BRPI0210746B8/pt not_active IP Right Cessation
- 2002-06-28 IL IL15949402A patent/IL159494A0/xx active IP Right Grant
- 2002-06-28 CA CA002452036A patent/CA2452036C/fr not_active Expired - Lifetime
- 2002-06-28 AU AU2002315625A patent/AU2002315625B2/en not_active Expired
- 2002-06-28 US US10/187,166 patent/US6818633B2/en not_active Expired - Lifetime
- 2002-06-28 EA EA200400117A patent/EA006020B1/ru unknown
- 2002-06-28 WO PCT/CZ2002/000038 patent/WO2003002580A1/fr active IP Right Grant
-
2003
- 2003-12-22 IL IL159494A patent/IL159494A/en unknown
- 2003-12-23 NO NO20035797A patent/NO333788B1/no not_active IP Right Cessation
-
2004
- 2004-01-13 ZA ZA200400236A patent/ZA200400236B/en unknown
- 2004-09-21 US US10/946,421 patent/US20050038058A1/en not_active Abandoned
-
2013
- 2013-08-09 NO NO20131091A patent/NO335725B1/no not_active IP Right Cessation
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| HUS2200038I1 (hu) | HIV-gátló pirimidinszármazékok | |
| HK1062300A1 (en) | 4-Amino-5-phenyl-7-cyclobutyl-pyrrolo (2,3-d)pyrimidine derivatives | |
| DK1416935T3 (da) | 4-Amino-6-phenyl-pyrrolo[2,3-d]pyrimidinderivater | |
| GB0112617D0 (en) | Antiviral nucleoside derivatives | |
| HUP0402171A3 (en) | Pyrazolopyrimidinone derivatives having pde7-inhibitory activity | |
| IL153754A0 (en) | Pyrimidine derivatives | |
| HK1070071A1 (en) | New pyrimidine compounds | |
| AU1041802A (en) | Tetrahydro-heterocycloazepinyl pyrimidine derivatives | |
| EP1458687A4 (fr) | Composes de pyrimidine | |
| IL159494A0 (en) | 6-2'-(phosphonomethoxy) alkoxy pyrimidine derivatives having antiviral activity | |
| HK1078079A1 (en) | Pyrimidine derivatives | |
| EP1406619A4 (fr) | Derives de guanidine ou de biguanidine antiviraux et antimicrobiens | |
| AU2002362806A1 (en) | Pyrimidine derivatives | |
| GB0112803D0 (en) | Pyrimidine derivatives | |
| PL373334A1 (en) | 4"-deoxy-4"-(s)-amido avermectin derivatives | |
| AU2002352782A8 (en) | Antitumor activity of bok | |
| GB0119477D0 (en) | Pyrimidine derivatives | |
| GB0119475D0 (en) | Pyrimidine derivatives | |
| GB0112809D0 (en) | Pyrimidine derivatives | |
| GB0112805D0 (en) | Pyrimidine derivatives | |
| GB0112807D0 (en) | Pyrimidine derivatives | |
| GB0112808D0 (en) | Pyrimidine derivatives | |
| GB0112804D0 (en) | Pyrimidine derivatives | |
| GB0130695D0 (en) | Pyrazola[4,3]pyrimidine | |
| SI1446399T1 (en) | Piperazine derivatives having sst1 antagonistic activity |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FF | Patent granted | ||
| FF | Patent granted |