IL159324A0 - Dopaminergic neurons and proliferation-competent precursor cells for treating parkinson's disease - Google Patents
Dopaminergic neurons and proliferation-competent precursor cells for treating parkinson's diseaseInfo
- Publication number
- IL159324A0 IL159324A0 IL15932402A IL15932402A IL159324A0 IL 159324 A0 IL159324 A0 IL 159324A0 IL 15932402 A IL15932402 A IL 15932402A IL 15932402 A IL15932402 A IL 15932402A IL 159324 A0 IL159324 A0 IL 159324A0
- Authority
- IL
- Israel
- Prior art keywords
- proliferation
- disease
- precursor cells
- dopaminergic neurons
- treating parkinson
- Prior art date
Links
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- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0603—Embryonic cells ; Embryoid bodies
- C12N5/0606—Pluripotent embryonic cells, e.g. embryonic stem cells [ES]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
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- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
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- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biomedical Technology (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- General Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Cell Biology (AREA)
- Developmental Biology & Embryology (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Immunology (AREA)
- Reproductive Health (AREA)
- Plant Pathology (AREA)
- Crystallography & Structural Chemistry (AREA)
- Gynecology & Obstetrics (AREA)
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- Pain & Pain Management (AREA)
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Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US09/888,309 US20020019046A1 (en) | 2000-01-11 | 2001-06-21 | Direct differentiation of human pluripotent stem cells and characterization of differentiated cells |
US10/157,288 US7250294B2 (en) | 2000-05-17 | 2002-05-28 | Screening small molecule drugs using neural cells differentiated from human embryonic stem cells |
PCT/US2002/019477 WO2003000868A1 (en) | 2001-06-21 | 2002-06-20 | Dopaminergic neurons and proliferation-competent precursor cells for treating parkinson's disease |
Publications (1)
Publication Number | Publication Date |
---|---|
IL159324A0 true IL159324A0 (en) | 2004-06-01 |
Family
ID=54328829
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IL15932402A IL159324A0 (en) | 2001-06-21 | 2002-06-20 | Dopaminergic neurons and proliferation-competent precursor cells for treating parkinson's disease |
IL159324A IL159324A (en) | 2001-06-21 | 2003-12-11 | Methods of differentiation of pPS cells for the population of neurons using antibodies to the TGF-β family |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IL159324A IL159324A (en) | 2001-06-21 | 2003-12-11 | Methods of differentiation of pPS cells for the population of neurons using antibodies to the TGF-β family |
Country Status (10)
Country | Link |
---|---|
US (1) | US7250294B2 (zh) |
EP (1) | EP1404812B1 (zh) |
JP (4) | JP4526265B2 (zh) |
KR (2) | KR101247037B1 (zh) |
CN (1) | CN100384986C (zh) |
AU (1) | AU2002322270B2 (zh) |
CA (1) | CA2451486C (zh) |
GB (1) | GB2393733B (zh) |
IL (2) | IL159324A0 (zh) |
WO (1) | WO2003000868A1 (zh) |
Families Citing this family (91)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB9518606D0 (en) | 1995-09-12 | 1995-11-15 | Inst Of Psychiatry | Neural transplantation |
US6667176B1 (en) * | 2000-01-11 | 2003-12-23 | Geron Corporation | cDNA libraries reflecting gene expression during growth and differentiation of human pluripotent stem cells |
US7410798B2 (en) | 2001-01-10 | 2008-08-12 | Geron Corporation | Culture system for rapid expansion of human embryonic stem cells |
US20050042749A1 (en) * | 2001-05-16 | 2005-02-24 | Carpenter Melissa K. | Dopaminergic neurons and proliferation-competent precursor cells for treating Parkinson's disease |
WO2001088104A2 (en) | 2000-05-17 | 2001-11-22 | Geron Corporation | Neural progenitor cell populations |
US20030134422A1 (en) * | 2002-01-16 | 2003-07-17 | Sayre Chauncey Bigelow | Stem cell maturation for all tissue lines |
US20050170506A1 (en) * | 2002-01-16 | 2005-08-04 | Primegen Biotech Llc | Therapeutic reprogramming, hybrid stem cells and maturation |
US20050090004A1 (en) * | 2003-01-16 | 2005-04-28 | Sayre Chauncey B. | Stem cell maturation for all tissue lines |
GB2427616B (en) * | 2002-06-05 | 2007-04-04 | Es Cell Int Pte Ltd | Stem cells |
US20050101014A1 (en) | 2002-07-11 | 2005-05-12 | Keirstead Hans S. | Oligodendrocytes derived from human embryonic stem cells for remyelination and treatment of spinal cord injury |
US7632679B2 (en) * | 2002-07-16 | 2009-12-15 | The Trustees Of Columbia University In The City Of New York | Systems and methods for screening for modulators of neural differentiation |
US20040224302A1 (en) * | 2002-07-16 | 2004-11-11 | Thomas Jessel | Systems and methods for screening for modulators of neural differentiation |
US8293488B2 (en) * | 2002-12-09 | 2012-10-23 | Neuralstem, Inc. | Method for screening neurogenic agents |
CA2508880C (en) | 2002-12-16 | 2018-02-06 | Technion Research And Development Foundation Ltd. | Methods of preparing feeder cells-free, xeno-free human embryonic stem cells and stem cell cultures prepared using same |
ZA200401646B (en) * | 2003-03-12 | 2004-06-07 | Reliance Life Sciences Pvt Ltd | Derivation of terminally differentiated dopaminergic neurons from human embryonic stem cells. |
CA2518577A1 (en) * | 2003-03-12 | 2004-09-23 | Reliance Life Sciences Pvt. Ltd. | Derivation of terminally differentiated dopaminergic neurons from human embryonic stem cells |
US7459152B2 (en) * | 2003-04-23 | 2008-12-02 | Rush University Medical Center | Erythropoietin administration to improve graft survival |
US7820439B2 (en) * | 2003-09-03 | 2010-10-26 | Reliance Life Sciences Pvt Ltd. | In vitro generation of GABAergic neurons from pluripotent stem cells |
WO2005046598A2 (en) * | 2003-11-07 | 2005-05-26 | University Of Florida Research Foundation, Inc. | Culturing and differentiating neural precursor cells |
JP4481706B2 (ja) * | 2004-03-31 | 2010-06-16 | 独立行政法人科学技術振興機構 | 脳梗塞疾患モデルマウス |
CN109136173B (zh) * | 2004-05-21 | 2022-01-18 | 威塞尔研究所股份有限公司 | 无饲养细胞的胚胎干细胞的长期培养物 |
US20070196918A1 (en) * | 2004-07-15 | 2007-08-23 | Sayre Chauncey B | Reprogramming of adult human testicular stem cells to pluripotent germ-line stem cells |
US20070020759A1 (en) * | 2004-07-15 | 2007-01-25 | Primegen Biotech Llc | Therapeutic reprogramming of germ line stem cells |
US20060188491A1 (en) * | 2004-07-15 | 2006-08-24 | Primegen Biotech, Llc | Use of nuclear material to therapeutically reprogram differentiated cells |
US20060069008A1 (en) * | 2004-09-28 | 2006-03-30 | Sanjay Mistry | Treatment of neurological deficits in the striatum or substanta nigra pars compacta |
DK1645626T3 (da) | 2004-09-30 | 2008-01-21 | Reneuron Ltd | Cellelinie |
WO2006055841A2 (en) * | 2004-11-19 | 2006-05-26 | University Of Florida Research Foundation, Inc. | Indefinite culture of human adult glia without immortalization and therapeutic uses thereof |
CN101233226B (zh) | 2005-06-22 | 2017-08-11 | 阿斯特利亚斯生物治疗股份公司 | 人胚胎干细胞的悬浮培养物 |
EP1904843A2 (en) * | 2005-07-08 | 2008-04-02 | Braincells, Inc. | Methods for identifying agents and conditions that modulate neurogenesis |
US9274099B2 (en) | 2005-07-22 | 2016-03-01 | The Board Of Trustees Of The Leland Stanford Junior University | Screening test drugs to identify their effects on cell membrane voltage-gated ion channel |
US8926959B2 (en) | 2005-07-22 | 2015-01-06 | The Board Of Trustees Of The Leland Stanford Junior University | System for optical stimulation of target cells |
WO2007024391A2 (en) | 2005-07-22 | 2007-03-01 | The Board Of Trustees Of The Leland Stanford Junior University | Light-activated cation channel and uses thereof |
WO2007026353A2 (en) | 2005-08-29 | 2007-03-08 | Technion Research & Development Foundation Ltd. | Media for culturing stem cells |
GB0526664D0 (en) * | 2005-11-30 | 2006-02-08 | Plasticell Ltd | Method |
KR100838013B1 (ko) * | 2006-06-07 | 2008-06-12 | 제일약품주식회사 | 인간배아줄기세포로부터 단계적 선별법을 통해 고수율로신경전구세포, 신경세포 및 기능성 도파민신경세포를생성하는 방법 |
US20080044847A1 (en) * | 2006-06-23 | 2008-02-21 | Shusta Eric V | Blood-Brain Barrier Model |
US9040297B2 (en) | 2006-08-02 | 2015-05-26 | Technion Research & Development Foundation Limited | Methods of expanding embryonic stem cells in a suspension culture |
US8398692B2 (en) | 2007-01-10 | 2013-03-19 | The Board Of Trustees Of The Leland Stanford Junior University | System for optical stimulation of target cells |
WO2008106694A2 (en) | 2007-03-01 | 2008-09-04 | The Board Of Trustees Of The Leland Stanford Junior University | Systems, methods and compositions for optical stimulation of target cells |
US9765297B2 (en) * | 2007-04-13 | 2017-09-19 | The Trustees Of Columbia University In The City Of New York | Stem cell-based culture system for drug development |
WO2008156708A2 (en) * | 2007-06-15 | 2008-12-24 | Massachusetts Institute Of Technology | Methods and compositions for enhanced differentiation from embryonic stem cells |
US10434327B2 (en) | 2007-10-31 | 2019-10-08 | The Board Of Trustees Of The Leland Stanford Junior University | Implantable optical stimulators |
CN101939362A (zh) | 2008-01-30 | 2011-01-05 | 杰龙公司 | 用于培养干细胞衍生的少突胶质细胞前体细胞的合成表面 |
AU2009238467B2 (en) | 2008-04-23 | 2015-06-25 | The Board Of Trustees Of The Leland Stanford Junior University | Systems, methods and compositions for optical stimulation of target cells |
MX2010014101A (es) | 2008-06-17 | 2011-03-04 | Univ Leland Stanford Junior | Aparato y metodos para controlar el desarrollo celular. |
US9101759B2 (en) | 2008-07-08 | 2015-08-11 | The Board Of Trustees Of The Leland Stanford Junior University | Materials and approaches for optical stimulation of the peripheral nervous system |
US8969081B2 (en) * | 2008-12-10 | 2015-03-03 | The Trustees Of Columbia University In The City Of New York | Caudal motor neuron derived from embryonic stem cells under conditions essentially free of any retinoid |
JPWO2010084970A1 (ja) * | 2009-01-23 | 2012-07-19 | 国立大学法人大阪大学 | 標的細胞誘導用フィーダー細胞 |
US8642334B2 (en) | 2009-02-17 | 2014-02-04 | Memorial Sloan Kettering Cancer Center | Methods of neural conversion of human embryonic stem cells |
EP2440660A4 (en) * | 2009-06-10 | 2013-08-28 | Brainstem Biotec Ltd | METHODS, SYSTEMS, AND COMPOSITIONS FOR NEURONAL DIFFERENTIATION OF PLURIPOTENT STROMAL CELLS |
US9388381B2 (en) | 2009-07-09 | 2016-07-12 | Massachusetts Institute Of Technology | Methods and compositions for increased safety of stem cell-derived populations |
CN102597218B (zh) * | 2009-08-12 | 2017-10-27 | 国立大学法人京都大学 | 用于诱导多能干细胞分化成神经前体细胞的方法 |
US11261425B2 (en) | 2009-08-12 | 2022-03-01 | Kyoto University | Method for inducing differentiation of pluripotent stem cells into neural precursor cells |
US9018010B2 (en) | 2009-11-12 | 2015-04-28 | Technion Research & Development Foundation Limited | Culture media, cell cultures and methods of culturing pluripotent stem cells in an undifferentiated state |
US20130059309A1 (en) * | 2010-02-22 | 2013-03-07 | Jian Feng | Dopaminergic Neurons Derived From Induced Pluripotent Stem Cells and Method of Making Same |
CA2796616A1 (en) | 2010-04-21 | 2011-10-27 | Research Development Foundation | Methods and compositions related to dopaminergic neuronal cells |
EP2582793B1 (en) | 2010-06-15 | 2017-09-06 | Cellular Dynamics International, Inc. | A compendium of ready-built stem cell models for interrogation of biological response |
EP4245370A3 (en) | 2010-07-12 | 2023-11-29 | University of Southern California | Biocompatible substrate for facilitating interconnections between stem cells and target tissues and methods for implanting same |
EP2598635B1 (en) | 2010-07-30 | 2014-10-22 | Cambridge Enterprise Limited | Corticogenesis of human pluripotent cells |
CA2806858C (en) | 2010-08-04 | 2021-06-15 | Cellular Dynamics International, Inc. | Reprogramming immortalized b cells |
EP2635111B1 (en) | 2010-11-05 | 2018-05-23 | The Board of Trustees of the Leland Stanford Junior University | Stabilized step function opsin proteins and methods of using the same |
WO2012061684A1 (en) | 2010-11-05 | 2012-05-10 | The Board Of Trustees Of The Leland Stanford Junior University | Upconversion of light for use in optogenetic methods |
US10086012B2 (en) | 2010-11-05 | 2018-10-02 | The Board Of Trustees Of The Leland Stanford Junior University | Control and characterization of memory function |
CA2816971A1 (en) | 2010-11-05 | 2012-05-10 | The Board Of Trustees Of The Leland Stanford Junior University | Light-activated chimeric opsins and methods of using the same |
US8696722B2 (en) | 2010-11-22 | 2014-04-15 | The Board Of Trustees Of The Leland Stanford Junior University | Optogenetic magnetic resonance imaging |
US8877489B2 (en) | 2011-12-05 | 2014-11-04 | California Institute Of Technology | Ultrathin parylene-C semipermeable membranes for biomedical applications |
WO2012149468A2 (en) | 2011-04-29 | 2012-11-01 | University Of Southern California | Instruments and methods for the implantation of cell-seeded substrates |
US9670463B2 (en) | 2011-10-14 | 2017-06-06 | Children's Medical Center Corporation | Inhibition and enhancement of reprogramming by chromatin modifying enzymes |
WO2013067362A1 (en) | 2011-11-04 | 2013-05-10 | Memorial Sloan-Kettering Cancer Center | Midbrain dopamine (da) neurons for engraftment |
US9248013B2 (en) | 2011-12-05 | 2016-02-02 | California Institute Of Technology | 3-Dimensional parylene scaffold cage |
AU2012352429B2 (en) | 2011-12-16 | 2018-07-19 | The Board Of Trustees Of The Leland Stanford Junior University | Opsin polypeptides and methods of use thereof |
WO2013126521A1 (en) | 2012-02-21 | 2013-08-29 | The Board Of Trustees Of The Leland Stanford Junior University | Compositions and methods for treating neurogenic disorders of the pelvic floor |
US9447378B2 (en) | 2012-04-27 | 2016-09-20 | Massachusetts Institute Of Technology | Method for differentiating human embryonic stem cells into β-cells for the treatment of type I diabetes |
AU2014227600B2 (en) | 2013-03-15 | 2018-10-04 | The Board Of Trustees Of The Leland Stanford Junior University | Optogenetic control of behavioral state |
EP2989198A4 (en) | 2013-04-26 | 2016-10-26 | Sloan Kettering Inst Cancer | CORTICAL INTERNEURONES AND OTHER NEURONAL CELLS PRODUCED BY DIRECTED DIFFERENTIATION OF PLURIPOTENT AND MULTIPOTENT CELLS |
CN105431046B (zh) | 2013-04-29 | 2020-04-17 | 小利兰·斯坦福大学托管委员会 | 用于靶细胞中的动作电位的光遗传学调节的装置、系统和方法 |
US9816070B2 (en) | 2013-06-14 | 2017-11-14 | Massachusetts Institute Of Technology | Articles and methods for stem cell differentiation |
CN105658788B (zh) * | 2013-08-06 | 2020-07-10 | 武田药品工业株式会社 | 多巴胺能神经元的制备方法 |
JP6621747B2 (ja) | 2013-08-14 | 2019-12-18 | ザ ボード オブ トラスティーズ オブ ザ レランド スタンフォード ジュニア ユニバーシティー | 疼痛を制御するための組成物及び方法 |
WO2015111602A1 (ja) | 2014-01-21 | 2015-07-30 | 独立行政法人科学技術振興機構 | アダルト型オリゴデンドロサイト前駆細胞の製造方法 |
ES2939807T3 (es) | 2014-03-21 | 2023-04-27 | Fujifilm Cellular Dynamics Inc | Producción de neuronas dopaminérgicas del mesencéfalo y métodos para su utilización |
JP6933898B2 (ja) | 2014-04-24 | 2021-09-08 | ボード オブ リージェンツ, ザ ユニバーシティ オブ テキサス システムBoard Of Regents, The University Of Texas System | 養子細胞治療製品を製造するための誘導多能性幹細胞の適用 |
JP6766032B2 (ja) * | 2014-07-31 | 2020-10-07 | ユニヴェルシテ デクス−マルセイユUniversite D’Aix−Marseille | ニューロン細胞及び筋細胞を産生するための方法 |
MX2017005186A (es) * | 2014-10-20 | 2017-07-26 | Neuralstem Inc | Celulas madre neurales estables que comprenden un polinucleótido exógeno que codifica un factor de crecimiento y métodos de uso de las mismas. |
JP6686361B2 (ja) * | 2014-11-26 | 2020-04-22 | 東ソー株式会社 | 細胞回収のための標本作製方法 |
KR101695429B1 (ko) * | 2015-10-15 | 2017-01-12 | 한국과학기술연구원 | 생체외에서 운동 신경세포의 배양 촉진을 위한 코엔자임 q10을 포함하는 조성물 |
FR3058892B1 (fr) * | 2016-11-23 | 2021-04-09 | Univ Bordeaux | Unite de tissu neural et utilisation d'une telle unite pour l'implantation dans le systeme nerveux d'un mammifere |
JP7274216B2 (ja) * | 2017-11-30 | 2023-05-16 | 国立大学法人京都大学 | 細胞興奮毒性評価方法 |
US20230139883A1 (en) * | 2020-04-13 | 2023-05-04 | Shimadzu Corporation | Peptides for Inducing Differentiation |
WO2023153464A1 (ja) * | 2022-02-09 | 2023-08-17 | 住友ファーマ株式会社 | 多能性幹細胞から中脳底板領域の神経系細胞への分化における、培養液中の細胞の分化能を判定する方法 |
KR20230145820A (ko) | 2022-04-11 | 2023-10-18 | 재단법인대구경북과학기술원 | 미세 유체 채널 장치, 이를 이용한 약물 스크리닝 시스템 및 그 방법 |
Family Cites Families (54)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US23376A (en) * | 1859-03-29 | Improvement in harvesters | ||
US4491632A (en) | 1979-10-22 | 1985-01-01 | The Massachusetts General Hospital | Process for producing antibodies to hepatitis virus and cell lines therefor |
US4444887A (en) | 1979-12-10 | 1984-04-24 | Sloan-Kettering Institute | Process for making human antibody producing B-lymphocytes |
EP0043718B1 (en) | 1980-07-07 | 1984-11-28 | National Research Development Corporation | Improvements in or relating to cell lines |
GB2197915B (en) | 1986-11-19 | 1990-11-14 | Rolls Royce Plc | Improvements in or relating to fluid bearings |
US5981165A (en) * | 1991-07-08 | 1999-11-09 | Neurospheres Holdings Ltd. | In vitro induction of dopaminergic cells |
US5851832A (en) * | 1991-07-08 | 1998-12-22 | Neurospheres, Ltd. | In vitro growth and proliferation of multipotent neural stem cells and their progeny |
EP1559778A1 (en) * | 1991-08-07 | 2005-08-03 | Albert Einstein College Of Medicine Of Yeshiva University | Proliferation of hepatocyte precursors |
US5672499A (en) * | 1992-07-27 | 1997-09-30 | California Institute Of Technology | Immoralized neural crest stem cells and methods of making |
US5849553A (en) * | 1992-07-27 | 1998-12-15 | California Institute Of Technology | Mammalian multipotent neural stem cells |
US5654183A (en) | 1992-07-27 | 1997-08-05 | California Institute Of Technology | Genetically engineered mammalian neural crest stem cells |
WO1994003199A1 (en) | 1992-08-04 | 1994-02-17 | Regeneron Pharmaceuticals, Inc. | Method of enhancing differentiation and survival of neuronal precursor cells |
US5766948A (en) * | 1993-01-06 | 1998-06-16 | The Regents Of The University Of California | Method for production of neuroblasts |
US5534404A (en) * | 1993-12-10 | 1996-07-09 | Cytotherapeutics, Inc. | Glucose responsive insulin secreting β-cell lines and method for producing same |
US5639618A (en) * | 1994-05-13 | 1997-06-17 | Plurion, Inc. | Method of isolating a lineage specific stem cell in vitro |
US5476975A (en) * | 1994-07-08 | 1995-12-19 | Ruddick; John N. R. | Extraction of toxic organic contaminants from wood and photodegradation of toxic organic contaminants |
US5843780A (en) * | 1995-01-20 | 1998-12-01 | Wisconsin Alumni Research Foundation | Primate embryonic stem cells |
GB9807935D0 (en) | 1998-04-14 | 1998-06-10 | Univ Edinburgh | Lineage specific cells and progenitor cells |
US5753506A (en) * | 1996-05-23 | 1998-05-19 | Cns Stem Cell Technology, Inc. | Isolation propagation and directed differentiation of stem cells from embryonic and adult central nervous system of mammals |
DE19743497A1 (de) | 1996-10-01 | 1998-08-20 | Geron Corp | Katalytische Untereinheit menschlicher Telomerase |
WO1998030679A1 (en) | 1997-01-10 | 1998-07-16 | Life Technologies, Inc. | Embryonic stem cell serum replacement |
US6090622A (en) * | 1997-03-31 | 2000-07-18 | The Johns Hopkins School Of Medicine | Human embryonic pluripotent germ cells |
US6361996B1 (en) | 1997-05-07 | 2002-03-26 | University Of Utah Research Foundation | Neuroepithelial stem cells and glial-restricted intermediate precursors |
US6235527B1 (en) | 1997-11-29 | 2001-05-22 | University Of Utah Research Foundation | Lineage restricted glial precursors from the central nervous system |
WO1999001159A1 (en) | 1997-07-04 | 1999-01-14 | University Of Utah Research Foundation | Lineage-restricted neuronal precursors |
US7144997B2 (en) | 1997-07-24 | 2006-12-05 | Curis, Inc. | Vertebrate embryonic patterning-inducing proteins, compositions and uses related therto |
US5852832A (en) | 1997-08-20 | 1998-12-29 | Voigt; Tricia Anne | Portable toilet seat |
US5968829A (en) * | 1997-09-05 | 1999-10-19 | Cytotherapeutics, Inc. | Human CNS neural stem cells |
AU729377B2 (en) | 1997-10-23 | 2001-02-01 | Asterias Biotherapeutics, Inc. | Methods and materials for the growth of primate-derived primordial stem cells in feeder-free culture |
DE19756864C5 (de) * | 1997-12-19 | 2014-07-10 | Oliver Brüstle | Neurale Vorläuferzellen, Verfahren zu ihrer Herstellung und ihre Verwendung zur Therapie von neuralen Defekten |
AU757036B2 (en) | 1998-02-27 | 2003-01-30 | Medical College Of Hampton Roads, The | Derivation of cells and tissues from embryonic pre-stem cells for transplantation therapies |
US6812027B2 (en) * | 1998-03-25 | 2004-11-02 | Cornell Research Foundation, Inc. | Discovery, localization, harvest, and propagation of an FGF2 and BDNF-responsive population of neural and neuronal progenitor cells in the adult human forebrain |
NZ507103A (en) | 1998-04-09 | 2002-10-25 | Bresagen Ltd | Cell differentiation/proliferation and maintenance factor and uses thereof |
JP3291698B2 (ja) * | 1998-07-24 | 2002-06-10 | スティーブン・カーティン | 可変眼鏡用レンズ |
WO2000017323A1 (en) | 1998-09-22 | 2000-03-30 | Neuralstem Biopharmaceuticals, Ltd. | Stable neural stem cell lines |
US6667176B1 (en) * | 2000-01-11 | 2003-12-23 | Geron Corporation | cDNA libraries reflecting gene expression during growth and differentiation of human pluripotent stem cells |
CA2356174A1 (en) * | 1998-12-21 | 2000-06-29 | Monash University | Kidney disease detection and treatment |
US6087168A (en) * | 1999-01-20 | 2000-07-11 | Cedars Sinai Medical Center | Conversion of non-neuronal cells into neurons: transdifferentiation of epidermal cells |
ATE377652T1 (de) | 1999-02-12 | 2007-11-15 | Stemcells Inc | Angereicherte zentralnervensystem- zellpopulationen |
US6238922B1 (en) * | 1999-02-26 | 2001-05-29 | Stemcells, Inc. | Use of collagenase in the preparation of neural stem cell cultures |
WO2000055312A2 (en) * | 1999-03-17 | 2000-09-21 | The University Of Tennessee Research Corporation | Rt-pcr of clonal neurospheres |
AU2913801A (en) | 1999-12-23 | 2001-07-03 | Cornell Research Foundation Inc. | A method for isolating and purifying multipotential neural progenitor cells and multipotential neural progenitor cells |
EP1254211A4 (en) | 2000-01-14 | 2003-07-16 | Bresagen Ltd | PRODUCTION OF CELLS |
US6602711B1 (en) * | 2000-02-21 | 2003-08-05 | Wisconsin Alumni Research Foundation | Method of making embryoid bodies from primate embryonic stem cells |
IL151170A0 (en) | 2000-03-14 | 2003-04-10 | Es Cell Int Pte Ltd | Embryonic stem cells and neural progenitor cells derived therefrom |
US6458589B1 (en) * | 2000-04-27 | 2002-10-01 | Geron Corporation | Hepatocyte lineage cells derived from pluripotent stem cells |
WO2001083715A2 (en) | 2000-05-01 | 2001-11-08 | THE GOVERNMENT OF THE UNITED STATES OF AMERICA as represented by the Secretary, | Derivation of midbrain dopaminergic neurons from embryonic stem cells |
US8273570B2 (en) * | 2000-05-16 | 2012-09-25 | Riken | Process of inducing differentiation of embryonic cell to cell expressing neural surface marker using OP9 or PA6 cells |
WO2001088104A2 (en) * | 2000-05-17 | 2001-11-22 | Geron Corporation | Neural progenitor cell populations |
EP2298867A3 (en) | 2000-06-20 | 2013-01-16 | ES Cell International Pte Ltd. | Method of controlling differentiation of embryonic stem (ES) cells by culturing ES cells in the presence of bmp-2 pathway antagonists |
JP3660601B2 (ja) | 2001-03-30 | 2005-06-15 | 独立行政法人科学技術振興機構 | 胚性幹細胞からの神経幹細胞、運動ニューロン及びgaba作動性ニューロンの製造法 |
EP1385938A1 (en) | 2001-04-23 | 2004-02-04 | Nsgene A/S | Method and culture medium for producing neural cells expressing tyrosine hydroxylase |
US7285415B2 (en) | 2002-07-11 | 2007-10-23 | The Regents Of The University Of California | Oligodendrocytes derived from human embryonic stem cells for remyelination and treatment of spinal cord injury |
HU227443B1 (en) | 2007-10-18 | 2011-06-28 | Pannon Egyetem | Multifunction-compatibilisation package of additives for plastic and rubber compositions |
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CN1630713A (zh) | 2005-06-22 |
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WO2003000868A1 (en) | 2003-01-03 |
EP1404812A4 (en) | 2005-01-19 |
JP2018029604A (ja) | 2018-03-01 |
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IL159324A (en) | 2012-04-30 |
GB2393733B (en) | 2005-09-14 |
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JP4526265B2 (ja) | 2010-08-18 |
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