IL159291A0 - Conjugates of macrocyclic metal complexes with biomolecules and the utilization thereof for producing agents for use in nmr diagnosis and radiodiagnosis and radiotherapy - Google Patents

Conjugates of macrocyclic metal complexes with biomolecules and the utilization thereof for producing agents for use in nmr diagnosis and radiodiagnosis and radiotherapy

Info

Publication number
IL159291A0
IL159291A0 IL15929102A IL15929102A IL159291A0 IL 159291 A0 IL159291 A0 IL 159291A0 IL 15929102 A IL15929102 A IL 15929102A IL 15929102 A IL15929102 A IL 15929102A IL 159291 A0 IL159291 A0 IL 159291A0
Authority
IL
Israel
Prior art keywords
radiodiagnosis
biomolecules
radiotherapy
conjugates
utilization
Prior art date
Application number
IL15929102A
Other languages
English (en)
Original Assignee
Schering Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Ag filed Critical Schering Ag
Publication of IL159291A0 publication Critical patent/IL159291A0/xx

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/10—Organic compounds
    • A61K49/14—Peptides, e.g. proteins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
    • C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/0002—General or multifunctional contrast agents, e.g. chelated agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/085—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier conjugated systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/10—Organic compounds
    • A61K49/14—Peptides, e.g. proteins
    • A61K49/143—Peptides, e.g. proteins the protein being an albumin, e.g. HSA, BSA, ovalbumin

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Radiology & Medical Imaging (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)
IL15929102A 2001-07-20 2002-07-18 Conjugates of macrocyclic metal complexes with biomolecules and the utilization thereof for producing agents for use in nmr diagnosis and radiodiagnosis and radiotherapy IL159291A0 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10135355A DE10135355C1 (de) 2001-07-20 2001-07-20 Konjugate makrocyclischer Metallkomplexe mit Biomolekülen und deren Verwendung zur Herstellung von Mitteln für die NMR- und Radiodiagnostik sowie die Radiotherapie
PCT/EP2002/008000 WO2003013617A2 (fr) 2001-07-20 2002-07-18 Conjugues de complexes metalliques macrocycliques contenant des biomolecules et leur utilisation dans la production d'agents destines au radiodiagnostic et au diagnostic par resonance magnetique ainsi qu'a la radiotherapie

Publications (1)

Publication Number Publication Date
IL159291A0 true IL159291A0 (en) 2004-06-01

Family

ID=7692470

Family Applications (1)

Application Number Title Priority Date Filing Date
IL15929102A IL159291A0 (en) 2001-07-20 2002-07-18 Conjugates of macrocyclic metal complexes with biomolecules and the utilization thereof for producing agents for use in nmr diagnosis and radiodiagnosis and radiotherapy

Country Status (19)

Country Link
US (2) US20030206865A1 (fr)
EP (1) EP1450864A2 (fr)
JP (1) JP2004536889A (fr)
KR (1) KR20040030825A (fr)
CN (1) CN1301750C (fr)
AR (1) AR036182A1 (fr)
AU (1) AU2002355333B2 (fr)
BR (1) BR0211150A (fr)
CA (1) CA2453214A1 (fr)
DE (1) DE10135355C1 (fr)
IL (1) IL159291A0 (fr)
MX (1) MXPA04000400A (fr)
NO (1) NO20040239L (fr)
PE (1) PE20030190A1 (fr)
PL (1) PL366421A1 (fr)
RU (1) RU2004105262A (fr)
TW (1) TWI238722B (fr)
UY (1) UY27389A1 (fr)
WO (1) WO2003013617A2 (fr)

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US7067111B1 (en) * 1999-10-25 2006-06-27 Board Of Regents, University Of Texas System Ethylenedicysteine (EC)-drug conjugates, compositions and methods for tissue specific disease imaging
JP5448284B2 (ja) * 2000-06-02 2014-03-19 ボード・オブ・リージエンツ，ザ・ユニバーシテイ・オブ・テキサス・システム エチレンジシステイン（ｅｃ）−薬物結合体
DE10135356C1 (de) * 2001-07-20 2003-04-17 Schering Ag Makrocyclische Metallkomplexe und deren Verwendung zur Herstellung von Konjugaten mit Biomolekülen
EP1466629A1 (fr) * 2003-04-11 2004-10-13 BRACCO IMAGING S.p.A. Produits d'addition entre reactifs pour RNM et substrats contenant des protons èchangeables pour des applications "CEST"
DE10325752A1 (de) * 2003-06-06 2004-12-30 Faustus Forschungs Cie. Translational Cancer Research Gmbh Lektin-Konjugate
FR2856689A1 (fr) * 2003-06-25 2004-12-31 Guerbet Sa Composes specifiques a forte relaxivite
JP2007521254A (ja) * 2003-06-25 2007-08-02 ゲルベ 診断画像用化合物
JP2007511503A (ja) * 2003-11-17 2007-05-10 コーニンクレッカ フィリップス エレクトロニクス エヌ ヴィ 医療画像化技術用の造影剤及びその使用
US9050378B2 (en) * 2003-12-10 2015-06-09 Board Of Regents, The University Of Texas System N2S2 chelate-targeting ligand conjugates
FR2868320B1 (fr) * 2004-03-31 2007-11-02 Centre Nat Rech Scient Cnrse Agent de contraste pour l'imagerie par resonance magnetique
EP1805188A4 (fr) 2004-09-30 2010-03-03 Mds Analytical Technologies Us Complexes de lanthanides luminescents
ATE439866T1 (de) * 2005-04-26 2009-09-15 Koninkl Philips Electronics Nv Kontrastmittel für die magnetresonanzbildgebung mit cest-aktivem paramagnetischem komplex
FI20055712A0 (fi) * 2005-12-29 2005-12-29 Wallac Oy Makrosykliset oligonukleotiidien leimausreagenssit ja niistä johdetut konjugaatit
US8758723B2 (en) * 2006-04-19 2014-06-24 The Board Of Regents Of The University Of Texas System Compositions and methods for cellular imaging and therapy
US10925977B2 (en) 2006-10-05 2021-02-23 Ceil>Point, LLC Efficient synthesis of chelators for nuclear imaging and radiotherapy: compositions and applications
BRPI0906797A2 (pt) 2008-01-09 2015-07-14 Molecular Insight Pharm Inc Inibidores de anidrase carbônica ix
EP2373622A2 (fr) * 2008-12-05 2011-10-12 Molecular Insight Pharmaceuticals, Inc. Produits radiopharmaceutiques spécifiques de ca-ix pour le traitement et l'imagerie de cancer
WO2010065906A2 (fr) 2008-12-05 2010-06-10 Molecular Insight Pharmaceuticals, Inc. Produits radiopharmaceutiques spécifiques de ca-ix pour le traitement et l'imagerie de cancer
WO2010065899A2 (fr) 2008-12-05 2010-06-10 Molecular Insight Pharmaceuticals, Inc. Complexes de technétium- et rhénium-bis (hétéroaryles) et leurs procédés d'utilisation
WO2010147965A2 (fr) 2009-06-15 2010-12-23 Molecular Insight Pharmaceuticals, Inc. Procédé de production d'hétérodimères d'acide glutamique
CN101912623B (zh) * 2010-08-24 2012-06-06 上海师范大学 具有靶向功能铁-钆双模式磁共振造影剂的制备及应用
CN102136339B (zh) * 2011-01-24 2012-05-23 南开大学 一种具有铁磁、铁电双功能的镝单分子磁体及其制备方法
AU2013207486A1 (en) 2012-01-06 2014-08-21 Molecular Insight Pharmaceuticals Metal complexes of poly(carboxyl)amine-containing ligands having an affinity for carbonic anhydrase IX
HUE044552T2 (hu) 2013-01-14 2019-11-28 Molecular Insight Pharm Inc Triazinalapú radiogyógyszerek és radiológiai képalkotó ágensek
WO2015075699A1 (fr) * 2013-11-25 2015-05-28 Sanofi Dérivés de dotam à usage thérapeutique
EP3101012A1 (fr) 2015-06-04 2016-12-07 Bayer Pharma Aktiengesellschaft Nouveaux composés de chélate de gadolinium pour une utilisation dans l'imagerie par résonance magnétique
KR102464647B1 (ko) 2016-11-28 2022-11-08 바이엘 파마 악티엔게젤샤프트 자기 공명 영상화에 사용하기 위한 높은 이완도 가돌리늄 킬레이트 화합물
AU2018261890A1 (en) 2017-05-05 2019-11-28 Centre For Probe Development And Commercialization IGF-1R monoclonal antibodies and uses thereof
US10093741B1 (en) 2017-05-05 2018-10-09 Fusion Pharmaceuticals Inc. IGF-1R monoclonal antibodies and uses thereof
EP3619191A4 (fr) 2017-05-05 2020-12-16 Fusion Pharmaceuticals Inc. Améliorations pharmacocinétiques de chélates bifonctionnels et leurs utilisations
BR112021007707A2 (pt) 2018-11-23 2021-07-27 Bayer Aktiengesellschaft formulação de meios de contraste e processo de preparação da mesma
FR3092580B1 (fr) * 2019-02-08 2021-03-19 Centre Nat Rech Scient Nouveaux dérivés azobenzènes, leur procédé de préparation et leur utilisation pour le traitement thérapeutique associé à des radiations ionisantes
EP3757098A1 (fr) * 2019-06-25 2020-12-30 Ustav Organicke Chemie a Biochemie AV CR, v.v.i. Composés à base de cyclène, composés de coordination, peptides, préparation pharmaceutique et utilisation associée
KR102203368B1 (ko) * 2020-10-30 2021-01-14 경북대학교 산학협력단 신규한 화합물 및 이를 함유하는 mri 조영제

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5049667A (en) * 1987-04-14 1991-09-17 Guerbet S.A. Nitrogen-containing cyclic ligands
JPH04154729A (ja) * 1990-10-16 1992-05-27 Nippon Mejifuijitsukusu Kk 磁気共鳴造影剤
DE4115789A1 (de) * 1991-05-10 1992-11-12 Schering Ag Makrocyclische polymer-komplexbildner, deren komplexe, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische mittel
AU663572B2 (en) * 1992-03-27 1995-10-12 Nihon Medi-Physics Co., Ltd. Tetraazacyclododecane derivative and its use
AU6048694A (en) * 1992-12-09 1994-07-04 Paul D. Jager Stabilized medicinal aerosol solution formulations
US6693190B1 (en) * 1994-05-11 2004-02-17 Bracco International B.V. Enhanced relaxivity monomeric and multimeric compounds
US6045776A (en) * 1996-12-04 2000-04-04 Schering Aktiengesellschaft Process for the production of metal-complex carboxylic acid amides
US6113880A (en) * 1997-12-17 2000-09-05 Schering Aktiengesellschaft Polyrotaxane derivatives for x-ray and nuclear magnetic resonance imaging
DE19905094C1 (de) * 1999-02-01 2000-10-12 Schering Ag Gadolinium (III)-Komplexe sowie ihre Verwendung für Zweischritt Strahlentherapieformen und diese enthaltende pharmazeutische Mittel

Also Published As

Publication number Publication date
TWI238722B (en) 2005-09-01
CA2453214A1 (fr) 2003-02-20
EP1450864A2 (fr) 2004-09-01
RU2004105262A (ru) 2005-07-10
NO20040239L (no) 2004-01-19
PL366421A1 (en) 2005-01-24
DE10135355C1 (de) 2003-04-17
WO2003013617A3 (fr) 2004-06-10
JP2004536889A (ja) 2004-12-09
CN1301750C (zh) 2007-02-28
UY27389A1 (es) 2003-02-28
AR036182A1 (es) 2004-08-18
KR20040030825A (ko) 2004-04-09
PE20030190A1 (es) 2003-03-22
US20030206865A1 (en) 2003-11-06
US20070014725A1 (en) 2007-01-18
AU2002355333B2 (en) 2007-01-04
CN1541114A (zh) 2004-10-27
MXPA04000400A (es) 2004-03-18
WO2003013617A2 (fr) 2003-02-20
BR0211150A (pt) 2004-06-29

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