IL159238A0 - Crystalline anticholinergic, method for its production, and use thereof in the production of a drug - Google Patents

Crystalline anticholinergic, method for its production, and use thereof in the production of a drug

Info

Publication number
IL159238A0
IL159238A0 IL15923802A IL15923802A IL159238A0 IL 159238 A0 IL159238 A0 IL 159238A0 IL 15923802 A IL15923802 A IL 15923802A IL 15923802 A IL15923802 A IL 15923802A IL 159238 A0 IL159238 A0 IL 159238A0
Authority
IL
Israel
Prior art keywords
production
drug
anticholinergic
crystalline
crystalline anticholinergic
Prior art date
Application number
IL15923802A
Other languages
English (en)
Original Assignee
Boehringer Ingelheim Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim Pharma filed Critical Boehringer Ingelheim Pharma
Publication of IL159238A0 publication Critical patent/IL159238A0/xx

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D451/00Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • C07D451/04Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
    • C07D451/06Oxygen atoms
    • C07D451/10Oxygen atoms acylated by aliphatic or araliphatic carboxylic acids, e.g. atropine, scopolamine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/468-Azabicyclo [3.2.1] octane; Derivatives thereof, e.g. atropine, cocaine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/06Antiasthmatics

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pulmonology (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Emergency Medicine (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicinal Preparation (AREA)
  • Steroid Compounds (AREA)
IL15923802A 2001-06-22 2002-06-08 Crystalline anticholinergic, method for its production, and use thereof in the production of a drug IL159238A0 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE10129710 2001-06-22
DE10215436 2002-04-08
PCT/EP2002/006291 WO2003000265A1 (fr) 2001-06-22 2002-06-08 Substance anticholinergique cristalline, son procede de production et son utilisation pour la production d'un medicament

Publications (1)

Publication Number Publication Date
IL159238A0 true IL159238A0 (en) 2004-06-01

Family

ID=26009556

Family Applications (2)

Application Number Title Priority Date Filing Date
IL15923802A IL159238A0 (en) 2001-06-22 2002-06-08 Crystalline anticholinergic, method for its production, and use thereof in the production of a drug
IL159238A IL159238A (en) 2001-06-22 2003-12-08 Crystalline anticholinergic, method for its production and use thereof in the production of a drug

Family Applications After (1)

Application Number Title Priority Date Filing Date
IL159238A IL159238A (en) 2001-06-22 2003-12-08 Crystalline anticholinergic, method for its production and use thereof in the production of a drug

Country Status (38)

Country Link
EP (1) EP1401445B1 (fr)
JP (1) JP2005504015A (fr)
KR (2) KR100971616B1 (fr)
CN (1) CN100586948C (fr)
AR (1) AR037491A1 (fr)
AT (1) ATE337006T1 (fr)
AU (1) AU2002345016B2 (fr)
BG (1) BG66303B1 (fr)
BR (1) BR0210537A (fr)
CA (1) CA2450961C (fr)
CO (1) CO5550423A2 (fr)
CY (1) CY1105223T1 (fr)
CZ (1) CZ302786B6 (fr)
DE (1) DE50207943D1 (fr)
DK (1) DK1401445T3 (fr)
EA (1) EA005813B1 (fr)
EE (1) EE05316B1 (fr)
EG (1) EG24851A (fr)
ES (1) ES2271280T3 (fr)
HK (1) HK1068540A1 (fr)
HR (1) HRP20031066B1 (fr)
HU (1) HUP0400333A3 (fr)
IL (2) IL159238A0 (fr)
ME (1) ME00412B (fr)
MX (1) MXPA03011718A (fr)
MY (1) MY122779A (fr)
NO (1) NO334301B1 (fr)
NZ (1) NZ530690A (fr)
PE (2) PE20030130A1 (fr)
PL (1) PL208137B1 (fr)
PT (1) PT1401445E (fr)
RS (1) RS50441B (fr)
SA (1) SA02230255B1 (fr)
SI (1) SI1401445T1 (fr)
SK (1) SK287262B6 (fr)
TW (2) TWI261589B (fr)
UY (1) UY27342A1 (fr)
WO (1) WO2003000265A1 (fr)

Families Citing this family (59)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10212264A1 (de) 2002-03-20 2003-10-02 Boehringer Ingelheim Pharma Kristallines Mikronisat, Verfahren zu dessen Herstellung und dessen Verwendung zur Herstellung eines Arzneimittels
US7056916B2 (en) 2002-11-15 2006-06-06 Boehringer Ingelheim Pharma Gmbh & Co. Kg Medicaments for the treatment of chronic obstructive pulmonary disease
US20050038004A1 (en) * 2003-07-31 2005-02-17 Robinson Cynthia B. Combination of dehydroepiandrosterone or dehydroepiandrosterone-sulfate with an anticholinergic bronchodilator for treatment of asthma or chronic obstructive pulmonary disease
RS20060291A (en) * 2003-11-03 2008-06-05 Boehringer Ingelheim International Gmbh., Novel crystalline anhydride with anticholinergic effect
DE102004016179A1 (de) * 2004-03-30 2005-10-20 Boehringer Ingelheim Pharma Verbindungen zur Behandlung von proliferativen Prozessen
KR101287460B1 (ko) 2004-04-22 2013-07-23 베링거 인겔하임 인터내셔날 게엠베하 벤즈옥사진을 함유하는 호흡기 질환 치료용 약제학적배합물
US7220742B2 (en) 2004-05-14 2007-05-22 Boehringer Ingelheim International Gmbh Enantiomerically pure beta agonists, process for the manufacture thereof and use thereof as medicaments
DE102004024454A1 (de) 2004-05-14 2005-12-08 Boehringer Ingelheim Pharma Gmbh & Co. Kg Neue Enantiomerenreine Betaagonisten, Verfahren zu deren Herstellung und deren Verwendung als Arzneimittel
ES2322148T3 (es) 2004-08-11 2009-06-17 BOEHRINGER INGELHEIM PHARMA GMBH &amp; CO. KG Medicamentos que contienen anticolinergicos para el tratamiento en las vias urinarias.
US20060079544A1 (en) * 2004-08-13 2006-04-13 Boehringer Ingelheim International Gmbh Medicaments for the prevention or treatment of alveolar pneumonia comprising an anticholinergic
DE102004048389A1 (de) 2004-10-01 2006-04-06 Boehringer Ingelheim Pharma Gmbh & Co. Kg Modifizierung von Oberflächen von Laktose als Hilfsstoff zur Verwendung für Pulverinhalativa
DE102005019201A1 (de) 2006-04-19 2006-11-02 Boehringer Ingelheim Pharma Gmbh & Co. Kg Neue Verbindungen zur Behandlung von entzündlichen Erkrankungen
JP5053997B2 (ja) 2005-04-28 2012-10-24 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング 炎症性疾患の治療用の新規化合物
CN101203513A (zh) * 2005-05-02 2008-06-18 贝林格尔·英格海姆国际有限公司 噻托溴铵的晶型
ES2393794T3 (es) * 2005-05-02 2012-12-28 Boehringer Ingelheim International Gmbh Nuevas formas cristalinas de bromuro de tiotropio
DE102005030733A1 (de) 2005-07-01 2007-01-04 Boehringer Ingelheim Pharma Gmbh & Co. Kg Neue Arzneimittelkombinationen zur Behandlung von Atemwegserkrankungen enthaltend langwirksame Beta-2-Agonisten und wenigstens einen weiteren Wirkstoff
MX2008001976A (es) 2005-08-15 2008-03-25 Boehringer Ingelheim Int Procedimiento para la preparacion de betamimeticos.
US20070086957A1 (en) 2005-10-10 2007-04-19 Thierry Bouyssou Combination of medicaments for the treatment of respiratory diseases
US7423146B2 (en) 2005-11-09 2008-09-09 Boehringer Ingelheim International Gmbh Process for the manufacturing of pharmaceutically active 3,1-benzoxazine-2-ones
US8163913B2 (en) * 2005-12-19 2012-04-24 Sicor Inc. Forms of tiotropium bromide and processes for preparation thereof
US9108962B2 (en) 2005-12-19 2015-08-18 Sicor, Inc. Forms of tiotropium bromide and processes for preparation thereof
CN100999521B (zh) * 2006-01-13 2010-12-08 江苏正大天晴药业股份有限公司 结晶性抗胆碱药噻托溴铵
EP1847543A1 (fr) 2006-04-19 2007-10-24 Boehringer Ingelheim Pharma GmbH & Co. KG Dihydrothienopyrimidines pour le traitement de maladies inflammatoires
ATE505193T1 (de) 2006-08-07 2011-04-15 Boehringer Ingelheim Int Arzneimittelkombinationen zur behandlung von atemwegserkrankungen
PE20080610A1 (es) 2006-08-22 2008-07-15 Boehringer Ingelheim Int Nuevos beta-agonistas enantiomericamente puros, procedimientos para su preparacion y uso como medicamentos
GB0716026D0 (en) 2007-08-16 2007-09-26 Norton Healthcare Ltd An inhalable medicament
CA2705414C (fr) 2007-10-19 2016-05-24 Boehringer Ingelheim International Gmbh Piperidino-dihydrothienopyrimidines substituees
EP2093219A1 (fr) 2008-02-22 2009-08-26 Boehringer Ingelheim International Gmbh Forme de sel à énantiomère pur et cristalline d'un bêtamimétique et son utilisation comme médicament
EA020548B1 (ru) 2008-12-19 2014-12-30 Бёрингер Ингельхайм Интернациональ Гмбх Циклические пиримидин-4-карбоксамиды в качестве антагонистов рецептора ccr2, предназначенные для лечения воспаления, астмы и хозл
EP2403851B1 (fr) 2009-03-06 2015-06-17 Mahmut Bilgic Nouvelles formes cristallines de bromure de tiotropium
JP5658272B2 (ja) 2009-12-17 2015-01-21 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング Ccr2の新規アンタゴニスト及びこれらの使用
NZ599770A (en) 2009-12-17 2014-06-27 Boehringer Ingelheim Int New ccr2 receptor antagonists and uses thereof
WO2011092128A1 (fr) 2010-01-29 2011-08-04 Boehringer Ingelheim International Gmbh Naphtyridines substituées et leur utilisation comme inhibiteurs de syk kinase
WO2011141474A1 (fr) 2010-05-12 2011-11-17 Boehringer Ingelheim International Gmbh Nouveaux antagonistes des récepteurs ccr2, procédé de production associé et application comme médicaments
WO2011141477A1 (fr) 2010-05-12 2011-11-17 Boehringer Ingelheim International Gmbh Nouveaux antagonistes du récepteur ccr2, leur procédé de production et leur utilisation en tant que médicaments
US8841313B2 (en) 2010-05-17 2014-09-23 Boehringer Ingelheim International Gmbh CCR2 antagonists and uses thereof
WO2011147772A1 (fr) 2010-05-25 2011-12-01 Boehringer Ingelheim International Gmbh Antagonistes du récepteur ccr2
US8962656B2 (en) 2010-06-01 2015-02-24 Boehringer Ingelheim International Gmbh CCR2 antagonists
TR201007108A2 (tr) * 2010-08-25 2012-03-21 B�Lg�� Mahmut Yeni tiotropyum bromür kristali ve üretim yöntemi.@
EP2668177B1 (fr) 2011-01-28 2014-10-22 Boehringer Ingelheim International GmbH Pyridinyl-pyrimidines substituées et leur utilisation en tant que médicaments
TR201101897A2 (tr) 2011-02-28 2012-09-21 Bi̇lgi̇ç Mahmut Tiotropyum bromür içeren kristal madde
TR201111589A2 (tr) * 2011-03-03 2012-09-21 Bi̇lgi̇ç Mahmut Tiotropyum bromür susuz kristal formu.
TR201102068A2 (tr) 2011-03-03 2012-09-21 Bi̇lgi̇ç Mahmut Tiotropyum bromür içeren kristal maddeler
JP5786257B2 (ja) 2011-06-16 2015-09-30 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング 新規の選択的ccr2拮抗薬
JP5786258B2 (ja) 2011-07-15 2015-09-30 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング 新規かつ選択的なccr2拮抗薬
CA2843022C (fr) 2011-07-26 2019-09-24 Boehringer Ingelheim International Gmbh Quinoleines substituees et leur utilisation comme medicaments
US20130059866A1 (en) 2011-08-24 2013-03-07 Boehringer Ingelheim International Gmbh Novel piperidino-dihydrothienopyrimidine sulfoxides and their use for treating copd and asthma
CR20190057A (es) 2011-11-25 2019-04-23 Adverio Pharma Gmbh PROCEDIMIENTO DE PREPARACIÓN DE 5-FLUORO-1H-PIRAZOLOPIRIDINAS SUSTITUIDAS (Divisional 2014-0237)
CZ304368B6 (cs) 2011-11-28 2014-04-02 Zentiva, K.S. Směsný solvát tiotropium bromidu a způsob jeho přípravy
GB201200525D0 (en) 2011-12-19 2012-02-29 Teva Branded Pharmaceutical Prod R & D Inc An inhalable medicament
PT106142B (pt) * 2012-02-10 2014-07-18 Hovione Farmaci Ncia S A Processo para a preparação de brometo de tiotrópio
US9096579B2 (en) 2012-04-20 2015-08-04 Boehringer Ingelheim International Gmbh Amino-indolyl-substituted imidazolyl-pyrimidines and their use as medicaments
EP2897955B1 (fr) * 2012-09-11 2019-11-06 Bilgic, Mahmut Nouvelle forme cristalline du bromure de tiotropium
EP2914593B1 (fr) 2012-11-05 2017-01-11 Zentiva, k.s. Stabilisation de solvates de tiotropium
CN104341412A (zh) * 2013-07-29 2015-02-11 天津金耀集团有限公司 一种无水噻托溴铵结晶的制备方法
PT3119772T (pt) 2014-03-19 2019-09-05 Boehringer Ingelheim Int Inibidores de syk heteroarilo
US10034866B2 (en) 2014-06-19 2018-07-31 Teva Branded Pharmaceutical Products R&D, Inc. Inhalable medicament comprising tiotropium
US10385078B2 (en) 2014-10-21 2019-08-20 Ariad Pharmaceuticals, Inc. Crystalline forms of 5-chloro-N4-[-2-(dimethylphosphoryl)phenyl]-N2-{2-methoxy-4-[4-(4-methylpiperazin-1-YL) piperidin-1-YL]phenyl}pyrimidine-2,4-diamine
WO2017138896A1 (fr) * 2016-02-11 2017-08-17 Sima Patent Ve Lisanslama Hizmetleri Ltd. Şti Forme cristalline d'anhydrate de bromure de tiotropium

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3931041C2 (de) * 1989-09-16 2000-04-06 Boehringer Ingelheim Kg Ester von Thienylcarbonsäuren mit Aminoalkoholen, ihre Quaternierungsprodukte, Verfahren zu ihrer Herstellung und diese enthaltende Arzneimittel
OA12403A (en) * 2000-10-12 2006-04-18 Boehringer Ingelheim Pharma Crystalline monohydrate, method for producing the same and the use thereof in the production of a medicament.
DE10064816A1 (de) * 2000-12-22 2002-06-27 Boehringer Ingelheim Pharma Verfahren zur Herstellung eines Anticholinergikums

Also Published As

Publication number Publication date
SI1401445T1 (sl) 2007-02-28
SA02230255B1 (ar) 2006-10-31
HK1068540A1 (en) 2005-04-29
BG108440A (en) 2004-08-31
HRP20031066B1 (en) 2011-10-31
AR037491A1 (es) 2004-11-17
CN100586948C (zh) 2010-02-03
ME00412B (fr) 2011-10-10
CO5550423A2 (es) 2005-08-31
NO334301B1 (no) 2014-02-03
ES2271280T3 (es) 2007-04-16
CZ2004120A3 (cs) 2004-05-12
BG66303B1 (bg) 2013-03-29
EG24851A (en) 2010-10-27
ATE337006T1 (de) 2006-09-15
HUP0400333A3 (en) 2012-10-29
YU99703A (sh) 2006-05-25
HUP0400333A2 (hu) 2004-12-28
DK1401445T3 (da) 2006-11-27
EE200400029A (et) 2004-04-15
BR0210537A (pt) 2004-06-22
CY1105223T1 (el) 2010-03-03
PL208137B1 (pl) 2011-03-31
EA200301293A1 (ru) 2004-08-26
UY27342A1 (es) 2003-02-28
MXPA03011718A (es) 2004-12-06
KR101011353B1 (ko) 2011-01-28
CN1520294A (zh) 2004-08-11
NZ530690A (en) 2005-05-27
DE50207943D1 (de) 2006-10-05
EE05316B1 (et) 2010-08-16
IL159238A (en) 2010-04-15
SK287262B6 (sk) 2010-04-07
NO20035696D0 (no) 2003-12-19
PE20030130A1 (es) 2003-04-02
HRP20031066A2 (en) 2004-04-30
PL364489A1 (en) 2004-12-13
KR20090031638A (ko) 2009-03-26
PT1401445E (pt) 2006-10-31
MY122779A (en) 2006-05-31
CZ302786B6 (cs) 2011-11-09
KR20040018285A (ko) 2004-03-02
MEP62008A (en) 2011-05-10
WO2003000265A1 (fr) 2003-01-03
TWI261589B (en) 2006-09-11
EP1401445A1 (fr) 2004-03-31
TW200617007A (en) 2006-06-01
EP1401445B1 (fr) 2006-08-23
CA2450961C (fr) 2010-03-30
RS50441B (sr) 2010-03-02
CA2450961A1 (fr) 2003-01-03
PE20081305A1 (es) 2008-10-01
KR100971616B1 (ko) 2010-07-22
JP2005504015A (ja) 2005-02-10
EA005813B1 (ru) 2005-06-30
SK522004A3 (en) 2004-06-08
AU2002345016B2 (en) 2008-04-17

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