IL157669A0 - Nitrogen-based camptothecin derivatives - Google Patents
Nitrogen-based camptothecin derivativesInfo
- Publication number
- IL157669A0 IL157669A0 IL15766902A IL15766902A IL157669A0 IL 157669 A0 IL157669 A0 IL 157669A0 IL 15766902 A IL15766902 A IL 15766902A IL 15766902 A IL15766902 A IL 15766902A IL 157669 A0 IL157669 A0 IL 157669A0
- Authority
- IL
- Israel
- Prior art keywords
- nitrogen
- camptothecin derivatives
- camptothecin
- based camptothecin
- esters
- Prior art date
Links
- VSJKWCGYPAHWDS-FQEVSTJZSA-N camptothecin Chemical class C1=CC=C2C=C(CN3C4=CC5=C(C3=O)COC(=O)[C@]5(O)CC)C4=NC2=C1 VSJKWCGYPAHWDS-FQEVSTJZSA-N 0.000 title abstract 4
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 title 2
- 229910052757 nitrogen Inorganic materials 0.000 title 1
- 239000002253 acid Substances 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 150000002148 esters Chemical class 0.000 abstract 2
- KLWPJMFMVPTNCC-UHFFFAOYSA-N Camptothecin Natural products CCC1(O)C(=O)OCC2=C1C=C3C4Nc5ccccc5C=C4CN3C2=O KLWPJMFMVPTNCC-UHFFFAOYSA-N 0.000 abstract 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 229940127093 camptothecin Drugs 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- VSJKWCGYPAHWDS-UHFFFAOYSA-N dl-camptothecin Natural products C1=CC=C2C=C(CN3C4=CC5=C(C3=O)COC(=O)C5(O)CC)C4=NC2=C1 VSJKWCGYPAHWDS-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/22—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains four or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Urology & Nephrology (AREA)
- Dermatology (AREA)
- Pulmonology (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US09/797,765 US6403604B1 (en) | 2001-03-01 | 2001-03-01 | Nitrogen-based camptothecin derivatives |
| PCT/US2002/003798 WO2002070525A2 (en) | 2001-03-01 | 2002-02-06 | Nitrogen-based camptothecin derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IL157669A0 true IL157669A0 (en) | 2004-03-28 |
Family
ID=25171748
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL15766902A IL157669A0 (en) | 2001-03-01 | 2002-02-06 | Nitrogen-based camptothecin derivatives |
| IL157669A IL157669A (en) | 2001-03-01 | 2003-08-31 | Nitrogen-based camptothecin derivatives |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL157669A IL157669A (en) | 2001-03-01 | 2003-08-31 | Nitrogen-based camptothecin derivatives |
Country Status (13)
| Country | Link |
|---|---|
| US (2) | US6403604B1 (enExample) |
| EP (1) | EP1383772B1 (enExample) |
| JP (1) | JP4584538B2 (enExample) |
| KR (1) | KR100853141B1 (enExample) |
| CN (1) | CN1246323C (enExample) |
| AT (1) | ATE338047T1 (enExample) |
| CA (1) | CA2439787C (enExample) |
| DE (1) | DE60214359T2 (enExample) |
| ES (1) | ES2274020T3 (enExample) |
| IL (2) | IL157669A0 (enExample) |
| MX (1) | MXPA03007896A (enExample) |
| NZ (1) | NZ528115A (enExample) |
| WO (1) | WO2002070525A2 (enExample) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6150343A (en) * | 1993-06-30 | 2000-11-21 | University Of Pittsburgh | Camptothecin analogs and methods of preparation thereof |
| US6492380B1 (en) * | 1999-05-17 | 2002-12-10 | Queen's University At Kingston | Method of inhibiting neurotrophin-receptor binding |
| US6350756B1 (en) | 2001-01-18 | 2002-02-26 | California Pacific Medical Center | Camptothecin derivatives |
| US6855720B2 (en) * | 2001-03-01 | 2005-02-15 | California Pacific Medical Center | Nitrogen-based camptothecin derivatives |
| US6403604B1 (en) * | 2001-03-01 | 2002-06-11 | California Pacific Medical Center | Nitrogen-based camptothecin derivatives |
| AU2003243397A1 (en) * | 2002-06-03 | 2003-12-19 | California Pacific Medical Center | Homo-camptothecin derivatives |
| US6933302B2 (en) * | 2002-06-03 | 2005-08-23 | California Pacific Medical Center | Nitrogen-based homo-camptothecin derivatives |
| FR2889528B1 (fr) * | 2005-08-05 | 2007-09-07 | Servier Lab | Nouveaux composes analogues de la camptothecine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
| FR2889527A1 (fr) * | 2005-08-05 | 2007-02-09 | Servier Lab | Nouveaux composes analogues de la camptothecine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
| US20070099900A1 (en) | 2005-09-15 | 2007-05-03 | Painceptor Pharma Corporation | Methods of modulating neurotrophin-mediated activity |
| US7875602B2 (en) * | 2005-10-21 | 2011-01-25 | Sutter West Bay Hospitals | Camptothecin derivatives as chemoradiosensitizing agents |
| CN100586952C (zh) * | 2006-11-10 | 2010-02-03 | 中国药科大学 | 噁唑骈喜树碱酯衍生物及其制备方法和用途 |
| US8420665B2 (en) * | 2008-01-11 | 2013-04-16 | Northwestern University | Anti-cancer compounds |
| JP5542804B2 (ja) * | 2008-05-23 | 2014-07-09 | ザ ユニヴァーシティ オブ ブリティッシュ コロンビア | リポソームナノ粒子中で使用するための修飾薬物 |
| EP2443125B1 (en) * | 2009-06-17 | 2014-11-26 | Threshold Pharmaceuticals, Inc. | Camptothecin derivatives |
| US10980798B2 (en) | 2011-11-03 | 2021-04-20 | Taiwan Liposome Company, Ltd. | Pharmaceutical compositions of hydrophobic camptothecin derivatives |
| TWI619496B (zh) | 2011-11-03 | 2018-04-01 | 台灣微脂體股份有限公司 | 疏水性喜樹鹼衍生物之醫藥組合物 |
| CN109575044A (zh) * | 2018-12-21 | 2019-04-05 | 西安交通大学 | 2-（喜树碱-10-氧基）乙酰胺类化合物和应用 |
| KR20240104214A (ko) * | 2019-03-29 | 2024-07-04 | 메디뮨 리미티드 | 화합물 및 이의 접합체 |
| US12029736B2 (en) | 2020-02-25 | 2024-07-09 | Mediboston Limited | Camptothecin derivatives and conjugates thereof |
| US12521444B2 (en) | 2021-02-25 | 2026-01-13 | Fortvita Biologics Limited | Anti-HER2 antibody-drug conjugates and uses thereof |
| KR20250079213A (ko) | 2022-10-09 | 2025-06-04 | 라노바 메디신즈 리미티드 | 화합물, 조성물 및 방법 |
| CN117285540B (zh) * | 2023-09-27 | 2025-07-11 | 中国海洋大学 | 12-位取代的喜树碱衍生物及其用途 |
Family Cites Families (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4943579A (en) | 1987-10-06 | 1990-07-24 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Water soluble prodrugs of camptothecin |
| GB9320781D0 (en) | 1993-10-08 | 1993-12-01 | Erba Carlo Spa | Polymer-bound camptothecin derivatives |
| US5965566A (en) | 1993-10-20 | 1999-10-12 | Enzon, Inc. | High molecular weight polymer-based prodrugs |
| US5919455A (en) | 1993-10-27 | 1999-07-06 | Enzon, Inc. | Non-antigenic branched polymer conjugates |
| US5646159A (en) | 1994-07-20 | 1997-07-08 | Research Triangle Institute | Water-soluble esters of camptothecin compounds |
| GB9504065D0 (en) | 1995-03-01 | 1995-04-19 | Pharmacia Spa | Poly-pyrrolecarboxamidonaphthalenic acid derivatives |
| JPH08333370A (ja) * | 1995-06-08 | 1996-12-17 | Kyorin Pharmaceut Co Ltd | 水に可溶な新規フルオロエチルカンプトテシン誘導体、及びその製造方法 |
| US6339091B1 (en) | 1995-06-21 | 2002-01-15 | Societe De Conseils De Recherches Et D'applications Scientifiques (S.C.R.A.S.) | Comptothecin analogues, preparation methods therefor, use thereof as drugs, and pharmaceutical compositions containing said analogues |
| WO1997019085A1 (en) | 1995-11-22 | 1997-05-29 | Research Triangle Institute | Camptothecin compounds with combined topoisomerase i inhibition and dna alkylation properties |
| US5731316A (en) | 1996-01-30 | 1998-03-24 | The Stehlin Foundation For Cancer Research | Derivatives of camptothecin and methods of treating cancer using these derivatives |
| US6096336A (en) | 1996-01-30 | 2000-08-01 | The Stehlin Foundation For Cancer Research | Liposomal prodrugs comprising derivatives of camptothecin and methods of treating cancer using these prodrugs |
| DE69728152T2 (de) | 1996-08-19 | 2004-08-05 | Bionumerik Pharmaceuticals, Inc., San Antonio | Hoch-lipophile campothecin-derivate |
| AU739028B2 (en) | 1996-09-27 | 2001-10-04 | Bristol-Myers Squibb Company | Hydrolyzable prodrugs for delivery of anticancer drugs to metastatic cells |
| WO1998014459A1 (de) | 1996-09-30 | 1998-04-09 | Bayer Aktiengesellschaft | Glycokonjugate von modifizierten camptothecin-derivaten (20-o-verknüpfung) |
| SG88737A1 (en) | 1996-10-30 | 2002-05-21 | Tanabe Seiyaku Co | S type 2-substituted hydroxy-2-indolidinylbutyric ester compounds and process for preparation thereof |
| UA57757C2 (uk) | 1996-12-20 | 2003-07-15 | Сос'Єте Де Консей Де Решерш Е Даплікасьон С'Єнтіфік (С.К.Р.А.С.) | Аналоги камптотецину, спосіб їх отримання (варіанти) і фармацевтична композиція |
| ID23424A (id) | 1997-05-14 | 2000-04-20 | Bayer Ag | Glikokonjugat dari 20(s)-kamptotesin |
| GB9721070D0 (en) | 1997-10-03 | 1997-12-03 | Pharmacia & Upjohn Spa | Bioactive derivatives of camptothecin |
| US6153655A (en) | 1998-04-17 | 2000-11-28 | Enzon, Inc. | Terminally-branched polymeric linkers and polymeric conjugates containing the same |
| US6057303A (en) | 1998-10-20 | 2000-05-02 | Bionumerik Pharmaceuticals, Inc. | Highly lipophilic Camptothecin derivatives |
| US6207832B1 (en) | 1999-04-09 | 2001-03-27 | University Of Pittsburgh | Camptothecin analogs and methods of preparation thereof |
| AU4822500A (en) | 1999-05-04 | 2000-11-17 | Bionumerik Pharmaceuticals, Inc. | Novel highly lipophilic camptothecin analogs |
| US6765019B1 (en) | 1999-05-06 | 2004-07-20 | University Of Kentucky Research Foundation | Permeable, water soluble, non-irritating prodrugs of chemotherapeutic agents with oxaalkanoic acids |
| US6288072B1 (en) * | 1999-12-29 | 2001-09-11 | Monroe E. Wall | Camptothecin β-alanine esters with topoisomerase I inhibition |
| US6350756B1 (en) | 2001-01-18 | 2002-02-26 | California Pacific Medical Center | Camptothecin derivatives |
| US6403604B1 (en) | 2001-03-01 | 2002-06-11 | California Pacific Medical Center | Nitrogen-based camptothecin derivatives |
| GB0119578D0 (en) | 2001-08-10 | 2001-10-03 | Pharmacia & Upjohn Spa | Fluoro linkers |
-
2001
- 2001-03-01 US US09/797,765 patent/US6403604B1/en not_active Expired - Lifetime
-
2002
- 2002-02-06 KR KR1020037011466A patent/KR100853141B1/ko not_active Expired - Fee Related
- 2002-02-06 IL IL15766902A patent/IL157669A0/xx unknown
- 2002-02-06 EP EP02718930A patent/EP1383772B1/en not_active Expired - Lifetime
- 2002-02-06 AT AT02718930T patent/ATE338047T1/de not_active IP Right Cessation
- 2002-02-06 MX MXPA03007896A patent/MXPA03007896A/es active IP Right Grant
- 2002-02-06 NZ NZ528115A patent/NZ528115A/en not_active IP Right Cessation
- 2002-02-06 WO PCT/US2002/003798 patent/WO2002070525A2/en not_active Ceased
- 2002-02-06 CA CA2439787A patent/CA2439787C/en not_active Expired - Fee Related
- 2002-02-06 JP JP2002569845A patent/JP4584538B2/ja not_active Expired - Fee Related
- 2002-02-06 ES ES02718930T patent/ES2274020T3/es not_active Expired - Lifetime
- 2002-02-06 CN CNB028090543A patent/CN1246323C/zh not_active Expired - Fee Related
- 2002-02-06 DE DE60214359T patent/DE60214359T2/de not_active Expired - Lifetime
- 2002-05-23 US US10/154,768 patent/US6825207B2/en not_active Expired - Fee Related
-
2003
- 2003-08-31 IL IL157669A patent/IL157669A/en not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| ATE338047T1 (de) | 2006-09-15 |
| ES2274020T3 (es) | 2007-05-16 |
| US6825207B2 (en) | 2004-11-30 |
| DE60214359D1 (en) | 2006-10-12 |
| NZ528115A (en) | 2006-04-28 |
| KR100853141B1 (ko) | 2008-08-20 |
| EP1383772B1 (en) | 2006-08-30 |
| DE60214359T2 (de) | 2007-08-30 |
| JP2004529114A (ja) | 2004-09-24 |
| US6403604B1 (en) | 2002-06-11 |
| US20030073698A1 (en) | 2003-04-17 |
| EP1383772A2 (en) | 2004-01-28 |
| WO2002070525A3 (en) | 2003-02-20 |
| WO2002070525A2 (en) | 2002-09-12 |
| CN1246323C (zh) | 2006-03-22 |
| CN1511159A (zh) | 2004-07-07 |
| CA2439787C (en) | 2011-05-24 |
| MXPA03007896A (es) | 2004-06-07 |
| CA2439787A1 (en) | 2002-09-12 |
| IL157669A (en) | 2010-11-30 |
| KR20040002872A (ko) | 2004-01-07 |
| JP4584538B2 (ja) | 2010-11-24 |
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