KR100853141B1 - 질소계 캄토테신 유도체 - Google Patents

질소계 캄토테신 유도체 Download PDF

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Publication number
KR100853141B1
KR100853141B1 KR1020037011466A KR20037011466A KR100853141B1 KR 100853141 B1 KR100853141 B1 KR 100853141B1 KR 1020037011466 A KR1020037011466 A KR 1020037011466A KR 20037011466 A KR20037011466 A KR 20037011466A KR 100853141 B1 KR100853141 B1 KR 100853141B1
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KR
South Korea
Prior art keywords
cpt
carbon atoms
hydroxy
alkyl
amino
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Expired - Fee Related
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KR1020037011466A
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English (en)
Korean (ko)
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KR20040002872A (ko
Inventor
양리시
판셴다오
왕후이쥐안
Original Assignee
캘리포니아 퍼시픽 메디컬 센터
카톨릭 헬스케어 웨스트, 두잉 비지니스 애즈 세인트 메리스 메디컬 센터
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Application filed by 캘리포니아 퍼시픽 메디컬 센터, 카톨릭 헬스케어 웨스트, 두잉 비지니스 애즈 세인트 메리스 메디컬 센터 filed Critical 캘리포니아 퍼시픽 메디컬 센터
Publication of KR20040002872A publication Critical patent/KR20040002872A/ko
Application granted granted Critical
Publication of KR100853141B1 publication Critical patent/KR100853141B1/ko
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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/22—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains four or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Urology & Nephrology (AREA)
  • Dermatology (AREA)
  • Pulmonology (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
KR1020037011466A 2001-03-01 2002-02-06 질소계 캄토테신 유도체 Expired - Fee Related KR100853141B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US09/797,765 US6403604B1 (en) 2001-03-01 2001-03-01 Nitrogen-based camptothecin derivatives
US09/797,765 2001-03-01
PCT/US2002/003798 WO2002070525A2 (en) 2001-03-01 2002-02-06 Nitrogen-based camptothecin derivatives

Publications (2)

Publication Number Publication Date
KR20040002872A KR20040002872A (ko) 2004-01-07
KR100853141B1 true KR100853141B1 (ko) 2008-08-20

Family

ID=25171748

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020037011466A Expired - Fee Related KR100853141B1 (ko) 2001-03-01 2002-02-06 질소계 캄토테신 유도체

Country Status (13)

Country Link
US (2) US6403604B1 (enExample)
EP (1) EP1383772B1 (enExample)
JP (1) JP4584538B2 (enExample)
KR (1) KR100853141B1 (enExample)
CN (1) CN1246323C (enExample)
AT (1) ATE338047T1 (enExample)
CA (1) CA2439787C (enExample)
DE (1) DE60214359T2 (enExample)
ES (1) ES2274020T3 (enExample)
IL (2) IL157669A0 (enExample)
MX (1) MXPA03007896A (enExample)
NZ (1) NZ528115A (enExample)
WO (1) WO2002070525A2 (enExample)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6150343A (en) * 1993-06-30 2000-11-21 University Of Pittsburgh Camptothecin analogs and methods of preparation thereof
US6492380B1 (en) * 1999-05-17 2002-12-10 Queen's University At Kingston Method of inhibiting neurotrophin-receptor binding
US6350756B1 (en) 2001-01-18 2002-02-26 California Pacific Medical Center Camptothecin derivatives
US6855720B2 (en) * 2001-03-01 2005-02-15 California Pacific Medical Center Nitrogen-based camptothecin derivatives
US6403604B1 (en) * 2001-03-01 2002-06-11 California Pacific Medical Center Nitrogen-based camptothecin derivatives
AU2003243397A1 (en) * 2002-06-03 2003-12-19 California Pacific Medical Center Homo-camptothecin derivatives
US6933302B2 (en) * 2002-06-03 2005-08-23 California Pacific Medical Center Nitrogen-based homo-camptothecin derivatives
FR2889528B1 (fr) * 2005-08-05 2007-09-07 Servier Lab Nouveaux composes analogues de la camptothecine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
FR2889527A1 (fr) * 2005-08-05 2007-02-09 Servier Lab Nouveaux composes analogues de la camptothecine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
US20070099900A1 (en) 2005-09-15 2007-05-03 Painceptor Pharma Corporation Methods of modulating neurotrophin-mediated activity
US7875602B2 (en) * 2005-10-21 2011-01-25 Sutter West Bay Hospitals Camptothecin derivatives as chemoradiosensitizing agents
CN100586952C (zh) * 2006-11-10 2010-02-03 中国药科大学 噁唑骈喜树碱酯衍生物及其制备方法和用途
US8420665B2 (en) * 2008-01-11 2013-04-16 Northwestern University Anti-cancer compounds
JP5542804B2 (ja) * 2008-05-23 2014-07-09 ザ ユニヴァーシティ オブ ブリティッシュ コロンビア リポソームナノ粒子中で使用するための修飾薬物
EP2443125B1 (en) * 2009-06-17 2014-11-26 Threshold Pharmaceuticals, Inc. Camptothecin derivatives
US10980798B2 (en) 2011-11-03 2021-04-20 Taiwan Liposome Company, Ltd. Pharmaceutical compositions of hydrophobic camptothecin derivatives
TWI619496B (zh) 2011-11-03 2018-04-01 台灣微脂體股份有限公司 疏水性喜樹鹼衍生物之醫藥組合物
CN109575044A (zh) * 2018-12-21 2019-04-05 西安交通大学 2-（喜树碱-10-氧基）乙酰胺类化合物和应用
KR20240104214A (ko) * 2019-03-29 2024-07-04 메디뮨 리미티드 화합물 및 이의 접합체
US12029736B2 (en) 2020-02-25 2024-07-09 Mediboston Limited Camptothecin derivatives and conjugates thereof
US12521444B2 (en) 2021-02-25 2026-01-13 Fortvita Biologics Limited Anti-HER2 antibody-drug conjugates and uses thereof
KR20250079213A (ko) 2022-10-09 2025-06-04 라노바 메디신즈 리미티드 화합물, 조성물 및 방법
CN117285540B (zh) * 2023-09-27 2025-07-11 中国海洋大学 12-位取代的喜树碱衍生物及其用途

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4943579A (en) 1987-10-06 1990-07-24 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Water soluble prodrugs of camptothecin

Family Cites Families (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9320781D0 (en) 1993-10-08 1993-12-01 Erba Carlo Spa Polymer-bound camptothecin derivatives
US5965566A (en) 1993-10-20 1999-10-12 Enzon, Inc. High molecular weight polymer-based prodrugs
US5919455A (en) 1993-10-27 1999-07-06 Enzon, Inc. Non-antigenic branched polymer conjugates
US5646159A (en) 1994-07-20 1997-07-08 Research Triangle Institute Water-soluble esters of camptothecin compounds
GB9504065D0 (en) 1995-03-01 1995-04-19 Pharmacia Spa Poly-pyrrolecarboxamidonaphthalenic acid derivatives
JPH08333370A (ja) * 1995-06-08 1996-12-17 Kyorin Pharmaceut Co Ltd 水に可溶な新規フルオロエチルカンプトテシン誘導体、及びその製造方法
US6339091B1 (en) 1995-06-21 2002-01-15 Societe De Conseils De Recherches Et D'applications Scientifiques (S.C.R.A.S.) Comptothecin analogues, preparation methods therefor, use thereof as drugs, and pharmaceutical compositions containing said analogues
WO1997019085A1 (en) 1995-11-22 1997-05-29 Research Triangle Institute Camptothecin compounds with combined topoisomerase i inhibition and dna alkylation properties
US5731316A (en) 1996-01-30 1998-03-24 The Stehlin Foundation For Cancer Research Derivatives of camptothecin and methods of treating cancer using these derivatives
US6096336A (en) 1996-01-30 2000-08-01 The Stehlin Foundation For Cancer Research Liposomal prodrugs comprising derivatives of camptothecin and methods of treating cancer using these prodrugs
DE69728152T2 (de) 1996-08-19 2004-08-05 Bionumerik Pharmaceuticals, Inc., San Antonio Hoch-lipophile campothecin-derivate
AU739028B2 (en) 1996-09-27 2001-10-04 Bristol-Myers Squibb Company Hydrolyzable prodrugs for delivery of anticancer drugs to metastatic cells
WO1998014459A1 (de) 1996-09-30 1998-04-09 Bayer Aktiengesellschaft Glycokonjugate von modifizierten camptothecin-derivaten (20-o-verknüpfung)
SG88737A1 (en) 1996-10-30 2002-05-21 Tanabe Seiyaku Co S type 2-substituted hydroxy-2-indolidinylbutyric ester compounds and process for preparation thereof
UA57757C2 (uk) 1996-12-20 2003-07-15 Сос'Єте Де Консей Де Решерш Е Даплікасьон С'Єнтіфік (С.К.Р.А.С.) Аналоги камптотецину, спосіб їх отримання (варіанти) і фармацевтична композиція
ID23424A (id) 1997-05-14 2000-04-20 Bayer Ag Glikokonjugat dari 20(s)-kamptotesin
GB9721070D0 (en) 1997-10-03 1997-12-03 Pharmacia & Upjohn Spa Bioactive derivatives of camptothecin
US6153655A (en) 1998-04-17 2000-11-28 Enzon, Inc. Terminally-branched polymeric linkers and polymeric conjugates containing the same
US6057303A (en) 1998-10-20 2000-05-02 Bionumerik Pharmaceuticals, Inc. Highly lipophilic Camptothecin derivatives
US6207832B1 (en) 1999-04-09 2001-03-27 University Of Pittsburgh Camptothecin analogs and methods of preparation thereof
AU4822500A (en) 1999-05-04 2000-11-17 Bionumerik Pharmaceuticals, Inc. Novel highly lipophilic camptothecin analogs
US6765019B1 (en) 1999-05-06 2004-07-20 University Of Kentucky Research Foundation Permeable, water soluble, non-irritating prodrugs of chemotherapeutic agents with oxaalkanoic acids
US6288072B1 (en) * 1999-12-29 2001-09-11 Monroe E. Wall Camptothecin β-alanine esters with topoisomerase I inhibition
US6350756B1 (en) 2001-01-18 2002-02-26 California Pacific Medical Center Camptothecin derivatives
US6403604B1 (en) 2001-03-01 2002-06-11 California Pacific Medical Center Nitrogen-based camptothecin derivatives
GB0119578D0 (en) 2001-08-10 2001-10-03 Pharmacia & Upjohn Spa Fluoro linkers

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4943579A (en) 1987-10-06 1990-07-24 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Water soluble prodrugs of camptothecin

Also Published As

Publication number Publication date
ATE338047T1 (de) 2006-09-15
ES2274020T3 (es) 2007-05-16
US6825207B2 (en) 2004-11-30
DE60214359D1 (en) 2006-10-12
NZ528115A (en) 2006-04-28
EP1383772B1 (en) 2006-08-30
DE60214359T2 (de) 2007-08-30
JP2004529114A (ja) 2004-09-24
US6403604B1 (en) 2002-06-11
IL157669A0 (en) 2004-03-28
US20030073698A1 (en) 2003-04-17
EP1383772A2 (en) 2004-01-28
WO2002070525A3 (en) 2003-02-20
WO2002070525A2 (en) 2002-09-12
CN1246323C (zh) 2006-03-22
CN1511159A (zh) 2004-07-07
CA2439787C (en) 2011-05-24
MXPA03007896A (es) 2004-06-07
CA2439787A1 (en) 2002-09-12
IL157669A (en) 2010-11-30
KR20040002872A (ko) 2004-01-07
JP4584538B2 (ja) 2010-11-24

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