ATE338047T1 - Stickstoffbasierte camptothecin-derivate - Google Patents
Stickstoffbasierte camptothecin-derivateInfo
- Publication number
- ATE338047T1 ATE338047T1 AT02718930T AT02718930T ATE338047T1 AT E338047 T1 ATE338047 T1 AT E338047T1 AT 02718930 T AT02718930 T AT 02718930T AT 02718930 T AT02718930 T AT 02718930T AT E338047 T1 ATE338047 T1 AT E338047T1
- Authority
- AT
- Austria
- Prior art keywords
- camptothecin derivatives
- nitrogen based
- camptothecin
- based camptothecin
- esters
- Prior art date
Links
- VSJKWCGYPAHWDS-FQEVSTJZSA-N camptothecin Chemical class C1=CC=C2C=C(CN3C4=CC5=C(C3=O)COC(=O)[C@]5(O)CC)C4=NC2=C1 VSJKWCGYPAHWDS-FQEVSTJZSA-N 0.000 title abstract 4
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 title 2
- 229910052757 nitrogen Inorganic materials 0.000 title 1
- 239000002253 acid Substances 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 150000002148 esters Chemical class 0.000 abstract 2
- KLWPJMFMVPTNCC-UHFFFAOYSA-N Camptothecin Natural products CCC1(O)C(=O)OCC2=C1C=C3C4Nc5ccccc5C=C4CN3C2=O KLWPJMFMVPTNCC-UHFFFAOYSA-N 0.000 abstract 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 229940127093 camptothecin Drugs 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- VSJKWCGYPAHWDS-UHFFFAOYSA-N dl-camptothecin Natural products C1=CC=C2C=C(CN3C4=CC5=C(C3=O)COC(=O)C5(O)CC)C4=NC2=C1 VSJKWCGYPAHWDS-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/22—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains four or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Urology & Nephrology (AREA)
- Oncology (AREA)
- Dermatology (AREA)
- Hematology (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Pulmonology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US09/797,765 US6403604B1 (en) | 2001-03-01 | 2001-03-01 | Nitrogen-based camptothecin derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE338047T1 true ATE338047T1 (de) | 2006-09-15 |
Family
ID=25171748
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT02718930T ATE338047T1 (de) | 2001-03-01 | 2002-02-06 | Stickstoffbasierte camptothecin-derivate |
Country Status (13)
| Country | Link |
|---|---|
| US (2) | US6403604B1 (enExample) |
| EP (1) | EP1383772B1 (enExample) |
| JP (1) | JP4584538B2 (enExample) |
| KR (1) | KR100853141B1 (enExample) |
| CN (1) | CN1246323C (enExample) |
| AT (1) | ATE338047T1 (enExample) |
| CA (1) | CA2439787C (enExample) |
| DE (1) | DE60214359T2 (enExample) |
| ES (1) | ES2274020T3 (enExample) |
| IL (2) | IL157669A0 (enExample) |
| MX (1) | MXPA03007896A (enExample) |
| NZ (1) | NZ528115A (enExample) |
| WO (1) | WO2002070525A2 (enExample) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6150343A (en) * | 1993-06-30 | 2000-11-21 | University Of Pittsburgh | Camptothecin analogs and methods of preparation thereof |
| US6492380B1 (en) * | 1999-05-17 | 2002-12-10 | Queen's University At Kingston | Method of inhibiting neurotrophin-receptor binding |
| US6350756B1 (en) | 2001-01-18 | 2002-02-26 | California Pacific Medical Center | Camptothecin derivatives |
| US6855720B2 (en) * | 2001-03-01 | 2005-02-15 | California Pacific Medical Center | Nitrogen-based camptothecin derivatives |
| US6403604B1 (en) * | 2001-03-01 | 2002-06-11 | California Pacific Medical Center | Nitrogen-based camptothecin derivatives |
| WO2003101998A1 (en) * | 2002-06-03 | 2003-12-11 | California Pacific Medical Center | Nitrogen-based homo-camptothecin derivatives |
| US20040034050A1 (en) * | 2002-06-03 | 2004-02-19 | Yang Li-Xi | Homo-camptothecin derivatives |
| FR2889528B1 (fr) * | 2005-08-05 | 2007-09-07 | Servier Lab | Nouveaux composes analogues de la camptothecine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
| FR2889527A1 (fr) * | 2005-08-05 | 2007-02-09 | Servier Lab | Nouveaux composes analogues de la camptothecine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
| KR20080058403A (ko) | 2005-09-15 | 2008-06-25 | 페인셉터 파마 코포레이션 | 뉴로트로핀 매개 활성 조절 방법 |
| US7875602B2 (en) * | 2005-10-21 | 2011-01-25 | Sutter West Bay Hospitals | Camptothecin derivatives as chemoradiosensitizing agents |
| CN100586952C (zh) * | 2006-11-10 | 2010-02-03 | 中国药科大学 | 噁唑骈喜树碱酯衍生物及其制备方法和用途 |
| WO2009089537A2 (en) | 2008-01-11 | 2009-07-16 | Northwestern University | Anti-cancer compounds |
| CN104622809B (zh) * | 2008-05-23 | 2019-04-19 | 英属哥伦比亚大学 | 用于脂质体纳米颗粒的修饰的药物 |
| CN102574866B (zh) * | 2009-06-17 | 2015-02-18 | 四川恒康发展有限责任公司 | 喜树碱衍生物 |
| IN2014DN00277A (enExample) | 2011-11-03 | 2015-06-05 | Taiwan Liposome Co Ltd | |
| US10980798B2 (en) | 2011-11-03 | 2021-04-20 | Taiwan Liposome Company, Ltd. | Pharmaceutical compositions of hydrophobic camptothecin derivatives |
| CN109575044A (zh) * | 2018-12-21 | 2019-04-05 | 西安交通大学 | 2-（喜树碱-10-氧基）乙酰胺类化合物和应用 |
| JP7210770B2 (ja) * | 2019-03-29 | 2023-01-23 | メドイミューン・リミテッド | 化合物及びその複合体 |
| WO2021173773A1 (en) | 2020-02-25 | 2021-09-02 | Mediboston, Inc. | Camptothecin derivatives and conjugates thereof |
| KR20250079213A (ko) | 2022-10-09 | 2025-06-04 | 라노바 메디신즈 리미티드 | 화합물, 조성물 및 방법 |
| CN117285540B (zh) * | 2023-09-27 | 2025-07-11 | 中国海洋大学 | 12-位取代的喜树碱衍生物及其用途 |
Family Cites Families (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4943579A (en) | 1987-10-06 | 1990-07-24 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Water soluble prodrugs of camptothecin |
| GB9320781D0 (en) | 1993-10-08 | 1993-12-01 | Erba Carlo Spa | Polymer-bound camptothecin derivatives |
| US5965566A (en) * | 1993-10-20 | 1999-10-12 | Enzon, Inc. | High molecular weight polymer-based prodrugs |
| US5919455A (en) | 1993-10-27 | 1999-07-06 | Enzon, Inc. | Non-antigenic branched polymer conjugates |
| US5646159A (en) | 1994-07-20 | 1997-07-08 | Research Triangle Institute | Water-soluble esters of camptothecin compounds |
| GB9504065D0 (en) | 1995-03-01 | 1995-04-19 | Pharmacia Spa | Poly-pyrrolecarboxamidonaphthalenic acid derivatives |
| JPH08333370A (ja) * | 1995-06-08 | 1996-12-17 | Kyorin Pharmaceut Co Ltd | 水に可溶な新規フルオロエチルカンプトテシン誘導体、及びその製造方法 |
| US6339091B1 (en) * | 1995-06-21 | 2002-01-15 | Societe De Conseils De Recherches Et D'applications Scientifiques (S.C.R.A.S.) | Comptothecin analogues, preparation methods therefor, use thereof as drugs, and pharmaceutical compositions containing said analogues |
| AU7732996A (en) | 1995-11-22 | 1997-06-11 | Research Triangle Institute | Camptothecin compounds with combined topoisomerase i inhibition and dna alkylation properties |
| US6096336A (en) | 1996-01-30 | 2000-08-01 | The Stehlin Foundation For Cancer Research | Liposomal prodrugs comprising derivatives of camptothecin and methods of treating cancer using these prodrugs |
| US5731316A (en) | 1996-01-30 | 1998-03-24 | The Stehlin Foundation For Cancer Research | Derivatives of camptothecin and methods of treating cancer using these derivatives |
| DE69728152T2 (de) | 1996-08-19 | 2004-08-05 | Bionumerik Pharmaceuticals, Inc., San Antonio | Hoch-lipophile campothecin-derivate |
| EP0961619A4 (en) | 1996-09-27 | 2001-09-26 | Bristol Myers Squibb Co | HYDROLYSABLE DRUGS FOR THE RELEASE OF ANTI-CANCER DRUGS IN METASTATIC CELLS |
| ATE210673T1 (de) | 1996-09-30 | 2001-12-15 | Bayer Ag | Glycokonjugate von modifizierten camptothecin- derivaten (20-o-verknüpfung) |
| SG103322A1 (en) | 1996-10-30 | 2004-04-29 | Tanabe Seiyaku Co | S type 2-substituted hydroxy-2-indolidinylbutyric ester compounds and process for preparation thereof |
| UA57757C2 (uk) | 1996-12-20 | 2003-07-15 | Сос'Єте Де Консей Де Решерш Е Даплікасьон С'Єнтіфік (С.К.Р.А.С.) | Аналоги камптотецину, спосіб їх отримання (варіанти) і фармацевтична композиція |
| ID23424A (id) | 1997-05-14 | 2000-04-20 | Bayer Ag | Glikokonjugat dari 20(s)-kamptotesin |
| GB9721070D0 (en) | 1997-10-03 | 1997-12-03 | Pharmacia & Upjohn Spa | Bioactive derivatives of camptothecin |
| US6153655A (en) | 1998-04-17 | 2000-11-28 | Enzon, Inc. | Terminally-branched polymeric linkers and polymeric conjugates containing the same |
| US6057303A (en) | 1998-10-20 | 2000-05-02 | Bionumerik Pharmaceuticals, Inc. | Highly lipophilic Camptothecin derivatives |
| US6207832B1 (en) * | 1999-04-09 | 2001-03-27 | University Of Pittsburgh | Camptothecin analogs and methods of preparation thereof |
| AU4822500A (en) | 1999-05-04 | 2000-11-17 | Bionumerik Pharmaceuticals, Inc. | Novel highly lipophilic camptothecin analogs |
| US6765019B1 (en) | 1999-05-06 | 2004-07-20 | University Of Kentucky Research Foundation | Permeable, water soluble, non-irritating prodrugs of chemotherapeutic agents with oxaalkanoic acids |
| US6288072B1 (en) * | 1999-12-29 | 2001-09-11 | Monroe E. Wall | Camptothecin β-alanine esters with topoisomerase I inhibition |
| US6350756B1 (en) * | 2001-01-18 | 2002-02-26 | California Pacific Medical Center | Camptothecin derivatives |
| US6403604B1 (en) * | 2001-03-01 | 2002-06-11 | California Pacific Medical Center | Nitrogen-based camptothecin derivatives |
| GB0119578D0 (en) | 2001-08-10 | 2001-10-03 | Pharmacia & Upjohn Spa | Fluoro linkers |
-
2001
- 2001-03-01 US US09/797,765 patent/US6403604B1/en not_active Expired - Lifetime
-
2002
- 2002-02-06 JP JP2002569845A patent/JP4584538B2/ja not_active Expired - Fee Related
- 2002-02-06 ES ES02718930T patent/ES2274020T3/es not_active Expired - Lifetime
- 2002-02-06 NZ NZ528115A patent/NZ528115A/en not_active IP Right Cessation
- 2002-02-06 EP EP02718930A patent/EP1383772B1/en not_active Expired - Lifetime
- 2002-02-06 MX MXPA03007896A patent/MXPA03007896A/es active IP Right Grant
- 2002-02-06 KR KR1020037011466A patent/KR100853141B1/ko not_active Expired - Fee Related
- 2002-02-06 CA CA2439787A patent/CA2439787C/en not_active Expired - Fee Related
- 2002-02-06 AT AT02718930T patent/ATE338047T1/de not_active IP Right Cessation
- 2002-02-06 IL IL15766902A patent/IL157669A0/xx unknown
- 2002-02-06 DE DE60214359T patent/DE60214359T2/de not_active Expired - Lifetime
- 2002-02-06 WO PCT/US2002/003798 patent/WO2002070525A2/en not_active Ceased
- 2002-02-06 CN CNB028090543A patent/CN1246323C/zh not_active Expired - Fee Related
- 2002-05-23 US US10/154,768 patent/US6825207B2/en not_active Expired - Fee Related
-
2003
- 2003-08-31 IL IL157669A patent/IL157669A/en not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| JP2004529114A (ja) | 2004-09-24 |
| KR100853141B1 (ko) | 2008-08-20 |
| JP4584538B2 (ja) | 2010-11-24 |
| CN1511159A (zh) | 2004-07-07 |
| WO2002070525A3 (en) | 2003-02-20 |
| US6825207B2 (en) | 2004-11-30 |
| DE60214359D1 (en) | 2006-10-12 |
| ES2274020T3 (es) | 2007-05-16 |
| IL157669A (en) | 2010-11-30 |
| IL157669A0 (en) | 2004-03-28 |
| KR20040002872A (ko) | 2004-01-07 |
| WO2002070525A2 (en) | 2002-09-12 |
| CA2439787A1 (en) | 2002-09-12 |
| CN1246323C (zh) | 2006-03-22 |
| MXPA03007896A (es) | 2004-06-07 |
| CA2439787C (en) | 2011-05-24 |
| EP1383772B1 (en) | 2006-08-30 |
| US20030073698A1 (en) | 2003-04-17 |
| EP1383772A2 (en) | 2004-01-28 |
| NZ528115A (en) | 2006-04-28 |
| US6403604B1 (en) | 2002-06-11 |
| DE60214359T2 (de) | 2007-08-30 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |