IL156504A0 - Human fgf23 protein mutant lowering blood phosphorus level - Google Patents

Human fgf23 protein mutant lowering blood phosphorus level

Info

Publication number
IL156504A0
IL156504A0 IL15650401A IL15650401A IL156504A0 IL 156504 A0 IL156504 A0 IL 156504A0 IL 15650401 A IL15650401 A IL 15650401A IL 15650401 A IL15650401 A IL 15650401A IL 156504 A0 IL156504 A0 IL 156504A0
Authority
IL
Israel
Prior art keywords
lowering blood
protein mutant
phosphorus level
blood phosphorus
human fgf23
Prior art date
Application number
IL15650401A
Other languages
English (en)
Original Assignee
Chugai Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chugai Pharmaceutical Co Ltd filed Critical Chugai Pharmaceutical Co Ltd
Publication of IL156504A0 publication Critical patent/IL156504A0/xx

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/11DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01KANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027New or modified breeds of vertebrates
    • A01K67/0275Genetically modified vertebrates, e.g. transgenic
    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01KANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027New or modified breeds of vertebrates
    • A01K67/0271Chimeric vertebrates, e.g. comprising exogenous cells
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/08Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/12Drugs for disorders of the metabolism for electrolyte homeostasis
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475Growth factors; Growth regulators
    • C07K14/50Fibroblast growth factor [FGF]
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/10Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034Isolating an individual clone by screening libraries
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5082Supracellular entities, e.g. tissue, organisms
    • G01N33/5088Supracellular entities, e.g. tissue, organisms of vertebrates
    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01KANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00Genetically modified animals
    • A01K2217/05Animals comprising random inserted nucleic acids (transgenic)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/51Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/53DNA (RNA) vaccination
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Environmental Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • Hematology (AREA)
  • Wood Science & Technology (AREA)
  • Cell Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Urology & Nephrology (AREA)
  • Biodiversity & Conservation Biology (AREA)
  • Animal Husbandry (AREA)
  • Toxicology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Plant Pathology (AREA)
  • Food Science & Technology (AREA)
  • General Physics & Mathematics (AREA)
  • Obesity (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Diabetes (AREA)
IL15650401A 2000-12-26 2001-12-26 Human fgf23 protein mutant lowering blood phosphorus level IL156504A0 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2000396316 2000-12-26
JP2001161370 2001-05-29
PCT/JP2001/011482 WO2002052009A1 (fr) 2000-12-26 2001-12-26 Mutant de la proteine fgf23 humaine reduisant le taux de phosphore dans le sang

Publications (1)

Publication Number Publication Date
IL156504A0 true IL156504A0 (en) 2004-01-04

Family

ID=26606754

Family Applications (1)

Application Number Title Priority Date Filing Date
IL15650401A IL156504A0 (en) 2000-12-26 2001-12-26 Human fgf23 protein mutant lowering blood phosphorus level

Country Status (10)

Country Link
US (1) US20040097414A1 (de)
EP (1) EP1354949A4 (de)
JP (1) JPWO2002052009A1 (de)
KR (1) KR20030074678A (de)
CN (1) CN1269960C (de)
CA (1) CA2433171A1 (de)
HK (1) HK1062835A1 (de)
IL (1) IL156504A0 (de)
RU (1) RU2003123108A (de)
WO (1) WO2002052009A1 (de)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8889621B2 (en) 2009-10-30 2014-11-18 New York University Inhibiting binding of FGF23 to the binary FGFR-Klotho complex for the treatment of hypophosphatemia
WO2013027191A1 (en) * 2011-08-25 2013-02-28 Novartis Ag Methods and compositions using fgf23 fusion polypeptides
RU2643326C2 (ru) 2012-03-30 2018-01-31 Новартис Аг Ингибитор рецептора фрф для применения в лечении гипофосфатемических заболеваний
US9657075B2 (en) 2012-06-07 2017-05-23 New York University Chimeric fibroblast growth factor 23 proteins and methods of use
CN103224557B (zh) * 2012-08-08 2014-10-01 温州医学院 一种长效型成纤维细胞生长因子-23拮抗剂的开发
WO2014130659A1 (en) 2013-02-22 2014-08-28 New York University Chimeric fibroblast growth factor 23 proteins and methods of use
CN106456714A (zh) 2014-03-28 2017-02-22 纽约大学 Fgf23融合蛋白

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU3774300A (en) * 1999-06-02 2000-12-18 Genentech Inc. Secreted and transmembrane polypeptides and nucleic acids encoding the same
EP1303536B1 (de) * 2000-07-19 2010-03-17 Advanced Research And Technology Institute, Inc. Neuer fibroblastwachstumsfaktor (fgf23) und methoden zur verwendung

Also Published As

Publication number Publication date
WO2002052009A1 (fr) 2002-07-04
RU2003123108A (ru) 2005-02-27
JPWO2002052009A1 (ja) 2004-04-30
US20040097414A1 (en) 2004-05-20
CN1269960C (zh) 2006-08-16
KR20030074678A (ko) 2003-09-19
EP1354949A1 (de) 2003-10-22
CA2433171A1 (en) 2002-07-04
EP1354949A4 (de) 2004-05-19
HK1062835A1 (en) 2004-11-26
CN1492927A (zh) 2004-04-28

Similar Documents

Publication Publication Date Title
GB0106588D0 (en) Tissue distracter
AU7680300A (en) Human dna sequences
IL154520A0 (en) Human coagulation factor vii variants
IL152353A0 (en) Medical implant
GB9926231D0 (en) Medical implants
IL135947A0 (en) Human blood bacterium
HK1055265A1 (en) Blood glucose level control
EP1077996A4 (de) Menschliches edg3sb-gen
AU2001262759A1 (en) Infant's chamber pot having health checking function
IL156504A0 (en) Human fgf23 protein mutant lowering blood phosphorus level
GB0014990D0 (en) Medical endoscope
WO2001098454A8 (en) Human dna sequences
AU2002217522A1 (en) Human FGF23 protein mutant lowering blood phosphorus level
EP1247073A4 (de) Gewebesensor
GB0023599D0 (en) Non-invasive method for determining human photodermatoogical skin-types
GB2343670B (en) Patient movement aid
DE60015634D1 (de) Krankenliege
EP1111992A4 (de) Verbesserte künstliche blutflüssigkeiten
IL142480A0 (en) Tissue growth stimulating system
GB0410147D0 (en) Human angiomotin-like protein 1
GB0122717D0 (en) Disposable insole
GB9811310D0 (en) Organism growth helper
GB9814241D0 (en) Medical implants
GB9828012D0 (en) Surgical arterial plug
GB0001660D0 (en) Artificial heart