IL153866A0 - Method and system for determining the effect of a molecular modification on the metabolism rate of a molecule - Google Patents

Method and system for determining the effect of a molecular modification on the metabolism rate of a molecule

Info

Publication number
IL153866A0
IL153866A0 IL15386601A IL15386601A IL153866A0 IL 153866 A0 IL153866 A0 IL 153866A0 IL 15386601 A IL15386601 A IL 15386601A IL 15386601 A IL15386601 A IL 15386601A IL 153866 A0 IL153866 A0 IL 153866A0
Authority
IL
Israel
Prior art keywords
molecule
determining
effect
molecular modification
metabolism rate
Prior art date
Application number
IL15386601A
Other languages
English (en)
Original Assignee
Arqule Inc
Univ Washington
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Arqule Inc, Univ Washington filed Critical Arqule Inc
Publication of IL153866A0 publication Critical patent/IL153866A0/xx

Links

Classifications

    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B15/00—ICT specially adapted for analysing two-dimensional or three-dimensional molecular structures, e.g. structural or functional relations or structure alignment
    • G16B15/30—Drug targeting using structural data; Docking or binding prediction
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/26—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving oxidoreductase
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B15/00—ICT specially adapted for analysing two-dimensional or three-dimensional molecular structures, e.g. structural or functional relations or structure alignment
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B5/00—ICT specially adapted for modelling or simulations in systems biology, e.g. gene-regulatory networks, protein interaction networks or metabolic networks
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/795—Porphyrin- or corrin-ring-containing peptides
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/795—Porphyrin- or corrin-ring-containing peptides
    • G01N2333/80—Cytochromes
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90—Enzymes; Proenzymes
    • G01N2333/902—Oxidoreductases (1.)
    • G01N2333/90245—Oxidoreductases (1.) acting on paired donors with incorporation of molecular oxygen (1.14)

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Biophysics (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Theoretical Computer Science (AREA)
  • Medical Informatics (AREA)
  • Evolutionary Biology (AREA)
  • Microbiology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • Zoology (AREA)
  • Analytical Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Cell Biology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Genetics & Genomics (AREA)
  • General Engineering & Computer Science (AREA)
  • Food Science & Technology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Physiology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines Containing Plant Substances (AREA)
IL15386601A 2000-07-10 2001-07-09 Method and system for determining the effect of a molecular modification on the metabolism rate of a molecule IL153866A0 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US09/613,875 US6625547B1 (en) 1998-08-05 2000-07-10 Relative rates of cytochrome p450 metabolism
PCT/US2001/021744 WO2002004659A2 (en) 2000-07-10 2001-07-09 Relative rates of cytochrome p450 metabolism

Publications (1)

Publication Number Publication Date
IL153866A0 true IL153866A0 (en) 2003-07-31

Family

ID=24459016

Family Applications (1)

Application Number Title Priority Date Filing Date
IL15386601A IL153866A0 (en) 2000-07-10 2001-07-09 Method and system for determining the effect of a molecular modification on the metabolism rate of a molecule

Country Status (7)

Country Link
US (2) US6625547B1 (xx)
EP (1) EP1303634A2 (xx)
JP (1) JP2004503222A (xx)
AU (1) AU2001275886A1 (xx)
CA (1) CA2416215A1 (xx)
IL (1) IL153866A0 (xx)
WO (1) WO2002004659A2 (xx)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5910403A (en) * 1997-05-15 1999-06-08 The Regents Of University Of California Methods for measuring cellular proliferation and destruction rates in vitro and in vivo
JP2005515452A (ja) * 2001-10-24 2005-05-26 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア アイソトープで標識された水を用いるヒトおよび実験系におけるタンパク質合成速度の測定
CA2475924C (en) * 2002-02-12 2016-03-29 The Regents Of The University Of California Non-invasive method for measuring rates of biosynthesis of biological molecules by label incorporation
AU2003234688A1 (en) * 2002-04-05 2003-10-27 The Regents Of The University Of California Method for isolating and measuring proliferation of long-term label retaining cells and stem cells
EP1546364A4 (en) 2002-07-30 2006-09-06 Univ California METHOD FOR THE LARGE-SCALE AUTOMATIC MEASUREMENT OF PROTEOMIC OR ORGANOMOMIC MOLECULAR FLOW RATES BY MASS SPECTROMETRY
WO2004021863A2 (en) * 2002-09-04 2004-03-18 The Regents Of The University Of California Methods for measuring rates of replication and death of nfectious microbial agents in an infected host organism
CA2498378C (en) * 2002-09-13 2013-12-17 The Regents Of The University Of California Methods for measuring rates of reverse cholesterol transport in vivo, as an index of anti-atherogenesis
US20070248540A1 (en) * 2002-09-16 2007-10-25 The Regents Of The University Of California Biochemical methods for measuring metabolic fitness of tissues or whole organisms
SG152923A1 (en) * 2002-09-16 2009-06-29 Univ California Biochemical methods for measuring metabolic fitness of tissues or whole organisms
AU2003291731B2 (en) * 2002-11-04 2009-09-10 The Regents Of The University Of California Deuterated glucose or fat tolerance tests for high-throughput measurement of the metabolism of sugars or fatty acids in the body
US7262020B2 (en) * 2003-07-03 2007-08-28 The Regents Of The University Of California Methods for comparing relative flux rates of two or more biological molecules in vivo through a single protocol
US20050202406A1 (en) * 2003-11-25 2005-09-15 The Regents Of The University Of California Method for high-throughput screening of compounds and combinations of compounds for discovery and quantification of actions, particularly unanticipated therapeutic or toxic actions, in biological systems
TW200538738A (en) 2004-02-20 2005-12-01 Univ California Molecular flux rates through critical pathways measured by stable isotope labeling in vivo, as biomarkers of drug action and disease activity
WO2005087943A1 (en) * 2004-03-11 2005-09-22 The Regents Of The University Of California Temporal or spatial characterization of biosynthetic events in living organisms by isotopic fingerprinting under conditions of imposed isotopic gradients
WO2005094327A2 (en) * 2004-03-29 2005-10-13 The Regents Of The University Of California Isolation of epithelial cells or their biochemical contents from excreta after in vivo isotopic labeling
US20060251576A1 (en) * 2005-05-03 2006-11-09 The Regents Of The University Of California Methods for measuring cholesterol metabolism and transport
TW200711660A (en) 2005-06-10 2007-04-01 Univ California Monitoring two dimensions of diabetes pathogenesis separately or concurrently (insulin sensitivity and beta-cell sufficiency): uses in diagnosis, prognosis, assessment of disease risk, and drug development
KR20100043502A (ko) * 2008-10-20 2010-04-29 삼성전자주식회사 효소 반응 속도 계산 방법, 컴퓨터 프로그램 산물 및 시료 중의 효소의 양을 결정하는 방법
US8321151B2 (en) 2008-12-30 2012-11-27 The Invention Science Fund I, Llc Computational methods and systems for treatment in relation to modulation of CYP450 enzyme activity
US8315815B2 (en) 2008-12-30 2012-11-20 The Invention Science Fund I, Llc Computational methods and systems for suggesting modulators of CYP450 as treatment options
US8073633B2 (en) * 2008-12-30 2011-12-06 The Invention Science Fund I, Llc Computational methods and systems for suggesting modulators of CYP450 as treatment options
US8569328B1 (en) * 2011-05-24 2013-10-29 Antecip Bioventures Ii Llc Compositions and methods comprising tilidine or related compounds and dextromethorphan
JP2014526685A (ja) 2011-09-08 2014-10-06 ザ・リージェンツ・オブ・ザ・ユニバーシティ・オブ・カリフォルニア 代謝流量測定、画像化、および顕微鏡法
ES2668678T3 (es) 2011-12-07 2018-05-21 Glaxosmithkline Llc Procedimiento de determinación de la masa muscular esquelética corporal total
US9134319B2 (en) 2013-03-15 2015-09-15 The Regents Of The University Of California Method for replacing biomarkers of protein kinetics from tissue samples by biomarkers of protein kinetics from body fluids after isotopic labeling in vivo
CN104928350B (zh) * 2015-03-24 2017-11-14 中国药科大学 九种人肝cyp450酶体外抑制效应快速筛选方法

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH09507300A (ja) 1994-01-06 1997-07-22 テラピン テクノロジーズ，インコーポレイテッド 標的の代用物および改良された参照パネル
JP2002522750A (ja) 1998-08-05 2002-07-23 ユニバーシティ・オブ・ピッツバーグ シトクロムｐ４５０媒介反応における有機化合物の反応性のモデル化

Also Published As

Publication number Publication date
EP1303634A2 (en) 2003-04-23
AU2001275886A1 (en) 2002-01-21
US6625547B1 (en) 2003-09-23
WO2002004659A2 (en) 2002-01-17
JP2004503222A (ja) 2004-02-05
WO2002004659A3 (en) 2002-07-25
CA2416215A1 (en) 2002-01-17
US20030212497A1 (en) 2003-11-13

Similar Documents

Publication Publication Date Title
IL153866A0 (en) Method and system for determining the effect of a molecular modification on the metabolism rate of a molecule
AU2001267065A1 (en) Method and system for detecting fraud
AU8928901A (en) System and method for meta-data-linked advertisements
AU2001272992A1 (en) System and method for computer-created advertisements
AU2002357091A8 (en) System and method for music inditification
AU2001288343A1 (en) Method and system for payment over the internet
AU2002219791A1 (en) Promotion pricing system and method
AU2001222534A1 (en) Method and system for on-line promotion
AU2071899A (en) Method and device for detecting rate
AU2002224573A1 (en) Multimedia player and browser system
AU2001259013A1 (en) Transaction system and method
AU2001222955A1 (en) Method and apparatus for determining the direction and rate of a rotating element
GB2371895B (en) Music delivery system and method thereof
GB0224114D0 (en) System and method for creating a multimedia presentation
AU2001263129A1 (en) System and method for orthokeratology
AU7598600A (en) Improved method and system for measuring multiphase flow using multiple pressuredifferentials
EP1203309A4 (en) SYSTEM AND METHOD FOR DISCOVERING TEKSTÄHNLICHICHITEN ABOUT SHORT PASSAGES
HK1054103A1 (en) A system and method for replaying a predefined path through the internet
IL134481A0 (en) System and method for cataloguing
AU2001244428A1 (en) Personalized health profiling system and method
AU2002228258A1 (en) System and method for determining affinity relationships
AU9422401A (en) Advertisement segment transaction method and system
HK1063861A1 (en) Method and system for internet advertising
AU2001271100A1 (en) Method and system for quick reading practice using internet
ITTO20010179A0 (it) Sistema e metodo per l'accesso a strutture multimediali.