IL152448A0 - 3-nitrogen-6, 7-dioxygen steroid derivatives and pharmaceutical compositions containing the same - Google Patents

3-nitrogen-6, 7-dioxygen steroid derivatives and pharmaceutical compositions containing the same

Info

Publication number
IL152448A0
IL152448A0 IL15244801A IL15244801A IL152448A0 IL 152448 A0 IL152448 A0 IL 152448A0 IL 15244801 A IL15244801 A IL 15244801A IL 15244801 A IL15244801 A IL 15244801A IL 152448 A0 IL152448 A0 IL 152448A0
Authority
IL
Israel
Prior art keywords
dioxygen
nitrogen
same
pharmaceutical compositions
compositions containing
Prior art date
Application number
IL15244801A
Other languages
English (en)
Original Assignee
Inflazyme Pharm Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Inflazyme Pharm Ltd filed Critical Inflazyme Pharm Ltd
Publication of IL152448A0 publication Critical patent/IL152448A0/xx

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07JSTEROIDS
    • C07J41/00Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/06Antiasthmatics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/02Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/14Antivirals for RNA viruses
    • A61P31/18Antivirals for RNA viruses for HIV
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/08Antiallergic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/06Antiarrhythmics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07JSTEROIDS
    • C07J41/00Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0005Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring the nitrogen atom being directly linked to the cyclopenta(a)hydro phenanthrene skeleton
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07JSTEROIDS
    • C07J41/00Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0005Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring the nitrogen atom being directly linked to the cyclopenta(a)hydro phenanthrene skeleton
    • C07J41/0011Unsubstituted amino radicals
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07JSTEROIDS
    • C07J43/00Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07JSTEROIDS
    • C07J71/00Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0036Nitrogen-containing hetero ring
    • C07J71/0042Nitrogen only
    • C07J71/0047Nitrogen only at position 2(3)
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07JSTEROIDS
    • C07J71/00Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0036Nitrogen-containing hetero ring
    • C07J71/0057Nitrogen and oxygen
    • C07J71/0063Nitrogen and oxygen at position 2(3)
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02PCLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00Technologies relating to chemical industry
    • Y02P20/50Improvements relating to the production of bulk chemicals
    • Y02P20/55Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Virology (AREA)
  • Vascular Medicine (AREA)
  • Oncology (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Communicable Diseases (AREA)
  • Urology & Nephrology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
IL15244801A 2000-04-28 2001-04-30 3-nitrogen-6, 7-dioxygen steroid derivatives and pharmaceutical compositions containing the same IL152448A0 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US20061700P 2000-04-28 2000-04-28
PCT/CA2001/000581 WO2001083512A1 (en) 2000-04-28 2001-04-30 3-nitrogen-6,7-dioxygen steroids and uses related thereto

Publications (1)

Publication Number Publication Date
IL152448A0 true IL152448A0 (en) 2003-05-29

Family

ID=22742458

Family Applications (2)

Application Number Title Priority Date Filing Date
IL15244801A IL152448A0 (en) 2000-04-28 2001-04-30 3-nitrogen-6, 7-dioxygen steroid derivatives and pharmaceutical compositions containing the same
IL152448A IL152448A (en) 2000-04-28 2002-10-24 History of nitrogen-converted steroids at position 3 and oxygen-converted positions at positions 6 and 7 and pharmaceutical preparations containing the same

Family Applications After (1)

Application Number Title Priority Date Filing Date
IL152448A IL152448A (en) 2000-04-28 2002-10-24 History of nitrogen-converted steroids at position 3 and oxygen-converted positions at positions 6 and 7 and pharmaceutical preparations containing the same

Country Status (34)

Country Link
US (4) US20040034216A1 (et)
EP (1) EP1278763B1 (et)
JP (1) JP2003531916A (et)
KR (1) KR20030045671A (et)
CN (1) CN1214039C (et)
AP (1) AP1825A (et)
AT (1) ATE353909T1 (et)
AU (2) AU2001252084B2 (et)
BG (1) BG107289A (et)
BR (1) BR0110419A (et)
CA (1) CA2418748A1 (et)
CO (1) CO5590904A2 (et)
DE (1) DE60126597T2 (et)
DK (1) DK1278763T3 (et)
DZ (1) DZ3355A1 (et)
EE (1) EE200200613A (et)
ES (1) ES2282247T3 (et)
HK (1) HK1050694A1 (et)
HR (1) HRP20020944A2 (et)
HU (1) HUP0300908A2 (et)
IL (2) IL152448A0 (et)
MA (1) MA25808A1 (et)
MX (1) MXPA02010645A (et)
NO (1) NO324873B1 (et)
NZ (1) NZ522181A (et)
OA (1) OA12255A (et)
PL (1) PL365798A1 (et)
PT (1) PT1278763E (et)
RU (1) RU2291873C2 (et)
SK (1) SK15692002A3 (et)
UA (1) UA79229C2 (et)
WO (1) WO2001083512A1 (et)
YU (1) YU88102A (et)
ZA (1) ZA200208631B (et)

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US20030083231A1 (en) * 1998-11-24 2003-05-01 Ahlem Clarence N. Blood cell deficiency treatment method
HUP0300908A2 (hu) * 2000-04-28 2003-07-28 Inflazyme Pharmaceuticals Limited 3-Nitrogén-6,7-dioxigén-szteroidok és alkalmazásuk és ezeket tartalmazó gyógyszerkészítmények
WO2002085296A2 (en) * 2001-04-24 2002-10-31 Epigenesis Pharmaceuticals, Inc. Composition, formulations and kit for treatment of respiratory and lung disease with non-glucocorticoid steroids and/or ubiquinone and a bronchodilating agent
WO2002094849A2 (en) 2001-05-22 2002-11-28 Inflazyme Pharmaceuticals Ltd. Process for the production of 6, 7 - dihydroxy steroid compounds by allylic oxidation of steroid - 5 - ene compounds to steroid - 5 - ene - 7 - one compounds followed by hydroboration and oxidation and intermediates of this process
DE60324562D1 (de) 2002-08-01 2008-12-18 Astellas Pharma Inc Kaliumabhängiger natrium-calcium-austauscher
US20050043282A1 (en) * 2003-07-31 2005-02-24 Robinson Cynthia B. Combination of dehydroepiandrosterone or dehydroepiandrosterone-sulfate with a lipoxygenase inhibitor for treatment of asthma or chronic obstructive pulmonary disease
US20090297611A1 (en) * 2003-07-31 2009-12-03 Robinson Cynthia B Combination of dehydroepiandrosterone or dehydroepiandrosterone-sulfate with a tyrosine kinase inhibitor, delta opioid receptor antagonist, neurokinin receptor antagonist, or vcam inhibitor for treatment of asthma or chronic obstructive pulmonary disease
US20090317476A1 (en) * 2003-07-31 2009-12-24 Robinson Cynthia B Combination of dehydroepiandrosterone or dehydroepiandrosterone-sulfate with a leukotriene receptor antagonist for treatment of asthma or chronic obstructive pulmonary disease
US20050101545A1 (en) * 2003-07-31 2005-05-12 Robinson Cynthia B. Combination of dehydroepiandrosterone or dehydroepiandrosterone-sulfate with an anticholinergic bronchodilator for treatment of asthma or chronic obstructive pulmonary disease
US20050026881A1 (en) * 2003-07-31 2005-02-03 Robinson Cynthia B. Combination of dehydroepiandrosterone or dehydroepiandrosterone-sulfate with an anti-IgE antibody for treatment of asthma or chronic obstructive pulmonary disease
US20110209699A1 (en) * 2003-07-31 2011-09-01 Robinson Cynthia B Combination of dehydroepiandrosterone or dehydroepiandrosterone-sulfate with a lipoxygenase inhibitor for treatment of asthma or chronic obstructive pulmonary disease
US20090263381A1 (en) * 2003-07-31 2009-10-22 Robinson Cynthia B Combination of dehydroepiandrosterone or dehydroepiandrosterone-sulfate with an anti-ige antibody for treatment of asthma or chronic obstructive pulmonary disease
US20090285900A1 (en) * 2003-07-31 2009-11-19 Robinson Cynthia B Combination of dehydroepiandrosterone or dehydroepiandrosterone-sulfate with a beta-agonist bronchodilator for treatment of asthma or chronic obstructive pulmonary disease
US20050026879A1 (en) * 2003-07-31 2005-02-03 Robinson Cynthia B. Combination of dehydroepiandrosterone or dehydroepiandrosterone-sulfate with a tyrosine kinase inhibitor, delta opioid receptor antagonist, neurokinin receptor antagonist, or VCAM inhibitor for treatment of asthma or chronic obstructive pulmonary disease
US20050026884A1 (en) * 2003-07-31 2005-02-03 Robinson Cynthia B. Combination of dehydroepiandrosterone or dehydroepiandrosterone-sulfate with a beta-agonist bronchodilator for treatment of asthma or chronic obstructive pulmonary disease
US20050113318A1 (en) * 2003-07-31 2005-05-26 Robinson Cynthia B. Combination of dehydroepiandrosterone or dehydroepiandrosterone-sulfate with a beta-agonist bronchodilator for treatment of asthma or chronic obstructive pulmonary disease
US20050026882A1 (en) * 2003-07-31 2005-02-03 Robinson Cynthia B. Combination of dehydroepiandrosterone or dehydroepiandrosterone-sulfate with a leukotriene receptor antagonist for treatment of asthma or chronic obstructive pulmonary disease
US20050038004A1 (en) * 2003-07-31 2005-02-17 Robinson Cynthia B. Combination of dehydroepiandrosterone or dehydroepiandrosterone-sulfate with an anticholinergic bronchodilator for treatment of asthma or chronic obstructive pulmonary disease
FR2861077B1 (fr) * 2003-10-20 2006-03-03 Aventis Pharma Sa Formes cristallines du chlorydrate de 3-beta-amino, 17-methylene, androstane-6-alpha, 7-beta-diol
US20080051382A1 (en) * 2003-10-20 2008-02-28 Inflazyme Pharmaceuticals Ltd. Crystalline Forms of 3-Beta-Amino 17-Methylene Androstane-6-Alpha 7-Beta-Diol Hydrochloride
CA2542821A1 (fr) * 2003-10-20 2005-04-28 Inflazyme Pharmaceuticals, Ltd Formes cristallines du chlorhydrate de 3-beta-amino, 17-methylene, androstane-6-alpha, 7-beta-diol
US20050222049A1 (en) * 2004-03-31 2005-10-06 Robinson Cynthia B Combination of dehydroepiandrosterone or dehydroepiandrosterone-sulfate with a glucocorticosteroid for treatment of asthma, chronic obstructive pulmonary disease or allergic rhinitis
US20090317477A1 (en) * 2004-03-31 2009-12-24 Robinson Cynthia B Combination of dehydroepiandrosterone or dehydroepiandrosterone-sulfate with a glucocorticosteroid for treatment of asthma, chronic obstructive pulmonary disease or allergic rhinitis
US20050227927A1 (en) * 2004-03-31 2005-10-13 Robinson Cynthia B Combination of dehydroepiandrosterone or dehydroepiandrosterone-sulfate with a glucocorticosteroid for treatment of asthma, chronic obstructive pulmonary disease or allergic rhinitis
CN101868253A (zh) * 2007-11-21 2010-10-20 宝洁公司 可用于咳嗽治疗的制剂、方法和试剂盒
JP5655243B2 (ja) * 2009-10-19 2015-01-21 国立大学法人 熊本大学 インドキシル硫酸の産生の阻害剤のスクリーニング方法、インドキシル硫酸代謝産生阻害剤、及び腎障害軽減剤
US8334376B2 (en) 2010-01-15 2012-12-18 Xiangping Qian Certain chemical entities, compositions, and methods
SG10201913700SA (en) 2010-07-09 2020-03-30 Bioverativ Therapeutics Inc Factor ix polypeptides and methods of use thereof
EP3453714B1 (en) 2011-02-02 2020-11-04 Suzhou Neupharma Co., Ltd Cardenolide and bufadienolide 3-carbonate and 3-carbamate derivatives for the treatment of cancer and compositions thereof
WO2013165924A1 (en) * 2012-04-29 2013-11-07 Neupharma, Inc. Certain chemical entities, compositions, and methods
TW201427685A (zh) 2012-09-25 2014-07-16 Biogen Idec Inc Fix多肽的應用
CN108892637A (zh) 2013-03-14 2018-11-27 阿奎诺克斯药物(加拿大)公司 Ship1调节剂及与其相关的方法
AU2014228574B2 (en) 2013-03-14 2018-07-26 Aquinox Pharmaceuticals (Canada) Inc. SHIP1 modulators and methods related thereto
TWI828269B (zh) 2013-03-15 2024-01-01 美商百歐維拉提夫治療公司 因子ix多肽調配物
CN104744547B (zh) * 2013-12-27 2017-02-15 天津医科大学 一种抗乳腺癌转移作用的孕甾烷生物碱衍生物及医药用途
AU2016281658A1 (en) 2015-06-26 2017-12-07 Aquinox Pharmaceuticals (Canada) Inc. Crystalline solid forms of the acetate salt of (1s,3s,4r)-4-((3as,4r,5s,7as)-4-(aminomethyl)-7a-methyl-1-methyleneoctahydro-1h-inden-5-yl)-3-(hydroxymethyl)-4-methylcyclohexanol
US10053415B2 (en) 2016-01-20 2018-08-21 Aquinox Pharmaceuticals (Canada) Inc. Synthesis of a substituted indene derivative
AU2019247496A1 (en) 2018-04-06 2020-10-22 Taro Pharmaceuticals Inc. Indene derivatives useful in treating pain and inflammation
JP2021521269A (ja) * 2018-04-06 2021-08-26 アキノックス ファーマシューティカルス(カナダ)インク. 疼痛及び炎症の治療に有用なヘキサデカヒドロ−1H−シクロペンタ[a]フェナントレン誘導体
CN112543753A (zh) 2018-04-06 2021-03-23 塔罗制药公司 可用于治疗疼痛和炎症的茚衍生物

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US6046185A (en) 1996-07-11 2000-04-04 Inflazyme Pharmaceuticals Ltd. 6,7-oxygenated steroids and uses related thereto
US6060465A (en) 1997-02-06 2000-05-09 Miljkovic; Dusan Bile acids and their derivatives as glycoregulatory agents
BR9815711B1 (pt) 1998-03-06 2014-10-29 Univ Brigham Young Composto antibiótico derivado de esteróide
HUP0300908A2 (hu) * 2000-04-28 2003-07-28 Inflazyme Pharmaceuticals Limited 3-Nitrogén-6,7-dioxigén-szteroidok és alkalmazásuk és ezeket tartalmazó gyógyszerkészítmények

Also Published As

Publication number Publication date
JP2003531916A (ja) 2003-10-28
HRP20020944A2 (en) 2004-02-29
US20070060553A1 (en) 2007-03-15
EP1278763B1 (en) 2007-02-14
UA79229C2 (en) 2007-06-11
CA2418748A1 (en) 2001-11-08
AU5208401A (en) 2001-11-12
CN1430625A (zh) 2003-07-16
EE200200613A (et) 2004-04-15
NO324873B1 (no) 2007-12-17
WO2001083512A1 (en) 2001-11-08
NO20025106D0 (no) 2002-10-24
DE60126597D1 (de) 2007-03-29
MXPA02010645A (es) 2004-04-20
NO20025106L (no) 2002-12-18
ES2282247T3 (es) 2007-10-16
US20040034216A1 (en) 2004-02-19
DK1278763T3 (da) 2007-06-11
EP1278763A1 (en) 2003-01-29
PT1278763E (pt) 2007-05-31
AU2001252084B2 (en) 2006-07-06
PL365798A1 (en) 2005-01-10
NZ522181A (en) 2005-04-29
US7112580B2 (en) 2006-09-26
IL152448A (en) 2006-12-31
DZ3355A1 (fr) 2001-11-08
RU2291873C2 (ru) 2007-01-20
ZA200208631B (en) 2004-02-23
CN1214039C (zh) 2005-08-10
DE60126597T2 (de) 2007-10-31
CO5590904A2 (es) 2005-12-30
MA25808A1 (fr) 2003-07-01
SK15692002A3 (sk) 2003-11-04
YU88102A (sh) 2006-01-16
HK1050694A1 (en) 2003-07-04
BR0110419A (pt) 2004-02-25
AP2002002659A0 (en) 2002-12-31
US20050215534A9 (en) 2005-09-29
US20020072510A1 (en) 2002-06-13
KR20030045671A (ko) 2003-06-11
BG107289A (bg) 2003-07-31
ATE353909T1 (de) 2007-03-15
AP1825A (en) 2008-02-03
OA12255A (en) 2006-05-11
US20040138186A1 (en) 2004-07-15
US6635629B2 (en) 2003-10-21
HUP0300908A2 (hu) 2003-07-28

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