IL152344A0 - Use of bile acid derivatives conjugated with metal ion chelated complexes for the diagnostic assessment of microvascular permeability - Google Patents

Use of bile acid derivatives conjugated with metal ion chelated complexes for the diagnostic assessment of microvascular permeability

Info

Publication number
IL152344A0
IL152344A0 IL15234401A IL15234401A IL152344A0 IL 152344 A0 IL152344 A0 IL 152344A0 IL 15234401 A IL15234401 A IL 15234401A IL 15234401 A IL15234401 A IL 15234401A IL 152344 A0 IL152344 A0 IL 152344A0
Authority
IL
Israel
Prior art keywords
metal ion
acid derivatives
bile acid
microvascular permeability
diagnostic assessment
Prior art date
Application number
IL15234401A
Other languages
English (en)
Original Assignee
Bracco Imaging Spa
Univ California
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bracco Imaging Spa, Univ California filed Critical Bracco Imaging Spa
Publication of IL152344A0 publication Critical patent/IL152344A0/xx

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/10—Organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/085—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier conjugated systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/0497—Organic compounds conjugates with a carrier being an organic compounds

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Radiology & Medical Imaging (AREA)
  • Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Physics & Mathematics (AREA)
  • Optics & Photonics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Magnetic Resonance Imaging Apparatus (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Investigating Or Analyzing Non-Biological Materials By The Use Of Chemical Means (AREA)
  • Steroid Compounds (AREA)
IL15234401A 2000-04-21 2001-04-17 Use of bile acid derivatives conjugated with metal ion chelated complexes for the diagnostic assessment of microvascular permeability IL152344A0 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT2000MI000899A IT1318485B1 (it) 2000-04-21 2000-04-21 Uso di derivati di acidi biliari coniugati con complessi di ionimetallici nella visualizzazione diagnostica di sistemi microvascolari
PCT/EP2001/004324 WO2001082974A2 (fr) 2000-04-21 2001-04-17 Utilisation de derives d'acide biliaires associes a des complexes chelates d'ions metalliques aux fins du diagnostic de la permeabilite microvasculaire

Publications (1)

Publication Number Publication Date
IL152344A0 true IL152344A0 (en) 2003-05-29

Family

ID=11444911

Family Applications (2)

Application Number Title Priority Date Filing Date
IL15234401A IL152344A0 (en) 2000-04-21 2001-04-17 Use of bile acid derivatives conjugated with metal ion chelated complexes for the diagnostic assessment of microvascular permeability
IL152344A IL152344A (en) 2000-04-21 2002-10-17 Use of bile juice history attached to metal ion-binding assemblies for diagnostic testing of vascular frequencies

Family Applications After (1)

Application Number Title Priority Date Filing Date
IL152344A IL152344A (en) 2000-04-21 2002-10-17 Use of bile juice history attached to metal ion-binding assemblies for diagnostic testing of vascular frequencies

Country Status (12)

Country Link
US (2) US7128895B2 (fr)
EP (1) EP1274465B1 (fr)
JP (1) JP4786112B2 (fr)
KR (1) KR100847912B1 (fr)
AT (1) ATE271395T1 (fr)
AU (2) AU2001273946B2 (fr)
CA (1) CA2406629C (fr)
DE (1) DE60104409T2 (fr)
HU (1) HU228437B1 (fr)
IL (2) IL152344A0 (fr)
IT (1) IT1318485B1 (fr)
WO (1) WO2001082974A2 (fr)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1318485B1 (it) * 2000-04-21 2003-08-25 Bracco Spa Uso di derivati di acidi biliari coniugati con complessi di ionimetallici nella visualizzazione diagnostica di sistemi microvascolari
US7303741B2 (en) * 2002-09-23 2007-12-04 General Electric Company Systems and methods for high-resolution in vivo imaging of biochemical activity in a living organism
ES2316961T3 (es) * 2003-02-17 2009-04-16 Upperton Limited Conjugados para la formacion de imagenes medicas que comprenden portador, resto orientador y un agente de contraste.
CN102526103B (zh) * 2010-12-07 2013-11-13 西藏海思科药业集团股份有限公司 一种多种微量元素注射液药物组合物及其制备方法
CN104168923A (zh) * 2012-03-05 2014-11-26 伯拉考成像股份公司 用于评价病理性组织内大分子转运的动态增强mri成像法和活性剂
US10294265B1 (en) 2017-11-17 2019-05-21 International Business Machines Corporation Functionalized bile acids for therapeutic and material applications

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL91933A (en) * 1988-10-11 1994-12-29 Univ Southern California Their immuno-bracelet and isophiles which are beneficial in increasing vascular permeability or blood supply to tumor or otherwise damaged tissue
NO940115D0 (no) 1994-01-13 1994-01-13 Nycomed Imaging As Kontrastmidler for roentgen- og magnettomografisk avbildning
IT1269839B (it) 1994-05-26 1997-04-15 Bracco Spa Coniugati di acidi biliari, loro derivati con complessi metallici e relativi usi
IT1304501B1 (it) 1998-12-23 2001-03-19 Bracco Spa Uso di derivati di acidi biliari coniugati con complessi metallicicome "blood pool agents" per l'indagine diagnostica tramite risonanza
IT1317862B1 (it) 2000-02-29 2003-07-15 Bracco Spa Coniugati di acidi biliari con chelati complessi di ioni metallici eloro uso.
IT1318485B1 (it) * 2000-04-21 2003-08-25 Bracco Spa Uso di derivati di acidi biliari coniugati con complessi di ionimetallici nella visualizzazione diagnostica di sistemi microvascolari

Also Published As

Publication number Publication date
US20070059246A1 (en) 2007-03-15
ITMI20000899A0 (it) 2000-04-21
DE60104409T2 (de) 2005-08-11
ATE271395T1 (de) 2004-08-15
EP1274465A2 (fr) 2003-01-15
CA2406629C (fr) 2009-10-13
HUP0300601A2 (hu) 2003-06-28
DE60104409D1 (de) 2004-08-26
CA2406629A1 (fr) 2001-11-08
KR20020089494A (ko) 2002-11-29
JP4786112B2 (ja) 2011-10-05
US20030103904A1 (en) 2003-06-05
WO2001082974A2 (fr) 2001-11-08
IT1318485B1 (it) 2003-08-25
HUP0300601A3 (en) 2010-03-29
KR100847912B1 (ko) 2008-07-22
ITMI20000899A1 (it) 2001-10-21
AU7394601A (en) 2001-11-12
WO2001082974A3 (fr) 2002-01-17
IL152344A (en) 2007-10-31
US7128895B2 (en) 2006-10-31
EP1274465B1 (fr) 2004-07-21
HU228437B1 (en) 2013-03-28
AU2001273946B2 (en) 2004-11-04
JP2003531870A (ja) 2003-10-28

Similar Documents

Publication Publication Date Title
CA2371818A1 (fr) Complexes salicylamides lanthanides utilises comme marqueurs luminescents
TR199900293T2 (xx) Alzheimer hastal��� tedavisi i�in bir farmas�tik bile�im �retmek �zere �elat maddesi clioquil'un kullan�m�.
LV11430A (lv) 2-Piridilmetilenpoliazamakrociklofosfonskabes to kompleksi un atvasinajumi izmantosanai par kontrastvielam
CA2234282A1 (fr) Complexes medicament/resine stabilises par des chelateurs
IT1304501B1 (it) Uso di derivati di acidi biliari coniugati con complessi metallicicome "blood pool agents" per l'indagine diagnostica tramite risonanza
MXPA00009593A (es) Compuestos de eter aminociclohexilico y sus usos.
DE69514350D1 (de) Gallensäurekonjugate, ihre metallkomplexe und verwandte verwendungen
NZ516349A (en) Conjugates of phytosterol or phytostanol with ascorbic acid and use thereof in treating or preventing cardiovascular disease
MX9603570A (es) Metodo y composiciones para incrementar la vida media en suero de agentes farmacologicamente activos.
CA2325933A1 (fr) Derives d'acides gras d'acides biliaires et derives d'acide biliaire
WO2000045800A3 (fr) Effets immunosuppresseurs des derives de pteridine
AU4064401A (en) Bile acids conjugates with metal ion chelates and the use thereof
IL152344A0 (en) Use of bile acid derivatives conjugated with metal ion chelated complexes for the diagnostic assessment of microvascular permeability
AU2001287850A1 (en) Iron compositions
IL148971A0 (en) Carbon monoxide source for preparation of transition-metal-carbonyl-complexer
UA66856C2 (uk) Тієнопіримідини, спосіб їх одержання, фармацевтична композиція та спосіб її одержання
EP1706452A4 (fr) Complexes aromatiques de triamide-lanthanide
WO1996041627A3 (fr) Composes de fer, compositions et procedes de fabrication de ces composes et leurs utilisations
CA2337667A1 (fr) Conjugues dextrane-leptine, compositions pharmaceutiques et methodes connexes
FR2812200B1 (fr) Composition contenant une proteine complexant le fer et un precurseur du metabolisme du monoxyde d'azote et/ou un donneur chimique de monoxyde d'azote ; et utilisations
TWI262791B (en) 6-methoxy-2-naphthylacetic acid prodrugs
WO2002038566A3 (fr) Porphyrines de carbene et porphyrinoides de carbene, et procedes de preparation et d'utilisation desdits composes
PT1210350E (pt) Esteres de sdz-rad soluveis em agua
WO2003032728A3 (fr) Procedes visant a prevenir ou faire retroceder l'asthme et compositions utilisees a cet effet
AU6765300A (en) Transition metal complexes of n,n',n"-trialkyl- cis,cis-1,3,5-triaminocyclohexane and related compositions and methods of synthesis and use

Legal Events

Date Code Title Description
FF Patent granted
KB Patent renewed