IL152211A0 - Alpha, beta-unsaturated sulfones for treating proliferative disorders - Google Patents
Alpha, beta-unsaturated sulfones for treating proliferative disordersInfo
- Publication number
- IL152211A0 IL152211A0 IL15221101A IL15221101A IL152211A0 IL 152211 A0 IL152211 A0 IL 152211A0 IL 15221101 A IL15221101 A IL 15221101A IL 15221101 A IL15221101 A IL 15221101A IL 152211 A0 IL152211 A0 IL 152211A0
- Authority
- IL
- Israel
- Prior art keywords
- group
- formula
- independently selected
- naphthyl
- nitro
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D207/32—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D207/33—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D207/333—Radicals substituted by oxygen or sulfur atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C317/00—Sulfones; Sulfoxides
- C07C317/02—Sulfones; Sulfoxides having sulfone or sulfoxide groups bound to acyclic carbon atoms
- C07C317/10—Sulfones; Sulfoxides having sulfone or sulfoxide groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/28—Radicals substituted by singly-bound oxygen or sulphur atoms
- C07D213/32—Sulfur atoms
- C07D213/34—Sulfur atoms to which a second hetero atom is attached
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/36—Sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/04—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C07D307/10—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
- C07D333/14—Radicals substituted by singly bound hetero atoms other than halogen
- C07D333/18—Radicals substituted by singly bound hetero atoms other than halogen by sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D333/42—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms with nitro or nitroso radicals directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/46—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings substituted on the ring sulfur atom
- C07D333/48—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings substituted on the ring sulfur atom by oxygen atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Physical Education & Sports Medicine (AREA)
- Hematology (AREA)
- Neurosurgery (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Heart & Thoracic Surgery (AREA)
- Diabetes (AREA)
- Cardiology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Vascular Medicine (AREA)
- Dermatology (AREA)
- Urology & Nephrology (AREA)
- Oncology (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pyridine Compounds (AREA)
- Pyrrole Compounds (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Furan Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US19736800P | 2000-04-14 | 2000-04-14 | |
PCT/US2001/012133 WO2001078733A1 (fr) | 2000-04-14 | 2001-04-13 | Sulfones alpha, beta insatures traitant les affections a caractere proliferatif |
Publications (1)
Publication Number | Publication Date |
---|---|
IL152211A0 true IL152211A0 (en) | 2003-05-29 |
Family
ID=22729111
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IL15221101A IL152211A0 (en) | 2000-04-14 | 2001-04-13 | Alpha, beta-unsaturated sulfones for treating proliferative disorders |
IL152211A IL152211A (en) | 2000-04-14 | 2002-10-09 | Pharmaceutical composition containing unsaturated alpha-beta sulfones for the treatment of culture disorders and some such novel compounds |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IL152211A IL152211A (en) | 2000-04-14 | 2002-10-09 | Pharmaceutical composition containing unsaturated alpha-beta sulfones for the treatment of culture disorders and some such novel compounds |
Country Status (11)
Country | Link |
---|---|
US (2) | US6541475B2 (fr) |
EP (1) | EP1292308B1 (fr) |
JP (1) | JP4972266B2 (fr) |
KR (1) | KR100828449B1 (fr) |
AT (1) | ATE470444T1 (fr) |
AU (2) | AU2001251614B2 (fr) |
CA (1) | CA2405172C (fr) |
DE (1) | DE60142336D1 (fr) |
IL (2) | IL152211A0 (fr) |
NZ (1) | NZ522715A (fr) |
WO (1) | WO2001078733A1 (fr) |
Families Citing this family (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU2001296677A1 (en) * | 2000-10-05 | 2002-04-15 | Temple University - Of The Commonwealth System Of Higher Education | Substituted (e)-styryl benzylsulfones for treating proliferative disorders |
DE10136485C1 (de) * | 2001-07-27 | 2003-03-06 | Bayer Ag | Polyaminosäure-katalysiertes Verfahren zur enantioselektiven Epoxidierung von alpha,ß-ungesättigten Eonen und alpha,ß-ungesättigten Sulfonen |
IL163608A0 (en) * | 2002-02-28 | 2005-12-18 | Univ Temple | Amino-substituted sulfonanilides and derivatives thereof for treating proliferative disorders |
IL163607A0 (en) * | 2002-02-28 | 2005-12-18 | Univ Temple | Amino-substituted 2,6-dialkoxystyryl 4-substitutedbenzylsulfones for treating proliferative disorders |
KR20060109871A (ko) * | 2003-11-14 | 2006-10-23 | 템플 유니버시티-오브 더 커먼웰쓰 시스템 오브 하이어 에듀케이션 | 증식성 질병 치료용 알파, 베타-불포화 설폭시드 |
HUE030786T2 (en) | 2004-03-16 | 2017-06-28 | Temple Univ - Of The Commonwealth System Of Higher Education | Substituted phenoxy and phenylthio derivatives for the treatment of proliferative disorders |
JP2008501804A (ja) * | 2004-06-08 | 2008-01-24 | テンプル・ユニバーシティ−オブ・ザ・コモンウェルス・システム・オブ・ハイアー・エデュケイション | ヘテロアリール、スルホン及びスルホンアミド並びにそれらの治療用途 |
ATE529106T1 (de) | 2004-06-24 | 2011-11-15 | Univ Temple | Alpha-, beta-ungesättigte sulfone, sulfonoxide, sulfonimide, sulfinimide, acylsulfonamide und acylsulfinamide und therapeutische verwendungen damit |
ATE536101T1 (de) * | 2005-01-05 | 2011-12-15 | Univ Temple | Behandlung heilmittelresistenter proliferativer erkrankungen |
SI1896401T1 (sl) * | 2005-02-25 | 2013-07-31 | Temple University - Of The Commonwealth System Of Higher Education | Sinteza nenasičenih sulfidov, sulfonov, sulfoksidov in sulfonamidov |
CA2661983C (fr) * | 2006-08-30 | 2015-05-05 | Mount Sinai School Of Medicine Of New York University | Composition et procedes permettant de traiter le syndrome myelodysplasique et la leucemie aigue myeloide |
EP2065374A1 (fr) * | 2007-11-30 | 2009-06-03 | Bayer CropScience AG | Dérivés de 2-(benzyl- et 1H-pyrazol-4-ylmethyl)sulfinyl-thiazole en tant qu'herbicides et régulateurs de la croissance de plantes |
CN110776447A (zh) | 2012-09-20 | 2020-02-11 | 坦普尔大学 | 取代的烷基二芳基衍生物、制备方法和用途 |
JP6462582B2 (ja) | 2012-12-07 | 2019-01-30 | オンコノバ・セラピューティックス・インコーポレーテッド | がんの治療のための方法および組成物 |
WO2017023912A1 (fr) | 2015-08-03 | 2017-02-09 | Temple University - Of The Commonwealth System Of Higher Education | 2,4,6-trialcoxystyrylarylsulfones, sulfonamides et carboxamides, et procédés de préparation et d'utilisation |
Family Cites Families (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2532612A (en) | 1945-08-29 | 1950-12-05 | Union Oil Co | Preparation of unsaturated thio-ethers |
US3185743A (en) | 1960-08-24 | 1965-05-25 | Union Carbide Corp | Production of olefinic compounds from allyl sulfones |
US3418101A (en) | 1965-12-15 | 1968-12-24 | Pennsalt Chemicals Corp | Process for plant desiccation |
US3514386A (en) | 1967-12-11 | 1970-05-26 | Exxon Research Engineering Co | Stereoselective addition of thiols to acetylenic compounds |
US3917714A (en) | 1972-09-06 | 1975-11-04 | American Cyanamid Co | Bis(alkylsulfonyl)vinylbenzenes |
US4161407A (en) | 1977-10-06 | 1979-07-17 | Eastman Kodak Company | Crosslinkable polymers having vinylsulfonyl groups or styrylsulfonyl groups and their use as hardeners for gelatin |
US4386221A (en) | 1981-10-28 | 1983-05-31 | Eastman Kodak Company | Process for the preparation of aryl alkyl sulfones and aryl vinyl sulfones |
US4937388A (en) | 1985-08-09 | 1990-06-26 | Imperial Chemical Industries Plc | Insecticidal ethers |
US5659087A (en) | 1995-06-07 | 1997-08-19 | Eli Lilly And Company | Diarylvinyl sulfoxides |
US5710173A (en) * | 1995-06-07 | 1998-01-20 | Sugen, Inc. | Thienyl compounds for inhibition of cell proliferative disorders |
JP3660395B2 (ja) * | 1995-06-22 | 2005-06-15 | 大鵬薬品工業株式会社 | フェニルスルホン誘導体及びその製造方法 |
CA2305790C (fr) | 1997-10-03 | 2008-09-23 | Temple University - Of The Commonwealth System Of Higher Education | Agents anticancereux au styrylsulfone |
US6201154B1 (en) * | 1999-03-31 | 2001-03-13 | Temple University-Of The Commonwealth Of Higher Education | Z-styryl sulfone anticancer agents |
WO2000059494A1 (fr) * | 1999-04-02 | 2000-10-12 | Temple University- Of The Commonwealth System Of Higher Education | Agents anticancereux au styrylsulfone |
JP4596651B2 (ja) * | 1999-04-02 | 2010-12-08 | テンプル・ユニバーシティ−オブ・ザ・コモンウェルス・システム・オブ・ハイアー・エデュケイション | (e)−スチリルスルホン抗癌剤 |
JP4780885B2 (ja) * | 1999-10-12 | 2011-09-28 | テンプル・ユニバーシティ−オブ・ザ・コモンウェルス・システム・オブ・ハイアー・エデュケイション | 正常細胞を化学療法剤の細胞毒性から保護するための方法 |
-
2001
- 2001-04-12 US US09/833,834 patent/US6541475B2/en not_active Expired - Lifetime
- 2001-04-13 EP EP01925013A patent/EP1292308B1/fr not_active Expired - Lifetime
- 2001-04-13 KR KR1020027013800A patent/KR100828449B1/ko not_active IP Right Cessation
- 2001-04-13 IL IL15221101A patent/IL152211A0/xx active IP Right Grant
- 2001-04-13 AU AU2001251614A patent/AU2001251614B2/en not_active Ceased
- 2001-04-13 JP JP2001576033A patent/JP4972266B2/ja not_active Expired - Fee Related
- 2001-04-13 AU AU5161401A patent/AU5161401A/xx active Pending
- 2001-04-13 AT AT01925013T patent/ATE470444T1/de not_active IP Right Cessation
- 2001-04-13 DE DE60142336T patent/DE60142336D1/de not_active Expired - Lifetime
- 2001-04-13 WO PCT/US2001/012133 patent/WO2001078733A1/fr active IP Right Grant
- 2001-04-13 NZ NZ522715A patent/NZ522715A/en not_active IP Right Cessation
- 2001-04-13 CA CA002405172A patent/CA2405172C/fr not_active Expired - Fee Related
-
2002
- 2002-10-09 IL IL152211A patent/IL152211A/en not_active IP Right Cessation
- 2002-11-21 US US10/301,332 patent/US6599932B1/en not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
WO2001078733A1 (fr) | 2001-10-25 |
US20030130339A1 (en) | 2003-07-10 |
ATE470444T1 (de) | 2010-06-15 |
US6541475B2 (en) | 2003-04-01 |
AU2001251614B2 (en) | 2005-05-05 |
JP2003530439A (ja) | 2003-10-14 |
EP1292308A4 (fr) | 2005-09-14 |
KR100828449B1 (ko) | 2008-05-13 |
CA2405172C (fr) | 2009-08-25 |
KR20030011304A (ko) | 2003-02-07 |
JP4972266B2 (ja) | 2012-07-11 |
EP1292308B1 (fr) | 2010-06-09 |
NZ522715A (en) | 2003-09-26 |
AU2001251614C1 (en) | 2001-10-30 |
DE60142336D1 (de) | 2010-07-22 |
IL152211A (en) | 2008-08-07 |
CA2405172A1 (fr) | 2001-10-25 |
AU5161401A (en) | 2001-10-30 |
EP1292308A1 (fr) | 2003-03-19 |
US6599932B1 (en) | 2003-07-29 |
US20020028818A1 (en) | 2002-03-07 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
AU5161401A (en) | Alpha,beta-unsaturated sulfones for treating proliferative disorders | |
MXPA02005604A (es) | Aminobenzofenonas como inhibidores de il-1beta y tnf-alfa. | |
MY136855A (en) | Benzoylsulfonamides and sulfonylbenzamidines for use as antitumour agents | |
MY147780A (en) | Carboxamide compounds and their use as calpain inhibitors | |
MXPA04002423A (es) | Derivados de piperazina con actividad antagonista del receptor ccr1. | |
HK1048465A1 (en) | Aminobenzophenones as inhibitors of il-1B and tnf-a. | |
MXPA02000973A (es) | Benzofurilpiperazinas y benzofurilhomopiperazinas: agonistas de serotonina. | |
BG106020A (en) | Inhibitors of impdh enzyme | |
ATE355282T1 (de) | Biologisch aktive derivate des methylenblaus | |
GB0124933D0 (en) | Chemical compounds | |
HUP0303624A2 (hu) | NEP inhibitor hatású N-fenpropil-ciklopentil-csoporttal szubsztituált glutáramid származékok és ezeket tartalmazó gyógyászati készítmények és eljárás a vegyületek előállítására | |
YU87202A (sh) | Derivati arilmetilamina koji se koriste kao inhibitori triptaze | |
GB9925955D0 (en) | Hcv n33 protease inhibitors | |
AU1367497A (en) | Use of 3,4-diphenyl chromans for the manufacture of a pharmaceutical composition for the treatment or prophylaxis of prostatic carcinoma | |
HK1045990A1 (en) | Novel derivatives and analogues of galanthamin. | |
HUP0002763A2 (hu) | N-Triazolil-2-indolkarboxamid-származékok és CCK-A agonistaként történő alkalmazásuk | |
HK1048464B (zh) | 作為IL-1β和TNF-α的抑制劑的氨基二苯酮 | |
HK1115728A1 (en) | Substituted alkylaminopyridazinone derivatives, process for the preparation thereof and pharmaceutical composition containing the same | |
SI1651596T1 (sl) | Novi derivati ditiobis aminobutan sulfonatov in sestavki ki jih vsebujejo | |
GB0206200D0 (en) | Pharmaceutical compositions | |
YU82302A (sh) | Derivati 2-aminokarbonil-9h-purina | |
AU758194C (en) | Novel benzimidazoles and benzoxazoles | |
MX9705218A (es) | Uso de los 3,4-difenil-cromanos para la fabricacion de una composicion farmaceutica para el tratamiento o profilaxis de ginecomastia idiopatica o fisiologica. |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
FF | Patent granted | ||
KB | Patent renewed |