IL150374A0 - Compounds and methods for modulating cerebral amyloid angiopathy - Google Patents

Compounds and methods for modulating cerebral amyloid angiopathy

Info

Publication number
IL150374A0
IL150374A0 IL15037400A IL15037400A IL150374A0 IL 150374 A0 IL150374 A0 IL 150374A0 IL 15037400 A IL15037400 A IL 15037400A IL 15037400 A IL15037400 A IL 15037400A IL 150374 A0 IL150374 A0 IL 150374A0
Authority
IL
Israel
Prior art keywords
compounds
methods
amyloid angiopathy
cerebral amyloid
modulating
Prior art date
Application number
IL15037400A
Other languages
English (en)
Original Assignee
Neurochem Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Neurochem Inc filed Critical Neurochem Inc
Publication of IL150374A0 publication Critical patent/IL150374A0/xx

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/66Phosphorus compounds
    • A61K31/662Phosphorus acids or esters thereof having P—C bonds, e.g. foscarnet, trichlorfon
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/185Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/14Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Vascular Medicine (AREA)
  • Biomedical Technology (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Diabetes (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
IL15037400A 1999-12-23 2000-12-22 Compounds and methods for modulating cerebral amyloid angiopathy IL150374A0 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US17187799P 1999-12-23 1999-12-23
PCT/IB2000/002078 WO2001085093A2 (fr) 1999-12-23 2000-12-22 Composes et methodes permettant la modulation de l'angiopathie cerebrale amyloide

Publications (1)

Publication Number Publication Date
IL150374A0 true IL150374A0 (en) 2002-12-01

Family

ID=22625484

Family Applications (1)

Application Number Title Priority Date Filing Date
IL15037400A IL150374A0 (en) 1999-12-23 2000-12-22 Compounds and methods for modulating cerebral amyloid angiopathy

Country Status (11)

Country Link
US (2) US6670399B2 (fr)
EP (1) EP1251837A2 (fr)
JP (1) JP2003532656A (fr)
KR (3) KR20080003945A (fr)
CN (1) CN1434706A (fr)
AU (1) AU8431301A (fr)
BR (1) BR0016652A (fr)
CA (1) CA2395314A1 (fr)
IL (1) IL150374A0 (fr)
MX (1) MXPA02006196A (fr)
WO (1) WO2001085093A2 (fr)

Families Citing this family (67)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040208875A1 (en) * 1995-03-15 2004-10-21 Queen's University At Kingston Method for treating amyloidosis
EP0866805A1 (fr) 1995-12-12 1998-09-30 Karolinska Innovations AB PEPTIDE FIXANT LA SEQUENCE KLVFF DE L'AMYLOIDE $g(b)
US20020022657A1 (en) * 1998-02-11 2002-02-21 Francine Gervais Methods for modulating neuronal cell death
US6310073B1 (en) * 1998-07-28 2001-10-30 Queen's University At Kingston Methods and compositions to treat glycosaminoglycan-associated molecular interactions
US7060670B1 (en) * 1999-05-05 2006-06-13 Neurochem (International) Limited Stereoselective antifibrillogenic peptides and peptidomimetics thereof
CA2375628A1 (fr) * 1999-07-09 2001-01-18 Isis Innovation Limited Composes destines a l'inhibition de maladies et a la preparation de cellules a transplanter
US20020094335A1 (en) * 1999-11-29 2002-07-18 Robert Chalifour Vaccine for the prevention and treatment of alzheimer's and amyloid related diseases
US20070135337A2 (en) * 1999-11-29 2007-06-14 Neurochem (International) Limited Vaccine for the Prevention and Treatment of Alzheimer's and Amyloid Related Diseases
CN1434706A (zh) * 1999-12-23 2003-08-06 神经化学公司 用于调节脑淀粉状蛋白性血管病的化合物和方法
US7311893B2 (en) * 2000-07-25 2007-12-25 Neurochem (International) Limited Amyloid targeting imaging agents and uses thereof
CA2477449A1 (fr) * 2002-03-01 2003-09-12 Merck & Co., Inc. Aminoalkylphosphonates et composes associes utilises en tant qu'agonistes du recepteur edg
MXPA05006940A (es) * 2002-12-24 2006-02-22 Neurochem Int Ltd Formulaciones terapeuticas para el tratamiento de enfermedades relacionadas con beta - amiloide.
DE10303974A1 (de) 2003-01-31 2004-08-05 Abbott Gmbh & Co. Kg Amyloid-β(1-42)-Oligomere, Verfahren zu deren Herstellung und deren Verwendung
EP1477493A1 (fr) * 2003-05-15 2004-11-17 Bayer HealthCare AG Marqueurs d'affinité codés par des isotopes
US20070010573A1 (en) * 2003-06-23 2007-01-11 Xianqi Kong Methods and compositions for treating amyloid-related diseases
AU2011250847B2 (en) * 2003-06-23 2013-06-20 Bhi Limited Partnership Methods and compositions for treating amyloid-related diseases
US20060079578A1 (en) * 2003-06-23 2006-04-13 Julie Laurin Pharmaceutical formulations of amyloid inhibiting compounds
US20050142191A1 (en) * 2003-06-23 2005-06-30 Neurochem (International) Limited Pharmaceutical formulations of amyloid inhibiting compounds
US7414076B2 (en) * 2003-06-23 2008-08-19 Neurochem (International) Limited Methods and compositions for treating amyloid-related diseases
NZ544684A (en) * 2003-06-23 2009-10-30 Bellus Health Int Ltd Methods and compositions for treating amyloid-related diseases
US7244764B2 (en) * 2003-06-23 2007-07-17 Neurochem (International) Limited Methods and compositions for treating amyloid-related diseases
CA2529269C (fr) * 2003-06-23 2012-02-07 Neurochem (International) Limited Candidats-medicaments pharmaceutiques ameliores et leurs procedes de preparation
US7262223B2 (en) 2004-01-23 2007-08-28 Neurochem (International) Limited Amidine derivatives for treating amyloidosis
EP1841460A2 (fr) * 2004-06-18 2007-10-10 Neurochem (International) Limited Formulations therapeutiques pour le traitement de maladies associees au beta-amyloide
MX2007000253A (es) 2004-07-09 2007-04-09 Sigma Aldrich Co Liquidos ionicos quirales mejorados opticamente.
US8182581B2 (en) 2004-07-23 2012-05-22 Sigma-Aldrich Co. Llc High stability diionic liquid salts
US8168830B2 (en) 2004-07-23 2012-05-01 Sigma-Aldrich Co. Llc High stability diionic liquid salts
WO2006017752A2 (fr) * 2004-08-05 2006-02-16 Ivax Corporation Oligosaccharides sulfates
EP1817305A2 (fr) * 2004-11-16 2007-08-15 Neurochem (International) Limited Composes pour le traitement de maladies associees au snc et a la proteine amyloide
JP4855268B2 (ja) * 2004-11-30 2012-01-18 アンジェスMg株式会社 アルツハイマー治療剤
US8044100B2 (en) * 2004-12-22 2011-10-25 Bellus Health Inc. Methods and compositions for treating amyloid-related diseases
KR20070120190A (ko) * 2005-04-12 2007-12-21 뉴로켐 (인터내셔널) 리미티드 아밀로이드 억제 화합물의 제약 제제
TW200716088A (en) * 2005-04-15 2007-05-01 Neurochem Int Ltd Formulations and methods for treating amyloidosis
WO2007023389A2 (fr) * 2005-07-21 2007-03-01 Neurochem (International) Limited Formes polymorphes de l'acide 3-amino-1-propanesulfonique
US8497072B2 (en) 2005-11-30 2013-07-30 Abbott Laboratories Amyloid-beta globulomer antibodies
PL1954718T3 (pl) 2005-11-30 2015-04-30 Abbvie Inc Przeciwciała skierowane przeciwko A globulomerowi, ich reszty wiążące antygeny, odpowiednie hybrydomy, kwasy nukleinowe, wektory, komórki gospodarze, sposoby wytwarzania tych przeciwciał, kompozycje zawierające te przeciwciała, zastosowania tych przeciwciał i sposoby stosowania tych przeciwciał
US8372886B2 (en) * 2005-12-22 2013-02-12 Kiacta Sarl Treatment of renal disorders, diabetic nephropathy and dyslipidemias
KR101742179B1 (ko) 2006-10-12 2017-05-31 비에이치아이 리미티드 파트너쉽 3-아미노-1-프로판설폰산을 전달하기 위한 방법, 화합물, 조성물 및 비히클
US8188046B2 (en) * 2006-10-16 2012-05-29 University Of South Florida Amyloid beta peptides and methods of use
US8455626B2 (en) 2006-11-30 2013-06-04 Abbott Laboratories Aβ conformer selective anti-aβ globulomer monoclonal antibodies
JP2010513219A (ja) * 2006-12-22 2010-04-30 ベラス ヘルス (インターナショナル) リミテッド 腎臓の疾患、糖尿病性腎症及び脂質代謝異常の治療
EP3124490A1 (fr) 2007-01-31 2017-02-01 Sigma-Aldrich Co. LLC Sels polyioniques liquides à haute stabilité
EP2486928A1 (fr) 2007-02-27 2012-08-15 Abbott GmbH & Co. KG Procédé pour le traitement des amyloses
WO2008106657A2 (fr) * 2007-03-01 2008-09-04 Intezyne Technologies, Inc. Peptides bêta-amyloïde encapsulés
GB0708507D0 (en) * 2007-05-02 2007-06-13 Queen Mary & Westfield College Substituted phosphonates and their use
US8613923B2 (en) 2007-06-12 2013-12-24 Ac Immune S.A. Monoclonal antibody
US8048420B2 (en) 2007-06-12 2011-11-01 Ac Immune S.A. Monoclonal antibody
EP2183258A2 (fr) * 2007-08-01 2010-05-12 Centre National de la Recherche Scientifique (CNRS) Dérivés de l'acide thiophosphi(o)nique et leurs applications thérapeutiques
US20090076167A1 (en) * 2007-09-17 2009-03-19 Protia, Llc Deuterium-enriched tramiprosate
US9403902B2 (en) 2007-10-05 2016-08-02 Ac Immune S.A. Methods of treating ocular disease associated with amyloid-beta-related pathology using an anti-amyloid-beta antibody
US8231895B2 (en) 2008-05-22 2012-07-31 Universidade De Coimbra Targeted delivery to human diseases and disorders
EP2180003A1 (fr) * 2008-10-21 2010-04-28 Zentiva, k.s. Préparation de l'ibandronate de trisodium
US9023767B2 (en) * 2009-05-07 2015-05-05 Memorial Sloan-Kettering Cancer Center γ-Secretase substrates and methods of use
CN102471248B (zh) * 2009-08-10 2015-01-07 Bhi有限合伙公司 用于递送1,3-丙二磺酸的方法、化合物和组合物
EP2289900A1 (fr) * 2009-08-26 2011-03-02 Humboldt Universität zu Berlin Bisphosphonates en tant qu'inhibiteurs d'acide sphingomyélinase
US8987419B2 (en) 2010-04-15 2015-03-24 AbbVie Deutschland GmbH & Co. KG Amyloid-beta binding proteins
BR112013002297A2 (pt) 2010-07-30 2016-05-24 Ac Immune Sa anticorpos humanizados seguros e funcionais
WO2012024187A1 (fr) 2010-08-14 2012-02-23 Abbott Laboratories Protéines de liaison bêta-amyloïdes
WO2012033831A2 (fr) 2010-09-07 2012-03-15 Memorial Sloan-Kettering Cancer Center Procédés et compositions pour un dosage de gamma-secrétase
US9599626B2 (en) * 2011-12-01 2017-03-21 Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College Therapeutic and diagnostic method for ataxia-telangiectasia
US10962553B2 (en) 2011-12-01 2021-03-30 Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College Compositions and methods for detecting proteinopathies
WO2013158846A1 (fr) * 2012-04-20 2013-10-24 Baylor College Of Medicine Nouveaux inhibiteurs de dxr pour une thérapie antimicrobienne
CN102793694B (zh) * 2012-08-14 2014-06-04 武汉华纳联合药业有限公司 3-氨基-1-丙烷磺酸及其衍生物在制备治疗脑卒中的药物中的应用
JP5804463B2 (ja) * 2012-12-27 2015-11-04 国立研究開発法人科学技術振興機構 環状ペプチド及びこれを含有する医薬
CN114805211A (zh) 2017-03-21 2022-07-29 润佳(苏州)医药科技有限公司 同位素富集3-氨基-1-丙磺酸衍生物、药物组合物及其用途
WO2018193999A1 (fr) * 2017-04-17 2018-10-25 国立大学法人京都大学 Acide 2-amino-phosphonoalcane optiquement actif, sel d'acide 2-amino-phosphonoalcane optiquement actif, et hydrates de ceux-ci
RU2696684C1 (ru) * 2018-09-18 2019-08-05 Федеральное государственное бюджетное научное учреждение "Научный центр неврологии" (ФГБНУ НЦН) Способ определения типов когнитивных расстройств у больных церебральной микроангиопатией

Family Cites Families (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1140049A (fr) 1977-12-22 1983-01-25 Dke J.E. Helgstran Substances pharmaceutiques obtenues a partir de derives d'acide hydroxycarbonylphosphonique
US5087618A (en) 1982-05-18 1992-02-11 University Of Florida Redox carriers for brain-specific drug delivery
US4540564A (en) 1982-05-18 1985-09-10 University Of Florida Brain-specific drug delivery
WO1995013796A1 (fr) 1993-11-16 1995-05-26 Depotech Corporation Vesicules a taux controle de liberation des principes actifs
US5166320A (en) 1987-04-22 1992-11-24 University Of Connecticut Carrier system and method for the introduction of genes into mammalian cells
US4883666A (en) 1987-04-29 1989-11-28 Massachusetts Institute Of Technology Controlled drug delivery system for treatment of neural disorders
US5194654A (en) 1989-11-22 1993-03-16 Vical, Inc. Lipid derivatives of phosphonoacids for liposomal incorporation and method of use
US5463092A (en) 1989-11-22 1995-10-31 Vestar, Inc. Lipid derivatives of phosphonacids for liposomal incorporation and method of use
US5643562A (en) 1993-03-29 1997-07-01 Queen's University Of Kingston Method for treating amyloidosis
US5972328A (en) 1993-03-29 1999-10-26 Queen's University At Kingston Method for treating amyloidosis
CA2159326C (fr) 1993-03-29 2000-05-30 Robert Kisilevsky Methode pour le traitement de l'amyloidose
US5840294A (en) 1993-03-29 1998-11-24 Queen's University At Kingston Method for treating amyloidosis
CA2161225C (fr) 1993-04-22 2003-07-01 Sinil Kim Cyclodextrine encapsulee liberant des composes pharmacologiques a partir de liposomes; methode d'utilisation
US5455044A (en) 1993-05-14 1995-10-03 Depotech Corporation Method for treating neurological disorders
WO1994027602A1 (fr) 1993-06-01 1994-12-08 Cortex Pharmaceuticals, Inc. Utilisation d'agonistes des recepteurs metabotropiques pour le traitement de neurodegenerescences evolutives
EP0740548B1 (fr) * 1994-02-28 2002-12-04 Nanopharm AG Systeme de ciblage d'un medicament, procede de preparation et utilisation de ce medicament
US6168776B1 (en) * 1994-07-19 2001-01-02 University Of Pittsburgh Alkyl, alkenyl and alkynyl Chrysamine G derivatives for the antemortem diagnosis of Alzheimer's disease and in vivo imaging and prevention of amyloid deposition
US5514653A (en) 1994-09-09 1996-05-07 Washington University Method of blocking the SEC receptor
DE4434654C2 (de) 1994-09-28 1996-10-10 Arburg Gmbh & Co Verfahren zur Beeinflussung zyklisch ablaufender Prozesse
US5817626A (en) * 1995-03-14 1998-10-06 Praecis Pharmaceuticals Incorporated Modulators of beta-amyloid peptide aggregation
US5948763A (en) 1995-06-07 1999-09-07 New York University Peptides and pharmaceutical compositions thereof for treatment of disorders or diseases associated with abnormal protein folding into amyloid or amyloid-like deposits
US5931809A (en) 1995-07-14 1999-08-03 Depotech Corporation Epidural administration of therapeutic compounds with sustained rate of release
JP2001508408A (ja) 1996-11-22 2001-06-26 エラン・ファーマシューティカルズ・インコーポレイテッド N―(アリール/ヘテロアリール)アミノ酸エステル、医薬組成物およびベータ―アミロイドペプチドの放出および/またはその合成を阻害する方法
TR199901128T2 (xx) 1996-11-22 1999-07-21 Elan Pharmaceuticals, Inc. N-(aril/heteroarilasetil) amino asit esterler, bunu ihtiva eden farmas�tik bile�imler ve bu t�r bile�ikler kullanarak �-amiloit peptit sal�n�m�n� ve/veya bunun sentezlenmesini inhibe etme y�ntemleri.
AR009655A1 (es) * 1996-12-10 2000-04-26 Novartis Ag Una composicion parenteralmente inyectable, un metodo para su preparacion, metodos para el tratamiento de enfermedades, una modificacion decristal de 1-decansulfonato de desferrioxamina, su uso, un proceso para la produccion de dicha modificacion de cristal y una preparacion farmaceutica que
AU5727798A (en) * 1996-12-23 1998-07-17 Texas A & M University, The Anti-amyloidogenic agents
US5869469A (en) 1997-08-18 1999-02-09 Queen's University At Kingston Phosphonocarboxylate compounds for treating amyloidosis
NZ550116A (en) 1997-08-18 2008-03-28 Neurochem Int Ltd Phosphono-carboxylate compounds for treating amyloidosis
US6037327A (en) * 1997-08-28 2000-03-14 University Of Washington Specific saccharide compositions and methods for treating Alzheimer's disease and other amyloidoses
MXPA00007815A (es) 1998-02-11 2002-04-24 Neurochem Inc Metodo para modular la activacion de macrofagos.
AU3726299A (en) * 1998-05-15 1999-12-06 Neurochem, Inc. Use of amyloid inhibitors for modulating neuronal cell death
DK1083889T3 (da) * 1998-06-01 2004-04-13 Ortho Mcneil Pharm Inc Tetrahydronaphthalenforbindelser og deres anvendelse til behandling af neurodegenerative sygdomme
US6586475B1 (en) 1998-11-20 2003-07-01 Takeda Chemical Industries, Ltd. β-amyloid protein production/secretion inhibitors
JP2003503312A (ja) 1999-05-05 2003-01-28 ニューロシェム インコーポレイテッド 立体選択的抗原線維形成ペプチドおよびそのペプチド模倣体
CN1434706A (zh) * 1999-12-23 2003-08-06 神经化学公司 用于调节脑淀粉状蛋白性血管病的化合物和方法

Also Published As

Publication number Publication date
JP2003532656A (ja) 2003-11-05
CA2395314A1 (fr) 2001-11-15
WO2001085093A9 (fr) 2002-09-26
CN1434706A (zh) 2003-08-06
US20030003141A1 (en) 2003-01-02
EP1251837A2 (fr) 2002-10-30
US6670399B2 (en) 2003-12-30
WO2001085093A3 (fr) 2002-08-29
KR20080003945A (ko) 2008-01-08
BR0016652A (pt) 2002-11-19
WO2001085093A2 (fr) 2001-11-15
AU8431301A (en) 2001-11-20
US20080317834A1 (en) 2008-12-25
KR20090016517A (ko) 2009-02-13
KR20020063266A (ko) 2002-08-01
MXPA02006196A (es) 2002-12-09

Similar Documents

Publication Publication Date Title
IL150374A0 (en) Compounds and methods for modulating cerebral amyloid angiopathy
EP1223932A4 (fr) Composes et methodes
GB0118297D0 (en) Synthetic closure
EP1146790A4 (fr) Composes et procedes
GB2333256B (en) Disk locking device
AU142485S (en) Closure
EP1102535A4 (fr) Composes et procedes
HK1037590A1 (en) An indirectly activated closure
PL350298A1 (en) Tamper evident closure
AU2001289123A1 (en) Compounds and methods for diagnosing and treating amyloid-related conditions
GB9915273D0 (en) Closure
HUP0201647A3 (en) Screening methods for compounds that affect melanogenesis
GB9919964D0 (en) Closure elements
GB2350989B (en) Background-noise reduction
GB2352714B (en) Tamper evident closure
AU142192S (en) Closure
GB2351755B (en) Safety gate
GB2342139B (en) Closure
GB9904001D0 (en) Radiotelephone buzzer
GB9909260D0 (en) Closure device
CA85715S (en) Flip-cap closure
GB9917366D0 (en) Easy fit closure
GB9923117D0 (en) Insect-paper and methods for its formation and use
IL133804A0 (en) Closure for shutter
GB9919349D0 (en) Closure