IL150083A0 - Trans olefinic glucokinase activators - Google Patents

Trans olefinic glucokinase activators

Info

Publication number
IL150083A0
IL150083A0 IL15008300A IL15008300A IL150083A0 IL 150083 A0 IL150083 A0 IL 150083A0 IL 15008300 A IL15008300 A IL 15008300A IL 15008300 A IL15008300 A IL 15008300A IL 150083 A0 IL150083 A0 IL 150083A0
Authority
IL
Israel
Prior art keywords
glucokinase activators
trans olefinic
olefinic
trans
glucokinase
Prior art date
Application number
IL15008300A
Other languages
English (en)
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of IL150083A0 publication Critical patent/IL150083A0/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C275/46—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups containing any of the groups, X being a hetero atom, Y being any atom, e.g. acylureas
    • C07C275/48—Y being a hydrogen or a carbon atom
    • C07C275/50—Y being a hydrogen or an acyclic carbon atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/75—Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C317/00—Sulfones; Sulfoxides
    • C07C317/44—Sulfones; Sulfoxides having sulfone or sulfoxide groups and carboxyl groups bound to the same carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/38—Nitrogen atoms
    • C07D277/44—Acylated amino or imino radicals
    • C07D277/46—Acylated amino or imino radicals by carboxylic acids, or sulfur or nitrogen analogues thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
    • C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Diabetes (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Detergent Compositions (AREA)
IL15008300A 1999-12-15 2000-12-12 Trans olefinic glucokinase activators IL150083A0 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US17078399P 1999-12-15 1999-12-15
PCT/EP2000/012612 WO2001044216A1 (fr) 1999-12-15 2000-12-12 Activateurs transolefiniques de glucokinase

Publications (1)

Publication Number Publication Date
IL150083A0 true IL150083A0 (en) 2002-12-01

Family

ID=22621235

Family Applications (2)

Application Number Title Priority Date Filing Date
IL15008300A IL150083A0 (en) 1999-12-15 2000-12-12 Trans olefinic glucokinase activators
IL150083A IL150083A (en) 1999-12-15 2002-06-06 Trans-olefin compounds and a process for their preparation

Family Applications After (1)

Application Number Title Priority Date Filing Date
IL150083A IL150083A (en) 1999-12-15 2002-06-06 Trans-olefin compounds and a process for their preparation

Country Status (33)

Country Link
US (1) US6353111B1 (fr)
EP (1) EP1242397B1 (fr)
JP (1) JP3824936B2 (fr)
KR (1) KR100502032B1 (fr)
CN (1) CN1185219C (fr)
AR (1) AR032752A1 (fr)
AT (1) ATE305461T1 (fr)
AU (1) AU781029B2 (fr)
CA (1) CA2392903C (fr)
CO (1) CO5050295A1 (fr)
CZ (1) CZ20022412A3 (fr)
DE (1) DE60022903T2 (fr)
DK (1) DK1242397T3 (fr)
ES (1) ES2249322T3 (fr)
GC (1) GC0000264A (fr)
HK (1) HK1054383B (fr)
HR (1) HRP20020514A2 (fr)
HU (1) HUP0203753A3 (fr)
IL (2) IL150083A0 (fr)
JO (1) JO2180B1 (fr)
MA (1) MA26855A1 (fr)
MX (1) MXPA02005874A (fr)
MY (1) MY125484A (fr)
NO (1) NO323142B1 (fr)
NZ (1) NZ518974A (fr)
PE (1) PE20011022A1 (fr)
PL (1) PL355815A1 (fr)
RU (1) RU2245332C2 (fr)
TW (1) TWI262916B (fr)
UY (1) UY26483A1 (fr)
WO (1) WO2001044216A1 (fr)
YU (1) YU41402A (fr)
ZA (1) ZA200203829B (fr)

Families Citing this family (64)

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SE0102299D0 (sv) 2001-06-26 2001-06-26 Astrazeneca Ab Compounds
SE0102300D0 (sv) * 2001-06-26 2001-06-26 Astrazeneca Ab Compounds
SE0102764D0 (sv) * 2001-08-17 2001-08-17 Astrazeneca Ab Compounds
WO2003055482A1 (fr) 2001-12-21 2003-07-10 Novo Nordisk A/S Derives amide utiles en tant qu'activateurs de la glucokinase
WO2003068242A1 (fr) 2002-02-11 2003-08-21 Vertex Pharmaceuticals Incorporated Phospholipides tels que des promedicaments inhibiteurs de caspases
DE60328671D1 (de) * 2002-03-26 2009-09-17 Banyu Pharma Co Ltd Neue aminobenzamidderivate
RU2340605C2 (ru) 2002-06-27 2008-12-10 Ново Нордиск А/С Арилкарбонильные производные в качестве терапевтических средств
CA2744893A1 (fr) 2002-06-27 2004-01-08 Novo Nordisk A/S Derives d'arylcarbonyle servant d'activateurs de glucokinase
AU2003302279B2 (en) * 2002-10-03 2008-06-12 Novartis Ag Substituted (thiazol-2-yl) -amide or sulfonamide as glycokinase activators useful in the treatment of Type 2 diabetes
GB0226930D0 (en) * 2002-11-19 2002-12-24 Astrazeneca Ab Chemical compounds
GB0226931D0 (en) 2002-11-19 2002-12-24 Astrazeneca Ab Chemical compounds
MY141521A (en) 2002-12-12 2010-05-14 Hoffmann La Roche 5-substituted-six-membered heteroaromatic glucokinase activators
WO2004063194A1 (fr) * 2003-01-06 2004-07-29 Eli Lilly And Company Composes heteroaryle
WO2004072066A1 (fr) * 2003-02-11 2004-08-26 Prosidion Limited Composes d'amide a substitution tri(cyclo), activateurs de la glucokinase
PL378117A1 (pl) * 2003-02-11 2006-03-06 Prosidion Limited Tricyklopodstawione związki amidowe
MXPA06007667A (es) 2004-01-06 2006-09-01 Novo Nordisk As Heteroaril-ureas y su uso como activadores de glucocinasa.
US20080280872A1 (en) 2004-02-18 2008-11-13 Craig Johnstone Benzamide Derivatives and Their Use as Glucokinase Activating Agents
CN1960995B (zh) * 2004-04-02 2010-12-08 诺瓦提斯公司 作为葡糖激酶活化剂、可用于治疗ⅱ型糖尿病的磺酰胺-噻唑并吡啶衍生物
RU2006138426A (ru) * 2004-04-02 2008-05-10 Новартис АГ (CH) Производные тиазолопиридина, содержащие их фармацевтические композиции и способы лечения состояний, опосредованных глюкокиназой
AU2005235798A1 (en) * 2004-04-21 2005-11-03 Prosidion Limited Tri(cyclo) substituted amide compounds
TW200600086A (en) 2004-06-05 2006-01-01 Astrazeneca Ab Chemical compound
EP1758611A2 (fr) * 2004-06-17 2007-03-07 Novo Nordisk A/S Utilisation d'activateurs de glucokinase selectifs du foie
KR20080105180A (ko) * 2004-08-12 2008-12-03 프로시디온 리미티드 치환된 페닐아세트아미드 및 글루코키나제 활성화제로서의 그의 용도
WO2007006760A1 (fr) 2005-07-08 2007-01-18 Novo Nordisk A/S Activateurs de dicycloalkylurée glucokinase
JP4651714B2 (ja) 2005-07-09 2011-03-16 アストラゼネカ アクチボラグ 糖尿病の治療においてｇｌｋ活性化剤として使用するためのヘテロアリールベンズアミド誘導体
WO2007015805A1 (fr) 2005-07-20 2007-02-08 Eli Lilly And Company Composés joints en position 1-amino
JP2007063225A (ja) * 2005-09-01 2007-03-15 Takeda Chem Ind Ltd イミダゾピリジン化合物
CA2624102A1 (fr) 2005-09-29 2007-04-12 Sanofi-Aventis Derives de phenyl-1,2,4-oxadiazolone : procedes de preparation et utilisation comme produits pharmaceutiques
GT200600429A (es) * 2005-09-30 2007-04-30 Compuestos organicos
GT200600428A (es) * 2005-09-30 2007-05-21 Compuestos organicos
JP2009514835A (ja) * 2005-11-03 2009-04-09 プロシディオン・リミテッド トリシクロ置換型アミド
AU2006342449B2 (en) 2005-11-17 2012-03-01 Eli Lilly And Company Glucagon receptor antagonists, preparation and therapeutic uses
JP2009515997A (ja) * 2005-11-18 2009-04-16 タケダ サン ディエゴ インコーポレイテッド グルコキナーゼ活性剤
WO2007104034A2 (fr) 2006-03-08 2007-09-13 Takeda San Diego, Inc. Activateurs de la glucokinase
PE20110235A1 (es) 2006-05-04 2011-04-14 Boehringer Ingelheim Int Combinaciones farmaceuticas que comprenden linagliptina y metmorfina
ATE522518T1 (de) * 2006-05-31 2011-09-15 Takeda San Diego Inc Indazol- und isoindolderivate als glucokinaseaktivierende stoffe
DK2054049T3 (en) 2006-08-24 2016-08-01 Univ Tennessee Res Found SUBSTITUTED ACYLANILIDES AND PROCEDURES FOR USING THEREOF
TW200825060A (en) 2006-10-26 2008-06-16 Astrazeneca Ab Chemical compounds
US7902248B2 (en) * 2006-12-14 2011-03-08 Hoffmann-La Roche Inc. Oxime glucokinase activators
EP2091947A2 (fr) 2006-12-20 2009-08-26 Takeda San Diego, Inc. Activateurs de glucokinase
TW200831081A (en) 2006-12-25 2008-08-01 Kyorin Seiyaku Kk Glucokinase activator
US8940900B2 (en) 2007-02-28 2015-01-27 Advinus Therapeutics Private Limited 2,2,2-tri-substituted acetamide derivatives as glucokinase activators, their process and pharmaceutical application
US8034819B2 (en) * 2007-03-07 2011-10-11 Kyorin Pharmaceutical Co., Ltd. Glucokinase activator
US8173645B2 (en) * 2007-03-21 2012-05-08 Takeda San Diego, Inc. Glucokinase activators
ATE513830T1 (de) * 2007-09-21 2011-07-15 Sanofi Aventis Phenothiazin-derivate mit doppelbindung, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
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CN101918363B (zh) 2008-01-18 2012-09-05 安斯泰来制药株式会社 苯乙酰胺衍生物
PL2275414T3 (pl) * 2008-04-28 2016-01-29 Kyorin Seiyaku Kk Pochodne cyklopentyloakryloamidu
WO2009140624A2 (fr) 2008-05-16 2009-11-19 Takeda San Diego, Inc. Activateurs de la glucokinase
US8450494B2 (en) 2009-06-22 2013-05-28 Cadila Healthcare Limited Disubstituted benzamide derivatives as glucokinase (GK) activators
DK2459554T3 (da) 2009-07-31 2014-01-06 Cadila Healthcare Ltd Substituerede benzamidderivater som glucokinase (GK)-aktivatorer
KR100970871B1 (ko) * 2009-11-30 2010-07-20 케이제이알디 (주) 바닥재 어셈블리 및 바닥재의 시공방법
BR112012013195A2 (pt) 2009-12-04 2016-08-09 Nissan Chemical Ind Ltd compostos de 2-piridona.
CN105176930B (zh) 2010-03-31 2021-05-04 斯克里普斯研究所 重编程细胞
US9969683B2 (en) 2012-07-13 2018-05-15 Gtx, Inc. Method of treating estrogen receptor (ER)-positive breast cancers with selective androgen receptor modulator (SARMS)
US10314807B2 (en) 2012-07-13 2019-06-11 Gtx, Inc. Method of treating HER2-positive breast cancers with selective androgen receptor modulators (SARMS)
US10987334B2 (en) 2012-07-13 2021-04-27 University Of Tennessee Research Foundation Method of treating ER mutant expressing breast cancers with selective androgen receptor modulators (SARMs)
US9744149B2 (en) 2012-07-13 2017-08-29 Gtx, Inc. Method of treating androgen receptor (AR)-positive breast cancers with selective androgen receptor modulator (SARMs)
KR102238970B1 (ko) 2012-07-13 2021-04-09 지티엑스, 인코포레이티드 선택적 안드로겐 수용체 조절자(sarms)를 이용한 안드로겐 수용체(ar) 양성 유방암의 치료 방법
US9622992B2 (en) 2012-07-13 2017-04-18 Gtx, Inc. Method of treating androgen receptor (AR)-positive breast cancers with selective androgen receptor modulator (SARMs)
US10258596B2 (en) 2012-07-13 2019-04-16 Gtx, Inc. Method of treating HER2-positive breast cancers with selective androgen receptor modulators (SARMS)
MY173812A (en) 2012-11-13 2020-02-24 Nissan Chemical Ind Ltd 2-pyridone compound
GB201714777D0 (en) 2017-09-14 2017-11-01 Univ London Queen Mary Agent
CN112040945A (zh) 2018-06-12 2020-12-04 Vtv治疗有限责任公司 葡萄糖激酶激活剂与胰岛素或胰岛素类似物组合的治疗用途

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GB8909574D0 (en) 1989-04-26 1989-06-14 Ici Plc Chemical process
US5169951A (en) 1990-04-23 1992-12-08 Ciba-Geigy Corporation Process for preparing nematicidal compositions
SI1169312T1 (en) * 1999-03-29 2005-02-28 F. Hoffmann-La Roche Ag Glucokinase activators

Also Published As

Publication number Publication date
AU781029B2 (en) 2005-04-28
CA2392903C (fr) 2008-08-05
JP2003516980A (ja) 2003-05-20
HUP0203753A3 (en) 2004-12-28
PL355815A1 (en) 2004-05-17
HK1054383B (zh) 2005-04-22
MY125484A (en) 2006-08-30
HK1054383A1 (en) 2003-11-28
JO2180B1 (en) 2003-04-23
KR100502032B1 (ko) 2005-07-25
CN1185219C (zh) 2005-01-19
EP1242397A1 (fr) 2002-09-25
EP1242397B1 (fr) 2005-09-28
NO323142B1 (no) 2007-01-08
UY26483A1 (es) 2001-06-29
AR032752A1 (es) 2003-11-26
CN1411453A (zh) 2003-04-16
NZ518974A (en) 2004-04-30
RU2245332C2 (ru) 2005-01-27
ATE305461T1 (de) 2005-10-15
KR20020067555A (ko) 2002-08-22
JP3824936B2 (ja) 2006-09-20
HRP20020514A2 (en) 2004-06-30
YU41402A (sh) 2005-07-19
AU2365201A (en) 2001-06-25
GC0000264A (en) 2006-11-01
TWI262916B (en) 2006-10-01
NO20022863L (no) 2002-06-14
ZA200203829B (en) 2003-08-14
NO20022863D0 (no) 2002-06-14
MA26855A1 (fr) 2004-12-20
US6353111B1 (en) 2002-03-05
WO2001044216A1 (fr) 2001-06-21
ES2249322T3 (es) 2006-04-01
PE20011022A1 (es) 2001-10-11
CA2392903A1 (fr) 2001-06-21
HUP0203753A2 (hu) 2003-03-28
DK1242397T3 (da) 2006-02-13
DE60022903D1 (de) 2006-02-09
MXPA02005874A (es) 2002-10-23
CZ20022412A3 (cs) 2002-10-16
DE60022903T2 (de) 2006-07-06
CO5050295A1 (es) 2001-06-27
IL150083A (en) 2010-04-15

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