IL149243A0 - Tetrapeptide-l-alanyl-l-glutamyl-l-aspartyl-l-proline and its salts and pharmaceutical compositions containing the same - Google Patents
Tetrapeptide-l-alanyl-l-glutamyl-l-aspartyl-l-proline and its salts and pharmaceutical compositions containing the sameInfo
- Publication number
- IL149243A0 IL149243A0 IL14924300A IL14924300A IL149243A0 IL 149243 A0 IL149243 A0 IL 149243A0 IL 14924300 A IL14924300 A IL 14924300A IL 14924300 A IL14924300 A IL 14924300A IL 149243 A0 IL149243 A0 IL 149243A0
- Authority
- IL
- Israel
- Prior art keywords
- salts
- tetrapeptide
- proposed
- neurones
- glu
- Prior art date
Links
- 150000003839 salts Chemical class 0.000 title abstract 5
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 230000005714 functional activity Effects 0.000 abstract 3
- 210000002569 neuron Anatomy 0.000 abstract 3
- 230000004936 stimulating effect Effects 0.000 abstract 3
- 239000003814 drug Substances 0.000 abstract 2
- 239000002831 pharmacologic agent Substances 0.000 abstract 2
- 230000001225 therapeutic effect Effects 0.000 abstract 2
- QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 abstract 1
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical class [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 abstract 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 abstract 1
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical class C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 abstract 1
- WHXSMMKQMYFTQS-UHFFFAOYSA-N Lithium Chemical class [Li] WHXSMMKQMYFTQS-UHFFFAOYSA-N 0.000 abstract 1
- FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical class [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 abstract 1
- MUBZPKHOEPUJKR-UHFFFAOYSA-N Oxalic acid Chemical compound OC(=O)C(O)=O MUBZPKHOEPUJKR-UHFFFAOYSA-N 0.000 abstract 1
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical class [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 abstract 1
- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical class [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 abstract 1
- 125000000539 amino acid group Chemical group 0.000 abstract 1
- 230000037396 body weight Effects 0.000 abstract 1
- 239000011575 calcium Chemical class 0.000 abstract 1
- 229910052791 calcium Inorganic materials 0.000 abstract 1
- 125000003178 carboxy group Chemical class [H]OC(*)=O 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 229910052744 lithium Inorganic materials 0.000 abstract 1
- 239000011777 magnesium Chemical class 0.000 abstract 1
- 229910052749 magnesium Inorganic materials 0.000 abstract 1
- 239000011591 potassium Chemical class 0.000 abstract 1
- 229910052700 potassium Inorganic materials 0.000 abstract 1
- 230000003449 preventive effect Effects 0.000 abstract 1
- 229960002429 proline Drugs 0.000 abstract 1
- 239000011734 sodium Substances 0.000 abstract 1
- 229910052708 sodium Inorganic materials 0.000 abstract 1
- ZMANZCXQSJIPKH-UHFFFAOYSA-O triethylammonium ion Chemical compound CC[NH+](CC)CC ZMANZCXQSJIPKH-UHFFFAOYSA-O 0.000 abstract 1
- 239000011701 zinc Chemical class 0.000 abstract 1
- 229910052725 zinc Inorganic materials 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/10—Tetrapeptides
- C07K5/1002—Tetrapeptides with the first amino acid being neutral
- C07K5/1005—Tetrapeptides with the first amino acid being neutral and aliphatic
- C07K5/1008—Tetrapeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atoms, i.e. Gly, Ala
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Molecular Biology (AREA)
- Veterinary Medicine (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| RU99121778/14A RU2155063C1 (ru) | 1999-10-20 | 1999-10-20 | Тетрапептид, стимулирующий функциональную активность нейронов, фармакологическое средство на его основе и способ его применения |
| PCT/RU2000/000218 WO2001029067A1 (en) | 1999-10-20 | 2000-05-25 | Tetrapeptide stimulating functional activity of neurones, pharmacological agent based thereon and method of use thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IL149243A0 true IL149243A0 (en) | 2002-11-10 |
Family
ID=20225904
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL14924300A IL149243A0 (en) | 1999-10-20 | 2000-05-25 | Tetrapeptide-l-alanyl-l-glutamyl-l-aspartyl-l-proline and its salts and pharmaceutical compositions containing the same |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US7189701B1 (xx) |
| EP (1) | EP1224212B1 (xx) |
| JP (1) | JP4668497B2 (xx) |
| AT (1) | ATE244727T1 (xx) |
| AU (1) | AU784578B2 (xx) |
| CA (1) | CA2388357A1 (xx) |
| DE (1) | DE60003837T2 (xx) |
| IL (1) | IL149243A0 (xx) |
| RU (1) | RU2155063C1 (xx) |
| WO (1) | WO2001029067A1 (xx) |
Families Citing this family (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7175679B2 (en) | 2001-03-29 | 2007-02-13 | Biotempt B.V. | Oligopeptide treatment of NF-κB mediated inflammation |
| US6844315B2 (en) | 1998-05-20 | 2005-01-18 | Erasmus Universiteit Rotterdam | Immunoregulator |
| US20030220258A1 (en) | 2001-12-21 | 2003-11-27 | Robbert Benner | Treatment of ischemic events |
| EP1138692A1 (en) | 2000-03-29 | 2001-10-04 | Erasmus Universiteit Rotterdam | Fragments of human chorionic gonadotropin (hcg) as immunoregulator |
| US8680059B2 (en) | 1998-05-20 | 2014-03-25 | Biotempt B.V. | Oligopeptide acetate and formulations thereof |
| US6921751B1 (en) | 1998-05-20 | 2005-07-26 | Erasmus Universiteit Rotterdam | Immunoregulator |
| USRE43279E1 (en) | 2000-03-29 | 2012-03-27 | Biotemp B.V. | Compositions capable of reducing elevated blood urea concentration |
| EP1300418A1 (en) | 2001-10-04 | 2003-04-09 | Erasmus Universiteit Rotterdam | Gene regulation by oligopeptides |
| US7358330B2 (en) | 2001-03-29 | 2008-04-15 | Biotempt B.V. | Immunoregulatory compositions |
| US7576174B2 (en) | 2000-03-29 | 2009-08-18 | Biotempt B.V. | Compositions capable of reducing elevated blood urea concentration |
| RU2161501C1 (ru) * | 2000-06-29 | 2001-01-10 | Санкт-Петербургская Общественная Организация "Санкт-Петербургский Институт Биорегуляции И Геронтологии Сзо Рамн" | Способ получения пептидов, обладающих тканеспецифической активностью, и фармацевтические композиции на их основе |
| RU2238938C2 (ru) * | 2001-05-24 | 2004-10-27 | Пятигорская государственная фармацевтическая академия | Производное имидазо-[1,2-а]-бензимидазола - средство, оказывающее церебропротекторное действие при радиационных поражениях |
| RU2224528C2 (ru) * | 2001-07-24 | 2004-02-27 | Брянский государственный университет им. акад. И.Г. Петровского | Способ получения биологически активных пептидов каудальной нейросекреторной системы (кнсс) позвоночных |
| US7351686B2 (en) * | 2001-12-06 | 2008-04-01 | Yeda Research And Development Co. Ltd. | Method for neuronal protection in amyotrophic lateral sclerosis by a vaccine comprising Copolymer-1 or Copolymer-1 related peptides |
| US7786084B2 (en) | 2001-12-21 | 2010-08-31 | Biotempt B.V. | Treatment of burns |
| US7560433B2 (en) | 2001-12-21 | 2009-07-14 | Biotempt B.V. | Treatment of multiple sclerosis (MS) |
| US7501391B2 (en) | 2001-12-21 | 2009-03-10 | Biotempt B.V. | Treatment of transplant survival |
| RU2236857C2 (ru) * | 2002-10-11 | 2004-09-27 | Яско Анатолий Константинович | Способ лечения атрофии мозга, гидроцефалии мозга препаратом ветом-7048 |
| RU2244928C2 (ru) * | 2003-02-19 | 2005-01-20 | Пинигина Нина Максимовна | Эндогенная фармацевтическая композиция, полученная на основе целенаправленной активации гуморальных медиаторов нервных окончаний коры головного мозга |
| JP4846799B2 (ja) | 2005-07-05 | 2011-12-28 | バイオテンプト ベー．フェー． | 腫瘍の治療 |
| EP1864692A1 (en) | 2006-06-07 | 2007-12-12 | Biotempt B.V. | Use of peptides for the control of radiation injury |
| EP1857463A1 (en) | 2006-05-03 | 2007-11-21 | Ebewe Pharma Ges.m.b.H. Nfg. KG | Peptide having neuroprotective effects |
| RU2301678C1 (ru) * | 2006-05-30 | 2007-06-27 | Общество С Ограниченной Ответственностью "Сиа Пептайдс" | Пептид, стимулирующий регенерацию нейронов центральной нервной системы, фармацевтическая композиция на его основе и способ ее применения |
| EP2000134A1 (en) * | 2007-06-06 | 2008-12-10 | Neuraxo Biopharmaceuticals GmbH | Use of a substance for the improvement of pns lesions |
| RU2362580C1 (ru) * | 2007-11-07 | 2009-07-27 | Федеральное государственное учреждение "Новокузнецкий научно-практический центр медико-социальной экспертизы и реабилитации инвалидов Федерального агентства по здравоохранению и социальному развитию" (ФГУ ННПЦ МСЭ и РИ Росздрава) | Способ лечения спастического и болевого синдромов у пациентов с последствиями позвоночно-спинномозговой травмы |
| US9265458B2 (en) | 2012-12-04 | 2016-02-23 | Sync-Think, Inc. | Application of smooth pursuit cognitive testing paradigms to clinical drug development |
| EA020866B1 (ru) | 2013-02-28 | 2015-02-27 | Замертон Холдингс Лимитед | Пептиды с цитопротекторной активностью и фармацевтическая композиция |
| US9380976B2 (en) | 2013-03-11 | 2016-07-05 | Sync-Think, Inc. | Optical neuroinformatics |
| EP3914280B1 (en) * | 2019-01-25 | 2024-03-27 | The Board of Regents of The University of Texas System | Novel non-opioid anti-pain medication |
| RU2768475C1 (ru) * | 2021-07-08 | 2022-03-24 | Общество с ограниченной ответственностью "ТЕРРАНОВА КАПИТАЛ" | Пептид, обладающий нейростимулирующей активностью и восстанавливающий способность к обучению и формированию памяти, фармацевтическая композиция на его основе и способ ее применения |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SU1623166A1 (ru) * | 1989-04-03 | 1994-02-15 | Институт биоорганической химии АН БССР | Нейтропептиды, обладающие поведенческой активностью |
| WO1991009051A1 (en) * | 1989-12-15 | 1991-06-27 | G.D. Searle & Co. | Substituted cyclic penicillanic acid tetrapeptides |
| US5652334A (en) * | 1993-09-08 | 1997-07-29 | City Of Hope | Method for design of substances that enhance memory and improve the quality of life |
-
1999
- 1999-10-20 RU RU99121778/14A patent/RU2155063C1/ru active
-
2000
- 2000-05-25 AT AT00937408T patent/ATE244727T1/de active
- 2000-05-25 AU AU52585/00A patent/AU784578B2/en not_active Ceased
- 2000-05-25 US US10/110,981 patent/US7189701B1/en not_active Expired - Fee Related
- 2000-05-25 IL IL14924300A patent/IL149243A0/xx unknown
- 2000-05-25 CA CA002388357A patent/CA2388357A1/en not_active Abandoned
- 2000-05-25 DE DE60003837T patent/DE60003837T2/de not_active Expired - Lifetime
- 2000-05-25 JP JP2001531865A patent/JP4668497B2/ja not_active Expired - Fee Related
- 2000-05-25 WO PCT/RU2000/000218 patent/WO2001029067A1/en not_active Ceased
- 2000-05-25 EP EP00937408A patent/EP1224212B1/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| DE60003837T2 (de) | 2004-06-03 |
| US7189701B1 (en) | 2007-03-13 |
| EP1224212A1 (en) | 2002-07-24 |
| AU5258500A (en) | 2001-04-30 |
| AU784578B2 (en) | 2006-05-04 |
| DE60003837D1 (de) | 2003-08-14 |
| ATE244727T1 (de) | 2003-07-15 |
| RU2155063C1 (ru) | 2000-08-27 |
| CA2388357A1 (en) | 2001-04-26 |
| EP1224212B1 (en) | 2003-07-09 |
| JP4668497B2 (ja) | 2011-04-13 |
| WO2001029067A1 (en) | 2001-04-26 |
| JP2003532630A (ja) | 2003-11-05 |
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