IL148916A0 - Design of high affinity rnase h recruiting oligonucleotide - Google Patents

Design of high affinity rnase h recruiting oligonucleotide

Info

Publication number
IL148916A0
IL148916A0 IL14891600A IL14891600A IL148916A0 IL 148916 A0 IL148916 A0 IL 148916A0 IL 14891600 A IL14891600 A IL 14891600A IL 14891600 A IL14891600 A IL 14891600A IL 148916 A0 IL148916 A0 IL 148916A0
Authority
IL
Israel
Prior art keywords
recruiting
rnase
oligonucleotide
design
high affinity
Prior art date
Application number
IL14891600A
Other languages
English (en)
Original Assignee
Exiqon As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Exiqon As filed Critical Exiqon As
Publication of IL148916A0 publication Critical patent/IL148916A0/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/32—Chemical structure of the sugar
    • C12N2310/323—Chemical structure of the sugar modified ring structure
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/34—Spatial arrangement of the modifications
    • C12N2310/341—Gapmers, i.e. of the type ===---===
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/34—Spatial arrangement of the modifications
    • C12N2310/345—Spatial arrangement of the modifications having at least two different backbone modifications
IL14891600A 1999-10-04 2000-10-03 Design of high affinity rnase h recruiting oligonucleotide IL148916A0 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DKPA199901422 1999-10-04
US15772499P 1999-10-05 1999-10-05
PCT/DK2000/000550 WO2001025248A2 (fr) 1999-10-04 2000-10-03 Conception d'un oligonucleotide de recrutement de rnase h a haute affinite

Publications (1)

Publication Number Publication Date
IL148916A0 true IL148916A0 (en) 2002-09-12

Family

ID=26065735

Family Applications (1)

Application Number Title Priority Date Filing Date
IL14891600A IL148916A0 (en) 1999-10-04 2000-10-03 Design of high affinity rnase h recruiting oligonucleotide

Country Status (6)

Country Link
EP (1) EP1224280A2 (fr)
JP (1) JP2003511016A (fr)
AU (1) AU7406700A (fr)
CA (1) CA2385853A1 (fr)
IL (1) IL148916A0 (fr)
WO (1) WO2001025248A2 (fr)

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CA2550258A1 (fr) 2003-12-23 2005-07-07 Santaris Pharma A/S Composes oligomeres permettant la modulation de bcl-2
US9447138B2 (en) 2004-11-09 2016-09-20 Roche Innovation Center Copenhagen A/S Potent LNA oligonucleotides for the inhibition of HIF-1a expression
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EP3000480A1 (fr) 2005-12-01 2016-03-30 ProNAi Therapeutics, Inc. Therapies contre le cancer et compositions pharmaceutiques utilisees dans ces therapies
EP2388328A1 (fr) * 2006-01-27 2011-11-23 Isis Pharmaceuticals, Inc. Composés oligomères et compositions pour une utilisation dans la modulation de micro ARN
EP2002004B1 (fr) 2006-03-23 2015-10-14 Roche Innovation Center Copenhagen A/S Arn interférant court segmenté à l'intérieur
JP5814505B2 (ja) 2006-04-03 2015-11-17 ロシュ・イノベーション・センター・コペンハーゲン・アクティーゼルスカブＲｏｃｈｅ Ｉｎｎｏｖａｔｉｏｎ Ｃｅｎｔｅｒ Ｃｏｐｅｎｈａｇｅｎ Ａ／Ｓ ａｎｔｉｍｉＲＮＡアンチセンスオリゴヌクレオチドを含む医薬組成物
EP3431602A1 (fr) 2006-04-03 2019-01-23 Roche Innovation Center Copenhagen A/S Composition pharmaceutique comprenant des oligonucléotides antisens anti-arnmi
AU2008228243B2 (en) 2007-03-22 2014-05-15 Santaris Pharma A/S RNA antagonist compounds for the inhibition of Apo-B100 expression
DK2149605T3 (da) 2007-03-22 2013-09-30 Santaris Pharma As Korte RNA antagonist forbindelser til modulering af det ønskede mRNA
ES2798758T3 (es) 2007-06-06 2020-12-14 Sarepta Therapeutics Inc Proteínas variantes de empalme her2 y her3 solubles, oligonucleótidos de cambio de empalme y su uso en el tratamiento de enfermedades
US8299237B2 (en) 2007-08-30 2012-10-30 Hadasit Medical Research Services & Development Ltd. Nucleic acid sequences comprising NF-κB binding site within O(6)-methylguanine-DNA-methyltransferase (MGMT) promoter region and uses thereof for the treatment of cancer and immune-related disorders
AU2008306327B2 (en) 2007-10-04 2014-05-15 Roche Innovation Center Copenhagen A/S Micromirs
CA2705213C (fr) 2007-11-07 2016-10-04 The University Of British Columbia Dispositif microfluidique et procede d'utilisation de ce dispositif
US8404659B2 (en) 2008-03-07 2013-03-26 Santaris Pharma A/S Pharmaceutical compositions for treatment of MicroRNA related diseases
ES2541442T3 (es) 2008-08-01 2015-07-20 Roche Innovation Center Copenhagen A/S Modulación mediada por microARN de factores estimulantes de colonias
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WO2011105902A2 (fr) 2010-02-23 2011-09-01 Academisch Ziekenhuis Bij De Universiteit Van Amsterdam Antagonistes de composant du complément 8-bêta (c8-bêta) et utilisations associées
WO2011105901A2 (fr) 2010-02-23 2011-09-01 Academisch Ziekenhuis Bij De Universiteit Van Amsterdam Antagonistes de composant du complément 9 (c9) et utilisations associées
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EP2943570B1 (fr) 2013-01-14 2018-01-03 Pierfrancesco Tassone Inhibiteurs des miarn 221 et 222 pour l'activité antitumorale dans le myélome multiple
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WO2015075166A1 (fr) 2013-11-22 2015-05-28 INSERM (Institut National de la Santé et de la Recherche Médicale) Méthodes et compositions pharmaceutiques pour traiter une infection bactérienne
US9765332B2 (en) 2014-01-29 2017-09-19 Inserm (Institut National De La Sante Et De La Recherche Medicale) Oligonucleotides and methods for inhibiting or reducing bacterial biofilms
CA2960728C (fr) 2014-09-18 2023-06-06 The University Of British Columbia Therapie allele-specifique pour les haplotypes de la maladie d'huntington
US20220354888A1 (en) 2016-08-03 2022-11-10 Aalborg Universitet ANTISENSE OLIGONUCLEOTIDES (ASOs) DESIGNED TO INHIBIT IMMUNE CHECKPOINT PROTEINS
WO2019076919A1 (fr) 2017-10-17 2019-04-25 INSERM (Institut National de la Santé et de la Recherche Médicale) Traitement combiné de la fibrose kystique
US20220251567A1 (en) 2019-07-10 2022-08-11 Inserm (Institut National De La Santè Et De La Recherche Médicale) Methods for the treatment of epilepsy
IT201900017234A1 (it) 2019-09-25 2021-03-25 Int Centre For Genetic Engineering And Biotechnology Anti-miRNA per il trattamento del leiomioma
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US20230016983A1 (en) 2019-11-19 2023-01-19 lNSERM (INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE) Antisense oligonucleotides and thier use for the treatment of cancer
US20240018524A1 (en) 2020-07-10 2024-01-18 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods and compositions for treating epilepsy
IL304956A (en) 2021-02-12 2023-10-01 Merand Pharmaceuticals Inc Materials, compositions and methods for treating hypoxia and ischemia-related disorders
JP2024510665A (ja) 2021-03-26 2024-03-08 ニューミルナ セラピューティクス エーピーエス マイクロＲＮＡ－２７ｂ阻害剤
WO2022200632A1 (fr) 2021-03-26 2022-09-29 Neumirna Therapeutics Aps Inhibiteurs de microarn-134
EP4347824A1 (fr) 2021-06-04 2024-04-10 Neumirna Therapeutics ApS Oligonucléotides antisens ciblant l'adénosine kinase
CA3229568A1 (fr) 2021-08-17 2023-02-23 Korea Advanced Institute Of Science And Technology Oligonucleotide antisens ciblant le gene cav3.1 et ses utilisations
CA3228833A1 (fr) 2021-08-19 2023-02-23 Neumirna Therapeutics Aps Oligonucleotides antisens ciblant l'adenosine kinase
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Also Published As

Publication number Publication date
JP2003511016A (ja) 2003-03-25
WO2001025248A3 (fr) 2001-08-30
EP1224280A2 (fr) 2002-07-24
AU7406700A (en) 2001-05-10
CA2385853A1 (fr) 2001-04-12
WO2001025248A2 (fr) 2001-04-12

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