IL143558A0 - Method of enhancing the biological activity of ligands - Google Patents
Method of enhancing the biological activity of ligandsInfo
- Publication number
- IL143558A0 IL143558A0 IL14355899A IL14355899A IL143558A0 IL 143558 A0 IL143558 A0 IL 143558A0 IL 14355899 A IL14355899 A IL 14355899A IL 14355899 A IL14355899 A IL 14355899A IL 143558 A0 IL143558 A0 IL 143558A0
- Authority
- IL
- Israel
- Prior art keywords
- polypeptide ligands
- fusion polypeptide
- ligands
- enhancing
- biological activity
- Prior art date
Links
- 239000003446 ligand Substances 0.000 title abstract 8
- 238000000034 method Methods 0.000 title abstract 2
- 230000004071 biological effect Effects 0.000 title 1
- 230000002708 enhancing effect Effects 0.000 title 1
- 229920001184 polypeptide Polymers 0.000 abstract 6
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 6
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 6
- 230000004927 fusion Effects 0.000 abstract 5
- 238000004519 manufacturing process Methods 0.000 abstract 3
- 102000039446 nucleic acids Human genes 0.000 abstract 2
- 108020004707 nucleic acids Proteins 0.000 abstract 2
- 150000007523 nucleic acids Chemical class 0.000 abstract 2
- 102000050554 Eph Family Receptors Human genes 0.000 abstract 1
- 108091008815 Eph receptors Proteins 0.000 abstract 1
- 102000012753 TIE-2 Receptor Human genes 0.000 abstract 1
- 108010090091 TIE-2 Receptor Proteins 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
- C07K14/515—Angiogenesic factors; Angiogenin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/62—DNA sequences coding for fusion proteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
- C07K2319/73—Fusion polypeptide containing domain for protein-protein interaction containing coiled-coiled motif (leucine zippers)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
- C07K2319/74—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor
- C07K2319/75—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor containing a fusion for activation of a cell surface receptor, e.g. thrombopoeitin, NPY and other peptide hormones
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Genetics & Genomics (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- General Health & Medical Sciences (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- Biotechnology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Wood Science & Technology (AREA)
- General Engineering & Computer Science (AREA)
- Toxicology (AREA)
- Physics & Mathematics (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Vascular Medicine (AREA)
- Microbiology (AREA)
- Plant Pathology (AREA)
- Psychiatry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Hospice & Palliative Care (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Compounds Of Unknown Constitution (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US11338798P | 1998-12-23 | 1998-12-23 | |
| PCT/US1999/030900 WO2000037642A1 (en) | 1998-12-23 | 1999-12-23 | Method of enhancing the biological activity of ligands |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IL143558A0 true IL143558A0 (en) | 2002-04-21 |
Family
ID=22349103
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL14355899A IL143558A0 (en) | 1998-12-23 | 1999-12-23 | Method of enhancing the biological activity of ligands |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US7008781B1 (https=) |
| EP (1) | EP1141294B1 (https=) |
| JP (1) | JP4493854B2 (https=) |
| AT (1) | ATE290089T1 (https=) |
| AU (1) | AU776393B2 (https=) |
| CA (1) | CA2354846A1 (https=) |
| DE (1) | DE69924009T2 (https=) |
| HK (1) | HK1040093B (https=) |
| IL (1) | IL143558A0 (https=) |
| NZ (1) | NZ512326A (https=) |
| PL (1) | PL199645B1 (https=) |
| WO (1) | WO2000037642A1 (https=) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE9901428D0 (sv) * | 1999-04-21 | 1999-04-21 | Karolinska Innovations Ab | Amphibodies |
| WO2001047951A2 (en) * | 1999-12-23 | 2001-07-05 | An-Go-Gen Inc. | Angiopoietin analogs |
| PL366000A1 (en) | 2000-08-08 | 2005-01-24 | M.G.V.S.Ltd. | Nucleic acid constructs, vascular cells transformed therewith, pharmaceutical compositions and methods utilizing same for inducing angiogenesis |
| US20030027751A1 (en) * | 2001-04-10 | 2003-02-06 | Genvec, Inc. | VEGF fusion proteins |
| WO2003034990A2 (en) | 2001-10-25 | 2003-05-01 | Regeneron Pharmaceuticals, Inc. | Angiopoietins and methods of use thereof |
| GB0201679D0 (en) * | 2002-01-25 | 2002-03-13 | Asterion Ltd | Polypeptide variants |
| US7081443B2 (en) * | 2002-05-21 | 2006-07-25 | Korea Advanced Institutes Of Science And Technology (Kaist) | Chimeric comp-ang1 molecule |
| US8298532B2 (en) | 2004-01-16 | 2012-10-30 | Regeneron Pharmaceuticals, Inc. | Fusion polypeptides capable of activating receptors |
| WO2008100288A2 (en) * | 2006-09-15 | 2008-08-21 | The Burnham Institute | High affinity ephb receptor binding compounds and methods of use thereof |
| ES2612258T3 (es) | 2006-10-27 | 2017-05-16 | Sunnybrook Health Sciences Center | Agonistas multiméricos de Tie 2 y usos de los mismos en la estimulación de la angiogénesis |
| EP2307456B1 (en) | 2008-06-27 | 2014-10-15 | Amgen Inc. | Ang-2 inhibition to treat multiple sclerosis |
| EP2714738B1 (en) | 2011-05-24 | 2018-10-10 | Zyngenia, Inc. | Multivalent and monovalent multispecific complexes and their uses |
| US10150800B2 (en) | 2013-03-15 | 2018-12-11 | Zyngenia, Inc. | EGFR-binding modular recognition domains |
| CA2909080C (en) | 2013-04-11 | 2022-07-26 | Sunnybrook Research Institute | Methods, uses and compositions of tie2 agonists |
| CA2928852A1 (en) | 2013-11-01 | 2015-05-07 | Regeneron Pharmaceuticals, Inc. | Angiopoietin-based interventions for treating cerebral malaria |
| ES2867249T3 (es) | 2015-11-06 | 2021-10-20 | Regeneron Pharma | Angiopoyetinas para usar en la promoción de la coagulación sanguínea y en el tratamiento de trastornos de la coagulación sanguínea |
| KR101685532B1 (ko) * | 2016-04-26 | 2016-12-13 | 한국프라임제약주식회사 | 혈관내피성장인자 수용체 융합단백질 |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0547163B1 (en) * | 1990-08-29 | 2002-02-06 | Centre Hospitalier Regional De Nantes | Protein polyligands joined to a stable protein core |
| US5401650A (en) * | 1990-10-24 | 1995-03-28 | The Mount Sinai School Of Medicine Of The City University Of New York | Cloning and expression of biologically active α-galactosidase A |
| JPH08505765A (ja) | 1992-11-13 | 1996-06-25 | アムジエン・インコーポレーテツド | Ｅｃｋ受容体リガンド |
| US5747033A (en) | 1993-10-28 | 1998-05-05 | Regeneron Pharmaceuticals, Inc. | Method of enhancing the biological activity of Eph family ligands |
| US5643755A (en) | 1994-10-07 | 1997-07-01 | Regeneron Pharmaceuticals Inc. | Nucleic acid encoding tie-2 ligand |
| US5879672A (en) | 1994-10-07 | 1999-03-09 | Regeneron Pharmaceuticals, Inc. | Tie-2 ligand 1 |
| ATE232901T1 (de) * | 1994-04-04 | 2003-03-15 | Regeneron Pharma | Biologisch aktive ligande der eph familie |
| US5650490A (en) | 1994-10-07 | 1997-07-22 | Regeneron Pharmaceuticals, Inc. | Tie-2 ligand 2 |
| US5814464A (en) | 1994-10-07 | 1998-09-29 | Regeneron Pharma | Nucleic acids encoding TIE-2 ligand-2 |
| JP4122056B2 (ja) | 1995-04-06 | 2008-07-23 | リジエネロン ファーマシューティカルズ，インコーポレイテッド | Ｔｉｅ−２リガンド、その作製方法および使用方法 |
| CA2222055A1 (en) * | 1995-05-23 | 1996-11-28 | Morphosys Gesellschaft Fur Proteinoptimierung Mbh | Multimeric proteins |
| WO1997015667A1 (en) | 1995-10-25 | 1997-05-01 | Regeneron Pharmaceuticals, Inc. | Biologically active eph family ligands |
| US6337387B1 (en) * | 1995-11-17 | 2002-01-08 | Asahi Kasei Kabushiki Kaisha | Differentiation-suppressive polypeptide |
| US5814478A (en) | 1995-12-15 | 1998-09-29 | Regeneron Pharmaceuticals, Inc. | Tyrosine kinase receptors and ligands |
| WO1997023639A1 (en) * | 1995-12-22 | 1997-07-03 | Toray Industries, Inc. | Process for producing biologically active fused proteins |
| US5851797A (en) | 1996-06-19 | 1998-12-22 | Regeneron Pharmaceuticals, Inc. | Tie ligand-3, methods of making and uses thereof |
| IL127623A0 (en) | 1996-06-19 | 1999-10-28 | Regeneron Pharma | Tie-2 receptor ligands (tie ligand-3; tie ligand-4) and their uses |
| US6265564B1 (en) * | 1996-08-02 | 2001-07-24 | Regeneron Pharmaceuticals, Inc. | Expressed ligand-vascular intercellular signalling molecule |
-
1999
- 1999-12-23 IL IL14355899A patent/IL143558A0/xx not_active IP Right Cessation
- 1999-12-23 JP JP2000589696A patent/JP4493854B2/ja not_active Expired - Lifetime
- 1999-12-23 HK HK02101186.0A patent/HK1040093B/en not_active IP Right Cessation
- 1999-12-23 PL PL349158A patent/PL199645B1/pl unknown
- 1999-12-23 CA CA002354846A patent/CA2354846A1/en not_active Abandoned
- 1999-12-23 WO PCT/US1999/030900 patent/WO2000037642A1/en not_active Ceased
- 1999-12-23 US US09/868,677 patent/US7008781B1/en not_active Expired - Lifetime
- 1999-12-23 EP EP99968956A patent/EP1141294B1/en not_active Expired - Lifetime
- 1999-12-23 DE DE69924009T patent/DE69924009T2/de not_active Expired - Lifetime
- 1999-12-23 NZ NZ512326A patent/NZ512326A/en not_active IP Right Cessation
- 1999-12-23 AT AT99968956T patent/ATE290089T1/de active
- 1999-12-23 AU AU27147/00A patent/AU776393B2/en not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| CA2354846A1 (en) | 2000-06-29 |
| PL199645B1 (pl) | 2008-10-31 |
| DE69924009D1 (de) | 2005-04-07 |
| HK1040093A1 (en) | 2002-05-24 |
| ATE290089T1 (de) | 2005-03-15 |
| JP4493854B2 (ja) | 2010-06-30 |
| NZ512326A (en) | 2003-11-28 |
| JP2003506008A (ja) | 2003-02-18 |
| WO2000037642A9 (en) | 2000-11-02 |
| HK1040093B (en) | 2005-05-06 |
| AU2714700A (en) | 2000-07-12 |
| PL349158A1 (en) | 2002-07-01 |
| WO2000037642A1 (en) | 2000-06-29 |
| US7008781B1 (en) | 2006-03-07 |
| AU776393B2 (en) | 2004-09-09 |
| DE69924009T2 (de) | 2006-04-13 |
| EP1141294A1 (en) | 2001-10-10 |
| EP1141294B1 (en) | 2005-03-02 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FF | Patent granted | ||
| KB | Patent renewed | ||
| KB | Patent renewed | ||
| KB | Patent renewed | ||
| KB | Patent renewed | ||
| EXP | Patent expired |