DE69924009D1 - Methode zur verstärkung der biologischen aktivität von liganden - Google Patents
Methode zur verstärkung der biologischen aktivität von ligandenInfo
- Publication number
- DE69924009D1 DE69924009D1 DE69924009T DE69924009T DE69924009D1 DE 69924009 D1 DE69924009 D1 DE 69924009D1 DE 69924009 T DE69924009 T DE 69924009T DE 69924009 T DE69924009 T DE 69924009T DE 69924009 D1 DE69924009 D1 DE 69924009D1
- Authority
- DE
- Germany
- Prior art keywords
- polypeptide ligands
- fusion polypeptide
- ligands
- increasing
- biological activity
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
- C07K14/515—Angiogenesic factors; Angiogenin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/62—DNA sequences coding for fusion proteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
- C07K2319/73—Fusion polypeptide containing domain for protein-protein interaction containing coiled-coiled motif (leucine zippers)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
- C07K2319/74—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor
- C07K2319/75—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor containing a fusion for activation of a cell surface receptor, e.g. thrombopoeitin, NPY and other peptide hormones
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- General Health & Medical Sciences (AREA)
- Biophysics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biochemistry (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Toxicology (AREA)
- Wood Science & Technology (AREA)
- Gastroenterology & Hepatology (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Plant Pathology (AREA)
- Neurosurgery (AREA)
- Microbiology (AREA)
- Physics & Mathematics (AREA)
- Vascular Medicine (AREA)
- Neurology (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Hospice & Palliative Care (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Psychiatry (AREA)
- Veterinary Medicine (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Compounds Of Unknown Constitution (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US11338798P | 1998-12-23 | 1998-12-23 | |
US113387P | 1998-12-23 | ||
PCT/US1999/030900 WO2000037642A1 (en) | 1998-12-23 | 1999-12-23 | Method of enhancing the biological activity of ligands |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69924009D1 true DE69924009D1 (de) | 2005-04-07 |
DE69924009T2 DE69924009T2 (de) | 2006-04-13 |
Family
ID=22349103
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69924009T Expired - Lifetime DE69924009T2 (de) | 1998-12-23 | 1999-12-23 | Methode zur verstärkung der biologischen aktivität von liganden |
Country Status (12)
Country | Link |
---|---|
US (1) | US7008781B1 (de) |
EP (1) | EP1141294B1 (de) |
JP (1) | JP4493854B2 (de) |
AT (1) | ATE290089T1 (de) |
AU (1) | AU776393B2 (de) |
CA (1) | CA2354846A1 (de) |
DE (1) | DE69924009T2 (de) |
HK (1) | HK1040093B (de) |
IL (1) | IL143558A0 (de) |
NZ (1) | NZ512326A (de) |
PL (1) | PL199645B1 (de) |
WO (1) | WO2000037642A1 (de) |
Families Citing this family (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SE9901428D0 (sv) * | 1999-04-21 | 1999-04-21 | Karolinska Innovations Ab | Amphibodies |
WO2001047951A2 (en) * | 1999-12-23 | 2001-07-05 | An-Go-Gen Inc. | Angiopoietin analogs |
EP1307582B1 (de) * | 2000-08-08 | 2008-05-28 | M.G.V.S. Ltd. | Nukleinsäurekonstrukte, damit transformierte vaskuläre zellen, pharmezeutische zusammensetzungen und verfahren zur induktion der angiogenese |
US20030027751A1 (en) * | 2001-04-10 | 2003-02-06 | Genvec, Inc. | VEGF fusion proteins |
US7052695B2 (en) | 2001-10-25 | 2006-05-30 | Regeneron Pharmaceuticals, Inc. | Angiopoietins and methods of treating hypertension |
GB0201679D0 (en) * | 2002-01-25 | 2002-03-13 | Asterion Ltd | Polypeptide variants |
US7081443B2 (en) | 2002-05-21 | 2006-07-25 | Korea Advanced Institutes Of Science And Technology (Kaist) | Chimeric comp-ang1 molecule |
US8298532B2 (en) | 2004-01-16 | 2012-10-30 | Regeneron Pharmaceuticals, Inc. | Fusion polypeptides capable of activating receptors |
WO2008100288A2 (en) * | 2006-09-15 | 2008-08-21 | The Burnham Institute | High affinity ephb receptor binding compounds and methods of use thereof |
CA2693383C (en) | 2006-10-27 | 2017-03-28 | Sunnybrook Health Sciences Center | Multimeric tie 2 agonists and uses thereof in stimulating angiogenesis |
EP2671891A3 (de) | 2008-06-27 | 2014-03-05 | Amgen Inc. | Ang-2-Hemmung zur Behandlung von Multipler Sklerose |
WO2012162561A2 (en) | 2011-05-24 | 2012-11-29 | Zyngenia, Inc. | Multivalent and monovalent multispecific complexes and their uses |
WO2014144600A2 (en) | 2013-03-15 | 2014-09-18 | Viktor Roschke | Multivalent and monovalent multispecific complexes and their uses |
PT2983695T (pt) | 2013-04-11 | 2019-09-09 | Sunnybrook Res Inst | Métodos, usos e composições dos agonistas do tie2 |
LT3062811T (lt) | 2013-11-01 | 2019-05-10 | Regeneron Pharmaceuticals, Inc. | Intervencijos angiopoietino pagrindu cerebrinės maliarijos gydymui |
EP3370757B1 (de) | 2015-11-06 | 2021-04-14 | Regeneron Pharmaceuticals, Inc. | Angiopoietine zur förderung der blutgerinnung und zur behandlung von blutgerinnungsstörungen |
KR101685532B1 (ko) * | 2016-04-26 | 2016-12-13 | 한국프라임제약주식회사 | 혈관내피성장인자 수용체 융합단백질 |
Family Cites Families (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2090105A1 (en) * | 1990-08-29 | 1992-03-01 | Jean-Paul Soulillou | Protein polyligands joined to a stable protein core |
US5401650A (en) * | 1990-10-24 | 1995-03-28 | The Mount Sinai School Of Medicine Of The City University Of New York | Cloning and expression of biologically active α-galactosidase A |
CA2149333C (en) | 1992-11-13 | 2002-01-22 | Timothy D. Bartley | Eck receptor ligands |
US5747033A (en) | 1993-10-28 | 1998-05-05 | Regeneron Pharmaceuticals, Inc. | Method of enhancing the biological activity of Eph family ligands |
US5643755A (en) | 1994-10-07 | 1997-07-01 | Regeneron Pharmaceuticals Inc. | Nucleic acid encoding tie-2 ligand |
US5879672A (en) | 1994-10-07 | 1999-03-09 | Regeneron Pharmaceuticals, Inc. | Tie-2 ligand 1 |
CA2187167A1 (en) | 1994-04-04 | 1995-10-12 | Samuel Davis | Biologically active eph family ligands |
US5814464A (en) | 1994-10-07 | 1998-09-29 | Regeneron Pharma | Nucleic acids encoding TIE-2 ligand-2 |
US5650490A (en) | 1994-10-07 | 1997-07-22 | Regeneron Pharmaceuticals, Inc. | Tie-2 ligand 2 |
ATE273384T1 (de) | 1995-04-06 | 2004-08-15 | Regeneron Pharma | Tie-2 liganden, herstellungsverfahren und verwendung |
CA2222055A1 (en) * | 1995-05-23 | 1996-11-28 | Morphosys Gesellschaft Fur Proteinoptimierung Mbh | Multimeric proteins |
US6602683B1 (en) | 1995-10-25 | 2003-08-05 | Regeneron Pharmaceuticals, Inc. | Biologically active Eph family ligands |
EP0861894B1 (de) * | 1995-11-17 | 2006-03-08 | Asahi Kasei Kabushiki Kaisha | Polypeptid, das die differenzierung unterdrueckt |
US5814478A (en) | 1995-12-15 | 1998-09-29 | Regeneron Pharmaceuticals, Inc. | Tyrosine kinase receptors and ligands |
WO1997023639A1 (fr) | 1995-12-22 | 1997-07-03 | Toray Industries, Inc. | Procede de production de proteines fusionnees biologiquement actives |
EP0939809B1 (de) | 1996-06-19 | 2003-03-26 | Regeneron Pharmaceuticals, Inc. | Ligand (tie ligand-4) vom tie-2 rezeptor und dessen verwendungen |
US5851797A (en) | 1996-06-19 | 1998-12-22 | Regeneron Pharmaceuticals, Inc. | Tie ligand-3, methods of making and uses thereof |
US6265564B1 (en) | 1996-08-02 | 2001-07-24 | Regeneron Pharmaceuticals, Inc. | Expressed ligand-vascular intercellular signalling molecule |
-
1999
- 1999-12-23 EP EP99968956A patent/EP1141294B1/de not_active Expired - Lifetime
- 1999-12-23 IL IL14355899A patent/IL143558A0/xx not_active IP Right Cessation
- 1999-12-23 PL PL349158A patent/PL199645B1/pl unknown
- 1999-12-23 DE DE69924009T patent/DE69924009T2/de not_active Expired - Lifetime
- 1999-12-23 JP JP2000589696A patent/JP4493854B2/ja not_active Expired - Lifetime
- 1999-12-23 AU AU27147/00A patent/AU776393B2/en not_active Expired
- 1999-12-23 CA CA002354846A patent/CA2354846A1/en not_active Abandoned
- 1999-12-23 US US09/868,677 patent/US7008781B1/en not_active Expired - Lifetime
- 1999-12-23 NZ NZ512326A patent/NZ512326A/en not_active IP Right Cessation
- 1999-12-23 AT AT99968956T patent/ATE290089T1/de active
- 1999-12-23 WO PCT/US1999/030900 patent/WO2000037642A1/en active IP Right Grant
-
2002
- 2002-02-19 HK HK02101186.0A patent/HK1040093B/zh not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
WO2000037642A1 (en) | 2000-06-29 |
IL143558A0 (en) | 2002-04-21 |
HK1040093B (zh) | 2005-05-06 |
JP4493854B2 (ja) | 2010-06-30 |
WO2000037642A9 (en) | 2000-11-02 |
PL349158A1 (en) | 2002-07-01 |
AU776393B2 (en) | 2004-09-09 |
EP1141294B1 (de) | 2005-03-02 |
ATE290089T1 (de) | 2005-03-15 |
NZ512326A (en) | 2003-11-28 |
JP2003506008A (ja) | 2003-02-18 |
AU2714700A (en) | 2000-07-12 |
PL199645B1 (pl) | 2008-10-31 |
US7008781B1 (en) | 2006-03-07 |
DE69924009T2 (de) | 2006-04-13 |
CA2354846A1 (en) | 2000-06-29 |
HK1040093A1 (en) | 2002-05-24 |
EP1141294A1 (de) | 2001-10-10 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition |