IL143508A0 - Phenethyl-5- bromopyridylthiourea (pbt) and dihydroalkoxybenzyloxopyrimdine (dabo) derivatives exhibiting spermicidal activity - Google Patents
Phenethyl-5- bromopyridylthiourea (pbt) and dihydroalkoxybenzyloxopyrimdine (dabo) derivatives exhibiting spermicidal activityInfo
- Publication number
- IL143508A0 IL143508A0 IL14350899A IL14350899A IL143508A0 IL 143508 A0 IL143508 A0 IL 143508A0 IL 14350899 A IL14350899 A IL 14350899A IL 14350899 A IL14350899 A IL 14350899A IL 143508 A0 IL143508 A0 IL 143508A0
- Authority
- IL
- Israel
- Prior art keywords
- bromopyridylthiourea
- dabo
- pbt
- phenethyl
- dihydroalkoxybenzyloxopyrimdine
- Prior art date
Links
- FTSGLGFFJMUGDU-UHFFFAOYSA-N 1-(5-bromopyridin-2-yl)-1-(2-phenylethyl)thiourea Chemical compound C=1C=C(Br)C=NC=1N(C(=S)N)CCC1=CC=CC=C1 FTSGLGFFJMUGDU-UHFFFAOYSA-N 0.000 title abstract 3
- 230000001150 spermicidal effect Effects 0.000 title abstract 3
- 230000001747 exhibiting effect Effects 0.000 title abstract 2
- 230000000840 anti-viral effect Effects 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 239000003433 contraceptive agent Substances 0.000 abstract 1
- 230000002254 contraceptive effect Effects 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/75—Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/06—Antiabortive agents; Labour repressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/16—Masculine contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/18—Feminine contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/61—Halogen atoms or nitro radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/32—One oxygen, sulfur or nitrogen atom
- C07D239/34—One oxygen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/32—One oxygen, sulfur or nitrogen atom
- C07D239/38—One sulfur atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/56—One oxygen atom and one sulfur atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0034—Urogenital system, e.g. vagina, uterus, cervix, penis, scrotum, urethra, bladder; Personal lubricants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0034—Urogenital system, e.g. vagina, uterus, cervix, penis, scrotum, urethra, bladder; Personal lubricants
- A61K9/0036—Devices retained in the vagina or cervix for a prolonged period, e.g. intravaginal rings, medicated tampons, medicated diaphragms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Reproductive Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Endocrinology (AREA)
- Gynecology & Obstetrics (AREA)
- Epidemiology (AREA)
- Virology (AREA)
- AIDS & HIV (AREA)
- Tropical Medicine & Parasitology (AREA)
- Molecular Biology (AREA)
- Oncology (AREA)
- Pregnancy & Childbirth (AREA)
- Communicable Diseases (AREA)
- Urology & Nephrology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyridine Compounds (AREA)
- Orthopedics, Nursing, And Contraception (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US09/224,677 US6136335A (en) | 1998-12-31 | 1998-12-31 | Phenethyl-5-bromopyridylthiourea (PBT) and dihydroalkoxybenzyloxopyrimidine (DABO) derivatives exhibiting spermicidal activity |
| PCT/US1999/031160 WO2000039095A2 (en) | 1998-12-31 | 1999-12-29 | Phenethyl-5-bromopyridylthiourea (pbt) and dihydroalkoxybenzyloxopyrimidine (dabo) derivatives exhibiting spermicidal activity |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IL143508A0 true IL143508A0 (en) | 2002-04-21 |
Family
ID=22841684
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL14350899A IL143508A0 (en) | 1998-12-31 | 1999-12-29 | Phenethyl-5- bromopyridylthiourea (pbt) and dihydroalkoxybenzyloxopyrimdine (dabo) derivatives exhibiting spermicidal activity |
Country Status (15)
| Country | Link |
|---|---|
| US (2) | US6136335A (ja) |
| EP (2) | EP1557197A1 (ja) |
| JP (1) | JP2002533444A (ja) |
| KR (1) | KR20010082772A (ja) |
| CN (1) | CN1371367A (ja) |
| AT (1) | ATE306475T1 (ja) |
| AU (1) | AU2396800A (ja) |
| BR (1) | BR9916620A (ja) |
| CA (1) | CA2362492A1 (ja) |
| DE (1) | DE69927710T2 (ja) |
| HU (1) | HUP0104904A2 (ja) |
| IL (1) | IL143508A0 (ja) |
| MX (1) | MXPA01006746A (ja) |
| NO (1) | NO20012817L (ja) |
| WO (1) | WO2000039095A2 (ja) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT1305313B1 (it) | 1998-07-17 | 2001-05-04 | Colla Paolo | 3,4 - diidro- 6- benzil-4-oxopirimidine sostituite e relativo processodi produzione e impiego nella terapia delle infezioni da hiv-1. |
| US6136335A (en) * | 1998-12-31 | 2000-10-24 | Hughes Institute | Phenethyl-5-bromopyridylthiourea (PBT) and dihydroalkoxybenzyloxopyrimidine (DABO) derivatives exhibiting spermicidal activity |
| US7064114B2 (en) * | 1999-03-19 | 2006-06-20 | Parker Hughes Institute | Gel-microemulsion formulations |
| BR0115474A (pt) * | 2000-11-17 | 2006-01-31 | Idenix Cayman Ltd | Composição e método para inibição da transmissão de hiv que usam 6-benzil-4-oxopirimidinas substituìdas aplicada por via tópica |
| SE0100733D0 (sv) | 2001-03-05 | 2001-03-05 | Medivir Ab | Non-nucleoside reverse transcriptase inhibitors |
| SE0102867D0 (sv) | 2001-08-28 | 2001-08-28 | Medivir Ab | Non-nucleoside reverse transcriptase inhibitors |
| US6929945B2 (en) * | 2002-12-09 | 2005-08-16 | Advanced Fluidix Laboratories Llc | Male fertility assay method and device |
| TW200600492A (en) | 2004-05-18 | 2006-01-01 | Achillion Pharmaceuticals Inc | Substituted aryl acylthioureas and related compounds; inhibitors of viral replication |
| WO2009102736A1 (en) | 2008-02-12 | 2009-08-20 | Dow Agrosciences Llc | Pesticidal compositions |
| CN101628996B (zh) * | 2008-07-18 | 2012-05-30 | 绿神（北京）乳胶业有限公司 | 一种乳胶避孕套的制备方法 |
| CN103491782B (zh) * | 2011-02-09 | 2016-02-24 | 陶氏益农公司 | 杀虫组合物及其相关方法 |
| CA2841450C (en) | 2011-07-12 | 2019-04-23 | Dow Agrosciences Llc | Pesticidal compositions and processes related thereto |
| CN103193771B (zh) * | 2013-03-29 | 2015-08-05 | 中国人民解放军军事医学科学院生物工程研究所 | 链状酰胺类ccr5受体抑制剂的药物新用途 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ZA892407B (en) | 1988-03-31 | 1989-11-29 | Mitsubishi Chem Ind | 6-substituted acyclopyrimidine nucleoside derivative and antiviral agent containing the same as active ingredient thereof |
| US5686428A (en) * | 1989-04-07 | 1997-11-11 | Aktiebolaget Astra | Pharmaceutical composition |
| HU205917B (en) * | 1989-09-29 | 1992-07-28 | Mitsubishi Chem Ind | Process for producing 6-substituted pyrimidine derivatives and antiviral pharmaceutical compositions containing them as active components |
| US5503978A (en) * | 1990-06-11 | 1996-04-02 | University Research Corporation | Method for identification of high affinity DNA ligands of HIV-1 reverse transcriptase |
| US5593993A (en) * | 1991-08-02 | 1997-01-14 | Medivir Ab | Method for inhibition of HIV related viruses |
| IL102548A (en) * | 1991-08-02 | 1998-08-16 | Medivir Ab | Use of painting derivatives in the preparation of drugs for VIH inhibition and treatment of SDIA and new compounds |
| JPH0725770A (ja) * | 1993-07-09 | 1995-01-27 | Mitsubishi Chem Corp | 経皮吸収性抗ウイルス剤 |
| DE69414708T2 (de) * | 1993-08-24 | 1999-04-15 | Medivir Ab | Verbindungen und methoden zur inhibition von hiv und verwandten viren |
| US5998411A (en) * | 1998-03-17 | 1999-12-07 | Hughes Institute | Heterocyclic nonnucleoside inhibitors of reverse transcriptase |
| IT1305313B1 (it) * | 1998-07-17 | 2001-05-04 | Colla Paolo | 3,4 - diidro- 6- benzil-4-oxopirimidine sostituite e relativo processodi produzione e impiego nella terapia delle infezioni da hiv-1. |
| US6136335A (en) * | 1998-12-31 | 2000-10-24 | Hughes Institute | Phenethyl-5-bromopyridylthiourea (PBT) and dihydroalkoxybenzyloxopyrimidine (DABO) derivatives exhibiting spermicidal activity |
-
1998
- 1998-12-31 US US09/224,677 patent/US6136335A/en not_active Expired - Fee Related
-
1999
- 1999-12-29 IL IL14350899A patent/IL143508A0/xx unknown
- 1999-12-29 HU HU0104904A patent/HUP0104904A2/hu unknown
- 1999-12-29 EP EP04030236A patent/EP1557197A1/en not_active Withdrawn
- 1999-12-29 KR KR1020017008222A patent/KR20010082772A/ko not_active Application Discontinuation
- 1999-12-29 WO PCT/US1999/031160 patent/WO2000039095A2/en active IP Right Grant
- 1999-12-29 CN CN99815250A patent/CN1371367A/zh active Pending
- 1999-12-29 AU AU23968/00A patent/AU2396800A/en not_active Abandoned
- 1999-12-29 JP JP2000591006A patent/JP2002533444A/ja not_active Withdrawn
- 1999-12-29 CA CA002362492A patent/CA2362492A1/en not_active Abandoned
- 1999-12-29 BR BR9916620-8A patent/BR9916620A/pt not_active Application Discontinuation
- 1999-12-29 DE DE69927710T patent/DE69927710T2/de not_active Expired - Fee Related
- 1999-12-29 EP EP99967737A patent/EP1140848B1/en not_active Expired - Lifetime
- 1999-12-29 AT AT99967737T patent/ATE306475T1/de not_active IP Right Cessation
- 1999-12-29 MX MXPA01006746A patent/MXPA01006746A/es unknown
-
2000
- 2000-03-20 US US09/533,267 patent/US6376504B1/en not_active Expired - Fee Related
-
2001
- 2001-06-07 NO NO20012817A patent/NO20012817L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| EP1140848A2 (en) | 2001-10-10 |
| ATE306475T1 (de) | 2005-10-15 |
| DE69927710D1 (de) | 2006-02-23 |
| NO20012817L (no) | 2001-08-29 |
| CN1371367A (zh) | 2002-09-25 |
| CA2362492A1 (en) | 2000-07-06 |
| US6136335A (en) | 2000-10-24 |
| KR20010082772A (ko) | 2001-08-30 |
| EP1140848B1 (en) | 2005-10-12 |
| BR9916620A (pt) | 2001-09-25 |
| DE69927710T2 (de) | 2006-07-20 |
| JP2002533444A (ja) | 2002-10-08 |
| MXPA01006746A (es) | 2002-04-24 |
| WO2000039095B1 (en) | 2001-06-21 |
| EP1557197A1 (en) | 2005-07-27 |
| WO2000039095A2 (en) | 2000-07-06 |
| WO2000039095A3 (en) | 2000-11-09 |
| AU2396800A (en) | 2000-07-31 |
| HUP0104904A2 (hu) | 2002-04-29 |
| NO20012817D0 (no) | 2001-06-07 |
| US6376504B1 (en) | 2002-04-23 |
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