IL140440A0 - Polyketides and ther synthesis - Google Patents

Polyketides and ther synthesis

Info

Publication number
IL140440A0
IL140440A0 IL14044099A IL14044099A IL140440A0 IL 140440 A0 IL140440 A0 IL 140440A0 IL 14044099 A IL14044099 A IL 14044099A IL 14044099 A IL14044099 A IL 14044099A IL 140440 A0 IL140440 A0 IL 140440A0
Authority
IL
Israel
Prior art keywords
pks
domain
loading
substituted
acyl
Prior art date
Application number
IL14044099A
Other languages
English (en)
Original Assignee
Biotica Tech Ltd
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biotica Tech Ltd, Pfizer filed Critical Biotica Tech Ltd
Publication of IL140440A0 publication Critical patent/IL140440A0/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1025—Acyltransferases (2.3)
    • C12N9/1029—Acyltransferases (2.3) transferring groups other than amino-acyl groups (2.3.1)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D313/00—Heterocyclic compounds containing rings of more than six members having one oxygen atom as the only ring hetero atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52—Genes encoding for enzymes or proenzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/02—Oxygen as only ring hetero atoms
    • C12P17/06—Oxygen as only ring hetero atoms containing a six-membered hetero ring, e.g. fluorescein
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/44—Preparation of O-glycosides, e.g. glucosides
    • C12P19/60—Preparation of O-glycosides, e.g. glucosides having an oxygen of the saccharide radical directly bound to a non-saccharide heterocyclic ring or a condensed ring system containing a non-saccharide heterocyclic ring, e.g. coumermycin, novobiocin
    • C12P19/62—Preparation of O-glycosides, e.g. glucosides having an oxygen of the saccharide radical directly bound to a non-saccharide heterocyclic ring or a condensed ring system containing a non-saccharide heterocyclic ring, e.g. coumermycin, novobiocin the hetero ring having eight or more ring members and only oxygen as ring hetero atoms, e.g. erythromycin, spiramycin, nystatin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Plant Pathology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Veterinary Medicine (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
  • Polymers With Sulfur, Phosphorus Or Metals In The Main Chain (AREA)
  • Polyesters Or Polycarbonates (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Polyoxymethylene Polymers And Polymers With Carbon-To-Carbon Bonds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Catalysts (AREA)
IL14044099A 1998-06-29 1999-06-29 Polyketides and ther synthesis IL140440A0 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB9814006.4A GB9814006D0 (en) 1998-06-29 1998-06-29 Polyketides and their synthesis
PCT/GB1999/002042 WO2000000500A2 (en) 1998-06-29 1999-06-29 Polyketides and their synthesis

Publications (1)

Publication Number Publication Date
IL140440A0 true IL140440A0 (en) 2002-02-10

Family

ID=10834580

Family Applications (2)

Application Number Title Priority Date Filing Date
IL14044099A IL140440A0 (en) 1998-06-29 1999-06-29 Polyketides and ther synthesis
IL14043899A IL140438A0 (en) 1998-06-29 1999-06-29 Polyketides and their synthesis

Family Applications After (1)

Application Number Title Priority Date Filing Date
IL14043899A IL140438A0 (en) 1998-06-29 1999-06-29 Polyketides and their synthesis

Country Status (22)

Country Link
US (3) US7148045B1 (cs)
EP (2) EP1091971B1 (cs)
JP (2) JP2002519014A (cs)
KR (2) KR20010071683A (cs)
CN (2) CN1315956A (cs)
AT (2) ATE461289T1 (cs)
AU (2) AU763230B2 (cs)
BR (2) BR9911710A (cs)
CA (2) CA2331764C (cs)
CZ (2) CZ20004913A3 (cs)
DE (2) DE69930510T2 (cs)
ES (1) ES2341403T3 (cs)
GB (1) GB9814006D0 (cs)
HU (2) HUP0105179A2 (cs)
ID (2) ID28285A (cs)
IL (2) IL140440A0 (cs)
MX (2) MXPA00012885A (cs)
NZ (2) NZ509600A (cs)
PL (2) PL345578A1 (cs)
TR (2) TR200003770T2 (cs)
WO (2) WO2000000618A2 (cs)
YU (2) YU82500A (cs)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7630006B2 (en) * 1997-10-09 2009-12-08 Fotonation Ireland Limited Detecting red eye filter and apparatus using meta-data
US7738015B2 (en) * 1997-10-09 2010-06-15 Fotonation Vision Limited Red-eye filter method and apparatus
GB9814622D0 (en) * 1998-07-06 1998-09-02 Biotica Tech Ltd Polyketides,their preparation,and materials for use therein
US6458771B1 (en) 1999-04-16 2002-10-01 Ortho-Mcneil Pharmaceutical, Inc. Ketolide antibacterials
US6590083B1 (en) 1999-04-16 2003-07-08 Ortho-Mcneil Pharmaceutical, Inc. Ketolide antibacterials
GB9912563D0 (en) * 1999-05-28 1999-07-28 Biotica Tech Ltd Polyketides and their synthesis
US7033818B2 (en) 1999-10-08 2006-04-25 Kosan Biosciences, Inc. Recombinant polyketide synthase genes
US6524841B1 (en) 1999-10-08 2003-02-25 Kosan Biosciences, Inc. Recombinant megalomicin biosynthetic genes and uses thereof
DE60140936D1 (de) 2000-04-13 2010-02-11 Biotica Tech Ltd Glycosylierte hybrid-verbindungen, deren herstellung und verwendung
EP1492404B1 (en) 2002-02-19 2011-12-28 Dow AgroSciences LLC Novel spinosyn-producing polyketide synthases
PT1589031E (pt) 2002-07-16 2007-11-28 Biotica Tech Ltd Produção de policétidos e outros produtos naturais
GB0327721D0 (en) * 2003-11-28 2003-12-31 Biotica Tech Ltd Polyketides and their synthesis
GB0327720D0 (en) * 2003-11-28 2003-12-31 Biotica Tech Ltd Erythromycins and process for their preparation
GB0417852D0 (en) 2004-08-11 2004-09-15 Biotica Tech Ltd Production of polyketides and other natural products
JP2011516045A (ja) * 2008-03-28 2011-05-26 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア ポリケチドシンターゼを使用するジカルボン酸の生成法
WO2009134899A2 (en) * 2008-04-29 2009-11-05 The Regents Of The University Of California Producing biofuels using polyketide synthases
GB0904540D0 (en) 2009-03-17 2009-04-29 Biotica Tech Ltd Novel compounds and methods for their production
US8765431B2 (en) * 2009-07-23 2014-07-01 The Regents Of The University Of Michigan Method for enzymatic production of decarboxylated polyketides and fatty acids
EP2456777A2 (en) 2009-07-24 2012-05-30 Université Henri Poincaré - Nancy 1 Stambomycin and derivatives, their production and their use as drugs
GB0914589D0 (en) 2009-08-20 2009-09-30 Biotica Tech Ltd Novel compounds and methods for their production
US8852902B2 (en) 2010-11-22 2014-10-07 The Regents Of The University Of California Producing a trimethylpentanoic acid using hybrid polyketide synthases
CA2908575C (en) 2013-04-04 2021-11-16 President And Fellows Of Harvard College Macrolides and methods of their preparation and use
HK1242920A1 (zh) 2014-10-08 2018-07-06 哈佛大学的校长及成员们 14-元酮内酯及其制备和使用方法
JP2018509452A (ja) 2015-03-25 2018-04-05 プレジデント アンド フェローズ オブ ハーバード カレッジ 修飾デソサミン糖をもつマクロライドおよびその使用
CN106591388A (zh) * 2016-10-13 2017-04-26 中国农业科学院生物技术研究所 具有聚酮类化合物合成功能的基因Dr2091
EP3585795B1 (en) 2017-02-22 2021-06-09 ISR Immune System Regulation Holding AB (publ) Novel immune stimulating macrolides
AU2018226340C1 (en) 2017-02-22 2022-04-21 ISR Immune System Regulation Holding AB (publ) Novel immune stimulating macrolides
CA3064619A1 (en) 2017-06-06 2018-12-13 Zymergen Inc. A high-throughput (htp) genomic engineering platform for improving saccharopolyspora spinosa
CN112188893A (zh) 2018-03-23 2021-01-05 Isr免疫系统调节控股公共有限公司 大环内酯化合物和免疫检查点抑制剂的组合

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5141926A (en) * 1990-04-18 1992-08-25 Abbott Laboratories Erythromycin derivatives
AU678058B2 (en) * 1993-09-20 1997-05-15 John Innes Centre Recombinant production of novel polyketides
US5712146A (en) * 1993-09-20 1998-01-27 The Leland Stanford Junior University Recombinant combinatorial genetic library for the production of novel polyketides
US5672491A (en) * 1993-09-20 1997-09-30 The Leland Stanford Junior University Recombinant production of novel polyketides
AU706445B2 (en) * 1995-07-06 1999-06-17 Brown University Research Foundation Cell-free synthesis of polyketides
CA2259420C (en) * 1996-07-05 2007-09-18 Biotica Technology Limited Erythromycins and process for their preparation
JPH10303641A (ja) * 1997-04-23 1998-11-13 Mitsubishi Electric Corp 発振器及び無線機
NZ500693A (en) * 1997-04-30 2004-01-30 Kosan Biosciences Inc Combinatorial polyketide libraries produced using a modular PKS gene cluster as scaffold
AP1060A (en) * 1998-01-02 2002-04-23 Pfizer Prod Inc Novel erythromycin derivatives.

Also Published As

Publication number Publication date
CA2331764A1 (en) 2000-01-06
BR9911712A (pt) 2001-03-20
JP2002519032A (ja) 2002-07-02
DE69930510T2 (de) 2006-12-07
ES2341403T3 (es) 2010-06-18
ID28285A (id) 2001-05-10
NZ509600A (en) 2004-03-26
AU4524599A (en) 2000-01-17
CZ20004913A3 (cs) 2001-11-14
US20050090461A1 (en) 2005-04-28
ATE321137T1 (de) 2006-04-15
KR20010071684A (ko) 2001-07-31
ID27419A (id) 2001-04-05
MXPA00012885A (es) 2002-07-02
AU763230B2 (en) 2003-07-17
US7198922B2 (en) 2007-04-03
JP2002519014A (ja) 2002-07-02
HUP0105179A2 (hu) 2002-05-29
TR200003771T2 (tr) 2001-10-22
ATE461289T1 (de) 2010-04-15
EP1091971A2 (en) 2001-04-18
CA2331764C (en) 2008-03-11
WO2000000500A3 (en) 2000-03-16
PL345575A1 (en) 2001-12-17
US20060240528A1 (en) 2006-10-26
KR20010071683A (ko) 2001-07-31
WO2000000618A3 (en) 2000-04-27
AU765257B2 (en) 2003-09-11
TR200003770T2 (tr) 2001-04-20
WO2000000500A2 (en) 2000-01-06
DE69930510D1 (de) 2006-05-11
YU82700A (sh) 2003-10-31
YU82500A (sh) 2004-03-12
JP4489947B2 (ja) 2010-06-23
GB9814006D0 (en) 1998-08-26
EP1091971B1 (en) 2010-03-17
NZ509601A (en) 2004-04-30
HK1034536A1 (en) 2001-10-26
EP1090123B1 (en) 2006-03-22
PL345578A1 (en) 2001-12-17
CN1316001A (zh) 2001-10-03
US7148045B1 (en) 2006-12-12
WO2000000618A2 (en) 2000-01-06
EP1090123A2 (en) 2001-04-11
CA2335523A1 (en) 2000-01-06
IL140438A0 (en) 2002-02-10
CN1315956A (zh) 2001-10-03
AU4524799A (en) 2000-01-17
MXPA00012936A (es) 2002-06-21
CZ20004912A3 (cs) 2001-08-15
BR9911710A (pt) 2001-03-20
DE69942149D1 (en) 2010-04-29
HUP0102945A2 (hu) 2001-12-28

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