IL136558A0 - Heterocyclic cytotoxic agents - Google Patents

Heterocyclic cytotoxic agents

Info

Publication number
IL136558A0
IL136558A0 IL13655898A IL13655898A IL136558A0 IL 136558 A0 IL136558 A0 IL 136558A0 IL 13655898 A IL13655898 A IL 13655898A IL 13655898 A IL13655898 A IL 13655898A IL 136558 A0 IL136558 A0 IL 136558A0
Authority
IL
Israel
Prior art keywords
heterocyclic
cytotoxic agents
present
substituents
atoms
Prior art date
Application number
IL13655898A
Other languages
English (en)
Original Assignee
Univ Rutgers
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Rutgers filed Critical Univ Rutgers
Publication of IL136558A0 publication Critical patent/IL136558A0/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/04—Ortho- or peri-condensed ring systems
    • C07D221/18—Ring systems of four or more rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
IL13655898A 1997-12-12 1998-12-11 Heterocyclic cytotoxic agents IL136558A0 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/989,576 US6140328A (en) 1997-12-12 1997-12-12 Heterocyclic cytotoxic agents
PCT/US1998/026292 WO1999031067A1 (en) 1997-12-12 1998-12-11 Heterocyclic cytotoxic agents

Publications (1)

Publication Number Publication Date
IL136558A0 true IL136558A0 (en) 2001-06-14

Family

ID=25535240

Family Applications (1)

Application Number Title Priority Date Filing Date
IL13655898A IL136558A0 (en) 1997-12-12 1998-12-11 Heterocyclic cytotoxic agents

Country Status (12)

Country Link
US (2) US6140328A (zh)
EP (1) EP1042294B1 (zh)
JP (1) JP2002508359A (zh)
CN (1) CN1286685A (zh)
AT (1) ATE273281T1 (zh)
AU (1) AU748624B2 (zh)
CA (1) CA2313797A1 (zh)
CZ (1) CZ20002176A3 (zh)
DE (1) DE69825626D1 (zh)
IL (1) IL136558A0 (zh)
PL (1) PL341050A1 (zh)
WO (1) WO1999031067A1 (zh)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6140328A (en) * 1997-12-12 2000-10-31 Rutgers, The State University Of New Jersey Heterocyclic cytotoxic agents
US6833373B1 (en) 1998-12-23 2004-12-21 G.D. Searle & Co. Method of using an integrin antagonist and one or more antineoplastic agents as a combination therapy in the treatment of neoplasia
US6740650B2 (en) * 1999-10-29 2004-05-25 Rutgers, The State University Of New Jersey Heterocyclic cytotoxic agents
SI1465625T1 (sl) 2001-11-14 2010-06-30 Univ Rutgers Solubilizirani topoizomerazni strupi
AU2002364953A1 (en) * 2001-11-14 2003-06-17 Edmond J. Lavoie Topoisomerase poison agents
ATE424200T1 (de) * 2001-11-14 2009-03-15 Univ Rutgers Solubilisierte topoisomerase-gift-mittel
EP1453812B1 (en) 2001-11-14 2008-08-20 Rutgers, The State University Cytotoxic agents
US6992088B2 (en) * 2002-08-09 2006-01-31 Rutgers, The State University Of New Jersey Nitro and amino substituted heterocycles as topoisomerase I targeting agents
US6989387B2 (en) * 2002-08-09 2006-01-24 Rutgers, The State University Of New Jersey Nitro and amino substituted topoisomerase agents
WO2004014906A2 (en) * 2002-08-09 2004-02-19 Rutgers, The State University Nitro and amino substituted dibenzonaphthyridines as topoisomerase agents
AU2003290818A1 (en) * 2002-11-12 2004-06-03 Edmond J. Lavoie Topoisomerase-targeting agents
PT3424932T (pt) 2005-02-16 2021-05-19 Anacor Pharmaceuticals Inc Boronoftalidas para utilização terapêutica
US7767657B2 (en) 2005-02-16 2010-08-03 Anacor Pharmaceuticals, Inc. Boron-containing small molecules
MX335993B (es) * 2005-12-30 2016-01-07 Anacor Pharmaceuticals Inc Moleculas pequeñas que contienen boro.
TW201038578A (en) 2009-01-30 2010-11-01 Univ Rutgers Methods to treat cancer
JP5773888B2 (ja) * 2009-03-06 2015-09-02 ラットガーズ，ザ・ステート・ユニバーシティ・オブ・ニュージャージー 癌治療に用いられるメチレンジオキシベンゾ［ｉ］フェナントリジン誘導体
WO2010127363A1 (en) 2009-05-01 2010-11-04 Rutgers, The State University Of New Jersey Toposiomerase inhibitors
CA3019945A1 (en) 2016-04-04 2017-10-12 Rutgers, The State University Of New Jersey Topoisomerase poisons

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
USRE26065E (en) 1966-07-19 Folybenzimidazoles and their preparation
US26065A (en) * 1859-11-08 Improvement in cotton-gins
US2985661A (en) * 1956-02-06 1961-05-23 American Cyanamid Co Preparation of 2(omicron-aminophenyl)-benzimidazole
CH420045A (de) * 1964-09-01 1967-03-15 Ciba Geigy Verwendung von neuen Poly-azolen als optische Aufhellmittel für textile organische Materialien
DE1670684A1 (de) * 1966-04-01 1970-12-03 Hoechst Ag Verfahren zur Herstellung von basisch substituierten Bis-benzimidazol-derivaten
US3912740A (en) * 1974-02-28 1975-10-14 Us Health Method for the preparation of oxygenated benzo{8 c{9 phenanthridine compounds
PT73763B (fr) * 1981-10-01 1983-10-26 Quatrum Empresa Nacional De Qu Procede pour la preparation de nouveaux epoxides d'alkaloides benzofenantridiniques et de compositions pharmaceutiques qui les contiennent
US4761417A (en) 1982-05-14 1988-08-02 Maroko Peter R Compounds, compositions and method of treatments for improving circulatory performance
US4749708A (en) 1982-05-14 1988-06-07 Maroko Peter R Composition for improving circulatory performance
US5153178A (en) 1982-05-14 1992-10-06 Maroko Peter R Compositions and method of treatment for improving circulatory performance
US5244903A (en) * 1987-03-31 1993-09-14 Research Triangle Institute Camptothecin analogs as potent inhibitors of topoisomerase I
JP2700475B2 (ja) * 1988-07-30 1998-01-21 コニカ株式会社 非線形光学材料および非線形光学素子
US4938949A (en) * 1988-09-12 1990-07-03 University Of New York Treatment of damaged bone marrow and dosage units therefor
US5106863A (en) * 1990-03-26 1992-04-21 Ortho Pharmaceutical Corporation Substituted imidazole and pyridine derivatives
US5126351A (en) * 1991-01-24 1992-06-30 Glaxo Inc. Antitumor compounds
US5223506A (en) * 1991-06-04 1993-06-29 Glaxo Inc. Cyclic antitumor compounds
ES2161442T3 (es) * 1996-02-12 2001-12-01 Univ Rutgers Analogos de coralina como inhibidores de topoisomerasa.
US6140328A (en) * 1997-12-12 2000-10-31 Rutgers, The State University Of New Jersey Heterocyclic cytotoxic agents

Also Published As

Publication number Publication date
PL341050A1 (en) 2001-03-26
AU748624B2 (en) 2002-06-06
JP2002508359A (ja) 2002-03-19
ATE273281T1 (de) 2004-08-15
US6486167B1 (en) 2002-11-26
EP1042294B1 (en) 2004-08-11
EP1042294A1 (en) 2000-10-11
US6140328A (en) 2000-10-31
CZ20002176A3 (cs) 2001-11-14
CA2313797A1 (en) 1999-06-24
DE69825626D1 (de) 2004-09-16
AU1909199A (en) 1999-07-05
CN1286685A (zh) 2001-03-07
WO1999031067A1 (en) 1999-06-24

Similar Documents

Publication Publication Date Title
IL136558A0 (en) Heterocyclic cytotoxic agents
BG103417A (en) Condensed pyrimidine bicyclic derivatives
GB9508195D0 (en) Novel biologically active compounds and compositions,their use and derivation
ZA200007222B (en) Glycopeptide derivatives and pharmaceutical compositions containing the same.
UY25679A1 (es) Derivados de quinolin-2-ona inhibidores de la farnesil proteína transferasa útiles como agentes contra el cáncer
TR199901765T2 (xx) S�lfomid-metalloproteaz inhibit�rleri
MX9702382A (es) Nuevos derivados de pirimidona con actividad antifungica.
DE69809754D1 (en) Substituierte 6-phenylphenanthridine
PL358281A1 (en) Novel compounds
AU2002319814A1 (en) Substituted 1h-dihydropyrazoles, their preparation and use
JO1971B1 (en) Nineteen derivatives of the ur-norifenin compound
BG103947A (en) Derivatives of 9-oxymerythromycin
EP1140900A4 (en) PYRAZOLE COMPOUNDS AND USE OF SUCH COMPOUNDS
IL151201A0 (en) Alkylated imidazopyridine derivatives and pharmaceutical compositions containing the same
IL137964A0 (en) Antitumor agents
AP2001002191A0 (en) 3,3- Biarylpiperine and 2,2-biarylmorpholine derivatives.
IL136359A0 (en) Dihydrobenzofuran derivatives and pharmaceutical compositions containing the same
SE0203070D0 (en) Novel compounds
BG104717A (en) Water soluble azoles as broad-spectrum antifungals
IL151198A0 (en) Tricyclic imidazopyridine derivatives and pharmaceutical compositions containing the same
MX9709451A (es) Derivados de benzisoxazol e indazol como agentes antipsicoticos.
MXPA04001773A (es) Derivados de 6,7-dihidroxitetrahidroisquinolinas 3-sustituidas parta uso como agentes antibacterianos.
YU46302A (sh) Supstituisani piroli
MY133140A (en) N-substituted azabicycloheptane derivatives, their preparation and use
BG106093A (en) 14beta-h-sterols, pharmaceutical compositions comprising them and the use of these derivatives for the preparation of meiosis regulating medicaments