IL136558A0 - Heterocyclic cytotoxic agents - Google Patents
Heterocyclic cytotoxic agentsInfo
- Publication number
- IL136558A0 IL136558A0 IL13655898A IL13655898A IL136558A0 IL 136558 A0 IL136558 A0 IL 136558A0 IL 13655898 A IL13655898 A IL 13655898A IL 13655898 A IL13655898 A IL 13655898A IL 136558 A0 IL136558 A0 IL 136558A0
- Authority
- IL
- Israel
- Prior art keywords
- heterocyclic
- cytotoxic agents
- present
- substituents
- atoms
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
- C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
- C07D221/04—Ortho- or peri-condensed ring systems
- C07D221/18—Ring systems of four or more rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/989,576 US6140328A (en) | 1997-12-12 | 1997-12-12 | Heterocyclic cytotoxic agents |
PCT/US1998/026292 WO1999031067A1 (en) | 1997-12-12 | 1998-12-11 | Heterocyclic cytotoxic agents |
Publications (1)
Publication Number | Publication Date |
---|---|
IL136558A0 true IL136558A0 (en) | 2001-06-14 |
Family
ID=25535240
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IL13655898A IL136558A0 (en) | 1997-12-12 | 1998-12-11 | Heterocyclic cytotoxic agents |
Country Status (12)
Country | Link |
---|---|
US (2) | US6140328A (xx) |
EP (1) | EP1042294B1 (xx) |
JP (1) | JP2002508359A (xx) |
CN (1) | CN1286685A (xx) |
AT (1) | ATE273281T1 (xx) |
AU (1) | AU748624B2 (xx) |
CA (1) | CA2313797A1 (xx) |
CZ (1) | CZ20002176A3 (xx) |
DE (1) | DE69825626D1 (xx) |
IL (1) | IL136558A0 (xx) |
PL (1) | PL341050A1 (xx) |
WO (1) | WO1999031067A1 (xx) |
Families Citing this family (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6140328A (en) * | 1997-12-12 | 2000-10-31 | Rutgers, The State University Of New Jersey | Heterocyclic cytotoxic agents |
US6833373B1 (en) | 1998-12-23 | 2004-12-21 | G.D. Searle & Co. | Method of using an integrin antagonist and one or more antineoplastic agents as a combination therapy in the treatment of neoplasia |
US6740650B2 (en) * | 1999-10-29 | 2004-05-25 | Rutgers, The State University Of New Jersey | Heterocyclic cytotoxic agents |
ATE405568T1 (de) * | 2001-11-14 | 2008-09-15 | Univ Rutgers | Cytotoxische mittel |
DE60225943T2 (de) * | 2001-11-14 | 2009-01-29 | Rutgers, The State University | Topoisomerase-giftmittel |
EP1453507B1 (en) * | 2001-11-14 | 2009-03-04 | Rutgers, The State University | Solubilized topoisomerase poison agents |
CA2467774C (en) * | 2001-11-14 | 2011-09-20 | Rutgers, The State University | Solubilized topoisomerase poisons |
WO2004014906A2 (en) * | 2002-08-09 | 2004-02-19 | Rutgers, The State University | Nitro and amino substituted dibenzonaphthyridines as topoisomerase agents |
WO2004014862A1 (en) * | 2002-08-09 | 2004-02-19 | Rutgers, The State University | Nitro and amino substituted heterocycles as topoisomerase i targeting agents |
AU2003265406A1 (en) * | 2002-08-09 | 2004-02-25 | Edmond J. Lavoie | Nitro and amino substituted topoisomerase agents |
JP4774212B2 (ja) | 2002-11-12 | 2011-09-14 | ラトガーズ、ザ・ステイト・ユニバーシテイ・オブ・ニユー・ジヤージー | トポイソメラーゼ−ターゲッティング剤 |
ES2540966T3 (es) | 2005-02-16 | 2015-07-15 | Anacor Pharmaceuticals, Inc. | Compuestos biocidas de boronoftalida |
CN102532180B (zh) * | 2005-12-30 | 2016-06-29 | 安纳考尔医药公司 | 含硼的小分子 |
BRPI0621279B1 (pt) | 2005-12-30 | 2021-07-20 | Anacor Pharmaceuticals, Inc | Moléculas pequenas contendo boro |
TW201038578A (en) | 2009-01-30 | 2010-11-01 | Univ Rutgers | Methods to treat cancer |
JP5773888B2 (ja) | 2009-03-06 | 2015-09-02 | ラットガーズ,ザ・ステート・ユニバーシティ・オブ・ニュージャージー | 癌治療に用いられるメチレンジオキシベンゾ[i]フェナントリジン誘導体 |
WO2010127363A1 (en) | 2009-05-01 | 2010-11-04 | Rutgers, The State University Of New Jersey | Toposiomerase inhibitors |
CA3019945A1 (en) | 2016-04-04 | 2017-10-12 | Rutgers, The State University Of New Jersey | Topoisomerase poisons |
Family Cites Families (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US26065A (en) * | 1859-11-08 | Improvement in cotton-gins | ||
USRE26065E (en) | 1966-07-19 | Folybenzimidazoles and their preparation | ||
US2985661A (en) * | 1956-02-06 | 1961-05-23 | American Cyanamid Co | Preparation of 2(omicron-aminophenyl)-benzimidazole |
CH420044A (de) * | 1964-09-01 | 1967-03-15 | Ciba Geigy | Verwendung von neuen Azol-Derivaten als optische Aufheller für textile organische Materialien |
DE1670684A1 (de) * | 1966-04-01 | 1970-12-03 | Hoechst Ag | Verfahren zur Herstellung von basisch substituierten Bis-benzimidazol-derivaten |
US3912740A (en) * | 1974-02-28 | 1975-10-14 | Us Health | Method for the preparation of oxygenated benzo{8 c{9 phenanthridine compounds |
PT73763B (fr) * | 1981-10-01 | 1983-10-26 | Quatrum Empresa Nacional De Qu | Procede pour la preparation de nouveaux epoxides d'alkaloides benzofenantridiniques et de compositions pharmaceutiques qui les contiennent |
US5153178A (en) | 1982-05-14 | 1992-10-06 | Maroko Peter R | Compositions and method of treatment for improving circulatory performance |
US4761417A (en) | 1982-05-14 | 1988-08-02 | Maroko Peter R | Compounds, compositions and method of treatments for improving circulatory performance |
US4749708A (en) | 1982-05-14 | 1988-06-07 | Maroko Peter R | Composition for improving circulatory performance |
US5244903A (en) * | 1987-03-31 | 1993-09-14 | Research Triangle Institute | Camptothecin analogs as potent inhibitors of topoisomerase I |
JP2700475B2 (ja) * | 1988-07-30 | 1998-01-21 | コニカ株式会社 | 非線形光学材料および非線形光学素子 |
US4938949A (en) * | 1988-09-12 | 1990-07-03 | University Of New York | Treatment of damaged bone marrow and dosage units therefor |
US5106863A (en) * | 1990-03-26 | 1992-04-21 | Ortho Pharmaceutical Corporation | Substituted imidazole and pyridine derivatives |
US5126351A (en) * | 1991-01-24 | 1992-06-30 | Glaxo Inc. | Antitumor compounds |
US5223506A (en) * | 1991-06-04 | 1993-06-29 | Glaxo Inc. | Cyclic antitumor compounds |
BR9707425A (pt) * | 1996-02-12 | 1999-07-20 | Univ Rutgers | Composto processo terapêutico para inibir o crescimento de células cancerosas e processo para utilizar o composto |
US6140328A (en) * | 1997-12-12 | 2000-10-31 | Rutgers, The State University Of New Jersey | Heterocyclic cytotoxic agents |
-
1997
- 1997-12-12 US US08/989,576 patent/US6140328A/en not_active Expired - Lifetime
-
1998
- 1998-12-11 CN CN98813518A patent/CN1286685A/zh active Pending
- 1998-12-11 IL IL13655898A patent/IL136558A0/xx unknown
- 1998-12-11 AU AU19091/99A patent/AU748624B2/en not_active Ceased
- 1998-12-11 PL PL98341050A patent/PL341050A1/xx unknown
- 1998-12-11 JP JP2000538994A patent/JP2002508359A/ja active Pending
- 1998-12-11 WO PCT/US1998/026292 patent/WO1999031067A1/en active IP Right Grant
- 1998-12-11 AT AT98963852T patent/ATE273281T1/de not_active IP Right Cessation
- 1998-12-11 DE DE69825626T patent/DE69825626D1/de not_active Expired - Lifetime
- 1998-12-11 US US09/581,365 patent/US6486167B1/en not_active Expired - Fee Related
- 1998-12-11 EP EP98963852A patent/EP1042294B1/en not_active Expired - Lifetime
- 1998-12-11 CA CA002313797A patent/CA2313797A1/en not_active Abandoned
- 1998-12-11 CZ CZ20002176A patent/CZ20002176A3/cs unknown
Also Published As
Publication number | Publication date |
---|---|
CZ20002176A3 (cs) | 2001-11-14 |
US6140328A (en) | 2000-10-31 |
US6486167B1 (en) | 2002-11-26 |
AU748624B2 (en) | 2002-06-06 |
JP2002508359A (ja) | 2002-03-19 |
EP1042294A1 (en) | 2000-10-11 |
DE69825626D1 (de) | 2004-09-16 |
ATE273281T1 (de) | 2004-08-15 |
CA2313797A1 (en) | 1999-06-24 |
WO1999031067A1 (en) | 1999-06-24 |
AU1909199A (en) | 1999-07-05 |
PL341050A1 (en) | 2001-03-26 |
EP1042294B1 (en) | 2004-08-11 |
CN1286685A (zh) | 2001-03-07 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
IL136558A0 (en) | Heterocyclic cytotoxic agents | |
BG103417A (en) | Condensed pyrimidine bicyclic derivatives | |
GB9508195D0 (en) | Novel biologically active compounds and compositions,their use and derivation | |
HK1040721A1 (en) | Glycopeptide derivatives and pharmaceutical compositions containing the same | |
UY25679A1 (es) | Derivados de quinolin-2-ona inhibidores de la farnesil proteína transferasa útiles como agentes contra el cáncer | |
TR199901765T2 (xx) | S�lfomid-metalloproteaz inhibit�rleri | |
MX9702382A (es) | Nuevos derivados de pirimidona con actividad antifungica. | |
DE69809754D1 (en) | Substituierte 6-phenylphenanthridine | |
PL358281A1 (en) | Novel compounds | |
AU2002319814A1 (en) | Substituted 1h-dihydropyrazoles, their preparation and use | |
MY116845A (en) | New 19-nor-pregnene derivatives | |
BG103947A (en) | Derivatives of 9-oxymerythromycin | |
EP1140900A4 (en) | PYRAZOLE COMPOUNDS AND USE OF SUCH COMPOUNDS | |
IL151201A0 (en) | Alkylated imidazopyridine derivatives and pharmaceutical compositions containing the same | |
HK1033574A1 (en) | Anitumor agents | |
AP2001002191A0 (en) | 3,3- Biarylpiperine and 2,2-biarylmorpholine derivatives. | |
IL136359A0 (en) | Dihydrobenzofuran derivatives and pharmaceutical compositions containing the same | |
SE0203070D0 (en) | Novel compounds | |
BG104717A (en) | Water soluble azoles as broad-spectrum antifungals | |
IL151198A0 (en) | Tricyclic imidazopyridine derivatives and pharmaceutical compositions containing the same | |
MX9709451A (es) | Derivados de benzisoxazol e indazol como agentes antipsicoticos. | |
MXPA04001773A (es) | Derivados de 6,7-dihidroxitetrahidroisquinolinas 3-sustituidas parta uso como agentes antibacterianos. | |
YU46302A (sh) | Supstituisani piroli | |
MY133140A (en) | N-substituted azabicycloheptane derivatives, their preparation and use | |
BG106093A (en) | 14beta-h-sterols, pharmaceutical compositions comprising them and the use of these derivatives for the preparation of meiosis regulating medicaments |