IL136551A0 - Preparation of peg-grf conjugates - Google Patents

Preparation of peg-grf conjugates

Info

Publication number
IL136551A0
IL136551A0 IL13655198A IL13655198A IL136551A0 IL 136551 A0 IL136551 A0 IL 136551A0 IL 13655198 A IL13655198 A IL 13655198A IL 13655198 A IL13655198 A IL 13655198A IL 136551 A0 IL136551 A0 IL 136551A0
Authority
IL
Israel
Prior art keywords
grf
conjugates
peg
preparation
grf conjugates
Prior art date
Application number
IL13655198A
Other languages
English (en)
Original Assignee
Applied Research Systems
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Applied Research Systems filed Critical Applied Research Systems
Publication of IL136551A0 publication Critical patent/IL136551A0/xx

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/64Proteins; Peptides; Derivatives or degradation products thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
    • A61K47/60Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00Drugs for disorders of the endocrine system
    • A61P5/02Drugs for disorders of the endocrine system of the hypothalamic hormones, e.g. TRH, GnRH, CRH, GRH, somatostatin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00Drugs for disorders of the endocrine system
    • A61P5/06Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Endocrinology (AREA)
  • Diabetes (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Birds (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
IL13655198A 1997-12-03 1998-12-01 Preparation of peg-grf conjugates IL136551A0 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP97121264A EP0922446A1 (en) 1997-12-03 1997-12-03 Solution-phase site-specific preparation of GRF-PEG conjugates
PCT/EP1998/007748 WO1999027897A1 (en) 1997-12-03 1998-12-01 Site-specific preparation of polyethylene glycol-grf conjugates

Publications (1)

Publication Number Publication Date
IL136551A0 true IL136551A0 (en) 2001-06-14

Family

ID=8227732

Family Applications (2)

Application Number Title Priority Date Filing Date
IL13655198A IL136551A0 (en) 1997-12-03 1998-12-01 Preparation of peg-grf conjugates
IL136551A IL136551A (en) 1997-12-03 2000-06-04 Preparation of PEG-GRF-linked

Family Applications After (1)

Application Number Title Priority Date Filing Date
IL136551A IL136551A (en) 1997-12-03 2000-06-04 Preparation of PEG-GRF-linked

Country Status (30)

Country Link
US (3) US6528485B1 (zh)
EP (2) EP0922446A1 (zh)
JP (2) JP2001524505A (zh)
KR (1) KR100561768B1 (zh)
CN (1) CN1149967C (zh)
AR (1) AR017780A1 (zh)
AT (1) ATE236607T1 (zh)
AU (1) AU755285B2 (zh)
BG (1) BG64815B1 (zh)
BR (1) BR9815159A (zh)
CA (1) CA2312004C (zh)
DE (1) DE69813291T2 (zh)
DK (1) DK1037587T3 (zh)
EA (1) EA004269B1 (zh)
EE (1) EE200000319A (zh)
ES (1) ES2194376T3 (zh)
HK (1) HK1034203A1 (zh)
HU (1) HUP0100507A3 (zh)
IL (2) IL136551A0 (zh)
NO (1) NO327238B1 (zh)
NZ (1) NZ504570A (zh)
PL (1) PL192082B1 (zh)
PT (1) PT1037587E (zh)
SI (1) SI1037587T1 (zh)
SK (1) SK8242000A3 (zh)
TR (1) TR200001615T2 (zh)
TW (1) TWI254641B (zh)
UA (1) UA73716C2 (zh)
WO (1) WO1999027897A1 (zh)
ZA (1) ZA9811068B (zh)

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US20010055581A1 (en) 1994-03-18 2001-12-27 Lawrence Tamarkin Composition and method for delivery of biologically-active factors
US6407218B1 (en) * 1997-11-10 2002-06-18 Cytimmune Sciences, Inc. Method and compositions for enhancing immune response and for the production of in vitro mabs
US7229841B2 (en) * 2001-04-30 2007-06-12 Cytimmune Sciences, Inc. Colloidal metal compositions and methods
IL155177A0 (en) * 2000-10-05 2003-11-23 Ares Trading Sa Method for the preparation of grf-peg conjugate
EP1234583A1 (en) 2001-02-23 2002-08-28 F. Hoffmann-La Roche Ag PEG-conjugates of HGF-NK4
US20030171285A1 (en) * 2001-11-20 2003-09-11 Finn Rory F. Chemically-modified human growth hormone conjugates
ES2291613T3 (es) 2002-01-16 2008-03-01 Biocompatibles Uk Limited Conjugados de polimeros.
US7998705B2 (en) * 2002-08-06 2011-08-16 FUJIFILM Diosynth Biotechnologies U.S.A., Inc Increased dynamic binding capacity in ion exchange chromatography by addition of polyethylene glycol
KR20050071498A (ko) * 2002-09-18 2005-07-07 상트르 오스피딸리에 드 루니버시떼 드 몬트리알 성장 호르몬 방출 호르몬 유사체
GB0301014D0 (en) * 2003-01-16 2003-02-19 Biocompatibles Ltd Conjugation reactions
JP4339797B2 (ja) * 2003-01-18 2009-10-07 ペスフェア カンパニー リミテッド 非標的部位のアミンが保護されたペプチド、その製造方法、及びこれを利用したpegが特異的に接合されたペプチドの製造方法
US20050058658A1 (en) * 2003-07-15 2005-03-17 Barros Research Institute Compositions and methods for immunotherapy of human immunodeficiency virus (HIV)
EP1644408A1 (en) * 2003-07-15 2006-04-12 Barros Research Institute Eimeria tenella antigen for immunotherapy of coccidiosis
EP1694301A4 (en) * 2003-12-02 2009-11-18 Cytimmune Sciences Inc METHOD AND COMPOSITIONS FOR THE PRODUCTION OF MONOCLONAL ANTIBODIES
EP1715971A4 (en) * 2004-01-28 2010-10-13 Cytimmune Sciences Inc FUNCTIONALIZED COLLOIDAL METAL COMPOSITIONS AND METHODS
CN100355784C (zh) * 2004-02-12 2007-12-19 江苏恒瑞医药股份有限公司 聚乙二醇修饰α-干扰素1b的制备方法
US20050261475A1 (en) * 2004-02-13 2005-11-24 Harvard Medical School Solid-phase capture-release-tag methods for phosphoproteomic analyses
US6986264B1 (en) * 2004-07-15 2006-01-17 Carrier Corporation Economized dehumidification system
HUE050542T2 (hu) 2004-11-12 2020-12-28 Bayer Healthcare Llc FVIII helyspecifikus módosítása
WO2007016105A2 (en) * 2005-07-26 2007-02-08 Rhodia Inc. Polymers with pendant poly(alkyleneoxy) substituent groups and their use in personal care applications
US20070238656A1 (en) * 2006-04-10 2007-10-11 Eastman Kodak Company Functionalized poly(ethylene glycol)
US7632492B2 (en) 2006-05-02 2009-12-15 Allozyne, Inc. Modified human interferon-β polypeptides
US20080096819A1 (en) 2006-05-02 2008-04-24 Allozyne, Inc. Amino acid substituted molecules
CA2659990C (en) * 2006-08-04 2016-03-22 Prolong Pharmaceuticals, Inc. Polyethylene glycol erythropoietin conjugates
US20080083154A1 (en) * 2006-10-05 2008-04-10 Timothy M Gregory Bait retention fish hook
CA2707840A1 (en) 2007-08-20 2009-02-26 Allozyne, Inc. Amino acid substituted molecules
JP2011520769A (ja) * 2007-09-21 2011-07-21 サイトイミューン サイエンシズ インコーポレイテッド ナノ治療コロイド金属組成物および方法
US20110014118A1 (en) * 2007-09-21 2011-01-20 Lawrence Tamarkin Nanotherapeutic colloidal metal compositions and methods
US7960145B2 (en) * 2007-11-08 2011-06-14 Cytimmune Sciences, Inc. Compositions and methods for generating antibodies
CA2742710A1 (en) * 2008-11-04 2010-05-14 Janssen Pharmaceutica Nv Crhr2 peptide agonists and uses thereof
JP5759976B2 (ja) 2009-03-20 2015-08-05 ハンミ・サイエンス・カンパニー・リミテッド 位置特異的な生理活性ポリペプチド結合体の調製方法
WO2010121351A1 (en) * 2009-04-20 2010-10-28 Theratechnologies Inc. Use of (hexenoyl trans-3)hgrf(1-44)nh2 and ritonavir in combination therapy
EP2421548A4 (en) * 2009-04-20 2012-09-26 Theratechnologies Inc USE OF (HEXENOYL-TRANS-3) HGRF (L-44) NH2 AND SIMVASTATIN IN COMBINATION THERAPY
WO2011005540A1 (en) 2009-06-22 2011-01-13 Burnham Institute For Medical Research Methods and compositions using peptides and proteins with c-terminal elements
JP2013510167A (ja) * 2009-11-04 2013-03-21 ヤンセン ファーマシューティカ エヌ.ベー. ストレスコピン様ペプチドによる心不全の治療方法
WO2012118778A1 (en) 2011-02-28 2012-09-07 Sanford-Burnham Medical Research Institute Truncated car peptides and methods and compositions using truncated car peptides
KR20140027284A (ko) 2011-04-21 2014-03-06 쎄러테크놀로지스 인코포레이티드 성장 호르몬 방출 인자(grf) 유사체 및 이의 용도
CA2837588A1 (en) 2011-05-31 2012-12-06 Airware, Inc. Re-calibration of ab ndir gas sensors
US10179801B2 (en) 2011-08-26 2019-01-15 Sanford-Burnham Medical Research Institute Truncated LYP-1 peptides and methods and compositions using truncated LYP-1 peptides
WO2013190520A2 (en) 2012-06-22 2013-12-27 The General Hospital Corporation Gh-releasing agents in the treatment of vascular stenosis and associated conditions
US10064940B2 (en) 2013-12-11 2018-09-04 Siva Therapeutics Inc. Multifunctional radiation delivery apparatus and method
CA2986927C (en) 2015-05-28 2023-12-19 Institut National De La Recherche Scientifique Inhibitors of prototypic galectin dimerization and uses thereof
BR112018070929A2 (pt) * 2016-04-19 2019-02-26 Griffon Pharmaceuticals Inc. peptídeos bioativos peguilados e seu uso
CN110317826B (zh) * 2019-05-22 2020-11-10 中国农业大学 调控PvGRF9含量或活性的物质在调控植物茎生长发育中的应用
WO2021133407A1 (en) 2019-12-27 2021-07-01 Compagnie Generale Des Etablissements Michelin Rubber mix with high specific surface area and high structure acetylene carbon black
CN117440966A (zh) 2021-01-28 2024-01-23 塔勒姆治疗有限责任公司 抗SARS-CoV-2刺突糖蛋白抗体及其治疗用途
WO2024081918A1 (en) 2022-10-14 2024-04-18 Talem Therapeutics Llc Anti-trkb/cd3 antibodies and uses thereof

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US4563352A (en) * 1982-10-04 1986-01-07 The Salk Institute For Biological Studies Human pancreatic GRF
DE69026306T2 (de) * 1989-05-27 1996-10-17 Seikagaku Kogyo Co Ltd Verfahren für die Herstellung von Polyethylenglykolderivate und modifizierte Proteine.
WO1992000095A1 (en) * 1990-06-29 1992-01-09 Hoffmann-La Roche Inc. Histidine substituted growth hormone releasing factor analogs
JP3051145B2 (ja) * 1990-08-28 2000-06-12 住友製薬株式会社 新規なポリエチレングリコール誘導体修飾ペプチド
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EP0518295A3 (en) * 1991-06-14 1993-09-01 Millipore Corporation Allyl side chain protection in peptide synthesis
FR2687681B1 (fr) * 1992-02-20 1995-10-13 Transgene Sa Conjugues polyethyleneglycol-hirudine, leur procede de preparation et leur emploi pour le traitement des thromboses.
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Also Published As

Publication number Publication date
HK1034203A1 (en) 2001-10-19
ES2194376T3 (es) 2003-11-16
DE69813291T2 (de) 2003-11-13
EA200000601A1 (ru) 2000-12-25
ZA9811068B (en) 1999-06-28
KR100561768B1 (ko) 2006-03-16
WO1999027897A1 (en) 1999-06-10
WO1999027897A9 (en) 1999-09-30
US20050159353A1 (en) 2005-07-21
JP2010024245A (ja) 2010-02-04
US6528485B1 (en) 2003-03-04
DE69813291D1 (de) 2003-05-15
CA2312004C (en) 2009-05-19
PT1037587E (pt) 2003-08-29
AR017780A1 (es) 2001-10-24
BR9815159A (pt) 2000-10-10
SK8242000A3 (en) 2001-01-18
NO327238B1 (no) 2009-05-18
CN1149967C (zh) 2004-05-19
HUP0100507A2 (hu) 2001-08-28
CN1280483A (zh) 2001-01-17
US6869932B2 (en) 2005-03-22
JP2001524505A (ja) 2001-12-04
KR20010032494A (ko) 2001-04-25
NZ504570A (en) 2003-10-31
AU1563399A (en) 1999-06-16
EE200000319A (et) 2001-08-15
DK1037587T3 (da) 2003-07-28
BG64815B1 (bg) 2006-05-31
ATE236607T1 (de) 2003-04-15
EA004269B1 (ru) 2004-02-26
US20040029794A1 (en) 2004-02-12
NO20002664L (no) 2000-07-13
US7317002B2 (en) 2008-01-08
SI1037587T1 (en) 2003-08-31
BG104484A (en) 2000-12-29
JP5431874B2 (ja) 2014-03-05
UA73716C2 (en) 2005-09-15
PL341139A1 (en) 2001-03-26
HUP0100507A3 (en) 2001-11-28
IL136551A (en) 2008-12-29
PL192082B1 (pl) 2006-08-31
AU755285B2 (en) 2002-12-05
TR200001615T2 (tr) 2000-12-21
EP1037587A1 (en) 2000-09-27
CA2312004A1 (en) 1999-06-10
EP0922446A1 (en) 1999-06-16
NO20002664D0 (no) 2000-05-24
EP1037587B1 (en) 2003-04-09
TWI254641B (en) 2006-05-11

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