IL135584A - Use of dual, non-selective antagonists ß-adrenoreceptor and α1-adrenoreceptor in the preparation of a drug for the treatment of amyloid diseases - Google Patents
Use of dual, non-selective antagonists ß-adrenoreceptor and α1-adrenoreceptor in the preparation of a drug for the treatment of amyloid diseasesInfo
- Publication number
- IL135584A IL135584A IL13558498A IL13558498A IL135584A IL 135584 A IL135584 A IL 135584A IL 13558498 A IL13558498 A IL 13558498A IL 13558498 A IL13558498 A IL 13558498A IL 135584 A IL135584 A IL 135584A
- Authority
- IL
- Israel
- Prior art keywords
- carbon atoms
- hydrogen
- adrenoceptor
- lower alkyl
- selective
- Prior art date
Links
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- 229920001223 polyethylene glycol Polymers 0.000 description 1
- 239000001267 polyvinylpyrrolidone Substances 0.000 description 1
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 description 1
- 230000012846 protein folding Effects 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 230000011514 reflex Effects 0.000 description 1
- 230000002441 reversible effect Effects 0.000 description 1
- 210000002966 serum Anatomy 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 239000001632 sodium acetate Substances 0.000 description 1
- 235000017281 sodium acetate Nutrition 0.000 description 1
- 239000001509 sodium citrate Substances 0.000 description 1
- NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 description 1
- 239000008107 starch Substances 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
- 239000008117 stearic acid Substances 0.000 description 1
- 238000013268 sustained release Methods 0.000 description 1
- 239000012730 sustained-release form Substances 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 206010042772 syncope Diseases 0.000 description 1
- 230000009885 systemic effect Effects 0.000 description 1
- 239000000454 talc Substances 0.000 description 1
- 235000012222 talc Nutrition 0.000 description 1
- 229910052623 talc Inorganic materials 0.000 description 1
- 230000002110 toxicologic effect Effects 0.000 description 1
- 231100000759 toxicological effect Toxicity 0.000 description 1
- 201000007905 transthyretin amyloidosis Diseases 0.000 description 1
- LENZDBCJOHFCAS-UHFFFAOYSA-N tris Chemical compound OCC(N)(CO)CO LENZDBCJOHFCAS-UHFFFAOYSA-N 0.000 description 1
- 239000003656 tris buffered saline Substances 0.000 description 1
- 230000000304 vasodilatating effect Effects 0.000 description 1
- 229940124549 vasodilator Drugs 0.000 description 1
- 239000003071 vasodilator agent Substances 0.000 description 1
- 230000035899 viability Effects 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Psychiatry (AREA)
- Immunology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Endocrinology (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Hospice & Palliative Care (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US6236697P | 1997-10-15 | 1997-10-15 | |
| PCT/US1998/021789 WO1999018794A1 (en) | 1997-10-15 | 1998-10-15 | Method for treating alzheimer's disease |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IL135584A0 IL135584A0 (en) | 2001-05-20 |
| IL135584A true IL135584A (en) | 2005-12-18 |
Family
ID=22042015
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL13558498A IL135584A (en) | 1997-10-15 | 1998-10-15 | Use of dual, non-selective antagonists ß-adrenoreceptor and α1-adrenoreceptor in the preparation of a drug for the treatment of amyloid diseases |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US6358990B1 (de) |
| EP (1) | EP1024697A4 (de) |
| JP (1) | JP2001519364A (de) |
| KR (1) | KR100573352B1 (de) |
| CN (1) | CN1281334A (de) |
| AU (1) | AU751526B2 (de) |
| BR (1) | BR9814075A (de) |
| CA (1) | CA2305262A1 (de) |
| HU (1) | HUP0100024A3 (de) |
| IL (1) | IL135584A (de) |
| NO (1) | NO20001869L (de) |
| NZ (1) | NZ504419A (de) |
| PL (1) | PL339910A1 (de) |
| TR (1) | TR200001018T2 (de) |
| WO (1) | WO1999018794A1 (de) |
| ZA (1) | ZA989365B (de) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE10142175A1 (de) * | 2001-10-09 | 2003-03-27 | Eucro Europe Contract Res Gmbh | Verwendung von ß-Adrenozeptor-Agonisten zur Behandlung von neurodegenerativen Erkrankungen |
| US8101209B2 (en) * | 2001-10-09 | 2012-01-24 | Flamel Technologies | Microparticulate oral galenical form for the delayed and controlled release of pharmaceutical active principles |
| CA2483054A1 (en) * | 2002-04-30 | 2003-11-13 | Sb Pharmco Puerto Rico Inc. | Carvedilol monocitrate monohydrate |
| KR20110134952A (ko) * | 2002-06-27 | 2011-12-15 | 스미스클라인 비이참 (코르크) 리미티드 | 카베딜롤 인산염 및(또는) 그의 용매화물, 상응하는 조성물, 및(또는) 치료 방법 |
| JP2005533822A (ja) * | 2002-06-27 | 2005-11-10 | エスビー・ファルムコ・プエルト・リコ・インコーポレイテッド | 臭化水素酸カルベジロール |
| US7750036B2 (en) * | 2003-11-25 | 2010-07-06 | Sb Pharmco Puerto Rico Inc. | Carvedilol salts, corresponding compositions, methods of delivery and/or treatment |
| EP1686967A4 (de) * | 2003-11-25 | 2012-08-08 | Smithkline Beecham Cork Ltd | Carvedilol-freie base, salze, wasserfreie formen oder solvate davon, entsprechende pharmazeutische zusammensetzungen, formulierungen mit kontrollierter freisetzung und behandlungs- oder abgabeverfahren |
| EP1691789B1 (de) * | 2003-11-25 | 2017-12-20 | SmithKline Beecham (Cork) Limited | Carvedilol-freie base, salze, wasserfreie formen oder solvate davon, entsprechende pharmazeutische zusammensetzungen, formulierungen mit kontrollierter freisetzung und behandlungs- oder abgabeverfahren |
| CN1991364A (zh) | 2005-12-26 | 2007-07-04 | 中国科学院上海生命科学研究院 | 预防和治疗阿尔兹海默症的g蛋白偶联受体拮抗剂 |
| US20100029654A1 (en) * | 2006-03-23 | 2010-02-04 | Mount Sinai School Of Medicine | Cardiovascular compositions and use of the same for the treatment of alzheimer's disease |
| WO2008021552A2 (en) * | 2006-08-18 | 2008-02-21 | Duke University | Biased ligands and methods of identifying same |
| US20090076116A1 (en) * | 2007-09-13 | 2009-03-19 | Protia, Llc | Deuterium-enriched carvediolo |
| US8932557B2 (en) | 2008-02-14 | 2015-01-13 | Eli Lilly And Company | Imaging agents for detecting neurological dysfunction |
| KR20100135235A (ko) | 2008-02-14 | 2010-12-24 | 지멘스 메디컬 솔루션즈 유에스에이, 인크. | 신경학적 기능이상을 검출하기 위한 조영제 |
| CN103172643B (zh) * | 2011-12-26 | 2016-03-02 | 中国医学科学院药物研究所 | 黄皮咔唑生物碱及其制备方法和其药物组合物与用途 |
| CN102816107B (zh) * | 2012-08-20 | 2015-06-03 | 东南大学 | 咔唑衍生物及其制备方法与用途 |
| EP3013342B1 (de) | 2013-06-27 | 2021-04-14 | Cedars-Sinai Medical Center | Adrenorezeptor-antagonisten zur vorbeugung und behandlung neurodegenerativer erkrankungen |
| US20230381139A1 (en) * | 2020-09-17 | 2023-11-30 | Uti Limited Partnership | Methods of treating and/or preventing alzheimer’s disease with r-carvedilol |
| CN115487297A (zh) * | 2021-06-17 | 2022-12-20 | 清华大学 | 治疗神经元蜡样质脂褐质沉积症的方法和药物 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2815926A1 (de) * | 1978-04-13 | 1979-10-18 | Boehringer Mannheim Gmbh | Neue carbazolyl-(4)-oxy-propanolamin-derivate, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel |
| DE3319027A1 (de) * | 1983-05-26 | 1984-11-29 | Boehringer Mannheim Gmbh, 6800 Mannheim | Verfahren zur herstellung von optisch aktiven carbazol-derivaten, neue r- und s-carbazol-derivate, sowie arzneimittel, die diese verbindungen enthalten |
| JP2608078B2 (ja) * | 1986-12-17 | 1997-05-07 | グラクソ、グループ、リミテッド | 医 薬 |
| US4868190A (en) * | 1988-12-27 | 1989-09-19 | Hoechst-Roussel Pharmaceuticals, Inc. | N-pyridinyl-9H-carbazol-9-amines |
| US4983608A (en) | 1989-09-05 | 1991-01-08 | Hoechst-Roussell Pharmaceuticals, Inc. | N-substituted-4-pyrimidinamines and pyrimidinediamines |
| JPH0558998A (ja) * | 1991-09-06 | 1993-03-09 | Taisho Pharmaceut Co Ltd | カルバゾール誘導体 |
| WO1996034853A1 (en) * | 1995-05-01 | 1996-11-07 | University Of Pittsburgh | Azocompounds for the antemortem diagnosis of alzheimer's disease and in vivo imaging and prevention of amyloid deposition |
| MX9700696A (es) * | 1994-07-27 | 1997-04-30 | Sankyo Co | Compuestos heterociclicos, utiles como productores de efecto aloesterico en receptores muscarinicos. |
| FR2724933A1 (fr) * | 1994-09-22 | 1996-03-29 | Pf Medicament | Nouveaux ethers aromatiques derives d'indoles utiles comme medicaments |
| US5760069A (en) * | 1995-02-08 | 1998-06-02 | Boehringer Mannheim Pharmaceuticals Corporation-Smithkline Beecham Corporation Limited Partnership #1 | Method of treatment for decreasing mortality resulting from congestive heart failure |
| FR2731222A1 (fr) * | 1995-03-02 | 1996-09-06 | Pf Medicament | Nouveaux derives de piperazine aminoindoles cycliques, leur procede de preparation et leur utilisation a titre de medicaments |
-
1998
- 1998-10-14 ZA ZA989365A patent/ZA989365B/xx unknown
- 1998-10-15 US US09/529,526 patent/US6358990B1/en not_active Expired - Fee Related
- 1998-10-15 JP JP2000515438A patent/JP2001519364A/ja active Pending
- 1998-10-15 TR TR2000/01018T patent/TR200001018T2/xx unknown
- 1998-10-15 KR KR1020007003990A patent/KR100573352B1/ko not_active Expired - Fee Related
- 1998-10-15 NZ NZ504419A patent/NZ504419A/xx unknown
- 1998-10-15 AU AU10897/99A patent/AU751526B2/en not_active Ceased
- 1998-10-15 PL PL98339910A patent/PL339910A1/xx unknown
- 1998-10-15 HU HU0100024A patent/HUP0100024A3/hu unknown
- 1998-10-15 EP EP98953558A patent/EP1024697A4/de not_active Withdrawn
- 1998-10-15 IL IL13558498A patent/IL135584A/en not_active IP Right Cessation
- 1998-10-15 BR BR9814075-2A patent/BR9814075A/pt not_active IP Right Cessation
- 1998-10-15 CN CN98812171A patent/CN1281334A/zh active Pending
- 1998-10-15 CA CA002305262A patent/CA2305262A1/en not_active Abandoned
- 1998-10-15 WO PCT/US1998/021789 patent/WO1999018794A1/en not_active Ceased
-
2000
- 2000-04-11 NO NO20001869A patent/NO20001869L/no unknown
Also Published As
| Publication number | Publication date |
|---|---|
| AU751526B2 (en) | 2002-08-22 |
| JP2001519364A (ja) | 2001-10-23 |
| KR100573352B1 (ko) | 2006-04-25 |
| HUP0100024A3 (en) | 2002-12-28 |
| IL135584A0 (en) | 2001-05-20 |
| TR200001018T2 (tr) | 2000-08-21 |
| EP1024697A4 (de) | 2007-05-02 |
| HUP0100024A2 (hu) | 2001-07-30 |
| US6358990B1 (en) | 2002-03-19 |
| ZA989365B (en) | 1999-04-15 |
| BR9814075A (pt) | 2000-09-26 |
| NZ504419A (en) | 2002-11-26 |
| NO20001869D0 (no) | 2000-04-11 |
| CN1281334A (zh) | 2001-01-24 |
| EP1024697A1 (de) | 2000-08-09 |
| WO1999018794A1 (en) | 1999-04-22 |
| AU1089799A (en) | 1999-05-03 |
| CA2305262A1 (en) | 1999-04-22 |
| PL339910A1 (en) | 2001-01-15 |
| NO20001869L (no) | 2000-06-14 |
| KR20010031108A (ko) | 2001-04-16 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FF | Patent granted | ||
| KB | Patent renewed | ||
| MM9K | Patent not in force due to non-payment of renewal fees |