IL133579A - Device and method for isolating cell material out of a tissue medium and/or a liquid - Google Patents
Device and method for isolating cell material out of a tissue medium and/or a liquidInfo
- Publication number
- IL133579A IL133579A IL13357998A IL13357998A IL133579A IL 133579 A IL133579 A IL 133579A IL 13357998 A IL13357998 A IL 13357998A IL 13357998 A IL13357998 A IL 13357998A IL 133579 A IL133579 A IL 133579A
- Authority
- IL
- Israel
- Prior art keywords
- isolating
- vessel
- tissue
- cell material
- disk
- Prior art date
Links
- 239000000463 material Substances 0.000 title claims abstract description 32
- 239000007788 liquid Substances 0.000 title claims abstract description 29
- 238000000034 method Methods 0.000 title claims description 20
- 239000012528 membrane Substances 0.000 claims abstract description 16
- 230000002093 peripheral effect Effects 0.000 claims abstract description 6
- 238000010008 shearing Methods 0.000 claims abstract description 6
- 239000003153 chemical reaction reagent Substances 0.000 claims description 6
- 239000011148 porous material Substances 0.000 claims description 4
- 229920002994 synthetic fiber Polymers 0.000 claims description 2
- 230000000717 retained effect Effects 0.000 claims 1
- 210000004027 cell Anatomy 0.000 description 67
- 210000001519 tissue Anatomy 0.000 description 57
- 238000004458 analytical method Methods 0.000 description 17
- 238000002955 isolation Methods 0.000 description 15
- 239000012634 fragment Substances 0.000 description 12
- 239000000725 suspension Substances 0.000 description 11
- 239000006285 cell suspension Substances 0.000 description 8
- 238000000926 separation method Methods 0.000 description 5
- NLXLAEXVIDQMFP-UHFFFAOYSA-N Ammonia chloride Chemical compound [NH4+].[Cl-] NLXLAEXVIDQMFP-UHFFFAOYSA-N 0.000 description 4
- 239000002699 waste material Substances 0.000 description 4
- 238000011109 contamination Methods 0.000 description 3
- 239000002245 particle Substances 0.000 description 3
- 210000000952 spleen Anatomy 0.000 description 3
- 230000032258 transport Effects 0.000 description 3
- 235000019270 ammonium chloride Nutrition 0.000 description 2
- 238000013459 approach Methods 0.000 description 2
- 210000004369 blood Anatomy 0.000 description 2
- 239000008280 blood Substances 0.000 description 2
- 210000004185 liver Anatomy 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 1
- 238000009825 accumulation Methods 0.000 description 1
- 244000052616 bacterial pathogen Species 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- 230000001419 dependent effect Effects 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 230000018109 developmental process Effects 0.000 description 1
- 238000003745 diagnosis Methods 0.000 description 1
- 238000004090 dissolution Methods 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 230000007613 environmental effect Effects 0.000 description 1
- 210000003743 erythrocyte Anatomy 0.000 description 1
- 238000000265 homogenisation Methods 0.000 description 1
- 230000036512 infertility Effects 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 210000005229 liver cell Anatomy 0.000 description 1
- 230000001717 pathogenic effect Effects 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 238000005070 sampling Methods 0.000 description 1
- 230000028327 secretion Effects 0.000 description 1
- 238000004062 sedimentation Methods 0.000 description 1
- 210000004872 soft tissue Anatomy 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 210000002700 urine Anatomy 0.000 description 1
- 230000000007 visual effect Effects 0.000 description 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
- G01N1/34—Purifying; Cleaning
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M45/00—Means for pre-treatment of biological substances
- C12M45/02—Means for pre-treatment of biological substances by mechanical forces; Stirring; Trituration; Comminuting
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
- G01N1/286—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q involving mechanical work, e.g. chopping, disintegrating, compacting, homogenising
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
- G01N1/40—Concentrating samples
- G01N1/4077—Concentrating samples by other techniques involving separation of suspended solids
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Physics & Mathematics (AREA)
- Molecular Biology (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Analytical Chemistry (AREA)
- Biomedical Technology (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Sustainable Development (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Mechanical Engineering (AREA)
- Sampling And Sample Adjustment (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Materials For Medical Uses (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19729028A DE19729028C1 (de) | 1997-07-08 | 1997-07-08 | Vorrichtung sowie Verfahren zur Isolierung von Zellmaterial aus einem Gewebeverband und/oder einer Flüssigkeit |
| PCT/DE1998/000864 WO1999002958A1 (de) | 1997-07-08 | 1998-03-24 | Vorrichtung sowie verfahren zur isolierung von zellmaterial aus einem gewebeverband und/oder einer flüssigkeit |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IL133579A0 IL133579A0 (en) | 2001-04-30 |
| IL133579A true IL133579A (en) | 2002-07-25 |
Family
ID=7834932
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL13357998A IL133579A (en) | 1997-07-08 | 1998-03-24 | Device and method for isolating cell material out of a tissue medium and/or a liquid |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US6358474B1 (cs) |
| EP (1) | EP0995097B1 (cs) |
| JP (1) | JP2001509590A (cs) |
| AT (1) | ATE241130T1 (cs) |
| CA (1) | CA2295580A1 (cs) |
| CZ (1) | CZ297441B6 (cs) |
| DE (2) | DE19729028C1 (cs) |
| DK (1) | DK0995097T3 (cs) |
| ES (1) | ES2200345T3 (cs) |
| HU (1) | HUP0002745A3 (cs) |
| IL (1) | IL133579A (cs) |
| PT (1) | PT995097E (cs) |
| WO (1) | WO1999002958A1 (cs) |
Families Citing this family (38)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6423237B1 (en) * | 1992-07-28 | 2002-07-23 | Lamina, Inc. | Method and apparatus for manually separating particulate matter from a liquid specimen |
| US7771662B2 (en) | 2001-10-19 | 2010-08-10 | Hologic, Inc | Vial system and method for processing liquid-based specimens |
| WO2003054552A2 (en) | 2001-10-19 | 2003-07-03 | Monogen, Inc. | Automated system and method for processing specimens to extract samples for both liquid-based and slide-based testing |
| US7211225B2 (en) * | 2002-08-26 | 2007-05-01 | Perceptronix Medical Inc. | Filter devices for depositing material and density gradients of material from sample suspension |
| US7608446B2 (en) * | 2004-09-30 | 2009-10-27 | Alcatel-Lucent Usa Inc. | Nanostructured surface for microparticle analysis and manipulation |
| US20070287193A1 (en) * | 2004-11-09 | 2007-12-13 | Monogen, Inc. | Vial Assembly, Sampling Apparatus And Method For Processing Liquid-Based Specimens |
| US8216528B2 (en) * | 2005-09-29 | 2012-07-10 | Sysmex Corporation | Sample preparation kit, sample preparation container, and sample processing device |
| JP4813140B2 (ja) * | 2005-09-29 | 2011-11-09 | シスメックス株式会社 | 試料調製容器および試料調製キット |
| JP4795765B2 (ja) * | 2005-09-29 | 2011-10-19 | シスメックス株式会社 | 試料処理装置 |
| WO2007140016A2 (en) * | 2006-05-26 | 2007-12-06 | Northeastern University | Devices, methods and applications for extraction of molecules from polymeric gel electrophoretic media |
| DE102007005369A1 (de) * | 2007-02-02 | 2008-08-07 | Eppendorf Ag | Vorrichtung und Verfahren zur mechanischen Vereinzelung von Zellen aus einem Zellverbund |
| US8703492B2 (en) | 2007-04-06 | 2014-04-22 | Qiagen Gaithersburg, Inc. | Open platform hybrid manual-automated sample processing system |
| US7985375B2 (en) * | 2007-04-06 | 2011-07-26 | Qiagen Gaithersburg, Inc. | Sample preparation system and method for processing clinical specimens |
| US7981054B2 (en) * | 2007-07-16 | 2011-07-19 | Phuong Nguyen | All-in-one biological specimen collecting, transporting and analyzing device |
| EP2573541A1 (en) * | 2007-10-24 | 2013-03-27 | Biomarker Strategies, Llc | Improved methods and devices for cellular analysis |
| FR2925066B1 (fr) * | 2007-12-18 | 2014-12-19 | Bertin Technologies Sa | Dispositif de broyage d'un echantillon biologique |
| DE102009005003A1 (de) * | 2008-08-01 | 2010-03-25 | Frankenförder Forschungsgesellschaft mbH | Vorrichtung und Verfahren für den mechanischen Ausschluss von Zellen |
| US20100112696A1 (en) * | 2008-11-03 | 2010-05-06 | Baxter International Inc. | Apparatus And Methods For Processing Tissue To Release Cells |
| US8309343B2 (en) | 2008-12-01 | 2012-11-13 | Baxter International Inc. | Apparatus and method for processing biological material |
| US8100874B1 (en) | 2009-05-22 | 2012-01-24 | Donnell Mark Jordan | Tissue refining device |
| WO2011063139A1 (en) | 2009-11-18 | 2011-05-26 | Qiagen | Laboratory central control unit method and system |
| JP5379095B2 (ja) * | 2010-08-26 | 2013-12-25 | 日本光電工業株式会社 | 細胞単離機器 |
| TWI467014B (zh) * | 2011-09-13 | 2015-01-01 | Taigen Bioscience Corp | 用於試管內生物樣本之液體處理柱塞 |
| AU2012335746B2 (en) | 2011-11-08 | 2017-04-27 | Auxocell Laboratories, Inc. | Systems and methods for processing cells |
| JP2013255447A (ja) * | 2012-06-12 | 2013-12-26 | Nippon Koden Corp | 細胞単離装置 |
| FR3021667B1 (fr) | 2014-05-28 | 2018-01-26 | Commissariat A L'energie Atomique Et Aux Energies Alternatives | Dispositif de lyse d'especes biologiques et procede mis en œuvre par ce dispositif |
| GB2515197B (en) * | 2014-07-10 | 2015-06-24 | Cambtek Ltd | Improved extraction apparatus |
| US10299767B2 (en) | 2015-05-20 | 2019-05-28 | Alpha-Tec Systems, Inc. | Sample collection apparatus |
| US10251990B2 (en) | 2016-04-29 | 2019-04-09 | Fenwal, Inc. | System and method for processing, incubating, and/or selecting biological cells |
| EP3238760B1 (en) | 2016-04-29 | 2019-10-02 | Fenwal, Inc. | System and method for selecting and culturing cells |
| WO2018106909A1 (en) * | 2016-12-08 | 2018-06-14 | Reaction Analytics, Inc. | Filter insert and sample vial using the same |
| US10274495B2 (en) | 2016-12-21 | 2019-04-30 | Fenwal, Inc. | System and method for separating cells incorporating magnetic separation |
| TWI611019B (zh) * | 2017-02-13 | 2018-01-11 | Scl Biotech Ltd | 組織細碎裝置及具有組織細碎裝置的設備 |
| US11638891B2 (en) * | 2017-05-23 | 2023-05-02 | Kohler Co. | Water filter system |
| CN111902528B (zh) * | 2018-01-24 | 2024-06-28 | 弗劳恩霍夫应用研究促进协会 | 用于组织解离的装置及方法 |
| JP2021132541A (ja) * | 2020-02-25 | 2021-09-13 | テルモ株式会社 | 生体由来組織を細切するための方法 |
| US20230407235A1 (en) * | 2020-11-12 | 2023-12-21 | The University Of Chicago | Microfluidic and mems cell lysis system and method |
| CN113583874A (zh) * | 2021-08-30 | 2021-11-02 | 艾一生命科技(广东)有限公司 | 用于组织块培养的固定装置、组织块培养系统及培养方法 |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3709395A (en) * | 1971-07-01 | 1973-01-09 | Hospital Service Technology Co | Closure for containers |
| US3941317A (en) * | 1973-10-26 | 1976-03-02 | Lnih, Inc. | Method and apparatus for tissue disaggregation |
| NO136062C (no) * | 1975-04-14 | 1977-07-13 | Henry Hirschberg | Fremgangsm}te og anordning for oppsamling av v{ske med innhold av radioaktive sporstoffer. |
| US4413059A (en) * | 1980-09-19 | 1983-11-01 | Bristol-Myers Company | Apparatus for preparing single cell suspension |
| US4350768A (en) | 1980-09-19 | 1982-09-21 | Bristol Myers Company | Method for preparing single cell suspension |
| US4317726A (en) * | 1981-02-12 | 1982-03-02 | The United States Of America As Represented By The Secretary Of The Army | Microbial filter assembly |
| CA1178183A (en) * | 1981-05-14 | 1984-11-20 | David J. Zahniser | Disaggregation device for cell suspensions |
| US5034135A (en) * | 1982-12-13 | 1991-07-23 | William F. McLaughlin | Blood fractionation system and method |
| US5372945A (en) * | 1985-06-06 | 1994-12-13 | Alchas; Paul G. | Device and method for collecting and processing fat tissue and procuring microvessel endothelial cells to produce endothelial cell product |
| US5114858A (en) * | 1990-06-26 | 1992-05-19 | E. I. Du Pont De Nemours And Company | Cellular component extraction process in a disposable filtration vessel |
| US5356814A (en) * | 1992-09-29 | 1994-10-18 | Hoffmann-La Roche Inc. | Disaggregation device for cytological specimens |
| US5391496A (en) * | 1993-09-01 | 1995-02-21 | Becton, Dickinson And Company | Culturing vessel and closure assembly |
| US6120985A (en) * | 1997-10-31 | 2000-09-19 | Bbi Bioseq, Inc. | Pressure-enhanced extraction and purification |
-
1997
- 1997-07-08 DE DE19729028A patent/DE19729028C1/de not_active Expired - Fee Related
-
1998
- 1998-03-24 AT AT98925437T patent/ATE241130T1/de not_active IP Right Cessation
- 1998-03-24 US US09/462,409 patent/US6358474B1/en not_active Expired - Fee Related
- 1998-03-24 DK DK98925437T patent/DK0995097T3/da active
- 1998-03-24 JP JP2000502391A patent/JP2001509590A/ja active Pending
- 1998-03-24 HU HU0002745A patent/HUP0002745A3/hu unknown
- 1998-03-24 CZ CZ20000005A patent/CZ297441B6/cs not_active IP Right Cessation
- 1998-03-24 EP EP98925437A patent/EP0995097B1/de not_active Expired - Lifetime
- 1998-03-24 ES ES98925437T patent/ES2200345T3/es not_active Expired - Lifetime
- 1998-03-24 WO PCT/DE1998/000864 patent/WO1999002958A1/de active IP Right Grant
- 1998-03-24 CA CA002295580A patent/CA2295580A1/en not_active Abandoned
- 1998-03-24 IL IL13357998A patent/IL133579A/en active IP Right Grant
- 1998-03-24 PT PT98925437T patent/PT995097E/pt unknown
- 1998-03-24 DE DE59808478T patent/DE59808478D1/de not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| HUP0002745A2 (hu) | 2000-12-28 |
| CZ20005A3 (cs) | 2000-11-15 |
| PT995097E (pt) | 2003-10-31 |
| WO1999002958A1 (de) | 1999-01-21 |
| DK0995097T3 (da) | 2003-08-25 |
| DE59808478D1 (de) | 2003-06-26 |
| EP0995097A1 (de) | 2000-04-26 |
| US6358474B1 (en) | 2002-03-19 |
| IL133579A0 (en) | 2001-04-30 |
| HUP0002745A3 (en) | 2005-11-28 |
| CA2295580A1 (en) | 1999-01-21 |
| EP0995097B1 (de) | 2003-05-21 |
| CZ297441B6 (cs) | 2006-12-13 |
| DE19729028C1 (de) | 1999-05-06 |
| ES2200345T3 (es) | 2004-03-01 |
| JP2001509590A (ja) | 2001-07-24 |
| ATE241130T1 (de) | 2003-06-15 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FF | Patent granted | ||
| KB | Patent renewed | ||
| KB | Patent renewed |