IL133140A0 - Novel process for the preparation of 4-aryl-piperidines - Google Patents
Novel process for the preparation of 4-aryl-piperidinesInfo
- Publication number
- IL133140A0 IL133140A0 IL13314098A IL13314098A IL133140A0 IL 133140 A0 IL133140 A0 IL 133140A0 IL 13314098 A IL13314098 A IL 13314098A IL 13314098 A IL13314098 A IL 13314098A IL 133140 A0 IL133140 A0 IL 133140A0
- Authority
- IL
- Israel
- Prior art keywords
- piperidines
- aryl
- preparation
- novel process
- novel
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/14—Drugs for dermatological disorders for baldness or alopecia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/32—Alcohol-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D211/20—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms
- C07D211/22—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms by oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D211/72—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D211/74—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D211/72—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D211/78—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Addiction (AREA)
- Obesity (AREA)
- Child & Adolescent Psychology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Hospice & Palliative Care (AREA)
- Dermatology (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Hydrogenated Pyridines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB9711095.1A GB9711095D0 (en) | 1997-05-29 | 1997-05-29 | Novel process |
GBGB9714875.3A GB9714875D0 (en) | 1997-07-15 | 1997-07-15 | Novel process |
PCT/US1998/011057 WO1998053824A1 (fr) | 1997-05-29 | 1998-05-29 | Nouveau procede |
Publications (1)
Publication Number | Publication Date |
---|---|
IL133140A0 true IL133140A0 (en) | 2001-03-19 |
Family
ID=26311618
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IL13314098A IL133140A0 (en) | 1997-05-29 | 1998-05-29 | Novel process for the preparation of 4-aryl-piperidines |
Country Status (22)
Country | Link |
---|---|
US (3) | US6489347B1 (fr) |
EP (1) | EP0986389B1 (fr) |
JP (1) | JP2002514222A (fr) |
CN (1) | CN1268889A (fr) |
AP (1) | AP9901698A0 (fr) |
AT (1) | ATE279393T1 (fr) |
AU (1) | AU7708998A (fr) |
BG (1) | BG104034A (fr) |
BR (1) | BR9809687A (fr) |
CA (1) | CA2291251A1 (fr) |
DE (1) | DE69827000D1 (fr) |
EA (1) | EA199901098A1 (fr) |
HU (1) | HUP0003958A3 (fr) |
ID (1) | ID24383A (fr) |
IL (1) | IL133140A0 (fr) |
NO (1) | NO995796L (fr) |
NZ (1) | NZ501285A (fr) |
OA (1) | OA11223A (fr) |
PL (1) | PL337513A1 (fr) |
SK (1) | SK159899A3 (fr) |
TR (1) | TR199902929T2 (fr) |
WO (1) | WO1998053824A1 (fr) |
Families Citing this family (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6438585B2 (en) * | 1998-05-29 | 2002-08-20 | Research In Motion Limited | System and method for redirecting message attachments between a host system and a mobile data communication device |
WO2000026187A1 (fr) * | 1998-11-02 | 2000-05-11 | Synthon B.V. | Procede de production de 4-arylpiperidine-3-carbinols et composes correspondants |
US20010053862A1 (en) * | 1998-12-22 | 2001-12-20 | Bruce Ronsen | Process for preparing arylpiperidine carbinol intermediates and derivatives |
GB9828767D0 (en) * | 1998-12-29 | 1999-02-17 | Smithkline Beecham Plc | Novel process |
IT1313702B1 (it) * | 1999-08-02 | 2002-09-09 | Chemi Spa | Processo per la preparazione di derivati 3-sostituiti di 4-fenil-piperidine. |
GB0003232D0 (en) * | 2000-02-11 | 2000-04-05 | Smithkline Beecham Plc | Novel composition |
US6833458B2 (en) * | 2000-06-05 | 2004-12-21 | Development Center For Biotechnology | Practical syntheses of chiral trans-3, 4-disubstituted piperidines and the intermediates |
DK1347960T3 (da) | 2001-01-04 | 2005-03-21 | Ferrer Int | Fremgangsmåde til fremstilling af (+/-) trans-4-p-fluorphenyl-3-hydromethyl-1-methylpiperidin |
PT1440067E (pt) | 2001-10-22 | 2005-02-28 | Synthon Bv | Derivados n-formilo de paroxetina |
US20080033050A1 (en) | 2006-08-04 | 2008-02-07 | Richards Patricia Allison Tewe | Method of treating thermoregulatory disfunction with paroxetine |
US9138430B2 (en) * | 2007-12-27 | 2015-09-22 | Mylan Specialty L.P. | Formulation and method for the release of paroxetine in the large intestine |
CN112645951A (zh) * | 2020-12-23 | 2021-04-13 | 上海博栋化学科技有限公司 | 由长春布宁合成的磺酸锍盐类光产酸剂及其合成方法 |
Family Cites Families (24)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2798432A (en) * | 1945-02-27 | 1957-07-09 | Leo T Meister | Delay action fuse |
US2498432A (en) | 1946-07-08 | 1950-02-21 | Hoffmann La Roche | 1-branched lower alkyl-4-phenyl-4-acyloxy-piperidines and their acid addition salts |
GB1422263A (en) | 1973-01-30 | 1976-01-21 | Ferrosan As | 4-phenyl-piperidine compounds |
US4585777A (en) | 1984-02-07 | 1986-04-29 | A/S Ferrosan | (-)-Trans-4-(4-fluorophenyl)-3-(4-methoxyphenoxy)methylpiperidine for potentiating 5-HT |
US4593036A (en) | 1984-02-07 | 1986-06-03 | A/S Ferrosan | (-)-Trans-4-(4-fluorophenyl)-3-[(4-methoxyphenoxy)methyl]-1-methylpiperidine useful as 5-HT potentiator |
EP0190496A3 (fr) * | 1984-12-13 | 1987-05-27 | Beecham Group Plc | Dérivés de la pipéridine à activité gastro-intestinale |
DE3680184D1 (de) * | 1985-08-10 | 1991-08-14 | Beecham Group Plc | Verfahren zur herstellung von arylpiperidincarbinol. |
GB8520154D0 (en) | 1985-08-10 | 1985-09-18 | Beecham Group Plc | Chemical process |
GB8714707D0 (en) | 1987-06-23 | 1987-07-29 | Beecham Group Plc | Chemical process |
DK715988D0 (da) | 1988-12-22 | 1988-12-22 | Ferrosan As | Etherifikation og dealkylering af piperidin-derivater samt intermediater |
IL98757A (en) * | 1990-07-18 | 1997-01-10 | Novo Nordisk As | Piperidine derivatives their preparation and pharmaceutical compositions containing them |
US5258517A (en) | 1992-08-06 | 1993-11-02 | Sepracor, Inc. | Method of preparing optically pure precursors of paroxetine |
GB9305175D0 (en) | 1993-03-13 | 1993-04-28 | Smithkline Beecham Plc | Novel process |
ES2102295B1 (es) | 1994-03-18 | 1998-04-01 | Ferrer Int | Nuevos compuestos derivados de la n-benzoilmetil-piperidina. |
US5856493A (en) | 1995-02-06 | 1999-01-05 | Smithkline Beecham Corporation | Process for making novel form of paroxeting hydrochloride anhydrate |
US5554383A (en) * | 1995-04-06 | 1996-09-10 | Trustees Of Tufts College | Veterinary method for clinically modifying the behavior of dogs exhibiting canine affective aggression |
AU721257B2 (en) | 1995-05-17 | 2000-06-29 | Novo Nordisk A/S | Process for preparing 4-aryl-piperidine derivatives |
DK0863875T3 (da) | 1995-09-07 | 2003-12-01 | Hoffmann La Roche | Hidtil ukendte 4-(oxyalkoxyphenyl)-3-oxy-piperiner til behandling af hjerte- og nyrelidelser |
ES2121685B1 (es) * | 1996-04-10 | 1999-09-16 | Vita Invest Sa | Procedimiento para la obtencion de (+)-trans-4(4-fluoro-fenil)-3-hidroximetil-1-metilpiperidina. |
JP3446468B2 (ja) * | 1996-04-15 | 2003-09-16 | 旭硝子株式会社 | ピペリジンカルビノール類の製造方法 |
EP1384720A1 (fr) | 1996-06-13 | 2004-01-28 | SUMIKA FINE CHEMICALS Co., Ltd. | Procédé de séchage pour le chlorhydrate de paroxetine |
CA2284732C (fr) | 1997-04-07 | 2008-06-17 | Georgetown University | Analogues de cocaine |
WO2000026187A1 (fr) | 1998-11-02 | 2000-05-11 | Synthon B.V. | Procede de production de 4-arylpiperidine-3-carbinols et composes correspondants |
US6051812A (en) * | 1998-11-16 | 2000-04-18 | Walker; Lawrence | Snow and ice melting blanket device |
-
1998
- 1998-05-29 ID IDW991488A patent/ID24383A/id unknown
- 1998-05-29 JP JP50100199A patent/JP2002514222A/ja not_active Ceased
- 1998-05-29 AU AU77089/98A patent/AU7708998A/en not_active Abandoned
- 1998-05-29 US US09/087,632 patent/US6489347B1/en not_active Expired - Fee Related
- 1998-05-29 NZ NZ501285A patent/NZ501285A/en unknown
- 1998-05-29 HU HU0003958A patent/HUP0003958A3/hu unknown
- 1998-05-29 AP APAP/P/1999/001698A patent/AP9901698A0/en unknown
- 1998-05-29 EP EP98925055A patent/EP0986389B1/fr not_active Expired - Lifetime
- 1998-05-29 CN CN98805522A patent/CN1268889A/zh active Pending
- 1998-05-29 IL IL13314098A patent/IL133140A0/xx unknown
- 1998-05-29 AT AT98925055T patent/ATE279393T1/de not_active IP Right Cessation
- 1998-05-29 BR BR9809687-7A patent/BR9809687A/pt not_active Application Discontinuation
- 1998-05-29 PL PL98337513A patent/PL337513A1/xx unknown
- 1998-05-29 DE DE1998627000 patent/DE69827000D1/de not_active Expired - Lifetime
- 1998-05-29 TR TR1999/02929T patent/TR199902929T2/xx unknown
- 1998-05-29 WO PCT/US1998/011057 patent/WO1998053824A1/fr not_active Application Discontinuation
- 1998-05-29 SK SK1598-99A patent/SK159899A3/sk unknown
- 1998-05-29 CA CA002291251A patent/CA2291251A1/fr not_active Abandoned
- 1998-05-29 EA EA199901098A patent/EA199901098A1/ru unknown
-
1999
- 1999-11-26 NO NO995796A patent/NO995796L/no not_active Application Discontinuation
- 1999-11-29 OA OA9900263A patent/OA11223A/en unknown
- 1999-12-17 BG BG104034A patent/BG104034A/xx unknown
-
2002
- 2002-05-03 US US10/138,553 patent/US6716985B2/en not_active Expired - Fee Related
-
2004
- 2004-01-14 US US10/757,147 patent/US20040147754A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
BR9809687A (pt) | 2000-07-11 |
US6489347B1 (en) | 2002-12-03 |
US6716985B2 (en) | 2004-04-06 |
HUP0003958A3 (en) | 2001-06-28 |
CA2291251A1 (fr) | 1998-12-03 |
PL337513A1 (en) | 2000-08-28 |
EP0986389A1 (fr) | 2000-03-22 |
EA199901098A1 (ru) | 2000-08-28 |
NO995796D0 (no) | 1999-11-26 |
US20020133011A1 (en) | 2002-09-19 |
ATE279393T1 (de) | 2004-10-15 |
OA11223A (en) | 2003-06-17 |
DE69827000D1 (de) | 2004-11-18 |
JP2002514222A (ja) | 2002-05-14 |
AP9901698A0 (en) | 1999-12-31 |
NO995796L (no) | 1999-11-26 |
US20040147754A1 (en) | 2004-07-29 |
HUP0003958A2 (hu) | 2001-05-28 |
EP0986389B1 (fr) | 2004-10-13 |
AU7708998A (en) | 1998-12-30 |
ID24383A (id) | 2000-07-13 |
NZ501285A (en) | 2001-10-26 |
BG104034A (en) | 2000-11-30 |
TR199902929T2 (xx) | 2000-06-21 |
EP0986389A4 (fr) | 2001-09-12 |
SK159899A3 (en) | 2000-06-12 |
WO1998053824A1 (fr) | 1998-12-03 |
CN1268889A (zh) | 2000-10-04 |
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