IL133088A0 - Novel triptolide derivatives useful in the treatment of autoimmune diseases - Google Patents

Novel triptolide derivatives useful in the treatment of autoimmune diseases

Info

Publication number
IL133088A0
IL133088A0 IL13308898A IL13308898A IL133088A0 IL 133088 A0 IL133088 A0 IL 133088A0 IL 13308898 A IL13308898 A IL 13308898A IL 13308898 A IL13308898 A IL 13308898A IL 133088 A0 IL133088 A0 IL 133088A0
Authority
IL
Israel
Prior art keywords
treatment
autoimmune diseases
derivatives useful
triptolide derivatives
novel triptolide
Prior art date
Application number
IL13308898A
Other languages
English (en)
Original Assignee
Hoechst Marion Roussel Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Marion Roussel Inc filed Critical Hoechst Marion Roussel Inc
Publication of IL133088A0 publication Critical patent/IL133088A0/xx

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D493/00Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/04Ortho-condensed systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D493/00Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/12Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains three hetero rings
    • C07D493/14Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
IL13308898A 1997-05-23 1998-04-27 Novel triptolide derivatives useful in the treatment of autoimmune diseases IL133088A0 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US86248897A 1997-05-23 1997-05-23
PCT/US1998/008470 WO1998052951A1 (en) 1997-05-23 1998-04-27 Novel triptolide derivatives useful in the treatment of autoimmune diseases

Publications (1)

Publication Number Publication Date
IL133088A0 true IL133088A0 (en) 2001-03-19

Family

ID=25338616

Family Applications (1)

Application Number Title Priority Date Filing Date
IL13308898A IL133088A0 (en) 1997-05-23 1998-04-27 Novel triptolide derivatives useful in the treatment of autoimmune diseases

Country Status (21)

Country Link
EP (1) EP0983275B1 (pt)
JP (1) JP2001525851A (pt)
KR (1) KR20010012822A (pt)
CN (1) CN1257507A (pt)
AR (1) AR012723A1 (pt)
AT (1) ATE222910T1 (pt)
AU (1) AU741917B2 (pt)
BR (1) BR9809678A (pt)
CA (1) CA2287977A1 (pt)
DE (1) DE69807466T2 (pt)
DK (1) DK0983275T3 (pt)
ES (1) ES2178207T3 (pt)
HK (1) HK1026096A1 (pt)
HU (1) HUP0003398A3 (pt)
IL (1) IL133088A0 (pt)
NO (1) NO995723L (pt)
NZ (1) NZ500762A (pt)
PT (1) PT983275E (pt)
TW (1) TW434235B (pt)
WO (1) WO1998052951A1 (pt)
ZA (1) ZA984174B (pt)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6329148B1 (en) 1999-02-16 2001-12-11 The Board Of Trustees Of The Leland Stanford University Combined therapy of diterpenoid triepoxides and death domain receptor ligands for synergistic killing of tumor cells
EP1390358A4 (en) * 2001-03-15 2004-06-16 Pharmagenesis Inc AMINO ACID DERIVATIVES OF TRIPTOLIDE COMPOUNDS AS IMMUNOMODULATORS AND ANTICROPHES
US7847109B2 (en) 2002-05-31 2010-12-07 Pharmagenesis, Inc. Triptolide derivatives for modulation of apoptosis and immunosuppression
CN100398544C (zh) * 2002-09-18 2008-07-02 成都达远药物有限公司 高免疫抑制活性的水溶性雷公藤内酯醇衍生物及其应用
CA2508217A1 (en) * 2002-12-17 2004-07-15 Pharmagenesis, Inc. Triptolide derivatives as immunomodulators and anticancer agents
CN1223595C (zh) * 2002-12-27 2005-10-19 中国科学院上海药物研究所 雷公藤内酯醇衍生物及其应用
US6943259B2 (en) * 2003-02-25 2005-09-13 Pharmagenesis, Inc. Halogenated triptolide derivatives as immunomodulators and anticancer agents
WO2005062913A2 (en) 2003-12-24 2005-07-14 Pharmagenesis, Inc. Triplide 5,6-derivatives as immunomodulators and anticancer agents
EP1722806A4 (en) 2004-02-09 2009-09-16 Pharmagenesis Inc METHOD OF ISOLATING TRIPTOLIDE COMPOUNDS FROM TRIPTERYGIUM WILFORDII
JP5057966B2 (ja) 2004-03-02 2012-10-24 ファーマジェネシス, インコーポレイテッド 免疫調節剤および抗癌剤としてのトリプトライドラクトン環誘導体
US20110104186A1 (en) 2004-06-24 2011-05-05 Nicholas Valiante Small molecule immunopotentiators and assays for their detection
US8617906B2 (en) 2004-10-13 2013-12-31 Pharmagenesis, Inc. Identification and screening of triptolide target molecules
CA2750844A1 (en) * 2009-02-05 2010-08-12 Pharmagenesis, Inc. Triptolide c-ring derivatives as anticancer agents and immune modulators
ES2909799T3 (es) * 2015-10-29 2022-05-10 Hangzhou Weben Pharmaceuticals Inc Derivados aminoacídicos de triptólido esterificados en el hidroxilo C14 y método de preparación y uso de los mismos
CN114716503B (zh) * 2022-03-23 2024-03-12 广东省中医院(广州中医药大学第二附属医院、广州中医药大学第二临床医学院、广东省中医药科学院) 一种雷公藤氯内酯醇的制备方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4005108A (en) * 1973-04-03 1977-01-25 Research Corporation Novel anti-leukemic diterpenoid triepoxides
US5430054A (en) * 1989-12-22 1995-07-04 Jiangsu Family Planning Institute Preparation methods of diterpene lactone compounds and application of the same to antifertility
US5663335A (en) * 1996-03-01 1997-09-02 Pharmagenesis, Inc. Immunosuppressive compounds and methods

Also Published As

Publication number Publication date
HUP0003398A3 (en) 2001-09-28
ATE222910T1 (de) 2002-09-15
HUP0003398A2 (en) 2001-03-28
DK0983275T3 (da) 2002-12-23
EP0983275B1 (en) 2002-08-28
PT983275E (pt) 2003-01-31
CN1257507A (zh) 2000-06-21
NZ500762A (en) 2001-08-31
AU7260798A (en) 1998-12-11
TW434235B (en) 2001-05-16
AU741917B2 (en) 2001-12-13
AR012723A1 (es) 2000-11-08
JP2001525851A (ja) 2001-12-11
BR9809678A (pt) 2000-07-11
DE69807466D1 (de) 2002-10-02
KR20010012822A (ko) 2001-02-26
NO995723D0 (no) 1999-11-22
WO1998052951A1 (en) 1998-11-26
HK1026096A1 (en) 2000-12-01
EP0983275A1 (en) 2000-03-08
DE69807466T2 (de) 2003-04-24
ES2178207T3 (es) 2002-12-16
CA2287977A1 (en) 1998-11-26
NO995723L (no) 2000-01-21
ZA984174B (en) 1998-11-23

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