HUP0003398A3 - Novel triptolide derivatives and pharmaceutical compositions thereof - Google Patents
Novel triptolide derivatives and pharmaceutical compositions thereofInfo
- Publication number
- HUP0003398A3 HUP0003398A3 HU0003398A HUP0003398A HUP0003398A3 HU P0003398 A3 HUP0003398 A3 HU P0003398A3 HU 0003398 A HU0003398 A HU 0003398A HU P0003398 A HUP0003398 A HU P0003398A HU P0003398 A3 HUP0003398 A3 HU P0003398A3
- Authority
- HU
- Hungary
- Prior art keywords
- pharmaceutical compositions
- triptolide derivatives
- novel triptolide
- novel
- derivatives
- Prior art date
Links
- DFBIRQPKNDILPW-CIVMWXNOSA-N Triptolide Chemical class O=C1OCC([C@@H]2C3)=C1CC[C@]2(C)[C@]12O[C@H]1[C@@H]1O[C@]1(C(C)C)[C@@H](O)[C@]21[C@H]3O1 DFBIRQPKNDILPW-CIVMWXNOSA-N 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/12—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains three hetero rings
- C07D493/14—Ortho-condensed systems
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US86248897A | 1997-05-23 | 1997-05-23 | |
| PCT/US1998/008470 WO1998052951A1 (en) | 1997-05-23 | 1998-04-27 | Novel triptolide derivatives useful in the treatment of autoimmune diseases |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| HUP0003398A2 HUP0003398A2 (en) | 2001-03-28 |
| HUP0003398A3 true HUP0003398A3 (en) | 2001-09-28 |
Family
ID=25338616
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HU0003398A HUP0003398A3 (en) | 1997-05-23 | 1998-04-27 | Novel triptolide derivatives and pharmaceutical compositions thereof |
Country Status (21)
| Country | Link |
|---|---|
| EP (1) | EP0983275B1 (hu) |
| JP (1) | JP2001525851A (hu) |
| KR (1) | KR20010012822A (hu) |
| CN (1) | CN1257507A (hu) |
| AR (1) | AR012723A1 (hu) |
| AT (1) | ATE222910T1 (hu) |
| AU (1) | AU741917B2 (hu) |
| BR (1) | BR9809678A (hu) |
| CA (1) | CA2287977A1 (hu) |
| DE (1) | DE69807466T2 (hu) |
| DK (1) | DK0983275T3 (hu) |
| ES (1) | ES2178207T3 (hu) |
| HK (1) | HK1026096A1 (hu) |
| HU (1) | HUP0003398A3 (hu) |
| IL (1) | IL133088A0 (hu) |
| NO (1) | NO995723L (hu) |
| NZ (1) | NZ500762A (hu) |
| PT (1) | PT983275E (hu) |
| TW (1) | TW434235B (hu) |
| WO (1) | WO1998052951A1 (hu) |
| ZA (1) | ZA984174B (hu) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6329148B1 (en) | 1999-02-16 | 2001-12-11 | The Board Of Trustees Of The Leland Stanford University | Combined therapy of diterpenoid triepoxides and death domain receptor ligands for synergistic killing of tumor cells |
| US6569893B2 (en) * | 2001-03-15 | 2003-05-27 | Pharmagenesis, Inc. | Amino acid derivatives of triptolide compounds as immune modulators and anticancer agents |
| CA2485794C (en) | 2002-05-31 | 2012-10-16 | Pharmagenesis, Inc. | Triptolide derivatives for modulation of apoptosis and immunosuppression |
| CN100398544C (zh) * | 2002-09-18 | 2008-07-02 | 成都达远药物有限公司 | 高免疫抑制活性的水溶性雷公藤内酯醇衍生物及其应用 |
| CN1726025A (zh) * | 2002-12-17 | 2006-01-25 | 泛华医药公司 | 作为免疫调节剂和抗癌剂的雷公藤内酯醇衍生物 |
| CN1223595C (zh) | 2002-12-27 | 2005-10-19 | 中国科学院上海药物研究所 | 雷公藤内酯醇衍生物及其应用 |
| US6943259B2 (en) * | 2003-02-25 | 2005-09-13 | Pharmagenesis, Inc. | Halogenated triptolide derivatives as immunomodulators and anticancer agents |
| WO2005062913A2 (en) | 2003-12-24 | 2005-07-14 | Pharmagenesis, Inc. | Triplide 5,6-derivatives as immunomodulators and anticancer agents |
| WO2005077008A2 (en) | 2004-02-09 | 2005-08-25 | Pharmagenesis, Inc. | Methods for isolation of triptolide compounds from tripterygium wilfordii |
| CA2557260C (en) | 2004-03-02 | 2013-02-12 | Pharmagenesis, Inc. | Triptolide lactone ring derivatives as immunomodulators and anticancer agents |
| EP1768662A2 (en) | 2004-06-24 | 2007-04-04 | Novartis Vaccines and Diagnostics, Inc. | Small molecule immunopotentiators and assays for their detection |
| WO2006044496A2 (en) | 2004-10-13 | 2006-04-27 | Pharmagenesis, Inc. | Identification and screening of triptolide target molecules |
| US8268882B2 (en) * | 2009-02-05 | 2012-09-18 | Pharmagenesis, Inc. | Triptolide C-ring derivatives as anticancer agents and immune modulators |
| CN107207525B (zh) * | 2015-10-29 | 2018-11-27 | 杭州卫本药业有限公司 | C14-位羟基酯化的雷公藤甲素氨基酸衍生物、及其制备方法和应用 |
| CN114716503B (zh) * | 2022-03-23 | 2024-03-12 | 广东省中医院（广州中医药大学第二附属医院、广州中医药大学第二临床医学院、广东省中医药科学院） | 一种雷公藤氯内酯醇的制备方法 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4005108A (en) * | 1973-04-03 | 1977-01-25 | Research Corporation | Novel anti-leukemic diterpenoid triepoxides |
| US5430054A (en) * | 1989-12-22 | 1995-07-04 | Jiangsu Family Planning Institute | Preparation methods of diterpene lactone compounds and application of the same to antifertility |
| US5663335A (en) * | 1996-03-01 | 1997-09-02 | Pharmagenesis, Inc. | Immunosuppressive compounds and methods |
-
1998
- 1998-04-27 KR KR19997010786A patent/KR20010012822A/ko not_active Application Discontinuation
- 1998-04-27 IL IL13308898A patent/IL133088A0/xx unknown
- 1998-04-27 AU AU72607/98A patent/AU741917B2/en not_active Ceased
- 1998-04-27 PT PT98919928T patent/PT983275E/pt unknown
- 1998-04-27 ES ES98919928T patent/ES2178207T3/es not_active Expired - Lifetime
- 1998-04-27 WO PCT/US1998/008470 patent/WO1998052951A1/en not_active Application Discontinuation
- 1998-04-27 AT AT98919928T patent/ATE222910T1/de active
- 1998-04-27 DE DE69807466T patent/DE69807466T2/de not_active Expired - Lifetime
- 1998-04-27 BR BR9809678-8A patent/BR9809678A/pt not_active Application Discontinuation
- 1998-04-27 HU HU0003398A patent/HUP0003398A3/hu unknown
- 1998-04-27 CA CA002287977A patent/CA2287977A1/en not_active Abandoned
- 1998-04-27 CN CN98805397A patent/CN1257507A/zh active Pending
- 1998-04-27 DK DK98919928T patent/DK0983275T3/da active
- 1998-04-27 EP EP98919928A patent/EP0983275B1/en not_active Expired - Lifetime
- 1998-04-27 NZ NZ500762A patent/NZ500762A/en not_active IP Right Cessation
- 1998-04-27 JP JP55037798A patent/JP2001525851A/ja active Pending
- 1998-05-18 ZA ZA984174A patent/ZA984174B/xx unknown
- 1998-05-19 TW TW087107719A patent/TW434235B/zh not_active IP Right Cessation
- 1998-05-20 AR ARP980102327A patent/AR012723A1/es unknown
-
1999
- 1999-11-22 NO NO995723A patent/NO995723L/no not_active Application Discontinuation
-
2000
- 2000-08-16 HK HK00105108A patent/HK1026096A1/xx not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| PT983275E (pt) | 2003-01-31 |
| NO995723L (no) | 2000-01-21 |
| ATE222910T1 (de) | 2002-09-15 |
| NZ500762A (en) | 2001-08-31 |
| EP0983275B1 (en) | 2002-08-28 |
| DK0983275T3 (da) | 2002-12-23 |
| ES2178207T3 (es) | 2002-12-16 |
| KR20010012822A (ko) | 2001-02-26 |
| HUP0003398A2 (en) | 2001-03-28 |
| CA2287977A1 (en) | 1998-11-26 |
| DE69807466T2 (de) | 2003-04-24 |
| WO1998052951A1 (en) | 1998-11-26 |
| CN1257507A (zh) | 2000-06-21 |
| HK1026096A1 (en) | 2000-12-01 |
| BR9809678A (pt) | 2000-07-11 |
| EP0983275A1 (en) | 2000-03-08 |
| AU741917B2 (en) | 2001-12-13 |
| ZA984174B (en) | 1998-11-23 |
| IL133088A0 (en) | 2001-03-19 |
| NO995723D0 (no) | 1999-11-22 |
| AU7260798A (en) | 1998-12-11 |
| DE69807466D1 (de) | 2002-10-02 |
| JP2001525851A (ja) | 2001-12-11 |
| TW434235B (en) | 2001-05-16 |
| AR012723A1 (es) | 2000-11-08 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| GB9A | Succession in title |
Owner name: AVENTISUB II INC., US Free format text: FORMER OWNER(S): HOECHST MARION ROUSSEL, INC., US; AVENTIS HOLDINGS INC., US; AVENTIS PHARMACEUTICALS, INC., US; HMR PHARMA, INC., US |
|
| FH91 | Appointment of a representative |
Free format text: FORMER REPRESENTATIVE(S): SOMLAI MARIA, S.B.G. & K. BUDAPESTI NEMZETKOEZI SZABADALMI IRODA, HU Representative=s name: DANUBIA SZABADALMI ES JOGI IRODA KFT., HU |
|
| FH92 | Termination of representative |
Representative=s name: SOMLAI MARIA, S.B.G. & K. BUDAPESTI NEMZETKOEZ, HU |
|
| FD9A | Lapse of provisional protection due to non-payment of fees |