IL132176A0 - Method for oral delivery of proteins - Google Patents

Method for oral delivery of proteins

Info

Publication number
IL132176A0
IL132176A0 IL13217698A IL13217698A IL132176A0 IL 132176 A0 IL132176 A0 IL 132176A0 IL 13217698 A IL13217698 A IL 13217698A IL 13217698 A IL13217698 A IL 13217698A IL 132176 A0 IL132176 A0 IL 132176A0
Authority
IL
Israel
Prior art keywords
proteins
oral delivery
oral
delivery
Prior art date
Application number
IL13217698A
Other languages
English (en)
Original Assignee
Purdue Research Foundation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Purdue Research Foundation filed Critical Purdue Research Foundation
Publication of IL132176A0 publication Critical patent/IL132176A0/xx

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/28—Insulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1635—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Endocrinology (AREA)
  • Immunology (AREA)
  • Diabetes (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Peptides Or Proteins (AREA)
IL13217698A 1997-04-02 1998-04-02 Method for oral delivery of proteins IL132176A0 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US4228097P 1997-04-02 1997-04-02
US6136797P 1997-10-08 1997-10-08
PCT/US1998/006563 WO1998043615A1 (en) 1997-04-02 1998-04-02 Method for oral delivery of proteins

Publications (1)

Publication Number Publication Date
IL132176A0 true IL132176A0 (en) 2001-03-19

Family

ID=26719055

Family Applications (1)

Application Number Title Priority Date Filing Date
IL13217698A IL132176A0 (en) 1997-04-02 1998-04-02 Method for oral delivery of proteins

Country Status (14)

Country Link
EP (1) EP0975328A1 (zh)
JP (1) JP2002512607A (zh)
KR (1) KR20010005952A (zh)
CN (1) CN1259045A (zh)
AU (1) AU727053B2 (zh)
BR (1) BR9808466A (zh)
CA (1) CA2285457A1 (zh)
IL (1) IL132176A0 (zh)
NO (1) NO994757L (zh)
NZ (1) NZ500075A (zh)
PL (1) PL335974A1 (zh)
TR (1) TR199903240T2 (zh)
WO (1) WO1998043615A1 (zh)
YU (1) YU49699A (zh)

Families Citing this family (43)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9006175B2 (en) 1999-06-29 2015-04-14 Mannkind Corporation Potentiation of glucose elimination
DE10040592A1 (de) * 2000-08-15 2002-03-07 Aventis Res & Tech Gmbh & Co Formulierung zur verbesserten Aufnahme von Wirkstoffen und deren Verwendung
US6878384B2 (en) 2001-03-13 2005-04-12 Microvention, Inc. Hydrogels that undergo volumetric expansion in response to changes in their environment and their methods of manufacture and use
DE60318938T2 (de) 2002-03-20 2009-01-22 Mannkind Corp., Valencia Inhalationsgerät
DK1786784T3 (da) 2004-08-20 2011-02-14 Mannkind Corp Katalyse af diketopiperazinsyntese
JP4990142B2 (ja) 2004-08-23 2012-08-01 マンカインド コーポレイション 薬物送達のためのジケトピペラジン塩、ジケトモルホリン塩、又はジケトジオキサン塩
US8110212B2 (en) 2005-04-07 2012-02-07 Drexel University Bioactive thermogelling polymer systems and methods of their use
AU2005334837B2 (en) 2005-07-29 2012-07-19 Stichting Groningen Centre For Drug Research PH-controlled pulsatile delivery system, methods for preparation and use thereof
MX2008001643A (es) * 2005-08-01 2008-04-07 Mannkind Corp Metodo para conservar la funcion de celulas productoras de insulina.
HUE028691T2 (en) 2005-09-14 2016-12-28 Mannkind Corp A method for formulating a drug based on increasing the affinity of crystalline microparticle surfaces towards active ingredients
AU2007216966C1 (en) 2006-02-22 2014-03-20 Mannkind Corporation A method for improving the pharmaceutic properties of microparticles comprising diketopiperazine and an active agent
CA2655026C (en) 2006-06-15 2016-08-02 Microvention, Inc. Embolization device constructed from expansible polymer
JP5698537B2 (ja) 2007-12-21 2015-04-08 マイクロベンション インコーポレイテッド 生物医学的使用のためのハイドロゲルフィラメント
ES2655921T3 (es) 2008-06-13 2018-02-22 Mannkind Corporation Un inhalador de polvo seco y sistema para administración de fármacos
US8485180B2 (en) 2008-06-13 2013-07-16 Mannkind Corporation Dry powder drug delivery system
ES2904623T3 (es) 2008-06-20 2022-04-05 Mannkind Corp Aparato interactivo para establecer un perfil en tiempo real de esfuerzos de inhalación
TWI532497B (zh) 2008-08-11 2016-05-11 曼凱公司 超快起作用胰島素之用途
US8314106B2 (en) 2008-12-29 2012-11-20 Mannkind Corporation Substituted diketopiperazine analogs for use as drug delivery agents
EP2405963B1 (en) 2009-03-11 2013-11-06 MannKind Corporation Apparatus, system and method for measuring resistance of an inhaler
WO2010144789A2 (en) 2009-06-12 2010-12-16 Mannkind Corporation Diketopiperazine microparticles with defined specific surface areas
HUP0900482A2 (en) 2009-08-03 2011-03-28 Cera Med Kft Pharmaceutical formulation for oral administration
JP2013505791A (ja) 2009-09-24 2013-02-21 マイクロベンション インコーポレイテッド 医学的使用のための注射用ヒドロゲル繊維
US9993252B2 (en) 2009-10-26 2018-06-12 Microvention, Inc. Embolization device constructed from expansile polymer
WO2011056889A1 (en) 2009-11-03 2011-05-12 Mannkind Corporation An apparatus and method for simulating inhalation efforts
KR20130117755A (ko) 2010-06-21 2013-10-28 맨카인드 코포레이션 건조 분말 약물 운반 시스템 및 방법
CN105667994B (zh) 2011-04-01 2018-04-06 曼金德公司 用于药物药盒的泡罩包装
WO2012145431A2 (en) 2011-04-18 2012-10-26 Microvention, Inc. Embolic devices
WO2012174472A1 (en) 2011-06-17 2012-12-20 Mannkind Corporation High capacity diketopiperazine microparticles
WO2013063160A1 (en) 2011-10-24 2013-05-02 Mannkind Corporation Methods and compositions for treating pain
US9011884B2 (en) 2012-04-18 2015-04-21 Microvention, Inc. Embolic devices
CN108057154B (zh) 2012-07-12 2021-04-16 曼金德公司 干粉药物输送系统和方法
US10159644B2 (en) 2012-10-26 2018-12-25 Mannkind Corporation Inhalable vaccine compositions and methods
JP6523247B2 (ja) 2013-03-15 2019-05-29 マンカインド コーポレイション 微結晶性ジケトピペラジン粒子の製造方法および乾燥粉末組成物の製造方法
EP3021834A1 (en) 2013-07-18 2016-05-25 MannKind Corporation Heat-stable dry powder pharmaceutical compositions and methods
EP3030294B1 (en) 2013-08-05 2020-10-07 MannKind Corporation Insufflation apparatus
WO2015021044A1 (en) * 2013-08-05 2015-02-12 University Of Rochester Compositions and methods for stimuli-responsive release of a therapeutic agent
US10307464B2 (en) 2014-03-28 2019-06-04 Mannkind Corporation Use of ultrarapid acting insulin
WO2015153996A1 (en) 2014-04-03 2015-10-08 Micro Vention, Inc. Embolic devices
WO2015167752A1 (en) 2014-04-29 2015-11-05 Microvention, Inc. Polymers including active agents
WO2015167751A1 (en) 2014-04-29 2015-11-05 Microvention, Inc. Polymers
US10561806B2 (en) 2014-10-02 2020-02-18 Mannkind Corporation Mouthpiece cover for an inhaler
US10265405B2 (en) 2014-11-18 2019-04-23 Board Of Regents, The University Of Texas System Polymers for delivery of factor VIII and/or factor IX
WO2016201250A1 (en) 2015-06-11 2016-12-15 Microvention, Inc. Expansile device for implantation

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2976576A (en) * 1956-04-24 1961-03-28 Wichterle Otto Process for producing shaped articles from three-dimensional hydrophilic high polymers
US3220960A (en) * 1960-12-21 1965-11-30 Wichterle Otto Cross-linked hydrophilic polymers and articles made therefrom
IT1050353B (it) * 1966-01-06 1981-03-10 Ceskoslovenska Akademie Ved Supporti per sostanze biologigamente attive
US3607848A (en) * 1967-08-07 1971-09-21 Ceskoslovenska Akademie Ved Method for preparing insoluble,cross-linked organic hydrogels comprising copolymers of glycol monoesters with diesters
US3885078A (en) * 1968-03-06 1975-05-20 Ceskoslovenska Akademie Ved Hydrogel laminates and method of manufacturing thereof
US4071508A (en) * 1975-02-11 1978-01-31 Plastomedical Sciences, Inc. Anionic hydrogels based on hydroxyalkyl acrylates and methacrylates
FR2601026B1 (fr) * 1986-04-15 1988-09-16 Rhone Poulenc Chimie Matiere seche hydratable en un gel aqueux contenant des particules de polymeres dispersees, procede pour sa preparation et son application en biologie

Also Published As

Publication number Publication date
CN1259045A (zh) 2000-07-05
YU49699A (sh) 2002-12-10
PL335974A1 (en) 2000-06-05
EP0975328A1 (en) 2000-02-02
WO1998043615A1 (en) 1998-10-08
CA2285457A1 (en) 1998-10-08
JP2002512607A (ja) 2002-04-23
AU727053B2 (en) 2000-11-30
AU6880998A (en) 1998-10-22
NO994757L (no) 1999-11-29
NO994757D0 (no) 1999-09-30
NZ500075A (en) 2001-03-30
KR20010005952A (ko) 2001-01-15
BR9808466A (pt) 2001-08-07
TR199903240T2 (xx) 2000-05-22

Similar Documents

Publication Publication Date Title
IL132176A0 (en) Method for oral delivery of proteins
IL113456A0 (en) Modified amino acids for oral drug delivery
AUPO066096A0 (en) Oral delivery of peptides
HUP9701554D0 (en) Pharmaceutical composition containing plazma proteins
IL134633A0 (en) Process for preparing glufosinate and intermediates therefor
IL134699A0 (en) Protein composition and process for isolating a protein composition from a muscle source
AU5705398A (en) Method for automatic dosing of drugs
EP0725145A4 (en) PROTEIN MODIFICATION PROCESS
NZ324642A (en) Composition for delivery of nucleic acids
GB9710800D0 (en) Pharmaceutical composition and method of preparing it
HUP0105460A2 (en) Hemiasterlin analogs and process for preparation thereof
EP0950663A4 (en) USEFUL PROTEIN STABILIZATION AND USEFUL PROTEIN COMPOSITIONS
PL341559A1 (en) Method of obtaining polyamides
ZA983065B (en) Inhibitors of protein farnesyltranferase
GB9719161D0 (en) New therapeutic method
ZA981885B (en) Method for the preparation of alpha-bromo-lactam derivatives
AU1328599A (en) Apparatus for placement of dental fillings
HK1022695A1 (en) Method for debenzylation of dibenzylbiotin
EP0976380A4 (en) METHOD FOR RECALCIFYING THE TEETH
IL136878A0 (en) Method for inhaling powdery substances
EP0987942A4 (en) PHARMACEUTICAL COMPOSITION AND METHOD OF USE
GB9724786D0 (en) Oral delivery system
AP9700964A0 (en) Phenyl peptides method for preparing same and pharmaceutical compositions containing said peptides
AP2000001781A0 (en) Process for preparation of azacycloalkylalkanoyl pseudotetrapeptides
GB9720059D0 (en) Method of bonding