IL128499A - Process for the preparation of N - [(1 - n-butyl - 4 - piperidyl) methyl] - 3, 4 - dihydro - 2H - [3,1] oxazino [2,3 - [a indole-10 - carboxamide and their new salts and intermediates Alkyl - 3, 4-dihydro - 2H - [1, 3] oxazino [a - 2, 3] indole - 10 - carboxylate - Google Patents

Process for the preparation of N - [(1 - n-butyl - 4 - piperidyl) methyl] - 3, 4 - dihydro - 2H - [3,1] oxazino [2,3 - [a indole-10 - carboxamide and their new salts and intermediates Alkyl - 3, 4-dihydro - 2H - [1, 3] oxazino [a - 2, 3] indole - 10 - carboxylate

Info

Publication number
IL128499A
IL128499A IL12849997A IL12849997A IL128499A IL 128499 A IL128499 A IL 128499A IL 12849997 A IL12849997 A IL 12849997A IL 12849997 A IL12849997 A IL 12849997A IL 128499 A IL128499 A IL 128499A
Authority
IL
Israel
Prior art keywords
indole
methyl
oxazino
dihydro
solution
Prior art date
Application number
IL12849997A
Other languages
English (en)
Hebrew (he)
Other versions
IL128499A0 (en
Original Assignee
Smithkline Beecham Plc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9617188.9A external-priority patent/GB9617188D0/en
Priority claimed from GBGB9618968.3A external-priority patent/GB9618968D0/en
Application filed by Smithkline Beecham Plc filed Critical Smithkline Beecham Plc
Priority to IL14323097A priority Critical patent/IL143230A/en
Publication of IL128499A0 publication Critical patent/IL128499A0/xx
Publication of IL128499A publication Critical patent/IL128499A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Indole Compounds (AREA)
IL12849997A 1996-08-16 1997-08-11 Process for the preparation of N - [(1 - n-butyl - 4 - piperidyl) methyl] - 3, 4 - dihydro - 2H - [3,1] oxazino [2,3 - [a indole-10 - carboxamide and their new salts and intermediates Alkyl - 3, 4-dihydro - 2H - [1, 3] oxazino [a - 2, 3] indole - 10 - carboxylate IL128499A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
IL14323097A IL143230A (en) 1996-08-16 1997-08-11 Methyl - 2 (-3-chloropropoxy) - indole - 3 carboxylate and its use in the process to form methyl 3 - 4 - dihydro - 2H - [3,1] oxazino [3, 2 - [a indole-10 - carboxylate

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB9617188.9A GB9617188D0 (en) 1996-08-16 1996-08-16 Pharmaceuticals
GBGB9618968.3A GB9618968D0 (en) 1996-09-11 1996-09-11 Pharmaceuticals
PCT/EP1997/004413 WO1998007728A1 (en) 1996-08-16 1997-08-11 PROCESS FOR THE PREPARATION OF N-[(1-nBUTYL-4-PIPERIDYL)METHYL] -3,4-DIHYDRO -2H-[1,3] OXAZINO[3,2-a] INDOLE-10-CARBOXAMIDE AND SALTS AND INTERMEDIATES IN THE PROCESS

Publications (2)

Publication Number Publication Date
IL128499A0 IL128499A0 (en) 2000-01-31
IL128499A true IL128499A (en) 2002-11-10

Family

ID=26309880

Family Applications (1)

Application Number Title Priority Date Filing Date
IL12849997A IL128499A (en) 1996-08-16 1997-08-11 Process for the preparation of N - [(1 - n-butyl - 4 - piperidyl) methyl] - 3, 4 - dihydro - 2H - [3,1] oxazino [2,3 - [a indole-10 - carboxamide and their new salts and intermediates Alkyl - 3, 4-dihydro - 2H - [1, 3] oxazino [a - 2, 3] indole - 10 - carboxylate

Country Status (25)

Country Link
EP (1) EP0922048B1 (ar)
JP (1) JP3911297B2 (ar)
KR (1) KR100494278B1 (ar)
CN (1) CN1104435C (ar)
AR (1) AR008297A1 (ar)
AT (1) ATE197588T1 (ar)
AU (1) AU717177B2 (ar)
BR (1) BR9711189A (ar)
CA (1) CA2263480C (ar)
CZ (1) CZ290517B6 (ar)
DE (1) DE69703554T2 (ar)
DK (1) DK0922048T3 (ar)
ES (1) ES2151743T3 (ar)
GR (1) GR3034895T3 (ar)
HK (1) HK1020731A1 (ar)
IL (1) IL128499A (ar)
NO (1) NO311574B1 (ar)
NZ (1) NZ334064A (ar)
PL (1) PL185815B1 (ar)
PT (1) PT922048E (ar)
SA (1) SA97180430B1 (ar)
SI (1) SI0922048T1 (ar)
TR (1) TR199900321T2 (ar)
TW (1) TW427990B (ar)
WO (1) WO1998007728A1 (ar)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9815483D0 (en) * 1998-07-16 1998-09-16 Smithkline Beecham Plc Pharmaceuticals
US20020091271A1 (en) * 1998-07-16 2002-07-11 Smithkline Beecham Plc Process for the preparation of an indole derivative
GB9815481D0 (en) * 1998-07-16 1998-09-16 Smithkline Beecham Plc Pharmaceuticals
US6277456B1 (en) * 1999-09-24 2001-08-21 Brady Worldwide, Inc. Labeling media and method of making
AU782863C (en) * 2000-08-07 2006-08-31 Glaxo Group Limited The use of 5HT4 receptor antagonists in the prophylaxis or treatment of certain cardiovascular conditions
AU782870C (en) * 2000-08-07 2007-03-15 Glaxo Group Limited The use of 5HT4 receptor antagonists in the prophylaxis or treatment of certain cardiovascular conditions
MXPA03001210A (es) * 2000-08-07 2004-08-12 Smithkline Beecham Corp Uso de antagonista del receptor 5-ht4 en la fabricacion de un medicamento para la profilaxis o tratamiento de fibrilacion atrial.
GB0211230D0 (en) 2002-05-16 2002-06-26 Medinnova Sf Treatment of heart failure
ITMI20030287A1 (it) 2003-02-18 2004-08-19 Acraf Indazolammidi dotate di attivita' analgesica metodo, per
ITMI20030972A1 (it) 2003-05-15 2004-11-16 Acraf Indazolo dotato di attivita' analgesica, metodo per prepararlo e composizione farmaceutica che lo comprende.

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0884319B1 (en) * 1992-03-12 2004-05-06 SmithKline Beecham plc N- (1-nButyl-4-piperidyl)methyl -3,4-dihydro-2H- 1,3 oxazino 3,2-a indole-10-carboxamide or a pharmaceutically acceptable salt thereof

Also Published As

Publication number Publication date
AR008297A1 (es) 1999-12-29
TW427990B (en) 2001-04-01
IL128499A0 (en) 2000-01-31
PL331647A1 (en) 1999-08-02
NO990697D0 (no) 1999-02-15
DE69703554T2 (de) 2001-07-05
JP2000516240A (ja) 2000-12-05
EP0922048A1 (en) 1999-06-16
NO311574B1 (no) 2001-12-10
SA97180430B1 (ar) 2006-10-29
NO990697L (no) 1999-02-15
PT922048E (pt) 2001-03-30
SI0922048T1 (en) 2001-02-28
DE69703554D1 (de) 2000-12-21
CN1233250A (zh) 1999-10-27
KR20000068174A (ko) 2000-11-25
CN1104435C (zh) 2003-04-02
CA2263480C (en) 2007-03-06
JP3911297B2 (ja) 2007-05-09
WO1998007728A1 (en) 1998-02-26
AU4204897A (en) 1998-03-06
TR199900321T2 (xx) 1999-04-21
AU717177B2 (en) 2000-03-16
PL185815B1 (pl) 2003-08-29
DK0922048T3 (da) 2001-01-08
CZ51699A3 (cs) 1999-07-14
ES2151743T3 (es) 2001-01-01
BR9711189A (pt) 1999-08-17
CZ290517B6 (cs) 2002-08-14
GR3034895T3 (en) 2001-02-28
KR100494278B1 (ko) 2005-06-13
HK1020731A1 (en) 2000-06-09
CA2263480A1 (en) 1998-02-26
ATE197588T1 (de) 2000-12-15
EP0922048B1 (en) 2000-11-15
NZ334064A (en) 2000-08-25

Similar Documents

Publication Publication Date Title
IL128499A (en) Process for the preparation of N - [(1 - n-butyl - 4 - piperidyl) methyl] - 3, 4 - dihydro - 2H - [3,1] oxazino [2,3 - [a indole-10 - carboxamide and their new salts and intermediates Alkyl - 3, 4-dihydro - 2H - [1, 3] oxazino [a - 2, 3] indole - 10 - carboxylate
NO301369B1 (no) 1-aminoetylindolderivater
CN1367776A (zh) 制备取代环戊烷衍生物的方法及其新的晶体结构
US7205402B2 (en) Synthesis of a benzoxazinone
IL143230A (en) Methyl - 2 (-3-chloropropoxy) - indole - 3 carboxylate and its use in the process to form methyl 3 - 4 - dihydro - 2H - [3,1] oxazino [3, 2 - [a indole-10 - carboxylate
US6583294B2 (en) Process for the preparation of an indole derivative
Chupakhin et al. Asymmetric induction in the reactions of azinones with C-nucleophiles
US6100397A (en) Process for the preparation of N-[(1-n butyl-4-piperidyl)methyl]-3,4-dihydro-2H-[1,3]oxazino[3,2-a] indole-10-carboxamide and salts and intermediates in the process
US20080139823A1 (en) Process for the Purification of Perindopril
EP1097135B1 (en) Process for the preparation of an indole derivative
EP1097136B1 (en) Process for the preparation of an indole derivative
EP0927163B1 (en) Preparation of 1-butyl-4-piperidinylmethylamine
CN115626903A (zh) 一种eed抑制剂中间体的制备方法
WO2024126634A1 (en) Process for the preparation of a quinazolinone derivative
NZ537947A (en) Method for producing highly pure hydroxy indolyl glyoxylic acid amides

Legal Events

Date Code Title Description
FF Patent granted
KB Patent renewed
KB Patent renewed
KB Patent renewed
MM9K Patent not in force due to non-payment of renewal fees