IL128376A0 - Synthesis of bisindolylmalimides - Google Patents
Synthesis of bisindolylmalimidesInfo
- Publication number
- IL128376A0 IL128376A0 IL12837697A IL12837697A IL128376A0 IL 128376 A0 IL128376 A0 IL 128376A0 IL 12837697 A IL12837697 A IL 12837697A IL 12837697 A IL12837697 A IL 12837697A IL 128376 A0 IL128376 A0 IL 128376A0
- Authority
- IL
- Israel
- Prior art keywords
- bisindolylmalimides
- synthesis
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/36—Oxygen or sulfur atoms
- C07D207/40—2,5-Pyrrolidine-diones
- C07D207/404—2,5-Pyrrolidine-diones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms, e.g. succinimide
- C07D207/408—Radicals containing only hydrogen and carbon atoms attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US2412096P | 1996-08-23 | 1996-08-23 | |
| PCT/US1997/014771 WO1998007693A1 (en) | 1996-08-23 | 1997-08-22 | Synthesis of bisindolylmalimides |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IL128376A0 true IL128376A0 (en) | 2000-01-31 |
Family
ID=21818966
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL12837697A IL128376A0 (en) | 1996-08-23 | 1997-08-22 | Synthesis of bisindolylmalimides |
Country Status (16)
| Country | Link |
|---|---|
| US (2) | US5990319A (ru) |
| EP (1) | EP0825190A1 (ru) |
| JP (1) | JP2000516632A (ru) |
| KR (1) | KR20000068323A (ru) |
| CN (1) | CN1228082A (ru) |
| AU (1) | AU716840B2 (ru) |
| BR (1) | BR9711363A (ru) |
| CA (1) | CA2263862A1 (ru) |
| EA (1) | EA001392B1 (ru) |
| HU (1) | HUP0003203A3 (ru) |
| IL (1) | IL128376A0 (ru) |
| NO (1) | NO990832L (ru) |
| NZ (1) | NZ334030A (ru) |
| PL (1) | PL331899A1 (ru) |
| WO (1) | WO1998007693A1 (ru) |
| YU (1) | YU9499A (ru) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AR017200A1 (es) | 1997-12-23 | 2001-08-22 | Astrazeneca Ab | Compuestos inhibidores de la proteina cinasa c, sales farmaceuticamente aceptables de los mismos, formulaciones farmaceuitcas que los comprenden, usode las mismas y proceso para la sintesis de dichos compuestos |
| SE9800835D0 (sv) | 1998-03-13 | 1998-03-13 | Astra Ab | New Compounds |
| US6492406B1 (en) | 1999-05-21 | 2002-12-10 | Astrazeneca Ab | Pharmaceutically active compounds |
| ZA200706530B (en) | 2005-02-09 | 2009-01-28 | Arqule Inc | Meleimide derivatives, pharmaceutical compositions and methods for treatment of cancer |
| AU2008268613A1 (en) | 2007-06-22 | 2008-12-31 | Arqule, Inc. | Quinazolinone compounds and methods of use thereof |
| CA2690782C (en) | 2007-06-22 | 2016-02-02 | Arqule, Inc. | Compositions and methods for treatment of cancer |
| CN101801961B (zh) | 2007-06-22 | 2014-09-24 | 艾科尔公司 | 吡咯烷酮、吡咯烷-2,5-二酮、吡咯烷和硫代琥珀酰亚胺衍生物、组合物以及治疗癌症的方法 |
| FR2927075A1 (fr) * | 2008-02-04 | 2009-08-07 | Centre Nat Rech Scient | Molecules comprenant un squelette bis-(heteroaryl)maleimide, et leur utilisation dans l'inhibition d'enzymes |
| CN104379144A (zh) * | 2012-04-23 | 2015-02-25 | 艾科尔公司 | 高度纯的吡咯并喹啉基-吡咯-2,5-二酮和吡咯并喹啉基-吡咯烷-2,5-二酮及其制备方法 |
| CN104496970B (zh) * | 2014-12-17 | 2017-01-11 | 河南师范大学 | 3,4-二(3-吲哚)-2,5-二酮-3-吡咯啉亚胺类化合物及其制备方法和应用 |
| CN104710412B (zh) * | 2015-03-27 | 2017-03-22 | 河南师范大学 | 具有抗癌活性的3,4‑二（3‑吲哚）‑2,5‑二酮‑1‑吡咯胺硫脲类化合物及其制备方法和应用 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CZ280738B6 (cs) * | 1988-02-10 | 1996-04-17 | F. Hoffmann - La Roche And Co., Aktiengesellschaft | Substituované pyrroly, jejich použití pro výrobu léčiv a léčiva na jejich bázi |
| GB9123396D0 (en) * | 1991-11-04 | 1991-12-18 | Hoffmann La Roche | A process for the manufacture of substituted maleimides |
| US5339712A (en) * | 1993-10-25 | 1994-08-23 | Daryoush Keyvani | Hand tool having offset work elements |
| US5624949A (en) * | 1993-12-07 | 1997-04-29 | Eli Lilly And Company | Protein kinase C inhibitors |
| US5541347A (en) * | 1993-12-07 | 1996-07-30 | Eli Lilly And Company | Synthesis of bisindolylmaleimides |
| US5559228A (en) * | 1995-03-30 | 1996-09-24 | Eli Lilly And Company | Synthesis of bisindolylmaleimides |
-
1997
- 1997-08-22 CN CN97197361A patent/CN1228082A/zh active Pending
- 1997-08-22 KR KR1019997001485A patent/KR20000068323A/ko not_active Application Discontinuation
- 1997-08-22 IL IL12837697A patent/IL128376A0/xx unknown
- 1997-08-22 YU YU9499A patent/YU9499A/sh unknown
- 1997-08-22 BR BR9711363A patent/BR9711363A/pt unknown
- 1997-08-22 JP JP10510991A patent/JP2000516632A/ja active Pending
- 1997-08-22 US US08/917,052 patent/US5990319A/en not_active Expired - Fee Related
- 1997-08-22 CA CA002263862A patent/CA2263862A1/en not_active Abandoned
- 1997-08-22 EA EA199900221A patent/EA001392B1/ru not_active IP Right Cessation
- 1997-08-22 HU HU0003203A patent/HUP0003203A3/hu unknown
- 1997-08-22 EP EP97306438A patent/EP0825190A1/en not_active Withdrawn
- 1997-08-22 PL PL97331899A patent/PL331899A1/xx unknown
- 1997-08-22 WO PCT/US1997/014771 patent/WO1998007693A1/en not_active Application Discontinuation
- 1997-08-22 AU AU41570/97A patent/AU716840B2/en not_active Ceased
- 1997-08-22 NZ NZ334030A patent/NZ334030A/xx unknown
-
1998
- 1998-05-19 US US09/081,252 patent/US5948907A/en not_active Expired - Fee Related
-
1999
- 1999-02-22 NO NO990832A patent/NO990832L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| AU716840B2 (en) | 2000-03-09 |
| NZ334030A (en) | 2000-08-25 |
| HUP0003203A2 (hu) | 2001-06-28 |
| US5948907A (en) | 1999-09-07 |
| JP2000516632A (ja) | 2000-12-12 |
| KR20000068323A (ko) | 2000-11-25 |
| PL331899A1 (en) | 1999-08-16 |
| CA2263862A1 (en) | 1998-02-26 |
| NO990832L (no) | 1999-04-13 |
| BR9711363A (pt) | 1999-08-17 |
| HUP0003203A3 (en) | 2002-01-28 |
| NO990832D0 (no) | 1999-02-22 |
| CN1228082A (zh) | 1999-09-08 |
| YU9499A (sh) | 2000-03-21 |
| EA001392B1 (ru) | 2001-02-26 |
| EA199900221A1 (ru) | 1999-08-26 |
| AU4157097A (en) | 1998-03-06 |
| EP0825190A1 (en) | 1998-02-25 |
| WO1998007693A1 (en) | 1998-02-26 |
| US5990319A (en) | 1999-11-23 |
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