IL127964A - Method for assessing chemosensitivity of patient cells - Google Patents

Method for assessing chemosensitivity of patient cells

Info

Publication number
IL127964A
IL127964A IL12796497A IL12796497A IL127964A IL 127964 A IL127964 A IL 127964A IL 12796497 A IL12796497 A IL 12796497A IL 12796497 A IL12796497 A IL 12796497A IL 127964 A IL127964 A IL 127964A
Authority
IL
Israel
Prior art keywords
cells
active agent
chemosensitivity
agent
patient
Prior art date
Application number
IL12796497A
Other languages
English (en)
Other versions
IL127964A0 (en
Original Assignee
Precision Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Precision Therapeutics Inc filed Critical Precision Therapeutics Inc
Publication of IL127964A0 publication Critical patent/IL127964A0/xx
Publication of IL127964A publication Critical patent/IL127964A/en

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5044—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving specific cell types
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5011—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing antineoplastic activity
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5014—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing toxicity
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/52—Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Molecular Biology (AREA)
  • Urology & Nephrology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Cell Biology (AREA)
  • Toxicology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Food Science & Technology (AREA)
  • Microbiology (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Biotechnology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Organic Chemistry (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Dermatology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)
IL12796497A 1996-07-12 1997-07-10 Method for assessing chemosensitivity of patient cells IL127964A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/679,056 US5728541A (en) 1996-07-12 1996-07-12 Method for preparing cell cultures from biologial specimens for chemotherapeutic and other assays
PCT/US1997/011595 WO1998002038A1 (en) 1996-07-12 1997-07-10 Precise efficacy assay methods for active agents including chemotherapeutic agents

Publications (2)

Publication Number Publication Date
IL127964A0 IL127964A0 (en) 1999-11-30
IL127964A true IL127964A (en) 2001-07-24

Family

ID=24725407

Family Applications (1)

Application Number Title Priority Date Filing Date
IL12796497A IL127964A (en) 1996-07-12 1997-07-10 Method for assessing chemosensitivity of patient cells

Country Status (13)

Country Link
US (13) US5728541A (de)
EP (1) EP0912085B1 (de)
JP (1) JP4108128B2 (de)
CN (1) CN1143618C (de)
AT (1) ATE360989T1 (de)
AU (1) AU712302B2 (de)
BR (1) BR9710348A (de)
CA (1) CA2259984C (de)
DE (1) DE69737684T2 (de)
ES (1) ES2283022T3 (de)
IL (1) IL127964A (de)
NZ (1) NZ333830A (de)
WO (1) WO1998002038A1 (de)

Families Citing this family (71)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5728541A (en) * 1996-07-12 1998-03-17 Precision Therapeutics, Inc. Method for preparing cell cultures from biologial specimens for chemotherapeutic and other assays
US20040023375A1 (en) * 2002-07-30 2004-02-05 Precision Therapeutics, Inc. Method for preparing cell cultures from biological specimens for chemotherapeutic and other assays
US6416967B2 (en) * 1996-07-12 2002-07-09 Precision Therapeutics, Inc. Method of using multicellular particulates to analyze malignant or hyperproliferative tissue
US20040072722A1 (en) 2002-10-10 2004-04-15 Kornblith Paul L. Methods for assessing efficacy of chemotherapeutic agents
US6171780B1 (en) 1997-06-02 2001-01-09 Aurora Biosciences Corporation Low fluorescence assay platforms and related methods for drug discovery
US6517781B1 (en) * 1997-06-02 2003-02-11 Aurora Biosciences Corporation Low fluorescence assay platforms and related methods for drug discovery
US6861035B2 (en) * 1998-02-24 2005-03-01 Aurora Discovery, Inc. Multi-well platforms, caddies, lids and combinations thereof
DE19912798C1 (de) * 1999-03-10 2000-02-17 Andreas Jordan Verfahren zur Kultivierung von Krebszellen aus Humangewebe und Vorrichtung zur Aufbereitung von Gewebeproben
US20040086888A1 (en) * 2001-10-18 2004-05-06 Kornblith Paul L Method for tandem genomic/proteomic analysis of proliferating cells
US7276351B2 (en) 2003-09-10 2007-10-02 Seahorse Bioscience Method and device for measuring multiple physiological properties of cells
US8658349B2 (en) * 2006-07-13 2014-02-25 Seahorse Bioscience Cell analysis apparatus and method
US20070087401A1 (en) * 2003-10-17 2007-04-19 Andy Neilson Analysis of metabolic activity in cells using extracellular flux rate measurements
WO2005114178A1 (de) * 2004-05-21 2005-12-01 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Multizelluläre testsysteme
EP1929306A4 (de) * 2005-09-01 2009-11-11 Precision Therapeutics Inc Chemosensible assays, die tumorzellen mit persistenten phänotypischen merkmalen
EP2136630A4 (de) * 2007-03-23 2010-06-02 Precision Therapeutics Inc Verfahren zur auswertung des angiogenen potentials in kultur
WO2008150496A2 (en) * 2007-05-31 2008-12-11 Genelux Corporation Assay for sensitivity to chemotherapeutic agents
EP2207892A4 (de) * 2007-10-15 2010-12-08 Precision Therapeutics Inc Verfahren zur selektion aktiver agentien für die krebsbehandlung
WO2009054996A2 (en) * 2007-10-25 2009-04-30 Genelux Corporation Systems and methods for viral therapy
NZ600339A (en) 2008-02-25 2013-12-20 Nestec Sa Drug selection for breast cancer therapy using antibody-based arrays
US20100311084A1 (en) * 2008-05-14 2010-12-09 Precision Therapeutics, Inc. Methods for predicting a patient's response to egfr inhibitors
MX2010012408A (es) * 2008-05-14 2011-03-30 Prec Therapeutics Inc Star Metodos para predecir la respuesta de un paciente a los inhibidores del egfr.
WO2010003057A2 (en) 2008-07-03 2010-01-07 Mayo Foundation For Medical Education And Research Treating cancer
US8202702B2 (en) * 2008-10-14 2012-06-19 Seahorse Bioscience Method and device for measuring extracellular acidification and oxygen consumption rate with higher precision
US20110238322A1 (en) * 2008-11-03 2011-09-29 Precision Therapeutics, Inc. Methods of simulating chemotherapy for a patient
US8357175B2 (en) * 2008-12-16 2013-01-22 Nico Corporation Positioning system for tissue removal device
US20100152762A1 (en) * 2008-12-16 2010-06-17 Mark Joseph L Tissue removal system with multi-directional foot actuator assembly for neurosurgical and spinal surgery applications
US9655639B2 (en) * 2008-12-16 2017-05-23 Nico Corporation Tissue removal device for use with imaging devices in neurosurgical and spinal surgery applications
US9216031B2 (en) 2008-12-16 2015-12-22 Nico Corporation Tissue removal device with adjustable fluid supply sleeve for neurosurgical and spinal surgery applications
US9279751B2 (en) 2008-12-16 2016-03-08 Nico Corporation System and method of taking and collecting tissue cores for treatment
US8496599B2 (en) * 2008-12-16 2013-07-30 Nico Corporation Tissue removal device for neurosurgical and spinal surgery applications
US10368890B2 (en) 2008-12-16 2019-08-06 Nico Corporation Multi-functional surgical device for neurosurgical and spinal surgery applications
US8460327B2 (en) * 2008-12-16 2013-06-11 Nico Corporation Tissue removal device for neurosurgical and spinal surgery applications
US9931105B2 (en) 2008-12-16 2018-04-03 Nico Corporation System and method of taking and collecting tissue cores for treatment
US9820480B2 (en) 2008-12-16 2017-11-21 Nico Corporation System for collecting and preserving tissue cores
US8430825B2 (en) * 2008-12-16 2013-04-30 Nico Corporation Tissue removal device for neurosurgical and spinal surgery applications
US10080578B2 (en) 2008-12-16 2018-09-25 Nico Corporation Tissue removal device with adjustable delivery sleeve for neurosurgical and spinal surgery applications
US9504247B2 (en) 2008-12-16 2016-11-29 Nico Corporation System for collecting and preserving tissue cores
US8657841B2 (en) 2008-12-16 2014-02-25 Nico Corporation Tissue removal device for neurosurgical and spinal surgery applications
US8702738B2 (en) * 2008-12-16 2014-04-22 Nico Corporation Tissue removal device for neurosurgical and spinal surgery applications
US20110014644A1 (en) 2009-06-22 2011-01-20 Precision Therapeutics, Inc. Methods for predicting a cancer patient's response to antifolate chemotherapy
AU2010273319B2 (en) 2009-07-15 2015-01-22 Nestec S.A. Drug selection for gastric cancer therapy using antibody-based arrays
US20110097748A1 (en) * 2009-10-28 2011-04-28 Warsaw Orthopedic, Inc. Use of cell lines to determine levels of efficacy of pharmaceutical formulations
JP5847733B2 (ja) 2010-01-28 2016-01-27 ザ リージェンツ オブ ザ ユニバーシティ オブ ミシガン 懸滴用アレイプレート
HRP20200793T1 (hr) 2011-05-09 2020-10-16 Mayo Foundation For Medical Education And Research Liječenje raka
US9963481B2 (en) 2011-09-07 2018-05-08 The Scripps Research Institute Chiral oligomeric pentenoate amides as bio-oligomer mimetics
WO2013109753A1 (en) 2012-01-17 2013-07-25 Nico Corporation System for collecting and preserving tissue cores
US8784795B2 (en) * 2012-07-05 2014-07-22 Caldera Health Limited Methods for determining personalized treatment compositions for prostate cancer and breast cancer
CA2917407C (en) 2012-10-01 2023-03-14 Mayo Foundation For Medical Education And Research Complexes containing albumin-containing nanoparticles and antibodies to treat cancer
US9494577B2 (en) 2012-11-13 2016-11-15 Seahorse Biosciences Apparatus and methods for three-dimensional tissue measurements based on controlled media flow
BR112015024780A2 (pt) * 2013-03-28 2017-10-10 Ct Hospitalier Universitaire Montpellier metodo para determinar radiosensibilidade
EP2796873A1 (de) * 2013-04-25 2014-10-29 QGel SA Verfahren zur zellbasierten Arzneimitteluntersuchungsprüfung und Verwendung davon
DE102013010528B3 (de) * 2013-06-25 2014-02-20 FLACOD GmbH Verfahren zur Erstellung einer Datenbank für die Vorabschätzung der Wirksamkeit von Wirkstoffen in der Tumortherapie
US10118177B2 (en) 2014-06-02 2018-11-06 Seahorse Bioscience Single column microplate system and carrier for analysis of biological samples
CA2950926A1 (en) 2014-06-13 2015-12-17 Mayo Foundation For Medical Education And Research Albumin-bound paclitaxel nanoparticle/rituximab complexes for treatment of cd20-expressing lymphomas
JP6600651B2 (ja) 2014-06-16 2019-10-30 マヨ ファウンデーション フォー メディカル エデュケーション アンド リサーチ 骨髄腫の治療
US20170138924A1 (en) * 2014-06-20 2017-05-18 Connecticut Children's Medical Center Automated cell culture system and corresponding methods
US9446148B2 (en) 2014-10-06 2016-09-20 Mayo Foundation For Medical Education And Research Carrier-antibody compositions and methods of making and using the same
TW201707725A (zh) 2015-08-18 2017-03-01 美國馬友醫藥教育研究基金會 載體-抗體組合物及其製造及使用方法
TW201713360A (en) 2015-10-06 2017-04-16 Mayo Foundation Methods of treating cancer using compositions of antibodies and carrier proteins
EP3399861A4 (de) 2016-01-07 2019-08-07 Mayo Foundation for Medical Education and Research Verfahren zur behandlung von krebs mit interferon
US11351254B2 (en) 2016-02-12 2022-06-07 Mayo Foundation For Medical Education And Research Hematologic cancer treatments
EP3432926A4 (de) 2016-03-21 2019-11-20 Mayo Foundation for Medical Education and Research Verfahren zur verminderung der toxizität eines chemotherapeutikums
CA3018340A1 (en) 2016-03-21 2017-09-28 Mayo Foundation For Medical Education And Research Methods for improving the therapeutic index for a chemotherapeutic drug
US10618969B2 (en) 2016-04-06 2020-04-14 Mayo Foundation For Medical Education And Research Carrier-binding agent compositions and methods of making and using the same
EP3506950A1 (de) 2016-09-01 2019-07-10 Mayo Foundation for Medical Education and Research Gegen t-zell-karzinome gerichtete verfahren und zusammensetzungen
JP7525999B2 (ja) 2016-09-01 2024-07-31 マヨ ファウンデーション フォー メディカル エデュケーション アンド リサーチ キャリアー-pd-l1結合剤組成物及び癌を処置する為にそれを使用する方法
EP3509635A1 (de) 2016-09-06 2019-07-17 Vavotar Life Sciences LLC Verfahren zur behandlung von dreifach negativem brustkrebs unter verwendung von zusammensetzungen aus antikörpern und trägerproteinen
RU2756892C2 (ru) 2016-09-06 2021-10-06 Мэйо Фаундейшн Фор Медикал Эдьюкейшн Энд Рисерч Композиции с паклитакселом, альбумином и связывающим средством и способы их применения и получения
CN109843924A (zh) 2016-09-06 2019-06-04 梅约医学教育与研究基金会 治疗表达pd-l1的癌症的方法
US20190168213A1 (en) * 2017-11-10 2019-06-06 Reliant Immune Diagnostics, Inc. System and method for determining efficacy and dosage using parallel/serial dual microfluidic chip
CN116622801A (zh) * 2023-07-24 2023-08-22 安泰康生物技术(北京)有限公司 一种患者来源超微组织培养药物敏感性检测方法

Family Cites Families (44)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4423145A (en) * 1981-05-07 1983-12-27 Stampfer Martha R Enhanced growth medium and method for culturing human mammary epithelial cells
US4668618A (en) 1981-09-14 1987-05-26 Thornthwaite Jerry T Nuclear isolation medium and procedure for separating cell nuclei
US4559299A (en) 1983-02-04 1985-12-17 Brown University Research Foundation Inc. Cytotoxicity assays in cell culturing devices
US4937187A (en) * 1983-02-04 1990-06-26 Brown University Research Foundation Methods for separating malignant cells from clinical specimens
US4937182A (en) 1985-12-19 1990-06-26 Peralta Cancer Research Institute Method for predicting chemosensitivity of anti-cancer drugs
US4816395A (en) 1985-12-19 1989-03-28 Peralta Cancer Research Institute Method for predicting chemosensitivity of anti-cancer drugs
US5266480A (en) * 1986-04-18 1993-11-30 Advanced Tissue Sciences, Inc. Three-dimensional skin culture system
US4996145A (en) 1987-10-27 1991-02-26 Oncotech Incorporated Method for detecting immune-mediated cytotoxicity
US5258541A (en) * 1988-02-16 1993-11-02 Daicel Chemical Industries, Ltd. Process for producing carbonic acid ester
US5242806A (en) * 1990-05-07 1993-09-07 Baxter Diagnostics Inc. Method for conducting the cytotoxicity assays on tumor cells
US5874218A (en) 1990-06-11 1999-02-23 Nexstar Pharmaceuticals, Inc. Method for detecting a target compound in a substance using a nucleic acid ligand
US5747469A (en) 1991-03-06 1998-05-05 Board Of Regents, The University Of Texas System Methods and compositions comprising DNA damaging agents and p53
US5270172A (en) * 1991-04-26 1993-12-14 Dekk-Tek, Inc. Method to predict tumor response to therapy
US5407653A (en) 1991-06-26 1995-04-18 Brigham And Women's Hospital Evaluation of the multidrug resistance phenotype
CA2121129A1 (en) 1991-10-29 1993-05-13 Patrick Soon-Shiong Crosslinkable polysaccharides, polycations and lipids useful for encapsulation and drug release
WO1994000470A1 (en) 1992-06-30 1994-01-06 The Wistar Institute Of Anatomy And Biology DEVELOPMENTAL EMBRYONIC MOUSE cDNA LIBRARIES
US7166423B1 (en) * 1992-10-21 2007-01-23 Miltenyi Biotec Gmbh Direct selection of cells by secretion product
US5856112A (en) * 1994-06-16 1999-01-05 Urocor, Inc. Method for selectively inducing biomarker expression in urologic tumor tissue for diagnosis and treatment thereof
GB9419716D0 (en) 1994-09-30 1994-11-16 Gearey David Electrochemical assessment of cell behaviour and metabolic activity
US5607918A (en) 1995-03-01 1997-03-04 Ludwig Institute For Cancer Research Vascular endothelial growth factor-B and DNA coding therefor
US5888765A (en) 1995-06-23 1999-03-30 President And Fellows Of Harvard College Endothelial-cell specific promoter
US6274576B1 (en) 1995-06-27 2001-08-14 The Henry Jackson Foundation For The Advancement Of Military Medicine Method of dynamic retardation of cell cycle kinetics to potentiate cell damage
US6020473A (en) 1995-08-25 2000-02-01 Genentech, Inc. Nucleic acids encoding variants of vascular endothelial cell growth factor
US5942385A (en) 1996-03-21 1999-08-24 Sugen, Inc. Method for molecular diagnosis of tumor angiogenesis and metastasis
US20020168679A1 (en) 1998-06-11 2002-11-14 Gregory J. Naus Staining agents and protocols for characterizing malignant cells in culture
US20040023375A1 (en) * 2002-07-30 2004-02-05 Precision Therapeutics, Inc. Method for preparing cell cultures from biological specimens for chemotherapeutic and other assays
US6416967B2 (en) * 1996-07-12 2002-07-09 Precision Therapeutics, Inc. Method of using multicellular particulates to analyze malignant or hyperproliferative tissue
US5728541A (en) * 1996-07-12 1998-03-17 Precision Therapeutics, Inc. Method for preparing cell cultures from biologial specimens for chemotherapeutic and other assays
US20040072722A1 (en) * 2002-10-10 2004-04-15 Kornblith Paul L. Methods for assessing efficacy of chemotherapeutic agents
US6008007A (en) 1997-01-31 1999-12-28 Oncotech, Inc. Radiation resistance assay for predicting treatment response and clinical outcome
US5840507A (en) 1997-03-19 1998-11-24 Oncotech, Inc. Methods for cancer prognosis and diagnosis
US5972639A (en) 1997-07-24 1999-10-26 Irori Fluorescence-based assays for measuring cell proliferation
US6111092A (en) 1998-06-03 2000-08-29 Millennium Pharmaceuticals, Inc. Nucleic acid molecules encoding DRT111 and uses thereof
US6537759B1 (en) 1998-07-20 2003-03-25 Variagenics, Inc. Folylpolyglutamate synthetase gene sequence variances having utility in determining the treatment of disease
AU3316600A (en) 1999-02-22 2000-09-21 Torben F. Orntoft Gene expression in bladder tumors
WO2001033228A2 (en) 1999-11-03 2001-05-10 Oncotech, Inc. Cancer diagnosis employing cell-sorting and gene-profiles
AU2002224435A1 (en) 2000-10-18 2002-04-29 Precision Therapeutics, Inc. Method for tandem genomic/proteomic analyses of proliferating cells
US7244578B2 (en) * 2001-04-06 2007-07-17 Department Of Veterans Affairs Methods for modeling infectious disease and chemosensitivity in cultured cells and tissues
US20040086888A1 (en) 2001-10-18 2004-05-06 Kornblith Paul L Method for tandem genomic/proteomic analysis of proliferating cells
WO2003042366A2 (en) * 2001-11-13 2003-05-22 Albert Einstein College Of Medicine Of Yeshiva University A novel saitohin gene and uses of same
US6900017B2 (en) * 2002-01-10 2005-05-31 The Board Of Trustees Of The University Of Illinois Human hematopoietic growth regulatory gene and uses
JP4175215B2 (ja) * 2003-08-08 2008-11-05 日産自動車株式会社 バイポーラ電池、組電池、複合組電池、および組電池または複合組電池を用いた車両
CA2593648A1 (en) * 2005-01-10 2006-07-13 Research Development Foundation Targeted chimeric molecules for cancer therapy
EP1929306A4 (de) * 2005-09-01 2009-11-11 Precision Therapeutics Inc Chemosensible assays, die tumorzellen mit persistenten phänotypischen merkmalen

Also Published As

Publication number Publication date
US8183009B2 (en) 2012-05-22
AU3649397A (en) 1998-02-09
BR9710348A (pt) 2000-01-11
AU712302B2 (en) 1999-11-04
US8058025B2 (en) 2011-11-15
DE69737684T2 (de) 2008-01-31
US20100330613A1 (en) 2010-12-30
US20090042225A1 (en) 2009-02-12
US20080076146A1 (en) 2008-03-27
US20050202411A1 (en) 2005-09-15
US20090042221A1 (en) 2009-02-12
US7501260B2 (en) 2009-03-10
EP0912085B1 (de) 2007-05-02
WO1998002038A1 (en) 1998-01-22
US7771963B2 (en) 2010-08-10
US7112415B2 (en) 2006-09-26
EP0912085A4 (de) 2002-07-03
US7563593B2 (en) 2009-07-21
US7314731B2 (en) 2008-01-01
US5728541A (en) 1998-03-17
ATE360989T1 (de) 2007-05-15
JP2002501609A (ja) 2002-01-15
US6900027B1 (en) 2005-05-31
US6887680B2 (en) 2005-05-03
CA2259984C (en) 2008-10-07
ES2283022T3 (es) 2007-10-16
US20020192638A1 (en) 2002-12-19
JP4108128B2 (ja) 2008-06-25
US20050202410A1 (en) 2005-09-15
CN1143618C (zh) 2004-03-31
DE69737684D1 (de) 2007-06-14
EP0912085A1 (de) 1999-05-06
US20100120070A1 (en) 2010-05-13
NZ333830A (en) 2002-12-20
US7678552B2 (en) 2010-03-16
US20070037136A1 (en) 2007-02-15
CA2259984A1 (en) 1998-01-22
US6933129B1 (en) 2005-08-23
CN1275885A (zh) 2000-12-06
IL127964A0 (en) 1999-11-30
US20120088264A1 (en) 2012-04-12

Similar Documents

Publication Publication Date Title
AU712302B2 (en) Precise efficacy assay methods for active agents including chemotherapeutic agents
US6416967B2 (en) Method of using multicellular particulates to analyze malignant or hyperproliferative tissue
US7972769B2 (en) Method for preparing cell cultures from biological specimens for chemotherapeutic and other assays
US20100216168A1 (en) Methods for evaluating angiogenic potential in culture
Er et al. Studying pre-formed fibril induced α-synuclein accumulation in primary embryonic mouse midbrain dopamine neurons
US20020168679A1 (en) Staining agents and protocols for characterizing malignant cells in culture
Fouda et al. A fluorescence-based lymphocyte assay suitable for high-throughput screening of small molecules
US6756194B2 (en) Control samples for use as standards for evaluating apoptosis in a selected tissue

Legal Events

Date Code Title Description
FF Patent granted
KB Patent renewed
KB Patent renewed
MM9K Patent not in force due to non-payment of renewal fees