BR9710348A - Métodos para testar a eficácia precisa de agentes ativos incluindo agentes quimioterapêuticos. - Google Patents

Métodos para testar a eficácia precisa de agentes ativos incluindo agentes quimioterapêuticos.

Info

Publication number
BR9710348A
BR9710348A BR9710348-9A BR9710348A BR9710348A BR 9710348 A BR9710348 A BR 9710348A BR 9710348 A BR9710348 A BR 9710348A BR 9710348 A BR9710348 A BR 9710348A
Authority
BR
Brazil
Prior art keywords
effectiveness
precise
test
methods
including chemotherapeutic
Prior art date
Application number
BR9710348-9A
Other languages
English (en)
Inventor
Paul L Kornblith
Original Assignee
Precision Therapheutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Precision Therapheutics Inc filed Critical Precision Therapheutics Inc
Publication of BR9710348A publication Critical patent/BR9710348A/pt

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Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5044—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving specific cell types
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5011—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing antineoplastic activity
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5014—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing toxicity
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/52—Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Molecular Biology (AREA)
  • Urology & Nephrology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Cell Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Toxicology (AREA)
  • Food Science & Technology (AREA)
  • Biochemistry (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Public Health (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Dermatology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)

Abstract

"MéTODO PARA PREPARAR UMA AMOSTRA DE TECIDOS CONTENDO CéLULAS MALIGNAS PARA BIOPSIA PARA TESTE DE QUIMIOSENSIBILIDADE". Um sistema aperfeiçoado para testar uma pluralidade de agentes terapêuticos ou quimioterapêuticos candidatos com relação à sua eficácia para um paciente específico, no qual uma amostra de tecido a partir do paciente é recolhida, mantida em uma cultura e separadamente exposta a uma pluralidade de tratamentos e/ou agentes terapêuticos para o próposito de objetivamente identificar o melhor tratamento ou agente para o paciente específico. Inovações de método específicas tais como as técnicas de preparação de amostra de tecido tornam este método tanto prática quanto teoricamente útil. Uma técnica de preparação de amostra de tecido particularmente importante é o preparo inicial de grupos coesos de partículas multicelulares da amostra de tecido, ao invés de suspensões ou preparações de células enzimaticamente dissociadas para o preparo de camadas únicas de cultura de tecido inicial. Pelo se submeter amostras uniformes de células a uma ampla variedade de agentes ativos (e concentrações dos mesmos), o agente e a concentração mais promissores para o tratamento de um paciente particular podem ser determinados.
BR9710348-9A 1996-07-12 1997-07-10 Métodos para testar a eficácia precisa de agentes ativos incluindo agentes quimioterapêuticos. BR9710348A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/679,056 US5728541A (en) 1996-07-12 1996-07-12 Method for preparing cell cultures from biologial specimens for chemotherapeutic and other assays
PCT/US1997/011595 WO1998002038A1 (en) 1996-07-12 1997-07-10 Precise efficacy assay methods for active agents including chemotherapeutic agents

Publications (1)

Publication Number Publication Date
BR9710348A true BR9710348A (pt) 2000-01-11

Family

ID=24725407

Family Applications (1)

Application Number Title Priority Date Filing Date
BR9710348-9A BR9710348A (pt) 1996-07-12 1997-07-10 Métodos para testar a eficácia precisa de agentes ativos incluindo agentes quimioterapêuticos.

Country Status (13)

Country Link
US (13) US5728541A (pt)
EP (1) EP0912085B1 (pt)
JP (1) JP4108128B2 (pt)
CN (1) CN1143618C (pt)
AT (1) ATE360989T1 (pt)
AU (1) AU712302B2 (pt)
BR (1) BR9710348A (pt)
CA (1) CA2259984C (pt)
DE (1) DE69737684T2 (pt)
ES (1) ES2283022T3 (pt)
IL (1) IL127964A (pt)
NZ (1) NZ333830A (pt)
WO (1) WO1998002038A1 (pt)

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US6933129B1 (en) 2005-08-23
EP0912085B1 (en) 2007-05-02
US8058025B2 (en) 2011-11-15
JP4108128B2 (ja) 2008-06-25
US20090042225A1 (en) 2009-02-12
IL127964A0 (en) 1999-11-30
US20100120070A1 (en) 2010-05-13
US20080076146A1 (en) 2008-03-27
ATE360989T1 (de) 2007-05-15
US20050202411A1 (en) 2005-09-15
US20100330613A1 (en) 2010-12-30
US20070037136A1 (en) 2007-02-15
AU3649397A (en) 1998-02-09
US20090042221A1 (en) 2009-02-12
EP0912085A1 (en) 1999-05-06
NZ333830A (en) 2002-12-20
WO1998002038A1 (en) 1998-01-22
CA2259984A1 (en) 1998-01-22
US5728541A (en) 1998-03-17
AU712302B2 (en) 1999-11-04
JP2002501609A (ja) 2002-01-15
US6900027B1 (en) 2005-05-31
US7112415B2 (en) 2006-09-26
US8183009B2 (en) 2012-05-22
CA2259984C (en) 2008-10-07
US20020192638A1 (en) 2002-12-19
IL127964A (en) 2001-07-24
CN1275885A (zh) 2000-12-06
EP0912085A4 (en) 2002-07-03
US7678552B2 (en) 2010-03-16
US7563593B2 (en) 2009-07-21
US7501260B2 (en) 2009-03-10
CN1143618C (zh) 2004-03-31
ES2283022T3 (es) 2007-10-16
US7314731B2 (en) 2008-01-01
DE69737684D1 (de) 2007-06-14
US20050202410A1 (en) 2005-09-15
US6887680B2 (en) 2005-05-03
US20120088264A1 (en) 2012-04-12
DE69737684T2 (de) 2008-01-31
US7771963B2 (en) 2010-08-10

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