IL127930A - שימוש ב- (r)- ורפמיל עבור ייצור של תרופה עבור טיפול באנגינה - Google Patents
שימוש ב- (r)- ורפמיל עבור ייצור של תרופה עבור טיפול באנגינהInfo
- Publication number
- IL127930A IL127930A IL12793097A IL12793097A IL127930A IL 127930 A IL127930 A IL 127930A IL 12793097 A IL12793097 A IL 12793097A IL 12793097 A IL12793097 A IL 12793097A IL 127930 A IL127930 A IL 127930A
- Authority
- IL
- Israel
- Prior art keywords
- verapamil
- angina
- treatment
- medicament
- manufacture
- Prior art date
Links
- 206010002383 Angina Pectoris Diseases 0.000 title claims abstract description 20
- SGTNSNPWRIOYBX-HHHXNRCGSA-N dexverapamil Chemical compound C1=C(OC)C(OC)=CC=C1CCN(C)CCC[C@@](C#N)(C(C)C)C1=CC=C(OC)C(OC)=C1 SGTNSNPWRIOYBX-HHHXNRCGSA-N 0.000 title claims abstract description 15
- 239000003814 drug Substances 0.000 title claims abstract description 7
- 238000004519 manufacturing process Methods 0.000 title claims abstract description 5
- 150000003839 salts Chemical class 0.000 claims abstract description 3
- 229960001722 verapamil Drugs 0.000 description 18
- SGTNSNPWRIOYBX-UHFFFAOYSA-N 2-(3,4-dimethoxyphenyl)-5-{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino}-2-(propan-2-yl)pentanenitrile Chemical compound C1=C(OC)C(OC)=CC=C1CCN(C)CCCC(C#N)(C(C)C)C1=CC=C(OC)C(OC)=C1 SGTNSNPWRIOYBX-UHFFFAOYSA-N 0.000 description 14
- SGTNSNPWRIOYBX-MHZLTWQESA-N (S)-verapamil Chemical compound C1=C(OC)C(OC)=CC=C1CCN(C)CCC[C@](C#N)(C(C)C)C1=CC=C(OC)C(OC)=C1 SGTNSNPWRIOYBX-MHZLTWQESA-N 0.000 description 6
- HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 description 6
- 238000001990 intravenous administration Methods 0.000 description 5
- 230000000304 vasodilatating effect Effects 0.000 description 5
- 230000001848 cardiodepressant effect Effects 0.000 description 4
- 238000001802 infusion Methods 0.000 description 4
- 238000002347 injection Methods 0.000 description 4
- 239000007924 injection Substances 0.000 description 4
- 230000036515 potency Effects 0.000 description 4
- 230000002861 ventricular Effects 0.000 description 4
- 210000004351 coronary vessel Anatomy 0.000 description 3
- 230000000694 effects Effects 0.000 description 3
- 208000028867 ischemia Diseases 0.000 description 3
- 230000001225 therapeutic effect Effects 0.000 description 3
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 2
- 230000003257 anti-anginal effect Effects 0.000 description 2
- 239000003218 coronary vasodilator agent Substances 0.000 description 2
- 229940079593 drug Drugs 0.000 description 2
- 238000009472 formulation Methods 0.000 description 2
- 230000000302 ischemic effect Effects 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- 230000002107 myocardial effect Effects 0.000 description 2
- 208000031225 myocardial ischemia Diseases 0.000 description 2
- 230000036284 oxygen consumption Effects 0.000 description 2
- 230000009467 reduction Effects 0.000 description 2
- 239000011780 sodium chloride Substances 0.000 description 2
- 241000282472 Canis lupus familiaris Species 0.000 description 1
- 206010019280 Heart failures Diseases 0.000 description 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 1
- 230000004913 activation Effects 0.000 description 1
- 206010000891 acute myocardial infarction Diseases 0.000 description 1
- 230000002411 adverse Effects 0.000 description 1
- 230000004071 biological effect Effects 0.000 description 1
- 230000017531 blood circulation Effects 0.000 description 1
- 230000036772 blood pressure Effects 0.000 description 1
- 230000037396 body weight Effects 0.000 description 1
- 230000002057 chronotropic effect Effects 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 208000029078 coronary artery disease Diseases 0.000 description 1
- 210000003748 coronary sinus Anatomy 0.000 description 1
- 230000002526 effect on cardiovascular system Effects 0.000 description 1
- 230000001077 hypotensive effect Effects 0.000 description 1
- 230000000297 inotrophic effect Effects 0.000 description 1
- 210000004185 liver Anatomy 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- HYIMSNHJOBLJNT-UHFFFAOYSA-N nifedipine Chemical compound COC(=O)C1=C(C)NC(C)=C(C(=O)OC)C1C1=CC=CC=C1[N+]([O-])=O HYIMSNHJOBLJNT-UHFFFAOYSA-N 0.000 description 1
- 229960001597 nifedipine Drugs 0.000 description 1
- 230000002093 peripheral effect Effects 0.000 description 1
- 230000003285 pharmacodynamic effect Effects 0.000 description 1
- 230000000144 pharmacologic effect Effects 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 238000011552 rat model Methods 0.000 description 1
- 238000013268 sustained release Methods 0.000 description 1
- 239000012730 sustained-release form Substances 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 230000000699 topical effect Effects 0.000 description 1
- 230000001052 transient effect Effects 0.000 description 1
- 230000024883 vasodilation Effects 0.000 description 1
- 230000002551 venodilator Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/075—Ethers or acetals
- A61K31/085—Ethers or acetals having an ether linkage to aromatic ring nuclear carbon
- A61K31/09—Ethers or acetals having an ether linkage to aromatic ring nuclear carbon having two or more such linkages
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/275—Nitriles; Isonitriles
- A61K31/277—Nitriles; Isonitriles having a ring, e.g. verapamil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Cardiology (AREA)
- Epidemiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Hospice & Palliative Care (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9616549.3A GB9616549D0 (en) | 1996-08-06 | 1996-08-06 | Therapeutic product and its use |
| PCT/GB1997/002095 WO1998005322A1 (en) | 1996-08-06 | 1997-08-06 | Verapamil as a medicament for the treatment of angina |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IL127930A0 IL127930A0 (en) | 1999-11-30 |
| IL127930A true IL127930A (he) | 2001-08-08 |
Family
ID=10798127
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL12793097A IL127930A (he) | 1996-08-06 | 1997-08-06 | שימוש ב- (r)- ורפמיל עבור ייצור של תרופה עבור טיפול באנגינה |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US5889060A (he) |
| EP (1) | EP0942719B1 (he) |
| JP (1) | JP2000515540A (he) |
| KR (1) | KR20000029768A (he) |
| AT (1) | ATE214923T1 (he) |
| AU (1) | AU721955B2 (he) |
| BR (1) | BR9711960A (he) |
| CA (1) | CA2260786A1 (he) |
| DE (1) | DE69711422T2 (he) |
| ES (1) | ES2174272T3 (he) |
| GB (1) | GB9616549D0 (he) |
| IL (1) | IL127930A (he) |
| PL (1) | PL331350A1 (he) |
| WO (1) | WO1998005322A1 (he) |
| ZA (1) | ZA977004B (he) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20030092765A1 (en) | 2001-11-15 | 2003-05-15 | John Kelly | Treatment of abnormal increases in gastrointestinal motility with (R)-verapamil |
| MX2009000923A (es) * | 2006-08-04 | 2009-03-09 | Agi Therapeutics Res Ltd | Metodos para tratar cuando menos una condicion que tiene receptor de mt1, receptor de 5ht2b, y actividad de canal de calcio tipo l. |
| WO2017198177A1 (en) * | 2016-05-20 | 2017-11-23 | Center Laboratories, Inc. | Method of treating hyperglycemia |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE4203547A1 (de) * | 1992-02-07 | 1993-08-12 | Knoll Ag | Verfahren zur racemattrennung von verapamil |
| GB9319918D0 (en) * | 1993-09-27 | 1993-11-10 | Chiros Ltd | Chiral compounds and their preparation |
| AU3778497A (en) * | 1996-08-06 | 1998-02-25 | Darwin Discovery Limited | Therapeutic utilities of verapamil enantiomers |
-
1996
- 1996-08-06 GB GBGB9616549.3A patent/GB9616549D0/en active Pending
-
1997
- 1997-08-06 EP EP97934643A patent/EP0942719B1/en not_active Expired - Lifetime
- 1997-08-06 AU AU37785/97A patent/AU721955B2/en not_active Ceased
- 1997-08-06 US US08/907,152 patent/US5889060A/en not_active Expired - Fee Related
- 1997-08-06 PL PL97331350A patent/PL331350A1/xx unknown
- 1997-08-06 BR BR9711960A patent/BR9711960A/pt not_active Application Discontinuation
- 1997-08-06 CA CA002260786A patent/CA2260786A1/en not_active Abandoned
- 1997-08-06 AT AT97934643T patent/ATE214923T1/de not_active IP Right Cessation
- 1997-08-06 ZA ZA977004A patent/ZA977004B/xx unknown
- 1997-08-06 DE DE69711422T patent/DE69711422T2/de not_active Expired - Fee Related
- 1997-08-06 JP JP10507727A patent/JP2000515540A/ja active Pending
- 1997-08-06 KR KR1019997000883A patent/KR20000029768A/ko not_active Withdrawn
- 1997-08-06 WO PCT/GB1997/002095 patent/WO1998005322A1/en not_active Ceased
- 1997-08-06 IL IL12793097A patent/IL127930A/he not_active IP Right Cessation
- 1997-08-06 ES ES97934643T patent/ES2174272T3/es not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| AU3778597A (en) | 1998-02-25 |
| ATE214923T1 (de) | 2002-04-15 |
| AU721955B2 (en) | 2000-07-20 |
| ZA977004B (en) | 1998-08-06 |
| CA2260786A1 (en) | 1998-02-12 |
| PL331350A1 (en) | 1999-07-05 |
| JP2000515540A (ja) | 2000-11-21 |
| IL127930A0 (en) | 1999-11-30 |
| EP0942719A1 (en) | 1999-09-22 |
| WO1998005322A1 (en) | 1998-02-12 |
| ES2174272T3 (es) | 2002-11-01 |
| BR9711960A (pt) | 1999-08-24 |
| DE69711422T2 (de) | 2002-10-31 |
| DE69711422D1 (de) | 2002-05-02 |
| KR20000029768A (ko) | 2000-05-25 |
| EP0942719B1 (en) | 2002-03-27 |
| GB9616549D0 (en) | 1996-09-25 |
| US5889060A (en) | 1999-03-30 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FF | Patent granted | ||
| MM9K | Patent not in force due to non-payment of renewal fees |