IL127784A - תולדות תיאזול, הכנתן ותכשירי רוקחות המכילים אותן - Google Patents
תולדות תיאזול, הכנתן ותכשירי רוקחות המכילים אותןInfo
- Publication number
- IL127784A IL127784A IL12778498A IL12778498A IL127784A IL 127784 A IL127784 A IL 127784A IL 12778498 A IL12778498 A IL 12778498A IL 12778498 A IL12778498 A IL 12778498A IL 127784 A IL127784 A IL 127784A
- Authority
- IL
- Israel
- Prior art keywords
- compounds
- carbonyl
- thiazole
- guanidino
- ylmethoxy
- Prior art date
Links
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- BRNULMACUQOKMR-UHFFFAOYSA-N thiomorpholine Chemical compound C1CSCCN1 BRNULMACUQOKMR-UHFFFAOYSA-N 0.000 description 1
- 125000004568 thiomorpholinyl group Chemical group 0.000 description 1
- 229960002898 threonine Drugs 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- JOXIMZWYDAKGHI-UHFFFAOYSA-N toluene-4-sulfonic acid Chemical compound CC1=CC=C(S(O)(=O)=O)C=C1 JOXIMZWYDAKGHI-UHFFFAOYSA-N 0.000 description 1
- 210000004881 tumor cell Anatomy 0.000 description 1
- 239000000080 wetting agent Substances 0.000 description 1
- JPZXHKDZASGCLU-LBPRGKRZSA-N β-(2-naphthyl)-alanine Chemical compound C1=CC=CC2=CC(C[C@H](N)C(O)=O)=CC=C21 JPZXHKDZASGCLU-LBPRGKRZSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P13/12—Drugs for disorders of the urinary system of the kidneys
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P17/06—Antipsoriatics
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
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- A—HUMAN NECESSITIES
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- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P27/02—Ophthalmic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/02—Nutrients, e.g. vitamins, minerals
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P35/04—Antineoplastic agents specific for metastasis
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/38—Nitrogen atoms
- C07D277/44—Acylated amino or imino radicals
- C07D277/48—Acylated amino or imino radicals by radicals derived from carbonic acid, or sulfur or nitrogen analogues thereof, e.g. carbonylguanidines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Physical Education & Sports Medicine (AREA)
- Rheumatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Oncology (AREA)
- Hematology (AREA)
- Communicable Diseases (AREA)
- Diabetes (AREA)
- Urology & Nephrology (AREA)
- Dermatology (AREA)
- Nutrition Science (AREA)
- Obesity (AREA)
- Virology (AREA)
- Cardiology (AREA)
- Immunology (AREA)
- Ophthalmology & Optometry (AREA)
- Heart & Thoracic Surgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Thiazole And Isothizaole Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP98100007 | 1998-01-02 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IL127784A0 IL127784A0 (en) | 1999-10-28 |
| IL127784A true IL127784A (he) | 2001-09-13 |
Family
ID=8231230
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL12778498A IL127784A (he) | 1998-01-02 | 1998-12-29 | תולדות תיאזול, הכנתן ותכשירי רוקחות המכילים אותן |
Country Status (28)
| Country | Link |
|---|---|
| US (1) | US6001855A (he) |
| JP (1) | JP3154982B2 (he) |
| KR (1) | KR100312900B1 (he) |
| CN (1) | CN1098849C (he) |
| AR (1) | AR014211A1 (he) |
| AT (1) | ATE217621T1 (he) |
| AU (1) | AU718659B2 (he) |
| BR (1) | BR9805750A (he) |
| CA (1) | CA2257322C (he) |
| CO (1) | CO4990935A1 (he) |
| DE (1) | DE69805392T2 (he) |
| DK (1) | DK0928793T3 (he) |
| ES (1) | ES2176895T3 (he) |
| HR (1) | HRP980644B1 (he) |
| HU (1) | HUP9803041A3 (he) |
| ID (1) | ID21878A (he) |
| IL (1) | IL127784A (he) |
| MA (1) | MA26590A1 (he) |
| NO (1) | NO312134B1 (he) |
| PE (1) | PE20000116A1 (he) |
| PL (1) | PL330620A1 (he) |
| PT (1) | PT928793E (he) |
| RU (1) | RU2166503C2 (he) |
| SG (1) | SG72911A1 (he) |
| TR (1) | TR199802766A3 (he) |
| UY (1) | UY25335A1 (he) |
| YU (1) | YU60998A (he) |
| ZA (1) | ZA9811923B (he) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL142090A0 (en) | 1998-10-22 | 2002-03-10 | Hoffmann La Roche | Thiazole derivatives |
| JP4517454B2 (ja) * | 2000-06-01 | 2010-08-04 | 宇部興産株式会社 | ４−（１−フルオロエチル）チアゾール−５−カルボン酸アミド誘導体及び農園芸用の有害生物防除剤 |
| US6420566B2 (en) * | 2000-06-09 | 2002-07-16 | Aventis Pharma S.A. | Pharmaceutical compositions containing a 4, 5-dihydro-1, 3-thiazol-2-ylamine derivative, novel derivatives and preparation thereof |
| US6451821B1 (en) * | 2000-06-09 | 2002-09-17 | Aventis Pharma S.A. | Use of 2-aminothiazoline derivatives as inhibitors of inducible no-synthase |
| MX2018006729A (es) * | 2015-12-04 | 2018-11-09 | Janssen Biotech Inc | Tratamiento de la degeneracion de la retina mediante el uso de celulas progenitoras. |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2138803B (en) * | 1983-04-26 | 1986-06-18 | Shionogi & Co | 2-guanidino-4-hydroxymethylthiazole and derivatives thereof |
| GB8714920D0 (en) * | 1987-06-25 | 1987-07-29 | Shell Int Research | Thiazole derivatives |
| IL95548A0 (en) * | 1989-09-15 | 1991-06-30 | Fujisawa Pharmaceutical Co | Thiazole derivatives,processes for the preparation thereof and pharmaceutical composition containing the same |
| TW201303B (he) * | 1990-07-05 | 1993-03-01 | Hoffmann La Roche | |
| JPH0867676A (ja) * | 1994-03-30 | 1996-03-12 | Eisai Kagaku Kk | 保護アミノチアゾリル酢酸誘導体 |
| MX9801716A (es) * | 1995-08-30 | 1998-05-31 | Searle & Co | Derivados de meta-guanidina, urea, tiourea o acido aminobenzoico azaciclico, como antagonistas de integrina. |
| EP0880511A4 (en) * | 1996-01-16 | 1999-06-16 | Merck & Co Inc | Integrin receptor antagonists |
| ATE244228T1 (de) * | 1997-02-13 | 2003-07-15 | Tokuyama Corp | Verfahren zur herstellung von chloroacetylaminothiazoleaceticsäure derivate |
| US6359134B1 (en) * | 1997-05-30 | 2002-03-19 | Takeda Chemical Industries, Ltd. | Sulfonamide derivatives, their production and use |
-
1998
- 1998-12-22 US US09/218,200 patent/US6001855A/en not_active Expired - Fee Related
- 1998-12-28 NO NO19986160A patent/NO312134B1/no unknown
- 1998-12-29 HR HR980644A patent/HRP980644B1/xx not_active IP Right Cessation
- 1998-12-29 AR ARP980106722A patent/AR014211A1/es not_active Application Discontinuation
- 1998-12-29 PE PE1998001292A patent/PE20000116A1/es not_active Application Discontinuation
- 1998-12-29 ZA ZA9811923A patent/ZA9811923B/xx unknown
- 1998-12-29 YU YU60998A patent/YU60998A/sh unknown
- 1998-12-29 IL IL12778498A patent/IL127784A/he not_active IP Right Cessation
- 1998-12-30 PL PL98330620A patent/PL330620A1/xx not_active Application Discontinuation
- 1998-12-30 ES ES98124819T patent/ES2176895T3/es not_active Expired - Lifetime
- 1998-12-30 AT AT98124819T patent/ATE217621T1/de not_active IP Right Cessation
- 1998-12-30 KR KR1019980061644A patent/KR100312900B1/ko not_active Expired - Fee Related
- 1998-12-30 CA CA002257322A patent/CA2257322C/en not_active Expired - Fee Related
- 1998-12-30 DE DE69805392T patent/DE69805392T2/de not_active Expired - Fee Related
- 1998-12-30 CO CO98077474A patent/CO4990935A1/es unknown
- 1998-12-30 HU HU9803041A patent/HUP9803041A3/hu unknown
- 1998-12-30 PT PT98124819T patent/PT928793E/pt unknown
- 1998-12-30 DK DK98124819T patent/DK0928793T3/da active
- 1998-12-30 SG SG1998005979A patent/SG72911A1/en unknown
- 1998-12-30 AU AU96145/98A patent/AU718659B2/en not_active Ceased
- 1998-12-30 MA MA25410A patent/MA26590A1/fr unknown
- 1998-12-30 TR TR1998/02766A patent/TR199802766A3/tr unknown
- 1998-12-31 UY UY25335A patent/UY25335A1/es not_active IP Right Cessation
- 1998-12-31 BR BR9805750-2A patent/BR9805750A/pt not_active Application Discontinuation
- 1998-12-31 CN CN98125981A patent/CN1098849C/zh not_active Expired - Fee Related
-
1999
- 1999-01-04 JP JP00020699A patent/JP3154982B2/ja not_active Expired - Fee Related
- 1999-01-04 ID IDP990002A patent/ID21878A/id unknown
- 1999-01-05 RU RU99100205/04A patent/RU2166503C2/ru not_active IP Right Cessation
Also Published As
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| KB | Patent renewed | ||
| MM9K | Patent not in force due to non-payment of renewal fees |