IL125578A - N-Methyl - N - 4 - (4 (H1 - Benzimidazole-2 - Eyal - Amino) Pipridine - 1 - Eyal) 2 - (Aryl) Butyl benzamides and pharmaceutical preparations useful for the treatment of allergic diseases - Google Patents

N-Methyl - N - 4 - (4 (H1 - Benzimidazole-2 - Eyal - Amino) Pipridine - 1 - Eyal) 2 - (Aryl) Butyl benzamides and pharmaceutical preparations useful for the treatment of allergic diseases

Info

Publication number
IL125578A
IL125578A IL12557897A IL12557897A IL125578A IL 125578 A IL125578 A IL 125578A IL 12557897 A IL12557897 A IL 12557897A IL 12557897 A IL12557897 A IL 12557897A IL 125578 A IL125578 A IL 125578A
Authority
IL
Israel
Prior art keywords
methyl
butyl
benzimidazol
amino
piperidin
Prior art date
Application number
IL12557897A
Other languages
English (en)
Hebrew (he)
Other versions
IL125578A0 (en
Original Assignee
Aventis Pharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/778,996 external-priority patent/US5922737A/en
Application filed by Aventis Pharma Inc filed Critical Aventis Pharma Inc
Publication of IL125578A0 publication Critical patent/IL125578A0/xx
Publication of IL125578A publication Critical patent/IL125578A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/16—Otologicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
IL12557897A 1996-02-21 1997-01-29 N-Methyl - N - 4 - (4 (H1 - Benzimidazole-2 - Eyal - Amino) Pipridine - 1 - Eyal) 2 - (Aryl) Butyl benzamides and pharmaceutical preparations useful for the treatment of allergic diseases IL125578A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US60421696A 1996-02-21 1996-02-21
US08/778,996 US5922737A (en) 1996-02-21 1997-01-06 Substituted N-methyl-N-(4-(4-(1H-Benzimidazol-2-YL-amino) piperidin-1-YL)-2-(arlyl) butyl) benzamides useful for the treatment of allergic diseases
PCT/US1997/001571 WO1997030989A1 (en) 1996-02-21 1997-01-29 Novel substituted n-methyl-n-(4-(4-(1h-benzimidazol-2-yl-amino)piperidin-1-yl)-2-(aryl)butyl)benzamides useful for the treatment of allergic diseases

Publications (2)

Publication Number Publication Date
IL125578A0 IL125578A0 (en) 1999-03-12
IL125578A true IL125578A (en) 2002-09-12

Family

ID=27084615

Family Applications (1)

Application Number Title Priority Date Filing Date
IL12557897A IL125578A (en) 1996-02-21 1997-01-29 N-Methyl - N - 4 - (4 (H1 - Benzimidazole-2 - Eyal - Amino) Pipridine - 1 - Eyal) 2 - (Aryl) Butyl benzamides and pharmaceutical preparations useful for the treatment of allergic diseases

Country Status (20)

Country Link
EP (1) EP0888336B1 (ko)
JP (1) JP2001504798A (ko)
KR (1) KR19990087131A (ko)
CN (1) CN1115341C (ko)
AR (1) AR005896A1 (ko)
AT (1) ATE221882T1 (ko)
AU (1) AU710488B2 (ko)
BR (1) BR9707652A (ko)
CA (1) CA2247105C (ko)
DE (1) DE69714579T2 (ko)
DK (1) DK0888336T3 (ko)
ES (1) ES2176687T3 (ko)
HK (1) HK1019734A1 (ko)
HU (1) HUP9901030A3 (ko)
IL (1) IL125578A (ko)
NO (1) NO983830L (ko)
NZ (1) NZ330908A (ko)
PT (1) PT888336E (ko)
TW (1) TW562804B (ko)
WO (1) WO1997030989A1 (ko)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6194406B1 (en) 1995-12-20 2001-02-27 Aventis Pharmaceuticals Inc. Substituted 4-(1H-benzimidazol-2-yl)[1,4]diazepanes useful for the treatment of allergic disease
US6423704B2 (en) 1995-12-20 2002-07-23 Aventis Pharmaceuticals Inc. Substituted 4-(1H-benzimidazol-2-yl)[1,4]diazepanes useful for the treatment of allergic diseases
GB0315203D0 (en) * 2003-06-28 2003-08-06 Celltech R&D Ltd Chemical compounds
BRPI0807972A2 (pt) 2007-01-24 2014-06-10 Glaxo Group Ltd Composições farmacêuticas compreendendo 3,5-diamino-6-(2,3-diclofenil)-l,2,4-triazina ou r(-)-2,4-diamino-5-(2,3-diclorofenil)-6-fluorometilpirim idina e uma nk1

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4219559A (en) * 1979-01-10 1980-08-26 Janssen Pharmaceutica N.V. N-Heterocyclyl-4-piperidinamines
FR2676054B1 (fr) * 1991-05-03 1993-09-03 Sanofi Elf Nouveaux composes n-alkylenepiperidino et leurs enantiomeres, procede pour leur preparation et compositions pharmaceutiques les contenant.
HU221434B (en) * 1994-08-25 2002-10-28 Merrell Pharma Inc Substituted piperidines, pharmaceutical compositions containing them and their use

Also Published As

Publication number Publication date
NO983830L (no) 1998-10-20
DE69714579D1 (de) 2002-09-12
DE69714579T2 (de) 2003-04-10
CN1115341C (zh) 2003-07-23
NO983830D0 (no) 1998-08-20
AU710488B2 (en) 1999-09-23
ES2176687T3 (es) 2002-12-01
AR005896A1 (es) 1999-07-21
JP2001504798A (ja) 2001-04-10
NZ330908A (en) 2001-04-27
HK1019734A1 (en) 2000-02-25
DK0888336T3 (da) 2002-12-02
KR19990087131A (ko) 1999-12-15
PT888336E (pt) 2002-12-31
CN1211246A (zh) 1999-03-17
EP0888336A1 (en) 1999-01-07
CA2247105A1 (en) 1997-08-28
AU2251997A (en) 1997-09-10
IL125578A0 (en) 1999-03-12
EP0888336B1 (en) 2002-08-07
WO1997030989A1 (en) 1997-08-28
HUP9901030A2 (hu) 1999-07-28
ATE221882T1 (de) 2002-08-15
HUP9901030A3 (en) 2002-01-28
TW562804B (en) 2003-11-21
CA2247105C (en) 2002-05-14
BR9707652A (pt) 1999-07-27

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Publication Publication Date Title
US6329392B1 (en) Substituted piperidines useful for the treatment of allergic diseases
US6423704B2 (en) Substituted 4-(1H-benzimidazol-2-yl)[1,4]diazepanes useful for the treatment of allergic diseases
US6194406B1 (en) Substituted 4-(1H-benzimidazol-2-yl)[1,4]diazepanes useful for the treatment of allergic disease
EP0920425B1 (en) Substituted 4-(1h-benzimidazol-2-yl-amino)piperidines useful for the treatment of allergic diseases
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US5998439A (en) Substituted N-methyl-N-(4-(piperidin-1-yl)-2-(aryl)butyl)benzamides useful for the treatment of allergic diseases
AU709215B2 (en) Novel substituted N-methyl-N-(4-(piperidin-1-yl)-2-(aryl)butyl)benzamides useful for the treatment of allergic diseases
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CA2247105C (en) Novel substituted n-methyl-n-(4-(4-(1h-benzimidazol-2-yl-amino)piperidin-1-yl)-2-(aryl)butyl)benzamides useful for the treatment of allergic di seases
US5922737A (en) Substituted N-methyl-N-(4-(4-(1H-Benzimidazol-2-YL-amino) piperidin-1-YL)-2-(arlyl) butyl) benzamides useful for the treatment of allergic diseases
US5932571A (en) Substituted N-methyl-N-(4-(4-(1H-benzimidazol-2-yl) {1,4}diazepan-1-yl)-2-(aryl) butyl) benzamides useful for the treatment of allergic diseases

Legal Events

Date Code Title Description
FF Patent granted
KB Patent renewed
MM9K Patent not in force due to non-payment of renewal fees