IL124396A - Substituted 4-(1h-benzimidazol-2yl-amino) piperidines and pharmaceutical compositions comprising them - Google Patents
Substituted 4-(1h-benzimidazol-2yl-amino) piperidines and pharmaceutical compositions comprising themInfo
- Publication number
- IL124396A IL124396A IL12439696A IL12439696A IL124396A IL 124396 A IL124396 A IL 124396A IL 12439696 A IL12439696 A IL 12439696A IL 12439696 A IL12439696 A IL 12439696A IL 124396 A IL124396 A IL 124396A
- Authority
- IL
- Israel
- Prior art keywords
- benzimidazol
- piperidines
- amino
- substituted
- pharmaceutical compositions
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/16—Otologicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Pulmonology (AREA)
- Toxicology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Hospice & Palliative Care (AREA)
- Otolaryngology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US56041995A | 1995-11-17 | 1995-11-17 | |
| US73450896A | 1996-10-17 | 1996-10-17 | |
| PCT/US1996/018001 WO1997019074A1 (en) | 1995-11-17 | 1996-11-07 | Substituted 4-(1h-benzimidazol-2-yl-amino)piperidines useful for the treatment of allergic diseases |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IL124396A0 IL124396A0 (en) | 1998-12-06 |
| IL124396A true IL124396A (en) | 2001-03-19 |
Family
ID=27072328
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL12439696A IL124396A (en) | 1995-11-17 | 1996-11-07 | Substituted 4-(1h-benzimidazol-2yl-amino) piperidines and pharmaceutical compositions comprising them |
Country Status (20)
| Country | Link |
|---|---|
| EP (1) | EP0920425B1 (no) |
| JP (1) | JPH11513991A (no) |
| KR (1) | KR19990067622A (no) |
| CN (1) | CN1098264C (no) |
| AT (1) | ATE232858T1 (no) |
| AU (1) | AU703701B2 (no) |
| CA (1) | CA2237971C (no) |
| DE (1) | DE69626321T2 (no) |
| DK (1) | DK0920425T3 (no) |
| ES (1) | ES2188801T3 (no) |
| HK (1) | HK1018065A1 (no) |
| HU (1) | HUP9900927A3 (no) |
| IL (1) | IL124396A (no) |
| MX (1) | MX9803815A (no) |
| NO (1) | NO982238L (no) |
| NZ (1) | NZ323543A (no) |
| PT (1) | PT920425E (no) |
| SI (1) | SI0920425T1 (no) |
| TW (1) | TW394771B (no) |
| WO (1) | WO1997019074A1 (no) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6423704B2 (en) | 1995-12-20 | 2002-07-23 | Aventis Pharmaceuticals Inc. | Substituted 4-(1H-benzimidazol-2-yl)[1,4]diazepanes useful for the treatment of allergic diseases |
| US6194406B1 (en) | 1995-12-20 | 2001-02-27 | Aventis Pharmaceuticals Inc. | Substituted 4-(1H-benzimidazol-2-yl)[1,4]diazepanes useful for the treatment of allergic disease |
| US5932571A (en) * | 1996-02-21 | 1999-08-03 | Hoechst Marion Roussel, Inc. | Substituted N-methyl-N-(4-(4-(1H-benzimidazol-2-yl) {1,4}diazepan-1-yl)-2-(aryl) butyl) benzamides useful for the treatment of allergic diseases |
| US5861417A (en) * | 1996-12-19 | 1999-01-19 | Hoechst Marion Roussel, Inc. | Heterocyclic substituted pyrrolidine amide derivatives |
| HUP0000315A3 (en) * | 1996-12-19 | 2002-01-28 | Aventis Pharmaceuticals Inc Br | Novel heterocyclic substituted pyrrolidine amide derivatives, process for producing them, pharmaceutical compositions containing them and their use |
| JP2002512614A (ja) * | 1997-03-26 | 2002-04-23 | セプラコア インコーポレーテッド | 化学的かつ熱的に安定なノルアステミゾール製剤 |
| US6713627B2 (en) | 1998-03-13 | 2004-03-30 | Aventis Pharmaceuticals Inc. | Processes for the preparation of (R)-α-(2,3-dimethoxyphenyl)-1-[2-(4-fluorophenyl)ethyl]-4-piperidinemethanol |
| PE20020507A1 (es) * | 2000-10-17 | 2002-06-25 | Schering Corp | Compuestos no-imidazoles como antagonistas del receptor histamina h3 |
| ATE529112T1 (de) * | 2002-04-18 | 2011-11-15 | Schering Corp | 1-(4-piperidinyl)benzimidazolone als histamin h3 antagonisten |
| JP5014983B2 (ja) | 2004-05-07 | 2012-08-29 | ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ | １１−ベータヒドロキシステロイドデヒドロゲナーゼ阻害剤としてのピロリジン−２−オン及びピペリジン−２−オン誘導体 |
| ATE397586T1 (de) | 2004-05-07 | 2008-06-15 | Janssen Pharmaceutica Nv | Adamantyl pyrrolidin-2-on-derivate als 11-beta hydroxysteroid dehydrogenas inhibitoren |
| EP1786774B1 (en) | 2004-08-30 | 2009-10-14 | Janssen Pharmaceutica N.V. | Tricyclic lactam derivatives as 11-beta hydroxysteroid dehydrogenase inhibitors |
| DE602005017159D1 (de) | 2004-08-30 | 2009-11-26 | Janssen Pharmaceutica Nv | Oxysteroid-dehydrogenase-inhibitoren |
| UA87328C2 (en) | 2004-08-30 | 2009-07-10 | Янссен Фармацевтика Н.В. | N-2 adamantanyl-2-phenoxy-acetamide derivatives as 11-beta hydroxysteroid dehydrogenase inhibitors |
| WO2008090114A1 (en) | 2007-01-24 | 2008-07-31 | Glaxo Group Limited | Pharmaceutical compositions comprising 2-methoxy-5- (5-trifluoromethyl-tetrazol-i-yl-benzyl) - (2s-phenyl-piperidin-3s-yl-) |
| EP3886854A4 (en) | 2018-11-30 | 2022-07-06 | Nuvation Bio Inc. | PYRROLE AND PYRAZOLE COMPOUNDS AND METHODS OF USE THERE |
| IL293481A (en) | 2019-12-06 | 2022-08-01 | Celgene Corp | Processes for the preparation of 2-(4-chlorophenyl)-n-((2-(2,6-dioxypyridin-3-yl)-1-oxoisoindolin-5-yl)methyl)-2,2-difluoroacetamide |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2676055B1 (fr) * | 1991-05-03 | 1993-09-03 | Sanofi Elf | Composes polycycliques amines et leurs enantiomeres, procede pour leur preparation et compositions pharmaceutiques les contenant. |
| FR2719311B1 (fr) * | 1994-03-18 | 1998-06-26 | Sanofi Sa | Composés antagonistes sélectifs du récepteur NK3 humain et leur utilisation comme médicaments et outils de diagnostic. |
| EP0777666B1 (en) * | 1994-08-25 | 1999-03-03 | Merrell Pharmaceuticals Inc. | Substituted piperidines useful for the treatment of allergic diseases |
| WO1996009094A1 (en) * | 1994-09-23 | 1996-03-28 | Tranås Rostfria AB | An arrangement for practising walking |
| CA2162786A1 (en) * | 1994-11-22 | 1996-05-23 | Philip Arthur Hipskind | Heterocyclic tachykinin receptor antagonists |
-
1996
- 1996-11-07 JP JP9519767A patent/JPH11513991A/ja not_active Abandoned
- 1996-11-07 WO PCT/US1996/018001 patent/WO1997019074A1/en not_active Application Discontinuation
- 1996-11-07 CN CN96198360A patent/CN1098264C/zh not_active Expired - Fee Related
- 1996-11-07 NZ NZ323543A patent/NZ323543A/xx unknown
- 1996-11-07 EP EP96941334A patent/EP0920425B1/en not_active Expired - Lifetime
- 1996-11-07 KR KR1019980703649A patent/KR19990067622A/ko active IP Right Grant
- 1996-11-07 SI SI9630597T patent/SI0920425T1/xx unknown
- 1996-11-07 HU HU9900927A patent/HUP9900927A3/hu unknown
- 1996-11-07 DE DE69626321T patent/DE69626321T2/de not_active Expired - Fee Related
- 1996-11-07 PT PT96941334T patent/PT920425E/pt unknown
- 1996-11-07 CA CA002237971A patent/CA2237971C/en not_active Expired - Fee Related
- 1996-11-07 ES ES96941334T patent/ES2188801T3/es not_active Expired - Lifetime
- 1996-11-07 AU AU10508/97A patent/AU703701B2/en not_active Ceased
- 1996-11-07 IL IL12439696A patent/IL124396A/xx not_active IP Right Cessation
- 1996-11-07 DK DK96941334T patent/DK0920425T3/da active
- 1996-11-07 AT AT96941334T patent/ATE232858T1/de not_active IP Right Cessation
- 1996-12-20 TW TW085115760A patent/TW394771B/zh not_active IP Right Cessation
-
1998
- 1998-05-13 MX MX9803815A patent/MX9803815A/es unknown
- 1998-05-15 NO NO982238A patent/NO982238L/no not_active Application Discontinuation
-
1999
- 1999-07-20 HK HK99103106A patent/HK1018065A1/xx not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| EP0920425A1 (en) | 1999-06-09 |
| HUP9900927A3 (en) | 2002-02-28 |
| NO982238L (no) | 1998-07-01 |
| DE69626321T2 (de) | 2003-08-14 |
| CN1098264C (zh) | 2003-01-08 |
| NZ323543A (en) | 1999-06-29 |
| AU1050897A (en) | 1997-06-11 |
| WO1997019074A1 (en) | 1997-05-29 |
| KR19990067622A (ko) | 1999-08-25 |
| DK0920425T3 (da) | 2003-05-26 |
| PT920425E (pt) | 2003-07-31 |
| DE69626321D1 (de) | 2003-03-27 |
| MX9803815A (es) | 1998-09-30 |
| CA2237971C (en) | 2002-01-22 |
| AU703701B2 (en) | 1999-04-01 |
| CN1202894A (zh) | 1998-12-23 |
| JPH11513991A (ja) | 1999-11-30 |
| ATE232858T1 (de) | 2003-03-15 |
| HUP9900927A2 (hu) | 2000-03-28 |
| IL124396A0 (en) | 1998-12-06 |
| NO982238D0 (no) | 1998-05-15 |
| TW394771B (en) | 2000-06-21 |
| HK1018065A1 (en) | 1999-12-10 |
| ES2188801T3 (es) | 2003-07-01 |
| SI0920425T1 (en) | 2003-08-31 |
| EP0920425B1 (en) | 2003-02-19 |
| CA2237971A1 (en) | 1997-05-29 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FF | Patent granted | ||
| KB | Patent renewed | ||
| KB | Patent renewed | ||
| MM9K | Patent not in force due to non-payment of renewal fees |